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Protein

Immediate early response gene 5-like protein

Gene

IER5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate early response gene 5-like protein
Gene namesi
Name:IER5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23679. IER5L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879111.

Polymorphism and mutation databases

BioMutaiIER5L.
DMDMi74745628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Immediate early response gene 5-like proteinPRO_0000334656Add
BLAST

Proteomic databases

EPDiQ5T953.
MaxQBiQ5T953.
PaxDbiQ5T953.
PRIDEiQ5T953.

Expressioni

Gene expression databases

BgeeiQ5T953.
CleanExiHS_IER5L.
GenevisibleiQ5T953. HS.

Organism-specific databases

HPAiHPA021327.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361569.

Structurei

3D structure databases

ProteinModelPortaliQ5T953.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 13072Gln-richAdd
BLAST
Compositional biasi138 – 23093Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

eggNOGiENOG410J77W. Eukaryota.
ENOG410YHIY. LUCA.
GeneTreeiENSGT00730000111126.
HOGENOMiHOG000112999.
HOVERGENiHBG107988.
InParanoidiQ5T953.
OMAiARFEDFC.
OrthoDBiEOG7XH6R3.
PhylomeDBiQ5T953.
TreeFamiTF331376.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 2 hits.
PfamiPF05760. IER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T953-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MECALDAQSL ISISLRKIHS SRTQRGGIKL HKNLLVSYVL RNARQLYLSE
60 70 80 90 100
RYAELYRRQQ QQQQQQPPHH QHQHLAYAAP GMPASAADFG PLQLGGGGDA
110 120 130 140 150
EAREPAARHQ LHQLHQLHQL HLQQQLHQHQ HPAPRGCAAA AAAGAPAGGA
160 170 180 190 200
GALSELPGCA ALQPPHGAPH RGQPLEPLQP GPAPLPLPLP PPAPAALCPR
210 220 230 240 250
DPRAPAACSA PPGAAPPAAA ASPPASPAPA SSPGFYRGAY PTPSDFGLHC
260 270 280 290 300
SSQTTVLDLD THVVTTVENG YLHQDCCASA HCPCCGQGAP GPGLASAAGC
310 320 330 340 350
KRKYYPGQEE EEDDEEDAGG LGAEPPGGAP FAPCKRARFE DFCPDSSPDA
360 370 380 390 400
SNISNLISIF GSGFSGLVSR QPDSSEQPPP LNGQLCAKQA LASLGAWTRA

IVAF
Length:404
Mass (Da):42,109
Last modified:December 21, 2004 - v1
Checksum:i72EF41BE313DEFB0
GO
Isoform 2 (identifier: Q5T953-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-237: PGAAPPAAAASPPASPAPASSPGFYR → RSPPASAPASRTSARTRPRTRPTSQT
     238-404: Missing.

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):25,264
Checksum:i36FF5C8F219B141B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti105 – 1051P → S.1 Publication
Corresponds to variant rs184457 [ dbSNP | Ensembl ].
VAR_043450

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei212 – 23726PGAAP…PGFYR → RSPPASAPASRTSARTRPRT RPTSQT in isoform 2. CuratedVSP_033726Add
BLAST
Alternative sequencei238 – 404167Missing in isoform 2. CuratedVSP_033727Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158151 Genomic DNA. Translation: CAI12875.1.
CH471090 Genomic DNA. Translation: EAW87886.1.
BC064028 mRNA. Translation: AAH64028.1.
CCDSiCCDS43888.1. [Q5T953-1]
RefSeqiNP_982258.2. NM_203434.2. [Q5T953-1]
UniGeneiHs.529857.

Genome annotation databases

EnsembliENST00000372491; ENSP00000361569; ENSG00000188483. [Q5T953-1]
GeneIDi389792.
KEGGihsa:389792.
UCSCiuc010myt.2. human. [Q5T953-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158151 Genomic DNA. Translation: CAI12875.1.
CH471090 Genomic DNA. Translation: EAW87886.1.
BC064028 mRNA. Translation: AAH64028.1.
CCDSiCCDS43888.1. [Q5T953-1]
RefSeqiNP_982258.2. NM_203434.2. [Q5T953-1]
UniGeneiHs.529857.

3D structure databases

ProteinModelPortaliQ5T953.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361569.

Polymorphism and mutation databases

BioMutaiIER5L.
DMDMi74745628.

Proteomic databases

EPDiQ5T953.
MaxQBiQ5T953.
PaxDbiQ5T953.
PRIDEiQ5T953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372491; ENSP00000361569; ENSG00000188483. [Q5T953-1]
GeneIDi389792.
KEGGihsa:389792.
UCSCiuc010myt.2. human. [Q5T953-1]

Organism-specific databases

CTDi389792.
GeneCardsiIER5L.
HGNCiHGNC:23679. IER5L.
HPAiHPA021327.
neXtProtiNX_Q5T953.
PharmGKBiPA134879111.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J77W. Eukaryota.
ENOG410YHIY. LUCA.
GeneTreeiENSGT00730000111126.
HOGENOMiHOG000112999.
HOVERGENiHBG107988.
InParanoidiQ5T953.
OMAiARFEDFC.
OrthoDBiEOG7XH6R3.
PhylomeDBiQ5T953.
TreeFamiTF331376.

Miscellaneous databases

ChiTaRSiIER5L. human.
GenomeRNAii389792.
PROiQ5T953.

Gene expression databases

BgeeiQ5T953.
CleanExiHS_IER5L.
GenevisibleiQ5T953. HS.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 2 hits.
PfamiPF05760. IER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-105.
    Tissue: Uterus.

Entry informationi

Entry nameiIER5L_HUMAN
AccessioniPrimary (citable) accession number: Q5T953
Secondary accession number(s): Q6P3E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.