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Q5T848 (GP158_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 158
Gene names
Name:GPR158
Synonyms:KIAA1136
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1215 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 3 family.

Sequence caution

The sequence AAS18315.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 12151192Probable G-protein coupled receptor 158
PRO_0000012969

Regions

Topological domain24 – 417394Extracellular Potential
Transmembrane418 – 43821Helical; Name=1; Potential
Topological domain439 – 45113Cytoplasmic Potential
Transmembrane452 – 47221Helical; Name=2; Potential
Topological domain473 – 48311Extracellular Potential
Transmembrane484 – 50623Helical; Name=3; Potential
Topological domain507 – 52822Cytoplasmic Potential
Transmembrane529 – 54921Helical; Name=4; Potential
Topological domain550 – 57930Extracellular Potential
Transmembrane580 – 60021Helical; Name=5; Potential
Topological domain601 – 61313Cytoplasmic Potential
Transmembrane614 – 63421Helical; Name=6; Potential
Topological domain635 – 6439Extracellular Potential
Transmembrane644 – 66421Helical; Name=7; Potential
Topological domain665 – 1215551Cytoplasmic Potential

Amino acid modifications

Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential
Glycosylation3331N-linked (GlcNAc...) Potential
Cross-link774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5

Natural variations

Natural variant4251A → G. Ref.1
Corresponds to variant rs2480345 [ dbSNP | Ensembl ].
VAR_049285
Natural variant12091I → V.
Corresponds to variant rs10828833 [ dbSNP | Ensembl ].
VAR_049286

Experimental info

Sequence conflict620 – 63011ELIISAIFHTI → SWIVNSMNSHF Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q5T848 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: E0B565E573B3ADE1

FASTA1,215135,489
        10         20         30         40         50         60 
MGAMAYPLLL CLLLAQLGLG AVGASRDPQG RPDSPRERTP KGKPHAQQPG RASASDSSAP 

        70         80         90        100        110        120 
WSRSTDGTIL AQKLAEEVPM DVASYLYTGD SHQLKRANCS GRYELAGLPG KWPALASAHP 

       130        140        150        160        170        180 
SLHRALDTLT HATNFLNVML QSNKSREQNL QDDLDWYQAL VWSLLEGEPS ISRAAITFST 

       190        200        210        220        230        240 
DSLSAPAPQV FLQATREESR ILLQDLSSSA PHLANATLET EWFHGLRRKW RPHLHRRGPN 

       250        260        270        280        290        300 
QGPRGLGHSW RRKDGLGGDK SHFKWSPPYL ECENGSYKPG WLVTLSSAIY GLQPNLVPEF 

       310        320        330        340        350        360 
RGVMKVDINL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY ECICKAGFYH 

       370        380        390        400        410        420 
PGVLPVNNFR RRGPDQHISG STKDVSEEAY VCLPCREGCP FCADDSPCFV QEDKYLRLAI 

       430        440        450        460        470        480 
ISFQALCMLL DFVSMLVVYH FRKAKSIRAS GLILLETILF GSLLLYFPVV ILYFEPSTFR 

       490        500        510        520        530        540 
CILLRWARLL GFATVYGTVT LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVILLVVFWF 

       550        560        570        580        590        600 
LIGWTSSVCQ NLEKQISLIG QGKTSDHLIF NMCLIDRWDY MTAVAEFLFL LWGVYLCYAV 

       610        620        630        640        650        660 
RTVPSAFHEP RYMAVAVHNE LIISAIFHTI RFVLASRLQS DWMLMLYFAH THLTVTVTIG 

       670        680        690        700        710        720 
LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI NSAWSEHSLD PEDIRDELKK 

       730        740        750        760        770        780 
LYAQLEIYKR KKMITNNPHL QKKRCSKKGL GRSIMRRITE IPETVSRQCS KEDKEGADHG 

       790        800        810        820        830        840 
TAKGTALIRK NPPESSGNTG KSKEETLKNR VFSLKKSHST YDHVRDQTEE SSSLPTESQE 

       850        860        870        880        890        900 
EETTENSTLE SLSGKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK TGHPRTSMLQ 

       910        920        930        940        950        960 
KSLSVIASAK EKTLGLAGKT QTAGVEERTK SQKPLPKDKE TNRNHSNSDN TETKDPAPQN 

       970        980        990       1000       1010       1020 
SNPAEEPRKP QKSGIMKQQR VNPTTANSDL NPGTTQMKDN FDIGEVCPWE VYDLTPGPVP 

      1030       1040       1050       1060       1070       1080 
SESKVQKHVS IVASEMEKNP TFSLKEKSHH KPKAAEVCQQ SNQKRIDKAE VCLWESQGQS 

      1090       1100       1110       1120       1130       1140 
ILEDEKLLIS KTPVLPERAK EENGGQPRAA NVCAGQSEEL PPKAVASKTE NENLNQIGHQ 

      1150       1160       1170       1180       1190       1200 
EKKTSSSEEN VRGSYNSSNN FQQPLTSRAE VCPWEFETPA QPNAGRSVAL PASSALSANK 

      1210 
IAGPRKEEIW DSFKV 

« Hide

References

« Hide 'large scale' references
[1]"Complete coding sequence of GPR158."
Bonner T.I., Nagle J.W., Kauffman D.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-425.
Tissue: Brain.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1215.
Tissue: Brain.
[4]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-774.
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY528411 mRNA. Translation: AAS18315.1. Different initiation.
AL161654, AL139821, AL355587 Genomic DNA. Translation: CAI16106.1.
AL355587, AL139821, AL161654 Genomic DNA. Translation: CAI15725.1.
AL139821, AL161654, AL355587 Genomic DNA. Translation: CAI16833.1.
AB032962 mRNA. Translation: BAA86450.2.
RefSeqNP_065803.2. NM_020752.2.
UniGeneHs.499108.

3D structure databases

ProteinModelPortalQ5T848.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121576. 1 interaction.
IntActQ5T848. 2 interactions.
STRING9606.ENSP00000365529.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ5T848.

Polymorphism databases

DMDM67461010.

Proteomic databases

PaxDbQ5T848.
PRIDEQ5T848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376351; ENSP00000365529; ENSG00000151025.
GeneID57512.
KEGGhsa:57512.
UCSCuc001isj.3. human.

Organism-specific databases

CTD57512.
GeneCardsGC10P025504.
HGNCHGNC:23689. GPR158.
HPAHPA013185.
MIM614573. gene.
neXtProtNX_Q5T848.
PharmGKBPA134939018.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG328237.
HOGENOMHOG000049235.
HOVERGENHBG080352.
InParanoidQ5T848.
KOK08469.
OMAYKPGWLV.
OrthoDBEOG71ZP0V.
PhylomeDBQ5T848.
TreeFamTF319114.

Gene expression databases

BgeeQ5T848.
CleanExHS_GPR158.
GenevestigatorQ5T848.

Family and domain databases

InterProIPR017978. GPCR_3_C.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR158.
GenomeRNAi57512.
NextBio63874.
PROQ5T848.
SOURCESearch...

Entry information

Entry nameGP158_HUMAN
AccessionPrimary (citable) accession number: Q5T848
Secondary accession number(s): Q6QR81, Q9ULT3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries