Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA-binding protein 26

Gene

RBM26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri288 – 316C3H1-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA processing Source: InterPro
  • negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139746-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 26
Alternative name(s):
CTCL tumor antigen se70-2
RNA-binding motif protein 26
Gene namesi
Name:RBM26
Synonyms:C13orf10
ORF Names:PRO1777
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20327. RBM26.

Pathology & Biotechi

Organism-specific databases

DisGeNETi64062.
OpenTargetsiENSG00000139746.
PharmGKBiPA134982324.

Polymorphism and mutation databases

DMDMi124021002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002733761 – 1007RNA-binding protein 26Add BLAST1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei127PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei510N6-acetyllysineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei616PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5T8P6.
MaxQBiQ5T8P6.
PaxDbiQ5T8P6.
PeptideAtlasiQ5T8P6.
PRIDEiQ5T8P6.

PTM databases

iPTMnetiQ5T8P6.
PhosphoSitePlusiQ5T8P6.

Miscellaneous databases

PMAP-CutDBQ5T8P6.

Expressioni

Gene expression databases

BgeeiENSG00000139746.
CleanExiHS_RBM26.
ExpressionAtlasiQ5T8P6. baseline and differential.
GenevisibleiQ5T8P6. HS.

Organism-specific databases

HPAiHPA040252.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK2O436393EBI-3232077,EBI-713635

Protein-protein interaction databases

BioGridi122035. 61 interactors.
IntActiQ5T8P6. 39 interactors.
MINTiMINT-4655019.
STRINGi9606.ENSP00000267229.

Structurei

3D structure databases

ProteinModelPortaliQ5T8P6.
SMRiQ5T8P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini532 – 606RRM 1PROSITE-ProRule annotationAdd BLAST75
Domaini891 – 960RRM 2PROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili719 – 795Sequence analysisAdd BLAST77
Coiled coili823 – 847Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 213Arg-richAdd BLAST80
Compositional biasi326 – 420Pro-richAdd BLAST95

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri288 – 316C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2135. Eukaryota.
ENOG41119BA. LUCA.
GeneTreeiENSGT00510000046929.
HOVERGENiHBG057372.
InParanoidiQ5T8P6.
KOiK13192.
PhylomeDBiQ5T8P6.
TreeFamiTF319253.

Family and domain databases

Gene3Di1.20.1390.10. 1 hit.
3.30.70.330. 2 hits.
4.10.1000.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR002483. PWI_dom.
IPR000504. RRM_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF01480. PWI. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T8P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSKMIIENF EALKSWLSKT LEPICDADPS ALAKYVLALV KKDKSEKELK
60 70 80 90 100
ALCIDQLDVF LQKETQIFVE KLFDAVNTKS YLPPPEQPSS GSLKVEFFPH
110 120 130 140 150
QEKDIKKEEI TKEEEREKKF SRRLNHSPPQ SSSRYRENRS RDERKKDDRS
160 170 180 190 200
RKRDYDRNPP RRDSYRDRYN RRRGRSRSYS RSRSRSWSKE RLRERDRDRS
210 220 230 240 250
RTRSRSRTRS RERDLVKPKY DLDRTDPLEN NYTPVSSVPS ISSGHYPVPT
260 270 280 290 300
LSSTITVIAP THHGNNTTES WSEFHEDQVD HNSYVRPPMP KKRCRDYDEK
310 320 330 340 350
GFCMRGDMCP FDHGSDPVVV EDVNLPGMLP FPAQPPVVEG PPPPGLPPPP
360 370 380 390 400
PILTPPPVNL RPPVPPPGPL PPSLPPVTGP PPPLPPLQPS GMDAPPNSAT
410 420 430 440 450
SSVPTVVTTG IHHQPPPAPP SLFTADTYDT DGYNPEAPSI TNTSRPMYRH
460 470 480 490 500
RVHAQRPNLI GLTSGDMDLP PREKPPNKSS MRIVVDSESR KRTIGSGEPG
510 520 530 540 550
VPTKKTWFDK PNFNRTNSPG FQKKVQFGNE NTKLELRKVP PELNNISKLN
560 570 580 590 600
EHFSRFGTLV NLQVAYNGDP EGALIQFATY EEAKKAISST EAVLNNRFIK
610 620 630 640 650
VYWHREGSTQ QLQTTSPKVM QPLVQQPILP VVKQSVKERL GPVPSSTIEP
660 670 680 690 700
AEAQSASSDL PQNVTKLSVK DRLGFVSKPS VSATEKVLST STGLTKTVYN
710 720 730 740 750
PAALKAAQKT LLVSTSAVDN NEAQKKKQEA LKLQQDVRKR KQEILEKHIE
760 770 780 790 800
TQKMLISKLE KNKTMKSEDK AEIMKTLEVL TKNITKLKDE VKAASPGRCL
810 820 830 840 850
PKSIKTKTQM QKELLDTELD LYKKMQAGEE VTELRRKYTE LQLEAAKRGI
860 870 880 890 900
LSSGRGRGIH SRGRGAVHGR GRGRGRGRGV PGHAVVDHRP RALEISAFTE
910 920 930 940 950
SDREDLLPHF AQYGEIEDCQ IDDSSLHAVI TFKTRAEAEA AAVHGARFKG
960 970 980 990 1000
QDLKLAWNKP VTNISAVETE EVEPDEEEFQ EESLVDDSLL QDDDEEEEDN

ESRSWRR
Length:1,007
Mass (Da):113,597
Last modified:January 23, 2007 - v3
Checksum:iDCA34DF4A9A42045
GO
Isoform 2 (identifier: Q5T8P6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     663-686: Missing.

Show »
Length:983
Mass (Da):111,024
Checksum:iDB5E498EF00A14E9
GO
Isoform 3 (identifier: Q5T8P6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     619-621: Missing.
     663-686: Missing.

Note: No experimental confirmation available.
Show »
Length:980
Mass (Da):110,666
Checksum:i6810866351CFDEF0
GO
Isoform 4 (identifier: Q5T8P6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-446: Missing.
     619-621: Missing.

Note: No experimental confirmation available.
Show »
Length:558
Mass (Da):62,580
Checksum:iC408F59C293D82EB
GO
Isoform 5 (identifier: Q5T8P6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-446: Missing.
     619-621: Missing.
     663-686: Missing.

Note: No experimental confirmation available.
Show »
Length:534
Mass (Da):60,007
Checksum:i26F03191A469E43E
GO
Isoform 6 (identifier: Q5T8P6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-120: ITKEEEREKKF → VTICVNTLQVI
     121-1007: Missing.

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):13,644
Checksum:i5E074B43B4BF4D65
GO

Sequence cautioni

The sequence AAG34912 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14933 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55125 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI12921 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95136 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12A → T in CAI56708 (PubMed:17974005).Curated1
Sequence conflicti66Q → H in CAI56708 (PubMed:17974005).Curated1
Sequence conflicti426D → A in CAI56708 (PubMed:17974005).Curated1
Sequence conflicti709K → E in BAB55046 (PubMed:14702039).Curated1
Sequence conflicti900E → G in BAB55046 (PubMed:14702039).Curated1
Sequence conflicti900E → G in BAB55125 (PubMed:14702039).Curated1
Sequence conflicti959K → E in BAB14933 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030137718V → D.Corresponds to variant rs10767dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225281 – 446Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST446
Alternative sequenceiVSP_022529110 – 120ITKEEEREKKF → VTICVNTLQVI in isoform 6. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_022530121 – 1007Missing in isoform 6. 1 PublicationAdd BLAST887
Alternative sequenceiVSP_022531619 – 621Missing in isoform 3, isoform 4 and isoform 5. 2 Publications3
Alternative sequenceiVSP_022532663 – 686Missing in isoform 2, isoform 3 and isoform 5. 3 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024610 mRNA. Translation: BAB14933.1. Different initiation.
AK027339 mRNA. Translation: BAB55046.1.
AK027456 mRNA. Translation: BAB55125.1. Different initiation.
AK302871 mRNA. Translation: BAG64052.1.
AF116667 mRNA. Translation: AAF71087.1.
AL159974, AL139006 Genomic DNA. Translation: CAI12921.2. Sequence problems.
AL159974, AL139006 Genomic DNA. Translation: CAI12923.3.
AL139006, AL159974 Genomic DNA. Translation: CAI95136.1. Sequence problems.
AL139006, AL159974 Genomic DNA. Translation: CAI95137.2.
BC041655 mRNA. Translation: AAH41655.1.
BC111697 mRNA. Translation: AAI11698.1.
BC111739 mRNA. Translation: AAI11740.1.
AL834343 mRNA. Translation: CAD39009.3.
BX648672 mRNA. Translation: CAI56708.1.
AF273052 mRNA. Translation: AAG34912.1. Different initiation.
CCDSiCCDS66566.1. [Q5T8P6-2]
CCDS9462.1. [Q5T8P6-3]
RefSeqiNP_001273560.1. NM_001286631.1.
NP_001273561.1. NM_001286632.1. [Q5T8P6-2]
NP_071401.3. NM_022118.4. [Q5T8P6-3]
XP_011533490.1. XM_011535188.2. [Q5T8P6-1]
XP_011533494.1. XM_011535192.2. [Q5T8P6-2]
XP_011533495.1. XM_011535193.2. [Q5T8P6-3]
UniGeneiHs.558528.
Hs.596629.
Hs.732265.

Genome annotation databases

EnsembliENST00000267229; ENSP00000267229; ENSG00000139746. [Q5T8P6-3]
ENST00000438724; ENSP00000390222; ENSG00000139746. [Q5T8P6-2]
ENST00000438737; ENSP00000387531; ENSG00000139746. [Q5T8P6-1]
GeneIDi64062.
KEGGihsa:64062.
UCSCiuc001vky.4. human. [Q5T8P6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024610 mRNA. Translation: BAB14933.1. Different initiation.
AK027339 mRNA. Translation: BAB55046.1.
AK027456 mRNA. Translation: BAB55125.1. Different initiation.
AK302871 mRNA. Translation: BAG64052.1.
AF116667 mRNA. Translation: AAF71087.1.
AL159974, AL139006 Genomic DNA. Translation: CAI12921.2. Sequence problems.
AL159974, AL139006 Genomic DNA. Translation: CAI12923.3.
AL139006, AL159974 Genomic DNA. Translation: CAI95136.1. Sequence problems.
AL139006, AL159974 Genomic DNA. Translation: CAI95137.2.
BC041655 mRNA. Translation: AAH41655.1.
BC111697 mRNA. Translation: AAI11698.1.
BC111739 mRNA. Translation: AAI11740.1.
AL834343 mRNA. Translation: CAD39009.3.
BX648672 mRNA. Translation: CAI56708.1.
AF273052 mRNA. Translation: AAG34912.1. Different initiation.
CCDSiCCDS66566.1. [Q5T8P6-2]
CCDS9462.1. [Q5T8P6-3]
RefSeqiNP_001273560.1. NM_001286631.1.
NP_001273561.1. NM_001286632.1. [Q5T8P6-2]
NP_071401.3. NM_022118.4. [Q5T8P6-3]
XP_011533490.1. XM_011535188.2. [Q5T8P6-1]
XP_011533494.1. XM_011535192.2. [Q5T8P6-2]
XP_011533495.1. XM_011535193.2. [Q5T8P6-3]
UniGeneiHs.558528.
Hs.596629.
Hs.732265.

3D structure databases

ProteinModelPortaliQ5T8P6.
SMRiQ5T8P6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122035. 61 interactors.
IntActiQ5T8P6. 39 interactors.
MINTiMINT-4655019.
STRINGi9606.ENSP00000267229.

PTM databases

iPTMnetiQ5T8P6.
PhosphoSitePlusiQ5T8P6.

Polymorphism and mutation databases

DMDMi124021002.

Proteomic databases

EPDiQ5T8P6.
MaxQBiQ5T8P6.
PaxDbiQ5T8P6.
PeptideAtlasiQ5T8P6.
PRIDEiQ5T8P6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267229; ENSP00000267229; ENSG00000139746. [Q5T8P6-3]
ENST00000438724; ENSP00000390222; ENSG00000139746. [Q5T8P6-2]
ENST00000438737; ENSP00000387531; ENSG00000139746. [Q5T8P6-1]
GeneIDi64062.
KEGGihsa:64062.
UCSCiuc001vky.4. human. [Q5T8P6-1]

Organism-specific databases

CTDi64062.
DisGeNETi64062.
GeneCardsiRBM26.
HGNCiHGNC:20327. RBM26.
HPAiHPA040252.
neXtProtiNX_Q5T8P6.
OpenTargetsiENSG00000139746.
PharmGKBiPA134982324.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2135. Eukaryota.
ENOG41119BA. LUCA.
GeneTreeiENSGT00510000046929.
HOVERGENiHBG057372.
InParanoidiQ5T8P6.
KOiK13192.
PhylomeDBiQ5T8P6.
TreeFamiTF319253.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139746-MONOMER.

Miscellaneous databases

ChiTaRSiRBM26. human.
GeneWikiiRBM26.
GenomeRNAii64062.
PMAP-CutDBQ5T8P6.
PROiQ5T8P6.

Gene expression databases

BgeeiENSG00000139746.
CleanExiHS_RBM26.
ExpressionAtlasiQ5T8P6. baseline and differential.
GenevisibleiQ5T8P6. HS.

Family and domain databases

Gene3Di1.20.1390.10. 1 hit.
3.30.70.330. 2 hits.
4.10.1000.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR002483. PWI_dom.
IPR000504. RRM_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF01480. PWI. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM26_HUMAN
AccessioniPrimary (citable) accession number: Q5T8P6
Secondary accession number(s): B4DZE0
, Q2NKM2, Q2NKQ2, Q5CZH8, Q5T8P5, Q5T8P8, Q5U5P5, Q5W0G7, Q8N3H5, Q96K92, Q96SZ3, Q9H2F8, Q9H7F9, Q9P1G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.