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Protein

Acyl-CoA-binding domain-containing protein 5

Gene

ACBD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98Acyl-CoA1
Binding sitei117Acyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

  • pexophagy Source: UniProtKB
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-390918. Peroxisomal lipid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 5
Gene namesi
Name:ACBD5
Synonyms:KIAA1996
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23338. ACBD5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: HPA
  • peroxisomal membrane Source: UniProtKB-SubCell
  • peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi91452.
OpenTargetsiENSG00000107897.
PharmGKBiPA134892991.

Polymorphism and mutation databases

DMDMi74745508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002873771 – 534Acyl-CoA-binding domain-containing protein 5Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei400PhosphothreonineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei469N6-acetyllysineBy similarity1
Isoform 4 (identifier: Q5T8D3-4)
Modified residuei63PhosphothreonineCombined sources1
Isoform 2 (identifier: Q5T8D3-2)
Modified residuei137PhosphothreonineCombined sources1
Isoform 3 (identifier: Q5T8D3-3)
Modified residuei172PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5T8D3.
MaxQBiQ5T8D3.
PaxDbiQ5T8D3.
PeptideAtlasiQ5T8D3.
PRIDEiQ5T8D3.

PTM databases

iPTMnetiQ5T8D3.
PhosphoSitePlusiQ5T8D3.

Expressioni

Gene expression databases

BgeeiENSG00000107897.
CleanExiHS_ACBD5.
ExpressionAtlasiQ5T8D3. baseline and differential.
GenevisibleiQ5T8D3. HS.

Organism-specific databases

HPAiHPA011861.
HPA012145.

Interactioni

Protein-protein interaction databases

BioGridi124836. 21 interactors.
IntActiQ5T8D3. 13 interactors.
MINTiMINT-3040525.
STRINGi9606.ENSP00000379568.

Structurei

Secondary structure

1534
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi41 – 58Combined sources18
Helixi65 – 79Combined sources15
Helixi93 – 104Combined sources12
Turni105 – 107Combined sources3
Helixi110 – 127Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FLVX-ray1.70A/B41-136[»]
ProteinModelPortaliQ5T8D3.
SMRiQ5T8D3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5T8D3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 130ACBPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 61Acyl-CoA binding10
Regioni72 – 76Acyl-CoA binding5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 219Sequence analysisAdd BLAST30
Coiled coili447 – 476Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 16Poly-Cys4
Compositional biasi201 – 204Poly-Glu4
Compositional biasi528 – 531Poly-Arg4

Sequence similaritiesi

Belongs to the ATG37 family.Curated
Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00840000129776.
HOVERGENiHBG106445.
InParanoidiQ5T8D3.
OMAiGRGHRMQ.
OrthoDBiEOG091G0NXJ.
PhylomeDBiQ5T8D3.
TreeFamiTF319446.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR016347. ACBD5.
IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PIRSFiPIRSF002412. MA_DBI. 1 hit.
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T8D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQFHAGSWE SWCCCCLIPA DRPWDRGQHW QLEMADTRSV HETRFEAAVK
60 70 80 90 100
VIQSLPKNGS FQPTNEMMLK FYSFYKQATE GPCKLSRPGF WDPIGRYKWD
110 120 130 140 150
AWSSLGDMTK EEAMIAYVEE MKKIIETMPM TEKVEELLRV IGPFYEIVED
160 170 180 190 200
KKSGRSSDIT SVRLEKISKC LEDLGNVLTS TPNAKTVNGK AESSDSGAES
210 220 230 240 250
EEEEAQEEVK GAEQSDNDKK MMKKSADHKN LEVIVTNGYD KDGFVQDIQN
260 270 280 290 300
DIHASSSLNG RSTEEVKPID ENLGQTGKSA VCIHQDINDD HVEDVTGIQH
310 320 330 340 350
LTSDSDSEVY CDSMEQFGQE ESLDSFTSNN GPFQYYLGGH SSQPMENSGF
360 370 380 390 400
REDIQVPPGN GNIGNMQVVA VEGKGEVKHG GEDGRNNSGA PHREKRGGET
410 420 430 440 450
DEFSNVRRGR GHRMQHLSEG TKGRQVGSGG DGERWGSDRG SRGSLNEQIA
460 470 480 490 500
LVLMRLQEDM QNVLQRLQKL ETLTALQAKS STSTLQTAPQ PTSQRPSWWP
510 520 530
FEMSPGVLTF AIIWPFIAQW LVYLYYQRRR RKLN
Length:534
Mass (Da):60,092
Last modified:December 21, 2004 - v1
Checksum:i8BE9A09967717653
GO
Isoform 2 (identifier: Q5T8D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     162-172: Missing.

Show »
Length:490
Mass (Da):54,786
Checksum:i35B7F4B27ECE706B
GO
Isoform 3 (identifier: Q5T8D3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MFQ → MLFLS
     162-172: Missing.

Show »
Length:525
Mass (Da):58,978
Checksum:i95E2AD87B672D414
GO
Isoform 4 (identifier: Q5T8D3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.
     162-172: Missing.

Show »
Length:416
Mass (Da):46,268
Checksum:i2FD7CD93EAA41CC9
GO

Sequence cautioni

The sequence AAH30555 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332P → Q in AAP30852 (Ref. 1) Curated1
Sequence conflicti419E → D in AAP30852 (Ref. 1) Curated1
Sequence conflicti478A → T in AAP30852 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032301472T → M.Corresponds to variant rs7918793dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0254481 – 107Missing in isoform 4. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_0254471 – 33Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0254461 – 3MFQ → MLFLS in isoform 3. 1 Publication3
Alternative sequenceiVSP_025449162 – 172Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF505653 mRNA. Translation: AAP30852.1.
AK057469 mRNA. Translation: BAG51918.1.
AL160291 Genomic DNA. Translation: CAI16911.1.
AL160291 Genomic DNA. Translation: CAI16912.1.
AL160291 Genomic DNA. Translation: CAI16913.1.
AL160291 Genomic DNA. Translation: CAI16914.1.
AL160291 Genomic DNA. Translation: CAI16915.1.
CH471072 Genomic DNA. Translation: EAW86062.1.
CH471072 Genomic DNA. Translation: EAW86061.1.
CH471072 Genomic DNA. Translation: EAW86063.1.
BC030555 mRNA. Translation: AAH30555.1. Different initiation.
AL133064 mRNA. Translation: CAB61388.1.
CCDSiCCDS44368.1. [Q5T8D3-3]
CCDS7154.1. [Q5T8D3-2]
CCDS76290.1. [Q5T8D3-4]
PIRiT42665.
RefSeqiNP_001035938.1. NM_001042473.3. [Q5T8D3-2]
NP_001288180.1. NM_001301251.1. [Q5T8D3-4]
NP_001288181.1. NM_001301252.1. [Q5T8D3-4]
NP_001288182.1. NM_001301253.1. [Q5T8D3-4]
NP_663736.2. NM_145698.4. [Q5T8D3-3]
XP_016872396.1. XM_017016907.1. [Q5T8D3-4]
XP_016872397.1. XM_017016908.1. [Q5T8D3-4]
UniGeneiHs.530597.

Genome annotation databases

EnsembliENST00000375888; ENSP00000365049; ENSG00000107897. [Q5T8D3-1]
ENST00000375901; ENSP00000365066; ENSG00000107897. [Q5T8D3-4]
ENST00000375905; ENSP00000365070; ENSG00000107897. [Q5T8D3-2]
ENST00000396271; ENSP00000379568; ENSG00000107897. [Q5T8D3-3]
GeneIDi91452.
KEGGihsa:91452.
UCSCiuc001ito.4. human. [Q5T8D3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF505653 mRNA. Translation: AAP30852.1.
AK057469 mRNA. Translation: BAG51918.1.
AL160291 Genomic DNA. Translation: CAI16911.1.
AL160291 Genomic DNA. Translation: CAI16912.1.
AL160291 Genomic DNA. Translation: CAI16913.1.
AL160291 Genomic DNA. Translation: CAI16914.1.
AL160291 Genomic DNA. Translation: CAI16915.1.
CH471072 Genomic DNA. Translation: EAW86062.1.
CH471072 Genomic DNA. Translation: EAW86061.1.
CH471072 Genomic DNA. Translation: EAW86063.1.
BC030555 mRNA. Translation: AAH30555.1. Different initiation.
AL133064 mRNA. Translation: CAB61388.1.
CCDSiCCDS44368.1. [Q5T8D3-3]
CCDS7154.1. [Q5T8D3-2]
CCDS76290.1. [Q5T8D3-4]
PIRiT42665.
RefSeqiNP_001035938.1. NM_001042473.3. [Q5T8D3-2]
NP_001288180.1. NM_001301251.1. [Q5T8D3-4]
NP_001288181.1. NM_001301252.1. [Q5T8D3-4]
NP_001288182.1. NM_001301253.1. [Q5T8D3-4]
NP_663736.2. NM_145698.4. [Q5T8D3-3]
XP_016872396.1. XM_017016907.1. [Q5T8D3-4]
XP_016872397.1. XM_017016908.1. [Q5T8D3-4]
UniGeneiHs.530597.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FLVX-ray1.70A/B41-136[»]
ProteinModelPortaliQ5T8D3.
SMRiQ5T8D3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124836. 21 interactors.
IntActiQ5T8D3. 13 interactors.
MINTiMINT-3040525.
STRINGi9606.ENSP00000379568.

PTM databases

iPTMnetiQ5T8D3.
PhosphoSitePlusiQ5T8D3.

Polymorphism and mutation databases

DMDMi74745508.

Proteomic databases

EPDiQ5T8D3.
MaxQBiQ5T8D3.
PaxDbiQ5T8D3.
PeptideAtlasiQ5T8D3.
PRIDEiQ5T8D3.

Protocols and materials databases

DNASUi91452.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375888; ENSP00000365049; ENSG00000107897. [Q5T8D3-1]
ENST00000375901; ENSP00000365066; ENSG00000107897. [Q5T8D3-4]
ENST00000375905; ENSP00000365070; ENSG00000107897. [Q5T8D3-2]
ENST00000396271; ENSP00000379568; ENSG00000107897. [Q5T8D3-3]
GeneIDi91452.
KEGGihsa:91452.
UCSCiuc001ito.4. human. [Q5T8D3-1]

Organism-specific databases

CTDi91452.
DisGeNETi91452.
GeneCardsiACBD5.
HGNCiHGNC:23338. ACBD5.
HPAiHPA011861.
HPA012145.
MIMi616618. gene.
neXtProtiNX_Q5T8D3.
OpenTargetsiENSG00000107897.
PharmGKBiPA134892991.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00840000129776.
HOVERGENiHBG106445.
InParanoidiQ5T8D3.
OMAiGRGHRMQ.
OrthoDBiEOG091G0NXJ.
PhylomeDBiQ5T8D3.
TreeFamiTF319446.

Enzyme and pathway databases

ReactomeiR-HSA-390918. Peroxisomal lipid metabolism.

Miscellaneous databases

ChiTaRSiACBD5. human.
EvolutionaryTraceiQ5T8D3.
GenomeRNAii91452.
PROiQ5T8D3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107897.
CleanExiHS_ACBD5.
ExpressionAtlasiQ5T8D3. baseline and differential.
GenevisibleiQ5T8D3. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR016347. ACBD5.
IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PIRSFiPIRSF002412. MA_DBI. 1 hit.
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACBD5_HUMAN
AccessioniPrimary (citable) accession number: Q5T8D3
Secondary accession number(s): B3KQ56
, D3DRW0, Q5T8D4, Q5T8E1, Q5T8E2, Q86UV1, Q8N6E3, Q9UFB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.