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Protein

Protein FAM102A

Gene

FAM102A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in estrogen action.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM102A
Alternative name(s):
Early estrogen-induced gene 1 protein
Gene namesi
Name:FAM102A
Synonyms:C9orf132, EEIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:31419. FAM102A.

Pathology & Biotechi

Organism-specific databases

DisGeNETi399665.
OpenTargetsiENSG00000167106.
PharmGKBiPA142671784.

Polymorphism and mutation databases

BioMutaiFAM102A.
DMDMi118572304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002616341 – 384Protein FAM102AAdd BLAST384

Proteomic databases

EPDiQ5T9C2.
MaxQBiQ5T9C2.
PaxDbiQ5T9C2.
PeptideAtlasiQ5T9C2.
PRIDEiQ5T9C2.

PTM databases

iPTMnetiQ5T9C2.
PhosphoSitePlusiQ5T9C2.

Expressioni

Inductioni

By 17-beta-estradiol but also by a group of natural and synthetic estrogens as well as by estrogenic environmental compounds. Repressed by the antiestrogen 4-hydroxy-tamoxifen.

Gene expression databases

BgeeiENSG00000167106.
CleanExiHS_FAM102A.
GenevisibleiQ5T9C2. HS.

Organism-specific databases

HPAiHPA036030.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ENKD1Q9H0I23EBI-10246318,EBI-744099
SH3GL1Q6FGM03EBI-10246318,EBI-10173690
SKAP1Q86WV13EBI-10246318,EBI-2477305

Protein-protein interaction databases

BioGridi134377. 5 interactors.
IntActiQ5T9C2. 5 interactors.
STRINGi9606.ENSP00000362187.

Structurei

3D structure databases

ProteinModelPortaliQ5T9C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 152NT-C2Sequence analysisAdd BLAST147

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 268Ser-richAdd BLAST112

Sequence similaritiesi

Belongs to the FAM102 family.Curated
Contains 1 NT-C2 domain.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IWVB. Eukaryota.
ENOG4110G47. LUCA.
GeneTreeiENSGT00390000011832.
HOGENOMiHOG000230902.
HOVERGENiHBG057729.
InParanoidiQ5T9C2.
OMAiLLDPCIC.
OrthoDBiEOG091G0RN5.
PhylomeDBiQ5T9C2.
TreeFamiTF320966.

Family and domain databases

InterProiIPR019448. NT-C2.
[Graphical view]
PfamiPF10358. NT-C2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T9C2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFLMKKKKF KFQTTFTLEE LTAVPFVNGV LFCKVRLLDG GDFVSLSSRE
60 70 80 90 100
EVQENCVRWR KRFTFVCKMS ANPATGLLDP CVFRVSVRKE LKGGKAYSKL
110 120 130 140 150
GFADLNLAEF AGSGSTVRCC LLEGYDTKNT RQDNSILKVT IGMFLLSGDP
160 170 180 190 200
CFKTPPSTAK SISIPGQDSS LQLTCKGGGT SSGGSSTNSL TGSRPPKARP
210 220 230 240 250
TILSSGLPEE PDQNLSSPEE VFHSGHSRNS SYASQQSKIS GYSTEHSRSS
260 270 280 290 300
SLSDLTHRRN TSTSSSASGG LGMTVEGPEG SEREHRPPEK PPRPPRPLHL
310 320 330 340 350
SDRSFRRKKD SVESHPTWVD DTRIDADAIV EKIVQSQDFT DGSNTEDSNL
360 370 380
RLFVSRDGSA TLSGIQLATR VSSGVYEPVV IESH
Length:384
Mass (Da):41,785
Last modified:November 28, 2006 - v2
Checksum:i330218BC18A0EA8C
GO
Isoform 2 (identifier: Q5T9C2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-384: Missing.

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):40,301
Checksum:iF7B3C15AF6E5C176
GO
Isoform 3 (identifier: Q5T9C2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Show »
Length:242
Mass (Da):25,893
Checksum:iBAF4393DEC3EA2EC
GO

Sequence cautioni

The sequence CAI12618 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0438571 – 142Missing in isoform 3. 1 PublicationAdd BLAST142
Alternative sequenceiVSP_021744371 – 384Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157935 Genomic DNA. Translation: CAI12618.1. Different initiation.
AL157935 Genomic DNA. Translation: CAM14149.1.
BC137087 mRNA. Translation: AAI37088.1.
BC137088 mRNA. Translation: AAI37089.1.
AK074108 mRNA. Translation: BAB84934.1.
CCDSiCCDS35150.1. [Q5T9C2-1]
CCDS6888.1. [Q5T9C2-3]
RefSeqiNP_001030331.1. NM_001035254.2. [Q5T9C2-1]
NP_976050.1. NM_203305.2. [Q5T9C2-3]
UniGeneiHs.535972.

Genome annotation databases

EnsembliENST00000373084; ENSP00000362176; ENSG00000167106. [Q5T9C2-3]
ENST00000373095; ENSP00000362187; ENSG00000167106. [Q5T9C2-1]
GeneIDi399665.
KEGGihsa:399665.
UCSCiuc004bsw.2. human. [Q5T9C2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157935 Genomic DNA. Translation: CAI12618.1. Different initiation.
AL157935 Genomic DNA. Translation: CAM14149.1.
BC137087 mRNA. Translation: AAI37088.1.
BC137088 mRNA. Translation: AAI37089.1.
AK074108 mRNA. Translation: BAB84934.1.
CCDSiCCDS35150.1. [Q5T9C2-1]
CCDS6888.1. [Q5T9C2-3]
RefSeqiNP_001030331.1. NM_001035254.2. [Q5T9C2-1]
NP_976050.1. NM_203305.2. [Q5T9C2-3]
UniGeneiHs.535972.

3D structure databases

ProteinModelPortaliQ5T9C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134377. 5 interactors.
IntActiQ5T9C2. 5 interactors.
STRINGi9606.ENSP00000362187.

PTM databases

iPTMnetiQ5T9C2.
PhosphoSitePlusiQ5T9C2.

Polymorphism and mutation databases

BioMutaiFAM102A.
DMDMi118572304.

Proteomic databases

EPDiQ5T9C2.
MaxQBiQ5T9C2.
PaxDbiQ5T9C2.
PeptideAtlasiQ5T9C2.
PRIDEiQ5T9C2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373084; ENSP00000362176; ENSG00000167106. [Q5T9C2-3]
ENST00000373095; ENSP00000362187; ENSG00000167106. [Q5T9C2-1]
GeneIDi399665.
KEGGihsa:399665.
UCSCiuc004bsw.2. human. [Q5T9C2-1]

Organism-specific databases

CTDi399665.
DisGeNETi399665.
GeneCardsiFAM102A.
HGNCiHGNC:31419. FAM102A.
HPAiHPA036030.
MIMi610891. gene.
neXtProtiNX_Q5T9C2.
OpenTargetsiENSG00000167106.
PharmGKBiPA142671784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWVB. Eukaryota.
ENOG4110G47. LUCA.
GeneTreeiENSGT00390000011832.
HOGENOMiHOG000230902.
HOVERGENiHBG057729.
InParanoidiQ5T9C2.
OMAiLLDPCIC.
OrthoDBiEOG091G0RN5.
PhylomeDBiQ5T9C2.
TreeFamiTF320966.

Miscellaneous databases

ChiTaRSiFAM102A. human.
GenomeRNAii399665.
PROiQ5T9C2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167106.
CleanExiHS_FAM102A.
GenevisibleiQ5T9C2. HS.

Family and domain databases

InterProiIPR019448. NT-C2.
[Graphical view]
PfamiPF10358. NT-C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF102A_HUMAN
AccessioniPrimary (citable) accession number: Q5T9C2
Secondary accession number(s): A2A329, Q8TEL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.