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Protein

Protein FAM102B

Gene

FAM102B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM102B
Gene namesi
Name:FAM102B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27637. FAM102B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671785.

Polymorphism and mutation databases

BioMutaiFAM102B.
DMDMi205831290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Protein FAM102BPRO_0000236180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei228 – 2281PhosphoserineCombined sources
Modified residuei276 – 2761PhosphoserineCombined sources
Modified residuei288 – 2881PhosphoserineCombined sources
Modified residuei320 – 3201PhosphoserineCombined sources
Modified residuei321 – 3211PhosphoserineCombined sources
Modified residuei350 – 3501PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T8I3.
MaxQBiQ5T8I3.
PaxDbiQ5T8I3.
PeptideAtlasiQ5T8I3.
PRIDEiQ5T8I3.

PTM databases

iPTMnetiQ5T8I3.
PhosphoSiteiQ5T8I3.

Expressioni

Gene expression databases

BgeeiENSG00000162636.
CleanExiHS_FAM102B.
GenevisibleiQ5T8I3. HS.

Organism-specific databases

HPAiHPA028451.

Interactioni

Protein-protein interaction databases

BioGridi129914. 7 interactions.
IntActiQ5T8I3. 5 interactions.
STRINGi9606.ENSP00000359052.

Structurei

3D structure databases

ProteinModelPortaliQ5T8I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 149147NT-C2Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 108Poly-Lys

Sequence similaritiesi

Belongs to the FAM102 family.Curated
Contains 1 NT-C2 domain.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IWVB. Eukaryota.
ENOG4110G47. LUCA.
GeneTreeiENSGT00390000011832.
HOGENOMiHOG000230902.
HOVERGENiHBG057729.
InParanoidiQ5T8I3.
OMAiGYSSCHS.
OrthoDBiEOG091G0RN5.
PhylomeDBiQ5T8I3.
TreeFamiTF320966.

Family and domain databases

InterProiIPR019448. NT-C2.
[Graphical view]
PfamiPF10358. NT-C2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T8I3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMKKKKFKFK VDFELEELSS VPFVNGVLFC KMRLLDGGSF TAESSREVVQ
60 70 80 90 100
ANCVRWRKKF SFMCKMSASA ATGILDPCIY RVSVRKELKG GKAYAKLGFA
110 120 130 140 150
DLNLAEFAGS GNTTRRCLLE GYDTKNTRQD NSILKVLISM QLMSGDPCFK
160 170 180 190 200
TPPSTSMSIP IAGESESLQE DRKGGETLKV HLGIADLSAK SASVPDELGA
210 220 230 240 250
CGHSRTSSYA SQQSKVSGYS TCHSRSSSFS ELCHRRNTSV GSTSTGVESI
260 270 280 290 300
LEPCDEIEQK IAEPNLDTAD KEDTASEKLS RCPVKQDSVE SQLKRVDDTR
310 320 330 340 350
VDADDIVEKI LQSQDFSLDS SAEEEGLRLF VGPGGSTTFG SHHLPNRVGS
360
GAYEQVVIKR
Length:360
Mass (Da):39,308
Last modified:July 22, 2008 - v2
Checksum:i6B10349E4B755FE4
GO
Isoform 2 (identifier: Q5T8I3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-360: RVGSGAYEQVVIKR → SALEAPSLL

Note: No experimental confirmation available.
Show »
Length:355
Mass (Da):38,647
Checksum:i4EE6DAEDB7F01040
GO

Sequence cautioni

The sequence AAI27899 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI40864 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI40866 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI50531 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei347 – 36014RVGSG…VVIKR → SALEAPSLL in isoform 2. CuratedVSP_034833Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160171 Genomic DNA. Translation: CAQ10401.1.
AL160171 Genomic DNA. Translation: CAQ10402.1.
CH471122 Genomic DNA. Translation: EAW56323.1.
BC127898 mRNA. Translation: AAI27899.2. Different initiation.
BC140863 mRNA. Translation: AAI40864.1. Different initiation.
BC140865 mRNA. Translation: AAI40866.1. Different initiation.
BC150530 mRNA. Translation: AAI50531.1. Different initiation.
CR749397 mRNA. Translation: CAH18243.1.
CCDSiCCDS30786.2. [Q5T8I3-1]
RefSeqiNP_001010883.2. NM_001010883.2. [Q5T8I3-1]
UniGeneiHs.200230.

Genome annotation databases

EnsembliENST00000370035; ENSP00000359052; ENSG00000162636. [Q5T8I3-1]
ENST00000405454; ENSP00000386084; ENSG00000162636. [Q5T8I3-2]
GeneIDi284611.
KEGGihsa:284611.
UCSCiuc010ouy.3. human. [Q5T8I3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160171 Genomic DNA. Translation: CAQ10401.1.
AL160171 Genomic DNA. Translation: CAQ10402.1.
CH471122 Genomic DNA. Translation: EAW56323.1.
BC127898 mRNA. Translation: AAI27899.2. Different initiation.
BC140863 mRNA. Translation: AAI40864.1. Different initiation.
BC140865 mRNA. Translation: AAI40866.1. Different initiation.
BC150530 mRNA. Translation: AAI50531.1. Different initiation.
CR749397 mRNA. Translation: CAH18243.1.
CCDSiCCDS30786.2. [Q5T8I3-1]
RefSeqiNP_001010883.2. NM_001010883.2. [Q5T8I3-1]
UniGeneiHs.200230.

3D structure databases

ProteinModelPortaliQ5T8I3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129914. 7 interactions.
IntActiQ5T8I3. 5 interactions.
STRINGi9606.ENSP00000359052.

PTM databases

iPTMnetiQ5T8I3.
PhosphoSiteiQ5T8I3.

Polymorphism and mutation databases

BioMutaiFAM102B.
DMDMi205831290.

Proteomic databases

EPDiQ5T8I3.
MaxQBiQ5T8I3.
PaxDbiQ5T8I3.
PeptideAtlasiQ5T8I3.
PRIDEiQ5T8I3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370035; ENSP00000359052; ENSG00000162636. [Q5T8I3-1]
ENST00000405454; ENSP00000386084; ENSG00000162636. [Q5T8I3-2]
GeneIDi284611.
KEGGihsa:284611.
UCSCiuc010ouy.3. human. [Q5T8I3-1]

Organism-specific databases

CTDi284611.
GeneCardsiFAM102B.
H-InvDBHIX0000835.
HGNCiHGNC:27637. FAM102B.
HPAiHPA028451.
neXtProtiNX_Q5T8I3.
PharmGKBiPA142671785.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWVB. Eukaryota.
ENOG4110G47. LUCA.
GeneTreeiENSGT00390000011832.
HOGENOMiHOG000230902.
HOVERGENiHBG057729.
InParanoidiQ5T8I3.
OMAiGYSSCHS.
OrthoDBiEOG091G0RN5.
PhylomeDBiQ5T8I3.
TreeFamiTF320966.

Miscellaneous databases

GenomeRNAii284611.
PROiQ5T8I3.

Gene expression databases

BgeeiENSG00000162636.
CleanExiHS_FAM102B.
GenevisibleiQ5T8I3. HS.

Family and domain databases

InterProiIPR019448. NT-C2.
[Graphical view]
PfamiPF10358. NT-C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF102B_HUMAN
AccessioniPrimary (citable) accession number: Q5T8I3
Secondary accession number(s): A1L1A1
, B0QZ46, B0QZ47, Q68DH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 22, 2008
Last modified: September 7, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.