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Protein

Serine/threonine-protein phosphatase 2A activator

Gene

PTPA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, RotamaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A activatorUniRule annotation (EC:5.2.1.8UniRule annotation)
Alternative name(s):
Phosphotyrosyl phosphatase activatorUniRule annotation
Gene namesi
Name:PTPAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:9308. PTPA.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119383.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ5T948.
PRIDEiQ5T948.

Expressioni

Gene expression databases

BgeeiENSG00000119383.
ExpressionAtlasiQ5T948. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPA-type PPIase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000011500.
HOGENOMiHOG000205736.
HOVERGENiHBG019168.

Family and domain databases

InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 2 hits.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5T948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGERQPPP DSSEEAPPAT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG
60 70 80 90 100
FILTLNEGVK GKKLTFEYRV SEMWNEVHEE KEQAAKQSVS CDECIPLPRA
110 120 130 140 150
GHCAPSEAIE KLVALLNTLD RWIDETPPVD QPSRFGNKAY RTWYAKLDEE
160 170 180 190 200
AENLVATVVP THLAAAVPEV AVYLKESVGN STRIDYGTGH EAAFAAFLCC
210 220 230 240 250
LCKIGVLRVD DQIAIVFKVF NRYLEVMRKL QKTYRMEPAG SQGVWGLDDF

QFL
Length:253
Mass (Da):28,483
Last modified:October 5, 2016 - v8
Checksum:iC86A8AD1D9117142
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei253Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158151 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000445241; ENSP00000406997; ENSG00000119383.
UCSCiuc064wjq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158151 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ5T948.
PRIDEiQ5T948.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445241; ENSP00000406997; ENSG00000119383.
UCSCiuc064wjq.1. human.

Organism-specific databases

HGNCiHGNC:9308. PTPA.
OpenTargetsiENSG00000119383.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000011500.
HOGENOMiHOG000205736.
HOVERGENiHBG019168.

Miscellaneous databases

ChiTaRSiPPP2R4. human.

Gene expression databases

BgeeiENSG00000119383.
ExpressionAtlasiQ5T948. baseline and differential.

Family and domain databases

InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 2 hits.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5T948_HUMAN
AccessioniPrimary (citable) accession number: Q5T948
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: October 5, 2016
Last modified: November 2, 2016
This is version 81 of the entry and version 8 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.