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Protein

Serine/threonine-protein phosphatase 2A activator

Gene

PTPA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase, RotamaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A activatorUniRule annotation (EC:5.2.1.8UniRule annotation)
Alternative name(s):
Phosphotyrosyl phosphatase activatorUniRule annotation
Gene namesi
Name:PTPAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000119383.19
HGNCiHGNC:9308 PTPA

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119383

PTM / Processingi

Proteomic databases

PeptideAtlasiQ5T948
PRIDEiQ5T948

Expressioni

Gene expression databases

BgeeiENSG00000119383
ExpressionAtlasiQ5T948 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5T948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPA-type PPIase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000011500
HOGENOMiHOG000205736
HOVERGENiHBG019168

Family and domain databases

InterProiView protein in InterPro
IPR004327 Phstyr_phstse_ac
IPR037218 PTPA_sf
PANTHERiPTHR10012 PTHR10012, 1 hit
PfamiView protein in Pfam
PF03095 PTPA, 1 hit
PIRSFiPIRSF016325 Phstyr_phstse_ac, 1 hit
SUPFAMiSSF140984 SSF140984, 2 hits

Sequencei

Sequence statusi: Fragment.

Q5T948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGERQPPP DSSEEAPPAT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG
60 70 80 90 100
FILTLNEGVK GKKLTFEYRV SEMWNEVHEE KEQAAKQSVS CDECIPLPRA
110 120 130 140 150
GHCAPSEAIE KLVALLNTLD RWIDETPPVD QPSRFGNKAY RTWYAKLDEE
160 170 180 190 200
AENLVATVVP THLAAAVPEV AVYLKESVGN STRIDYGTGH EAAFAAFLCC
210 220 230 240 250
LCKIGVLRVD DQIAIVFKVF NRYLEVMRKL QKTYRMEPAG SQGVWGLDDF

QFL
Length:253
Mass (Da):28,483
Last modified:October 5, 2016 - v8
Checksum:iC86A8AD1D9117142
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei253Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158151 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000445241; ENSP00000406997; ENSG00000119383
UCSCiuc064wjq.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5T948_HUMAN
AccessioniPrimary (citable) accession number: Q5T948
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: October 5, 2016
Last modified: May 23, 2018
This is version 89 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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