ID   Q5T852_HUMAN            Unreviewed;       219 AA.
AC   Q5T852;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   21-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   SubName: Full=Mitochondrial poly(A) polymerase {ECO:0000313|Ensembl:ENSP00000404392.1};
DE   Flags: Fragment;
GN   Name=MTPAP {ECO:0000313|Ensembl:ENSP00000404392.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000404392.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000404392.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0007829|PubMed:19608861}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA   Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [3] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [4] {ECO:0000313|Ensembl:ENSP00000404392.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AL161651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5T852; -.
DR   SMR; Q5T852; -.
DR   MassIVE; Q5T852; -.
DR   MaxQB; Q5T852; -.
DR   PeptideAtlas; Q5T852; -.
DR   ProteomicsDB; 64707; -.
DR   Antibodypedia; 35309; 115 antibodies from 17 providers.
DR   Ensembl; ENST00000417581.1; ENSP00000404392.1; ENSG00000107951.15.
DR   UCSC; uc057sni.1; human.
DR   HGNC; HGNC:25532; MTPAP.
DR   VEuPathDB; HostDB:ENSG00000107951; -.
DR   GeneTree; ENSGT00940000158582; -.
DR   HOGENOM; CLU_085243_0_0_1; -.
DR   OMA; RTVLIKC; -.
DR   ChiTaRS; MTPAP; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000107951; Expressed in oocyte and 199 other cell types or tissues.
DR   ExpressionAtlas; Q5T852; baseline and differential.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0016071; P:mRNA metabolic process; IEA:UniProt.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR041252; RL.
DR   PANTHER; PTHR12271; POLY A POLYMERASE CID PAP -RELATED; 1.
DR   PANTHER; PTHR12271:SF133; POLY(A) RNA POLYMERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF17797; RL; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:Q5T852,
KW   ECO:0007829|MaxQB:Q5T852};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          1..66
FT                   /note="RL"
FT                   /evidence="ECO:0000259|Pfam:PF17797"
FT   NON_TER         219
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000404392.1"
SQ   SEQUENCE   219 AA;  25308 MW;  DAD6F4847C01BA75 CRC64;
     MQNERREQAQ RTVLIHCPEK ISENKFLKYL SQFGPINNHF FYESFGLYAV VEFCQKESIG
     SLQNGTHTPS TAMETAIPFR SRFFNLKLKN QTSERSRVRS SNQLPRSNKQ LFELLCYAES
     IDDQLNTLLK EFQLTEENTK LRYLTCSLIE DMAAAYFPDC IVRPFGSSVN TFGKLGCDLD
     MFLDLDETRN LSAHKISGNF LMEFQVKNVP SERIATQKI
//