Q5T9C2 (F102A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM102A

Alternative name(s):
Early estrogen-induced gene 1 protein

Gene names

Name:	FAM102A
Synonyms:	C9orf132, EEIG1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in estrogen action. Ref.3
Induction	By 17-beta-estradiol but also by a group of natural and synthetic estrogens as well as by estrogenic environmental compounds. Repressed by the antiestrogen 4-hydroxy-tamoxifen.
Sequence similarities	Belongs to the FAM102 family.
Sequence caution	The sequence CAI12618.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T9C2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T9C2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     371-384: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Protein FAM102A		PRO_0000261634
Regions
	Compositional bias	157 – 268	112	Ser-rich
Amino acid modifications
	Modified residue	251	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	371 – 384	14	Missing in isoform 2.		VSP_021744

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: 330218BC18A0EA8C	FASTA	384	41,785
	10 20 30 40 50 60 MAFLMKKKKF KFQTTFTLEE LTAVPFVNGV LFCKVRLLDG GDFVSLSSRE EVQENCVRWR 70 80 90 100 110 120 KRFTFVCKMS ANPATGLLDP CVFRVSVRKE LKGGKAYSKL GFADLNLAEF AGSGSTVRCC 130 140 150 160 170 180 LLEGYDTKNT RQDNSILKVT IGMFLLSGDP CFKTPPSTAK SISIPGQDSS LQLTCKGGGT 190 200 210 220 230 240 SSGGSSTNSL TGSRPPKARP TILSSGLPEE PDQNLSSPEE VFHSGHSRNS SYASQQSKIS 250 260 270 280 290 300 GYSTEHSRSS SLSDLTHRRN TSTSSSASGG LGMTVEGPEG SEREHRPPEK PPRPPRPLHL 310 320 330 340 350 360 SDRSFRRKKD SVESHPTWVD DTRIDADAIV EKIVQSQDFT DGSNTEDSNL RLFVSRDGSA 370 380 TLSGIQLATR VSSGVYEPVV IESH
	Isoform 2 [UniParc]. Checksum: F7B3C15AF6E5C176	FASTA	370	40,301
	10 20 30 40 50 60 MAFLMKKKKF KFQTTFTLEE LTAVPFVNGV LFCKVRLLDG GDFVSLSSRE EVQENCVRWR 70 80 90 100 110 120 KRFTFVCKMS ANPATGLLDP CVFRVSVRKE LKGGKAYSKL GFADLNLAEF AGSGSTVRCC 130 140 150 160 170 180 LLEGYDTKNT RQDNSILKVT IGMFLLSGDP CFKTPPSTAK SISIPGQDSS LQLTCKGGGT 190 200 210 220 230 240 SSGGSSTNSL TGSRPPKARP TILSSGLPEE PDQNLSSPEE VFHSGHSRNS SYASQQSKIS 250 260 270 280 290 300 GYSTEHSRSS SLSDLTHRRN TSTSSSASGG LGMTVEGPEG SEREHRPPEK PPRPPRPLHL 310 320 330 340 350 360 SDRSFRRKKD SVESHPTWVD DTRIDADAIV EKIVQSQDFT DGSNTEDSNL RLFVSRDGSA 370 TLSGIQLATR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 177-384 (ISOFORM 2). Tissue: Spleen.
[3]	"Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1." Wang D.Y., Fulthorpe R., Liss S.N., Edwards E.A. Mol. Endocrinol. 18:402-411(2004) [PubMed: 14605097] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL157935 Genomic DNA. Translation: CAI12618.1. Different initiation. AK074108 mRNA. Translation: BAB84934.1.
IPI	IPI00411980. IPI00807610.
RefSeq	NP_001030331.1. NM_001035254.2.
UniGene	Hs.535972.
3D structure databases
ProteinModelPortal	Q5T9C2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5T9C2.
PTM databases
PhosphoSite	Q5T9C2.
Polymorphism databases
DMDM	118572304.
Proteomic databases
PRIDE	Q5T9C2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373095; ENSP00000362187; ENSG00000167106.
GeneID	399665.
KEGG	hsa:399665.
UCSC	uc004bsx.1. human.
Organism-specific databases
CTD	399665.
GeneCards	GC09M130702.
HGNC	HGNC:31419. FAM102A.
HPA	HPA036030.
MIM	610891. gene.
neXtProt	NX_Q5T9C2.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000011832.
HOGENOM	HBG446042.
HOVERGEN	HBG057729.
InParanoid	Q5T9C2.
OMA	FQTTFTL.
OrthoDB	EOG4D52Z1.
PhylomeDB	Q5T9C2.
Gene expression databases
ArrayExpress	Q5T9C2.
Bgee	Q5T9C2.
CleanEx	HS_FAM102A.
Genevestigator	Q5T9C2.
GermOnline	ENSG00000167106. Homo sapiens.
Family and domain databases
InterPro	IPR019448. Oestrogen-resp_Fam102A/B_N. [Graphical view]
Pfam	PF10358. Eeig1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	105469.
SOURCE	Search...

Entry information

Entry name

F102A_HUMAN

Accession

Primary (citable) accession number: Q5T9C2
Secondary accession number(s): Q8TEL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.