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Protein

Protein phosphatase 1 regulatory subunit 26

Gene

PPP1R26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation.2 Publications

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 26
Gene namesi
Name:PPP1R26
Synonyms:KIAA0649
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:29089. PPP1R26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869847.

Polymorphism and mutation databases

BioMutaiPPP1R26.
DMDMi74745497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12091209Protein phosphatase 1 regulatory subunit 26PRO_0000309218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1161 – 11611PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T8A7.
MaxQBiQ5T8A7.
PaxDbiQ5T8A7.
PeptideAtlasiQ5T8A7.
PRIDEiQ5T8A7.

PTM databases

iPTMnetiQ5T8A7.
PhosphoSiteiQ5T8A7.

Expressioni

Tissue specificityi

Ubiquitous in normal tissues. Expressed in numerous adenocarcinoma cell lines.1 Publication

Gene expression databases

BgeeiQ5T8A7.
CleanExiHS_KIAA0649.
GenevisibleiQ5T8A7. HS.

Organism-specific databases

HPAiHPA044686.

Interactioni

Subunit structurei

Interacts with UTP20 and PPP1CA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-308500,EBI-357253
UTP20O756914EBI-308500,EBI-356062

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115192. 5 interactions.
IntActiQ5T8A7. 5 interactions.
MINTiMINT-1190258.
STRINGi9606.ENSP00000349274.

Structurei

3D structure databases

ProteinModelPortaliQ5T8A7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGYJ. Eukaryota.
ENOG4111MX8. LUCA.
GeneTreeiENSGT00390000014118.
HOGENOMiHOG000113155.
HOVERGENiHBG094902.
InParanoidiQ5T8A7.
KOiK17565.
OMAiEKRQHET.
OrthoDBiEOG73803X.
PhylomeDBiQ5T8A7.
TreeFamiTF331544.

Family and domain databases

InterProiIPR026130. PPP1R26.
IPR031474. PPP1R26_N.
[Graphical view]
PANTHERiPTHR15724. PTHR15724. 1 hit.
PfamiPF15740. PPP1R26_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T8A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLMNASPVV ALQSKWEAFG PPGSCRFPRC FSEADEGVES ASVSARVQML
60 70 80 90 100
ISTLQRDGAA RGTSDERAAQ RGHRAEGCHD ARPAAKPTVH KEPPALAVCG
110 120 130 140 150
LVADFDPMGE EETTDFGPLV LDSDSDDSVD RDIEEAIQEY LKAKSGAAQP
160 170 180 190 200
GAGGAQPGAA QPSRAAGGGS RCKPEPAHGS APTALCPPKL VPGSGGGPGS
210 220 230 240 250
QVGSSKDQGS ASPVSVSSDD SFEQSIRAEI EQFLNEKRQH ETQKCDGSVE
260 270 280 290 300
KKPDTNENSA KSLLKSHQEP PTKVVHRQGL LGVQKEFAFR KPPRLAKMNV
310 320 330 340 350
QPRSLRSKVT TTQENEGSTK PATPCRPSEA AQNKGGIKRS ASAARRGKRV
360 370 380 390 400
MSAAQASEAS DSSSDDGIEE AIQLYQLQKT RKEADGDLPQ RVQLREERAP
410 420 430 440 450
DPPAHSTSSA TKSALPETHR KTPSKKKLVA TKTMDPGPGG LDTDHAPKLL
460 470 480 490 500
KETKAPPPAS PASRSEFVER SSCRADTSAE LMCAEAILDI SKTILPAPVE
510 520 530 540 550
GSDGSLSASP LFYSPNVPSR SDGDSSSVDS DDSIEQEIRT FLALKAQSGS
560 570 580 590 600
LLARGESCPQ AAQGPLLPPG LNSQTGGHKT PLSKTPDPLL GCKRKRRGGG
610 620 630 640 650
HVRPSTPKKM QEVVKDGSQD ADHSQGRAEP GHERRDLPIQ GKASEALGGE
660 670 680 690 700
GTARGPGDTR MSQGQGKTDE ARRLDEKESS EDKSSSLDSD EDLDTAIKDL
710 720 730 740 750
LRSKRKLKKR CREPRAACRK KVRFSTAQTH FLEQLGGLRR DWKDRGPPVL
760 770 780 790 800
KSCLSKSKRD SGEGPGKKPP SVFGSTAERM RQEGAASQDA ALAFRVRRPA
810 820 830 840 850
SASASEGNPF PRESQGPAPS PGSLSDDSSS VDSNDSIELE IRKFLAEKAK
860 870 880 890 900
ESVSSSEVQA EGPTALGTGG PARPEVLCRK EPAPPPGVCT RSQRARGVPH
910 920 930 940 950
LAEGLRGTES AGAQGTAGLF SQGGKGLPAA PARGDPVPPR STSGGVSAKG
960 970 980 990 1000
LSVSRRNVYV HKDQSPRGAE PAAKSAFGQL PSCATAGTEA GGARGTFHMG
1010 1020 1030 1040 1050
CGSPSFLTPS PGAERDAGAQ ADRTPPWSDF AHQSRLPSPW VLRSEGRDAV
1060 1070 1080 1090 1100
WRGGVGSERD KGSEGPARGL PSLPLAGFSP LLSTQLFHFG KGVSWGGRQA
1110 1120 1130 1140 1150
GLFSPHLGLP LQGPSFSAFR EAQAGPSPVF GSPHLLAKKD GGPWPTRKAQ
1160 1170 1180 1190 1200
AGLSLHDRRS SGSEESILDL RYRRRVNRDD QEQDALGSDA SDFSDTSTED

SGGSSVVKV
Length:1,209
Mass (Da):127,351
Last modified:December 21, 2004 - v1
Checksum:iB30872DE87E37E93
GO

Sequence cautioni

The sequence BAA31624.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti689 – 6891S → I in AAH17511 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981V → A.1 Publication
Corresponds to variant rs3748192 [ dbSNP | Ensembl ].
VAR_036906
Natural varianti206 – 2061K → E.1 Publication
Corresponds to variant rs3928777 [ dbSNP | Ensembl ].
VAR_036907
Natural varianti346 – 3461R → K.
Corresponds to variant rs914644 [ dbSNP | Ensembl ].
VAR_036908
Natural varianti434 – 4341M → T.1 Publication
Corresponds to variant rs1808998 [ dbSNP | Ensembl ].
VAR_036909
Natural varianti520 – 5201R → H.
Corresponds to variant rs3748195 [ dbSNP | Ensembl ].
VAR_036910
Natural varianti576 – 5761G → S.1 Publication
Corresponds to variant rs17854528 [ dbSNP | Ensembl ].
VAR_036911
Natural varianti834 – 8341N → D.2 Publications
Corresponds to variant rs2078266 [ dbSNP | Ensembl ].
VAR_036912

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014549 mRNA. Translation: BAA31624.2. Different initiation.
AL161452 Genomic DNA. Translation: CAI14051.1.
BC017511 mRNA. Translation: AAH17511.1.
BC047935 mRNA. Translation: AAH47935.1.
CCDSiCCDS6988.1.
PIRiT00373.
RefSeqiNP_055626.3. NM_014811.3.
XP_005263468.1. XM_005263411.2.
XP_011517547.1. XM_011519245.1.
UniGeneiHs.533260.

Genome annotation databases

EnsembliENST00000356818; ENSP00000349274; ENSG00000196422.
ENST00000401470; ENSP00000385826; ENSG00000196422.
ENST00000604351; ENSP00000473820; ENSG00000196422.
ENST00000605286; ENSP00000474807; ENSG00000196422.
ENST00000605660; ENSP00000474794; ENSG00000196422.
GeneIDi9858.
KEGGihsa:9858.
UCSCiuc004cfr.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014549 mRNA. Translation: BAA31624.2. Different initiation.
AL161452 Genomic DNA. Translation: CAI14051.1.
BC017511 mRNA. Translation: AAH17511.1.
BC047935 mRNA. Translation: AAH47935.1.
CCDSiCCDS6988.1.
PIRiT00373.
RefSeqiNP_055626.3. NM_014811.3.
XP_005263468.1. XM_005263411.2.
XP_011517547.1. XM_011519245.1.
UniGeneiHs.533260.

3D structure databases

ProteinModelPortaliQ5T8A7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115192. 5 interactions.
IntActiQ5T8A7. 5 interactions.
MINTiMINT-1190258.
STRINGi9606.ENSP00000349274.

PTM databases

iPTMnetiQ5T8A7.
PhosphoSiteiQ5T8A7.

Polymorphism and mutation databases

BioMutaiPPP1R26.
DMDMi74745497.

Proteomic databases

EPDiQ5T8A7.
MaxQBiQ5T8A7.
PaxDbiQ5T8A7.
PeptideAtlasiQ5T8A7.
PRIDEiQ5T8A7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356818; ENSP00000349274; ENSG00000196422.
ENST00000401470; ENSP00000385826; ENSG00000196422.
ENST00000604351; ENSP00000473820; ENSG00000196422.
ENST00000605286; ENSP00000474807; ENSG00000196422.
ENST00000605660; ENSP00000474794; ENSG00000196422.
GeneIDi9858.
KEGGihsa:9858.
UCSCiuc004cfr.1. human.

Organism-specific databases

CTDi9858.
GeneCardsiPPP1R26.
HGNCiHGNC:29089. PPP1R26.
HPAiHPA044686.
MIMi614056. gene.
neXtProtiNX_Q5T8A7.
PharmGKBiPA134869847.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGYJ. Eukaryota.
ENOG4111MX8. LUCA.
GeneTreeiENSGT00390000014118.
HOGENOMiHOG000113155.
HOVERGENiHBG094902.
InParanoidiQ5T8A7.
KOiK17565.
OMAiEKRQHET.
OrthoDBiEOG73803X.
PhylomeDBiQ5T8A7.
TreeFamiTF331544.

Miscellaneous databases

GenomeRNAii9858.
PROiQ5T8A7.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T8A7.
CleanExiHS_KIAA0649.
GenevisibleiQ5T8A7. HS.

Family and domain databases

InterProiIPR026130. PPP1R26.
IPR031474. PPP1R26_N.
[Graphical view]
PANTHERiPTHR15724. PTHR15724. 1 hit.
PfamiPF15740. PPP1R26_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-834.
    Tissue: Brain.
  2. Ohara O., Suyama M., Nagase T., Ishikawa K.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-98; GLU-206; THR-434; SER-576 AND ASP-834.
    Tissue: Brain and Colon.
  5. "KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential."
    Yang L., Zhao J., Lu W., Li Y., Du X., Ning T., Lu G., Ke Y.
    Biochem. Biophys. Res. Commun. 334:884-890(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH UTP20, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Docking motif-guided mapping of the interactome of protein phosphatase-1."
    Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A., Nicolaescu E., Lesage B., Bollen M.
    Chem. Biol. 16:365-371(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PPP1CA.
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiPPR26_HUMAN
AccessioniPrimary (citable) accession number: Q5T8A7
Secondary accession number(s): Q86WU0, Q8WVV0, Q9Y4D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.