Q5T8I3 (F102B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM102B

Gene names

Name:

FAM102B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the FAM102 family.
Sequence caution	The sequence AAI27899.2 differs from that shown. Reason: Erroneous initiation. The sequence AAI40864.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI40866.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI50531.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T8I3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T8I3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     347-360: RVGSGAYEQVVIKR → SALEAPSLL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Protein FAM102B		PRO_0000236180
Regions
	Compositional bias	3 – 10	8	Poly-Lys
Amino acid modifications
	Modified residue	110	1	Phosphoserine Ref.6
	Modified residue	228	1	Phosphoserine By similarity
	Modified residue	320	1	Phosphoserine Ref.5 Ref.7
	Modified residue	321	1	Phosphoserine Ref.5 Ref.7
Natural variations
	Alternative sequence	347 – 360	14	RVGSG…VVIKR → SALEAPSLL in isoform 2.		VSP_034833

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 22, 2008. Version 2. Checksum: 6B10349E4B755FE4	FASTA	360	39,308
	10 20 30 40 50 60 MMKKKKFKFK VDFELEELSS VPFVNGVLFC KMRLLDGGSF TAESSREVVQ ANCVRWRKKF 70 80 90 100 110 120 SFMCKMSASA ATGILDPCIY RVSVRKELKG GKAYAKLGFA DLNLAEFAGS GNTTRRCLLE 130 140 150 160 170 180 GYDTKNTRQD NSILKVLISM QLMSGDPCFK TPPSTSMSIP IAGESESLQE DRKGGETLKV 190 200 210 220 230 240 HLGIADLSAK SASVPDELGA CGHSRTSSYA SQQSKVSGYS TCHSRSSSFS ELCHRRNTSV 250 260 270 280 290 300 GSTSTGVESI LEPCDEIEQK IAEPNLDTAD KEDTASEKLS RCPVKQDSVE SQLKRVDDTR 310 320 330 340 350 360 VDADDIVEKI LQSQDFSLDS SAEEEGLRLF VGPGGSTTFG SHHLPNRVGS GAYEQVVIKR
	Isoform 2 [UniParc]. Checksum: 4EE6DAEDB7F01040	FASTA	355	38,647
	10 20 30 40 50 60 MMKKKKFKFK VDFELEELSS VPFVNGVLFC KMRLLDGGSF TAESSREVVQ ANCVRWRKKF 70 80 90 100 110 120 SFMCKMSASA ATGILDPCIY RVSVRKELKG GKAYAKLGFA DLNLAEFAGS GNTTRRCLLE 130 140 150 160 170 180 GYDTKNTRQD NSILKVLISM QLMSGDPCFK TPPSTSMSIP IAGESESLQE DRKGGETLKV 190 200 210 220 230 240 HLGIADLSAK SASVPDELGA CGHSRTSSYA SQQSKVSGYS TCHSRSSSFS ELCHRRNTSV 250 260 270 280 290 300 GSTSTGVESI LEPCDEIEQK IAEPNLDTAD KEDTASEKLS RCPVKQDSVE SQLKRVDDTR 310 320 330 340 350 VDADDIVEKI LQSQDFSLDS SAEEEGLRLF VGPGGSTTFG SHHLPNSALE APSLL

References

[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 118-360 (ISOFORM 1). Tissue: Liver.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320 AND SER-321, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction." Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R. Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed: 17693683] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320 AND SER-321, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL160171 Genomic DNA. Translation: CAQ10401.1. AL160171 Genomic DNA. Translation: CAQ10402.1. CH471122 Genomic DNA. Translation: EAW56323.1. BC127898 mRNA. Translation: AAI27899.2. Different initiation. BC140863 mRNA. Translation: AAI40864.1. Different initiation. BC140865 mRNA. Translation: AAI40866.1. Different initiation. BC150530 mRNA. Translation: AAI50531.1. Different initiation. CR749397 mRNA. Translation: CAH18243.1.
IPI	IPI00374018. IPI00893233.
RefSeq	NP_001010883.2. NM_001010883.2.
UniGene	Hs.200230.
3D structure databases
ProteinModelPortal	Q5T8I3.
ModBase	Search...
PTM databases
PhosphoSite	Q5T8I3.
Polymorphism databases
DMDM	205831290.
Proteomic databases
PRIDE	Q5T8I3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370035; ENSP00000359052; ENSG00000162636.
GeneID	284611.
KEGG	hsa:284611.
Organism-specific databases
CTD	284611.
GeneCards	GC01P109102.
H-InvDB	HIX0000835.
HGNC	HGNC:27637. FAM102B.
HPA	HPA028451.
neXtProt	NX_Q5T8I3.
PharmGKB	PA142671785.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06272.
GeneTree	ENSGT00390000011832.
HOGENOM	HBG446042.
HOVERGEN	HBG057729.
InParanoid	Q5T8I3.
OMA	PNLDTAD.
OrthoDB	EOG4BP1C2.
PhylomeDB	Q5T8I3.
Gene expression databases
ArrayExpress	Q5T8I3.
Bgee	Q5T8I3.
CleanEx	HS_FAM102B.
Genevestigator	Q5T8I3.
GermOnline	ENSG00000162636. Homo sapiens.
Family and domain databases
InterPro	IPR019448. Oestrogen-resp_Fam102A/B_N. [Graphical view]
Pfam	PF10358. Eeig1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	94991.

Entry information

Entry name

F102B_HUMAN

Accession

Primary (citable) accession number: Q5T8I3
Secondary accession number(s): A1L1A1 , B0QZ46, B0QZ47, Q68DH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.