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Protein

Probable G-protein coupled receptor 158

Gene

GPR158

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 158
Gene namesi
Name:GPR158
Synonyms:KIAA1136
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23689. GPR158.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 417ExtracellularSequence analysisAdd BLAST394
Transmembranei418 – 438Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini439 – 451CytoplasmicSequence analysisAdd BLAST13
Transmembranei452 – 472Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini473 – 483ExtracellularSequence analysisAdd BLAST11
Transmembranei484 – 506Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini507 – 528CytoplasmicSequence analysisAdd BLAST22
Transmembranei529 – 549Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini550 – 579ExtracellularSequence analysisAdd BLAST30
Transmembranei580 – 600Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini601 – 613CytoplasmicSequence analysisAdd BLAST13
Transmembranei614 – 634Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini635 – 643ExtracellularSequence analysis9
Transmembranei644 – 664Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini665 – 1215CytoplasmicSequence analysisAdd BLAST551

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57512.
OpenTargetsiENSG00000151025.
PharmGKBiPA134939018.

Polymorphism and mutation databases

BioMutaiGPR158.
DMDMi67461010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001296924 – 1215Probable G-protein coupled receptor 158Add BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1
Modified residuei694PhosphoserineBy similarity1
Modified residuei705PhosphoserineBy similarity1
Modified residuei708PhosphoserineBy similarity1
Cross-linki774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei865PhosphoserineBy similarity1
Modified residuei946PhosphoserineBy similarity1
Modified residuei1080PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5T848.
PaxDbiQ5T848.
PeptideAtlasiQ5T848.
PRIDEiQ5T848.

PTM databases

iPTMnetiQ5T848.
PhosphoSitePlusiQ5T848.

Expressioni

Gene expression databases

BgeeiENSG00000151025.
CleanExiHS_GPR158.
GenevisibleiQ5T848. HS.

Organism-specific databases

HPAiHPA013185.

Interactioni

Protein-protein interaction databases

IntActiQ5T848. 2 interactors.
STRINGi9606.ENSP00000365529.

Structurei

3D structure databases

ProteinModelPortaliQ5T848.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4418. Eukaryota.
ENOG410XXEC. LUCA.
GeneTreeiENSGT00390000010934.
HOGENOMiHOG000049235.
HOVERGENiHBG080352.
InParanoidiQ5T848.
KOiK08469.
OMAiETEWFHG.
OrthoDBiEOG091G0GG1.
PhylomeDBiQ5T848.
TreeFamiTF319114.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5T848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAMAYPLLL CLLLAQLGLG AVGASRDPQG RPDSPRERTP KGKPHAQQPG
60 70 80 90 100
RASASDSSAP WSRSTDGTIL AQKLAEEVPM DVASYLYTGD SHQLKRANCS
110 120 130 140 150
GRYELAGLPG KWPALASAHP SLHRALDTLT HATNFLNVML QSNKSREQNL
160 170 180 190 200
QDDLDWYQAL VWSLLEGEPS ISRAAITFST DSLSAPAPQV FLQATREESR
210 220 230 240 250
ILLQDLSSSA PHLANATLET EWFHGLRRKW RPHLHRRGPN QGPRGLGHSW
260 270 280 290 300
RRKDGLGGDK SHFKWSPPYL ECENGSYKPG WLVTLSSAIY GLQPNLVPEF
310 320 330 340 350
RGVMKVDINL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY
360 370 380 390 400
ECICKAGFYH PGVLPVNNFR RRGPDQHISG STKDVSEEAY VCLPCREGCP
410 420 430 440 450
FCADDSPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS
460 470 480 490 500
GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWARLL GFATVYGTVT
510 520 530 540 550
LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVILLVVFWF LIGWTSSVCQ
560 570 580 590 600
NLEKQISLIG QGKTSDHLIF NMCLIDRWDY MTAVAEFLFL LWGVYLCYAV
610 620 630 640 650
RTVPSAFHEP RYMAVAVHNE LIISAIFHTI RFVLASRLQS DWMLMLYFAH
660 670 680 690 700
THLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI
710 720 730 740 750
NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL
760 770 780 790 800
GRSIMRRITE IPETVSRQCS KEDKEGADHG TAKGTALIRK NPPESSGNTG
810 820 830 840 850
KSKEETLKNR VFSLKKSHST YDHVRDQTEE SSSLPTESQE EETTENSTLE
860 870 880 890 900
SLSGKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK TGHPRTSMLQ
910 920 930 940 950
KSLSVIASAK EKTLGLAGKT QTAGVEERTK SQKPLPKDKE TNRNHSNSDN
960 970 980 990 1000
TETKDPAPQN SNPAEEPRKP QKSGIMKQQR VNPTTANSDL NPGTTQMKDN
1010 1020 1030 1040 1050
FDIGEVCPWE VYDLTPGPVP SESKVQKHVS IVASEMEKNP TFSLKEKSHH
1060 1070 1080 1090 1100
KPKAAEVCQQ SNQKRIDKAE VCLWESQGQS ILEDEKLLIS KTPVLPERAK
1110 1120 1130 1140 1150
EENGGQPRAA NVCAGQSEEL PPKAVASKTE NENLNQIGHQ EKKTSSSEEN
1160 1170 1180 1190 1200
VRGSYNSSNN FQQPLTSRAE VCPWEFETPA QPNAGRSVAL PASSALSANK
1210
IAGPRKEEIW DSFKV
Length:1,215
Mass (Da):135,489
Last modified:December 21, 2004 - v1
Checksum:iE0B565E573B3ADE1
GO

Sequence cautioni

The sequence AAS18315 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti620 – 630ELIISAIFHTI → SWIVNSMNSHF (PubMed:10574461).CuratedAdd BLAST11

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049285425A → G.1 PublicationCorresponds to variant rs2480345dbSNPEnsembl.1
Natural variantiVAR_0492861209I → V.Corresponds to variant rs10828833dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY528411 mRNA. Translation: AAS18315.1. Different initiation.
AL161654, AL139821, AL355587 Genomic DNA. Translation: CAI16106.1.
AL355587, AL139821, AL161654 Genomic DNA. Translation: CAI15725.1.
AL139821, AL161654, AL355587 Genomic DNA. Translation: CAI16833.1.
AB032962 mRNA. Translation: BAA86450.2.
CCDSiCCDS31166.1.
RefSeqiNP_065803.2. NM_020752.2.
UniGeneiHs.499108.

Genome annotation databases

EnsembliENST00000376351; ENSP00000365529; ENSG00000151025.
GeneIDi57512.
KEGGihsa:57512.
UCSCiuc001isj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY528411 mRNA. Translation: AAS18315.1. Different initiation.
AL161654, AL139821, AL355587 Genomic DNA. Translation: CAI16106.1.
AL355587, AL139821, AL161654 Genomic DNA. Translation: CAI15725.1.
AL139821, AL161654, AL355587 Genomic DNA. Translation: CAI16833.1.
AB032962 mRNA. Translation: BAA86450.2.
CCDSiCCDS31166.1.
RefSeqiNP_065803.2. NM_020752.2.
UniGeneiHs.499108.

3D structure databases

ProteinModelPortaliQ5T848.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5T848. 2 interactors.
STRINGi9606.ENSP00000365529.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ5T848.
PhosphoSitePlusiQ5T848.

Polymorphism and mutation databases

BioMutaiGPR158.
DMDMi67461010.

Proteomic databases

EPDiQ5T848.
PaxDbiQ5T848.
PeptideAtlasiQ5T848.
PRIDEiQ5T848.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376351; ENSP00000365529; ENSG00000151025.
GeneIDi57512.
KEGGihsa:57512.
UCSCiuc001isj.4. human.

Organism-specific databases

CTDi57512.
DisGeNETi57512.
GeneCardsiGPR158.
HGNCiHGNC:23689. GPR158.
HPAiHPA013185.
MIMi614573. gene.
neXtProtiNX_Q5T848.
OpenTargetsiENSG00000151025.
PharmGKBiPA134939018.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4418. Eukaryota.
ENOG410XXEC. LUCA.
GeneTreeiENSGT00390000010934.
HOGENOMiHOG000049235.
HOVERGENiHBG080352.
InParanoidiQ5T848.
KOiK08469.
OMAiETEWFHG.
OrthoDBiEOG091G0GG1.
PhylomeDBiQ5T848.
TreeFamiTF319114.

Miscellaneous databases

GeneWikiiGPR158.
GenomeRNAii57512.
PROiQ5T848.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151025.
CleanExiHS_GPR158.
GenevisibleiQ5T848. HS.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP158_HUMAN
AccessioniPrimary (citable) accession number: Q5T848
Secondary accession number(s): Q6QR81, Q9ULT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.