Q5T8D3 (ACBD5_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acyl-CoA-binding domain-containing protein 5 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 534 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Subcellular location | Peroxisome membrane; Single-pass membrane protein By similarity. |
| Sequence similarities | Contains 1 ACB (acyl-CoA-binding) domain. |
| Sequence caution | The sequence AAH30555.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transport |
| Cellular component | Membrane Peroxisome |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Coiled coil Transmembrane Transmembrane helix |
| Ligand | Lipid-binding |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW peroxisomal membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | fatty-acyl-CoA binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q5T8D3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q5T8D3-2) The sequence of this isoform differs from the canonical sequence as follows: 1-33: Missing. 162-172: Missing. | ||||||
| Isoform 3 (identifier: Q5T8D3-3) The sequence of this isoform differs from the canonical sequence as follows: 1-3: MFQ → MLFLS 162-172: Missing. | ||||||
| Isoform 4 (identifier: Q5T8D3-4) The sequence of this isoform differs from the canonical sequence as follows: 1-107: Missing. 162-172: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||
Molecule processing | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 534 | 534 | Acyl-CoA-binding domain-containing protein 5 | PRO_0000287377 | ||||||||||||||
Regions | ||||||||||||||||||
| Transmembrane | 506 – 526 | 21 | Helical; Potential | |||||||||||||||
| Domain | 41 – 130 | 90 | ACB | |||||||||||||||
| Coiled coil | 190 – 219 | 30 | Potential | |||||||||||||||
| Coiled coil | 447 – 476 | 30 | Potential | |||||||||||||||
| Compositional bias | 13 – 16 | 4 | Poly-Cys | |||||||||||||||
| Compositional bias | 201 – 204 | 4 | Poly-Glu | |||||||||||||||
| Compositional bias | 528 – 531 | 4 | Poly-Arg | |||||||||||||||
Amino acid modifications | ||||||||||||||||||
| Modified residue | 127 | 1 | Phosphothreonine Ref.9 | |||||||||||||||
| Modified residue | 131 | 1 | Phosphothreonine Ref.9 | |||||||||||||||
| Modified residue | 156 | 1 | Phosphoserine Ref.7 | |||||||||||||||
| Modified residue | 160 | 1 | Phosphothreonine By similarity | |||||||||||||||
| Modified residue | 181 | 1 | Phosphothreonine Ref.13 | |||||||||||||||
| Modified residue | 193 | 1 | Phosphoserine Ref.11 | |||||||||||||||
| Modified residue | 194 | 1 | Phosphoserine Ref.11 | |||||||||||||||
| Modified residue | 196 | 1 | Phosphoserine Ref.10 Ref.11 Ref.12 | |||||||||||||||
| Modified residue | 200 | 1 | Phosphoserine Ref.10 Ref.11 Ref.12 | |||||||||||||||
| Modified residue | 215 | 1 | Phosphoserine Ref.10 | |||||||||||||||
| Modified residue | 256 | 1 | Phosphoserine Ref.10 | |||||||||||||||
| Modified residue | 296 | 1 | Phosphothreonine Ref.8 | |||||||||||||||
| Modified residue | 388 | 1 | Phosphoserine Ref.10 | |||||||||||||||
| Modified residue | 400 | 1 | Phosphothreonine Ref.10 | |||||||||||||||
| Modified residue | 418 | 1 | Phosphoserine Ref.10 | |||||||||||||||
| Modified residue | 428 | 1 | Phosphoserine Ref.10 | |||||||||||||||
| Modified residue | 437 | 1 | Phosphoserine Ref.10 | |||||||||||||||
| Modified residue | 441 | 1 | Phosphoserine By similarity | |||||||||||||||
Natural variations | ||||||||||||||||||
| Alternative sequence | 1 – 107 | 107 | Missing in isoform 4. | VSP_025448 | ||||||||||||||
| Alternative sequence | 1 – 33 | 33 | Missing in isoform 2. | VSP_025447 | ||||||||||||||
| Alternative sequence | 1 – 3 | 3 | MFQ → MLFLS in isoform 3. | VSP_025446 | ||||||||||||||
| Alternative sequence | 162 – 172 | 11 | Missing in isoform 2, isoform 3 and isoform 4. | VSP_025449 | ||||||||||||||
| Natural variant | 472 | 1 | T → M. Corresponds to variant rs7918793 [ dbSNP | Ensembl ]. | VAR_032301 | ||||||||||||||
Experimental info | ||||||||||||||||||
| Sequence conflict | 332 | 1 | P → Q in AAP30852. Ref.1 | |||||||||||||||
| Sequence conflict | 419 | 1 | E → D in AAP30852. Ref.1 | |||||||||||||||
| Sequence conflict | 478 | 1 | A → T in AAP30852. Ref.1 | |||||||||||||||
Secondary structure | ||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||
| Helix | 41 – 54 | 14 | ||||||||||||||||
| Turn | 55 – 57 | 3 | ||||||||||||||||
| Helix | 65 – 79 | 15 | ||||||||||||||||
| Helix | 97 – 104 | 8 | ||||||||||||||||
| Helix | 110 – 127 | 18 | ||||||||||||||||
Sequences
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References
| [1] | "Functional research of a new human gene related to endozepine." Ye X., Mao Y., Xie Y. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis. |
| [3] | "The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Blood. |
| [6] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 252-534. Tissue: Testis. |
| [7] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [8] | "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-296, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [9] | "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-127 AND THR-131, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [10] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196; SER-200; SER-215; SER-256; SER-388; THR-400; SER-418; SER-428 AND SER-437, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [11] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193; SER-194; SER-196 AND SER-200, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [12] | "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196 AND SER-200, MASS SPECTROMETRY. Tissue: Liver. |
| [13] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-181, MASS SPECTROMETRY. Tissue: Leukemic T-cell. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AF505653 mRNA. Translation: AAP30852.1. AK057469 mRNA. Translation: BAG51918.1. AL160291 Genomic DNA. Translation: CAI16911.1. AL160291 Genomic DNA. Translation: CAI16912.1. AL160291 Genomic DNA. Translation: CAI16913.1. AL160291 Genomic DNA. Translation: CAI16914.1. AL160291 Genomic DNA. Translation: CAI16915.1. CH471072 Genomic DNA. Translation: EAW86062.1. CH471072 Genomic DNA. Translation: EAW86061.1. CH471072 Genomic DNA. Translation: EAW86063.1. BC030555 mRNA. Translation: AAH30555.1. Different initiation. AL133064 mRNA. Translation: CAB61388.1. | ||||||||||||
| IPI | IPI00186681. IPI00550377. IPI00640010. IPI00644427. | ||||||||||||
| PIR | T42665. | ||||||||||||
| RefSeq | NP_001035938.1. NM_001042473.2. NP_663736.2. NM_145698.3. | ||||||||||||
| UniGene | Hs.530597. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | Q5T8D3. | ||||||||||||
| SMR | Q5T8D3. Positions 39-130. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | Q5T8D3. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q5T8D3. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 74745508. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q5T8D3. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000375888; ENSP00000365049; ENSG00000107897. | ||||||||||||
| GeneID | 91452. | ||||||||||||
| KEGG | hsa:91452. | ||||||||||||
| UCSC | uc001itn.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 91452. | ||||||||||||
| GeneCards | GC10M027484. | ||||||||||||
| HGNC | HGNC:23338. ACBD5. | ||||||||||||
| HPA | HPA011861. HPA012145. | ||||||||||||
| neXtProt | NX_Q5T8D3. | ||||||||||||
| PharmGKB | PA134892991. | ||||||||||||
| HUGE | Search... | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| GeneTree | ENSGT00530000063580. | ||||||||||||
| HOVERGEN | HBG106445. | ||||||||||||
| OMA | GHRMQHL. | ||||||||||||
| PhylomeDB | Q5T8D3. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q5T8D3. | ||||||||||||
| Bgee | Q5T8D3. | ||||||||||||
| CleanEx | HS_ACBD5. | ||||||||||||
| Genevestigator | Q5T8D3. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR022408. Acyl-CoA-binding_prot_CS. IPR000582. Acyl-CoA-binding_protein. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR016347. M-assoc_diazepam-bd-inh. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.20.80.10. ACBP. 1 hit. | ||||||||||||
| Pfam | PF00887. ACBP. 1 hit. [Graphical view] | ||||||||||||
| PIRSF | PIRSF002412. MA_DBI. 1 hit. | ||||||||||||
| PRINTS | PR00689. ACOABINDINGP. | ||||||||||||
| SUPFAM | SSF47027. ACBP. 1 hit. | ||||||||||||
| PROSITE | PS00880. ACB_1. 1 hit. PS51228. ACB_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 77259. | ||||||||||||
Entry information
| Entry name | ACBD5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q5T8D3 Secondary accession number(s): B3KQ56 Q9UFB5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with