ID   Q5T8U3_HUMAN            Unreviewed;       191 AA.
AC   Q5T8U3;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   21-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 128.
DE   RecName: Full=60S ribosomal protein L7a {ECO:0000256|RuleBase:RU367042};
DE   Flags: Fragment;
GN   Name=RPL7A {ECO:0000313|EMBL:CAI12833.1,
GN   ECO:0000313|Ensembl:ENSP00000416638.1};
GN   ORFNames=RP11-244N20.10-004 {ECO:0000313|EMBL:CAI12833.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAI12833.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000416638.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0007829|PubMed:19608861}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA   Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [3] {ECO:0000313|EMBL:CAI12833.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Clark G.;
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [5] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [6] {ECO:0007829|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [7] {ECO:0007829|PubMed:28112733}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-modification
RT   with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
RN   [8] {ECO:0000313|Ensembl:ENSP00000416638.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the ribosome. {ECO:0000256|RuleBase:RU367042}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC       {ECO:0000256|ARBA:ARBA00007337, ECO:0000256|RuleBase:RU367042}.
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DR   EMBL; AL593848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL772161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL158826; CAI12833.1; -; Genomic_DNA.
DR   ProteomicsDB; 64759; -.
DR   Antibodypedia; 31830; 178 antibodies from 28 providers.
DR   Ensembl; ENST00000426651.1; ENSP00000416638.1; ENSG00000148303.17.
DR   UCSC; uc064wun.1; human.
DR   HGNC; HGNC:10364; RPL7A.
DR   VEuPathDB; HostDB:ENSG00000148303; -.
DR   GeneTree; ENSGT00940000153294; -.
DR   HOGENOM; CLU_055193_2_0_1; -.
DR   ChiTaRS; RPL7A; human.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000148303; Expressed in primordial germ cell in gonad and 100 other cell types or tissues.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR   InterPro; IPR001921; Ribosomal_eL8.
DR   InterPro; IPR004038; Ribosomal_eL8/eL30/eS12/Gad45.
DR   InterPro; IPR018492; Ribosomal_eL8/Nhp2.
DR   PANTHER; PTHR23105:SF1; 60S RIBOSOMAL PROTEIN L7A; 1.
DR   PANTHER; PTHR23105; RIBOSOMAL PROTEIN L7AE FAMILY MEMBER; 1.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   PRINTS; PR00881; L7ARS6FAMILY.
DR   PRINTS; PR00882; RIBOSOMALL7A.
DR   SUPFAM; SSF55315; L30e-like; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:Q5T8U3,
KW   ECO:0007829|MaxQB:Q5T8U3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW   ECO:0000256|RuleBase:RU367042};
KW   Ribosomal protein {ECO:0000256|RuleBase:RU367042,
KW   ECO:0000313|EMBL:CAI12833.1}.
FT   DOMAIN          157..191
FT                   /note="Ribosomal protein eL8/eL30/eS12/Gadd45"
FT                   /evidence="ECO:0000259|Pfam:PF01248"
FT   NON_TER         191
FT                   /evidence="ECO:0000313|EMBL:CAI12833.1"
SQ   SEQUENCE   191 AA;  21545 MW;  A6D4E7349DD65D19 CRC64;
     MLVRLNVRCS CRGVVLGGCR KLLASLVQPK GKKAKGKKVA PAPAVVKKQE AKKVVNPLFE
     KRPKNFGIGQ DIQPKRDLTR FVKWPRYIRL QRQRAILYKR LKVPPAINQF TQALDRQTAT
     QLLKLAHKYR PETKQEKKQR LLARAEKKAA GKGDVPTKRP PVLRAGVNTV TTLVENKKAQ
     LVVIAHDVDP I
//