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Protein

Late cornified envelope-like proline-rich protein 1

Gene

LELP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope-like proline-rich protein 1
Alternative name(s):
Novel small proline-rich protein
Gene namesi
Name:LELP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32046. LELP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671557.

Polymorphism and mutation databases

DMDMi74745484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Late cornified envelope-like proline-rich protein 1PRO_0000271603Add
BLAST

Proteomic databases

PaxDbiQ5T871.
PeptideAtlasiQ5T871.
PRIDEiQ5T871.

Expressioni

Gene expression databases

BgeeiQ5T871.
CleanExiHS_LELP1.
GenevisibleiQ5T871. HS.

Organism-specific databases

HPAiHPA046932.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357736.

Structurei

3D structure databases

ProteinModelPortaliQ5T871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 9779Cys/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Phylogenomic databases

eggNOGiENOG410JIHW. Eukaryota.
ENOG41117NW. LUCA.
GeneTreeiENSGT00730000111592.
HOGENOMiHOG000113313.
InParanoidiQ5T871.
OMAiNEPKNCE.
OrthoDBiEOG7BS4DS.
PhylomeDBiQ5T871.

Family and domain databases

InterProiIPR026076. Lelp1.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF15042. LELP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDDKSKSN DPKTEPKNCD PKCEQKCESK CQPSCLKKLL QRCFEKCPWE
60 70 80 90
KCPAPPKCLP CPSQSPSSCP PQPCTKPCPP KCPSSCPHAC PPPCPPPE
Length:98
Mass (Da):10,697
Last modified:December 21, 2004 - v1
Checksum:i473BDFEB85D3EEA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161636 Genomic DNA. Translation: CAI19557.1.
BC087854 mRNA. Translation: AAH87854.1.
BC130507 mRNA. Translation: AAI30508.1.
BC130511 mRNA. Translation: AAI30512.1.
CCDSiCCDS30869.1.
RefSeqiNP_001010857.1. NM_001010857.2.
UniGeneiHs.125785.

Genome annotation databases

EnsembliENST00000368747; ENSP00000357736; ENSG00000203784.
GeneIDi149018.
KEGGihsa:149018.
UCSCiuc001fbl.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161636 Genomic DNA. Translation: CAI19557.1.
BC087854 mRNA. Translation: AAH87854.1.
BC130507 mRNA. Translation: AAI30508.1.
BC130511 mRNA. Translation: AAI30512.1.
CCDSiCCDS30869.1.
RefSeqiNP_001010857.1. NM_001010857.2.
UniGeneiHs.125785.

3D structure databases

ProteinModelPortaliQ5T871.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357736.

Polymorphism and mutation databases

DMDMi74745484.

Proteomic databases

PaxDbiQ5T871.
PeptideAtlasiQ5T871.
PRIDEiQ5T871.

Protocols and materials databases

DNASUi149018.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368747; ENSP00000357736; ENSG00000203784.
GeneIDi149018.
KEGGihsa:149018.
UCSCiuc001fbl.5. human.

Organism-specific databases

CTDi149018.
GeneCardsiLELP1.
HGNCiHGNC:32046. LELP1.
HPAiHPA046932.
MIMi611042. gene.
neXtProtiNX_Q5T871.
PharmGKBiPA142671557.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JIHW. Eukaryota.
ENOG41117NW. LUCA.
GeneTreeiENSGT00730000111592.
HOGENOMiHOG000113313.
InParanoidiQ5T871.
OMAiNEPKNCE.
OrthoDBiEOG7BS4DS.
PhylomeDBiQ5T871.

Miscellaneous databases

GenomeRNAii149018.
PROiQ5T871.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T871.
CleanExiHS_LELP1.
GenevisibleiQ5T871. HS.

Family and domain databases

InterProiIPR026076. Lelp1.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF15042. LELP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiLELP1_HUMAN
AccessioniPrimary (citable) accession number: Q5T871
Secondary accession number(s): A1L4E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.