Q5T953 (IER5L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immediate early response gene 5-like protein

Gene names

Name:

IER5L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the IER family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T953-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T953-2)

The sequence of this isoform differs from the canonical sequence as follows:
     212-237: PGAAPPAAAASPPASPAPASSPGFYR → RSPPASAPASRTSARTRPRTRPTSQT
     238-404: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Immediate early response gene 5-like protein		PRO_0000334656
Regions
	Compositional bias	59 – 130	72	Gln-rich
	Compositional bias	138 – 230	93	Ala-rich
Natural variations
	Alternative sequence	212 – 237	26	PGAAP…PGFYR → RSPPASAPASRTSARTRPRT RPTSQT in isoform 2.		VSP_033726
	Alternative sequence	238 – 404	167	Missing in isoform 2.		VSP_033727
	Natural variant	105	1	P → S. Ref.3 Corresponds to variant rs184457 [ dbSNP | Ensembl ].		VAR_043450

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 72EF41BE313DEFB0	FASTA	404	42,109
	10 20 30 40 50 60 MECALDAQSL ISISLRKIHS SRTQRGGIKL HKNLLVSYVL RNARQLYLSE RYAELYRRQQ 70 80 90 100 110 120 QQQQQQPPHH QHQHLAYAAP GMPASAADFG PLQLGGGGDA EAREPAARHQ LHQLHQLHQL 130 140 150 160 170 180 HLQQQLHQHQ HPAPRGCAAA AAAGAPAGGA GALSELPGCA ALQPPHGAPH RGQPLEPLQP 190 200 210 220 230 240 GPAPLPLPLP PPAPAALCPR DPRAPAACSA PPGAAPPAAA ASPPASPAPA SSPGFYRGAY 250 260 270 280 290 300 PTPSDFGLHC SSQTTVLDLD THVVTTVENG YLHQDCCASA HCPCCGQGAP GPGLASAAGC 310 320 330 340 350 360 KRKYYPGQEE EEDDEEDAGG LGAEPPGGAP FAPCKRARFE DFCPDSSPDA SNISNLISIF 370 380 390 400 GSGFSGLVSR QPDSSEQPPP LNGQLCAKQA LASLGAWTRA IVAF
	Isoform 2 [UniParc]. Checksum: 36FF5C8F219B141B	FASTA	237	25,264
	10 20 30 40 50 60 MECALDAQSL ISISLRKIHS SRTQRGGIKL HKNLLVSYVL RNARQLYLSE RYAELYRRQQ 70 80 90 100 110 120 QQQQQQPPHH QHQHLAYAAP GMPASAADFG PLQLGGGGDA EAREPAARHQ LHQLHQLHQL 130 140 150 160 170 180 HLQQQLHQHQ HPAPRGCAAA AAAGAPAGGA GALSELPGCA ALQPPHGAPH RGQPLEPLQP 190 200 210 220 230 GPAPLPLPLP PPAPAALCPR DPRAPAACSA PRSPPASAPA SRTSARTRPR TRPTSQT

References

[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-105. Tissue: Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL158151 Genomic DNA. Translation: CAI12875.1. CH471090 Genomic DNA. Translation: EAW87886.1. BC064028 mRNA. Translation: AAH64028.1.
IPI	IPI00401073. IPI00892732.
RefSeq	NP_982258.2. NM_203434.2.
UniGene	Hs.529857.
3D structure databases
ProteinModelPortal	Q5T953.
ModBase	Search...
Polymorphism databases
DMDM	74745628.
Proteomic databases
PRIDE	Q5T953.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372491; ENSP00000361569; ENSG00000188483.
GeneID	389792.
KEGG	hsa:389792.
UCSC	uc010myt.1. human.
Organism-specific databases
CTD	389792.
GeneCards	GC09M131937.
HGNC	HGNC:23679. IER5L.
HPA	HPA021327.
neXtProt	NX_Q5T953.
PharmGKB	PA134879111.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG18947.
GeneTree	ENSGT00530000064009.
HOGENOM	HBG716493.
HOVERGEN	HBG107988.
InParanoid	Q5T953.
OMA	RNARQVY.
OrthoDB	EOG40P47J.
Gene expression databases
ArrayExpress	Q5T953.
Bgee	Q5T953.
CleanEx	HS_IER5L.
Genevestigator	Q5T953.
Family and domain databases
InterPro	IPR008653. IER. [Graphical view]
PANTHER	PTHR15895. IER. 1 hit.
Pfam	PF05760. IER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	103095.

Entry information

Entry name

IER5L_HUMAN

Accession

Primary (citable) accession number: Q5T953
Secondary accession number(s): Q6P3E2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.