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Protein
Submitted name:

Monocarboxylate transporter 1

Gene

SLC16A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Monocarboxylate transporter 1Imported
Submitted name:
Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_aImported
Gene namesi
Name:SLC16A1Imported
ORF Names:hCG_37455Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000155380.11.
HGNCiHGNC:10922. SLC16A1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 36HelicalSequence analysisAdd BLAST20
Transmembranei87 – 105HelicalSequence analysisAdd BLAST19
Transmembranei111 – 132HelicalSequence analysisAdd BLAST22
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei176 – 195HelicalSequence analysisAdd BLAST20
Transmembranei263 – 287HelicalSequence analysisAdd BLAST25
Transmembranei331 – 347HelicalSequence analysisAdd BLAST17
Transmembranei353 – 375HelicalSequence analysisAdd BLAST23
Transmembranei387 – 409HelicalSequence analysisAdd BLAST23
Transmembranei421 – 443HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155380.

PTM / Processingi

Proteomic databases

MaxQBiQ5T8R5.

Expressioni

Gene expression databases

BgeeiENSG00000155380.
ExpressionAtlasiQ5T8R5. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 452MFSInterPro annotationAdd BLAST434

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR004743. MCT.
IPR030757. MCT1.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR036259. MFS_trans_sf.
PANTHERiPTHR11360:SF24. PTHR11360:SF24. 1 hit.
PfamiView protein in Pfam
PF07690. MFS_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5T8R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI
60 70 80 90 100
FHATTSEVSW ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL
110 120 130 140 150
IAASFCNTVQ QLYVCIGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA
160 170 180 190 200
MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI LGGLLLNCCV AGALMRPIGP
210 220 230 240 250
KPTKAGKDKS KASLEKAGKS GVKKDLHDAN TDLIGRHPKQ EKRSVFQTIN
260 270 280 290 300
QFLDLTLFTH RGFLLYLSGN VIMFFGLFAP LVFLSSYGKS QHYSSEKSAF
310 320 330 340 350
LLSILAFVDM VARPSMGLVA NTKPIRPRIQ YFFAASVVAN GVCHMLAPLS
360 370 380 390 400
TTYVGFCVYA GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC
410 420 430 440 450
PVLLGPPLLG RLNDMYGDYK YTYWACGVVL IISGIYLFIG MGINYRLLAK

EQKANE
Length:456
Mass (Da):49,219
Last modified:December 21, 2004 - v1
Checksum:i2800172CE8700B22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei456Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158844 Genomic DNA. No translation available.
CH471122 Genomic DNA. Translation: EAW56551.1.
UniGeneiHs.75231.

Genome annotation databases

EnsembliENST00000458229; ENSP00000416167; ENSG00000155380.
ENST00000629920; ENSP00000486874; ENSG00000281917.
UCSCiuc057jmx.1. human.

Similar proteinsi

Entry informationi

Entry nameiQ5T8R5_HUMAN
AccessioniPrimary (citable) accession number: Q5T8R5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported