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Protein

Probable G-protein coupled receptor 158

Gene

GPR158

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. protein localization to plasma membrane Source: Ensembl
  2. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 158
Gene namesi
Name:GPR158
Synonyms:KIAA1136
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23689. GPR158.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 417394ExtracellularSequence AnalysisAdd
BLAST
Transmembranei418 – 43821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini439 – 45113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei452 – 47221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini473 – 48311ExtracellularSequence AnalysisAdd
BLAST
Transmembranei484 – 50623Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini507 – 52822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei529 – 54921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini550 – 57930ExtracellularSequence AnalysisAdd
BLAST
Transmembranei580 – 60021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini601 – 61313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei614 – 63421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini635 – 6439ExtracellularSequence Analysis
Transmembranei644 – 66421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini665 – 1215551CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 12151192Probable G-protein coupled receptor 158PRO_0000012969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
Cross-linki774 – 774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5T848.
PRIDEiQ5T848.

PTM databases

PhosphoSiteiQ5T848.

Expressioni

Gene expression databases

BgeeiQ5T848.
CleanExiHS_GPR158.
GenevestigatoriQ5T848.

Organism-specific databases

HPAiHPA013185.

Interactioni

Protein-protein interaction databases

BioGridi121576. 1 interaction.
IntActiQ5T848. 2 interactions.
STRINGi9606.ENSP00000365529.

Structurei

3D structure databases

ProteinModelPortaliQ5T848.
SMRiQ5T848. Positions 421-666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG328237.
GeneTreeiENSGT00390000010934.
HOGENOMiHOG000049235.
HOVERGENiHBG080352.
InParanoidiQ5T848.
KOiK08469.
OMAiETEWFHG.
OrthoDBiEOG71ZP0V.
PhylomeDBiQ5T848.
TreeFamiTF319114.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5T848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAMAYPLLL CLLLAQLGLG AVGASRDPQG RPDSPRERTP KGKPHAQQPG
60 70 80 90 100
RASASDSSAP WSRSTDGTIL AQKLAEEVPM DVASYLYTGD SHQLKRANCS
110 120 130 140 150
GRYELAGLPG KWPALASAHP SLHRALDTLT HATNFLNVML QSNKSREQNL
160 170 180 190 200
QDDLDWYQAL VWSLLEGEPS ISRAAITFST DSLSAPAPQV FLQATREESR
210 220 230 240 250
ILLQDLSSSA PHLANATLET EWFHGLRRKW RPHLHRRGPN QGPRGLGHSW
260 270 280 290 300
RRKDGLGGDK SHFKWSPPYL ECENGSYKPG WLVTLSSAIY GLQPNLVPEF
310 320 330 340 350
RGVMKVDINL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY
360 370 380 390 400
ECICKAGFYH PGVLPVNNFR RRGPDQHISG STKDVSEEAY VCLPCREGCP
410 420 430 440 450
FCADDSPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS
460 470 480 490 500
GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWARLL GFATVYGTVT
510 520 530 540 550
LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVILLVVFWF LIGWTSSVCQ
560 570 580 590 600
NLEKQISLIG QGKTSDHLIF NMCLIDRWDY MTAVAEFLFL LWGVYLCYAV
610 620 630 640 650
RTVPSAFHEP RYMAVAVHNE LIISAIFHTI RFVLASRLQS DWMLMLYFAH
660 670 680 690 700
THLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI
710 720 730 740 750
NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL
760 770 780 790 800
GRSIMRRITE IPETVSRQCS KEDKEGADHG TAKGTALIRK NPPESSGNTG
810 820 830 840 850
KSKEETLKNR VFSLKKSHST YDHVRDQTEE SSSLPTESQE EETTENSTLE
860 870 880 890 900
SLSGKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK TGHPRTSMLQ
910 920 930 940 950
KSLSVIASAK EKTLGLAGKT QTAGVEERTK SQKPLPKDKE TNRNHSNSDN
960 970 980 990 1000
TETKDPAPQN SNPAEEPRKP QKSGIMKQQR VNPTTANSDL NPGTTQMKDN
1010 1020 1030 1040 1050
FDIGEVCPWE VYDLTPGPVP SESKVQKHVS IVASEMEKNP TFSLKEKSHH
1060 1070 1080 1090 1100
KPKAAEVCQQ SNQKRIDKAE VCLWESQGQS ILEDEKLLIS KTPVLPERAK
1110 1120 1130 1140 1150
EENGGQPRAA NVCAGQSEEL PPKAVASKTE NENLNQIGHQ EKKTSSSEEN
1160 1170 1180 1190 1200
VRGSYNSSNN FQQPLTSRAE VCPWEFETPA QPNAGRSVAL PASSALSANK
1210
IAGPRKEEIW DSFKV
Length:1,215
Mass (Da):135,489
Last modified:December 21, 2004 - v1
Checksum:iE0B565E573B3ADE1
GO

Sequence cautioni

The sequence AAS18315.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti620 – 63011ELIISAIFHTI → SWIVNSMNSHF (PubMed:10574461).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti425 – 4251A → G.1 Publication
Corresponds to variant rs2480345 [ dbSNP | Ensembl ].
VAR_049285
Natural varianti1209 – 12091I → V.
Corresponds to variant rs10828833 [ dbSNP | Ensembl ].
VAR_049286

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY528411 mRNA. Translation: AAS18315.1. Different initiation.
AL161654, AL139821, AL355587 Genomic DNA. Translation: CAI16106.1.
AL355587, AL139821, AL161654 Genomic DNA. Translation: CAI15725.1.
AL139821, AL161654, AL355587 Genomic DNA. Translation: CAI16833.1.
AB032962 mRNA. Translation: BAA86450.2.
CCDSiCCDS31166.1.
RefSeqiNP_065803.2. NM_020752.2.
UniGeneiHs.499108.

Genome annotation databases

EnsembliENST00000376351; ENSP00000365529; ENSG00000151025.
GeneIDi57512.
KEGGihsa:57512.
UCSCiuc001isj.3. human.

Polymorphism databases

DMDMi67461010.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY528411 mRNA. Translation: AAS18315.1. Different initiation.
AL161654, AL139821, AL355587 Genomic DNA. Translation: CAI16106.1.
AL355587, AL139821, AL161654 Genomic DNA. Translation: CAI15725.1.
AL139821, AL161654, AL355587 Genomic DNA. Translation: CAI16833.1.
AB032962 mRNA. Translation: BAA86450.2.
CCDSiCCDS31166.1.
RefSeqiNP_065803.2. NM_020752.2.
UniGeneiHs.499108.

3D structure databases

ProteinModelPortaliQ5T848.
SMRiQ5T848. Positions 421-666.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121576. 1 interaction.
IntActiQ5T848. 2 interactions.
STRINGi9606.ENSP00000365529.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ5T848.

Polymorphism databases

DMDMi67461010.

Proteomic databases

PaxDbiQ5T848.
PRIDEiQ5T848.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376351; ENSP00000365529; ENSG00000151025.
GeneIDi57512.
KEGGihsa:57512.
UCSCiuc001isj.3. human.

Organism-specific databases

CTDi57512.
GeneCardsiGC10P025504.
HGNCiHGNC:23689. GPR158.
HPAiHPA013185.
MIMi614573. gene.
neXtProtiNX_Q5T848.
PharmGKBiPA134939018.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG328237.
GeneTreeiENSGT00390000010934.
HOGENOMiHOG000049235.
HOVERGENiHBG080352.
InParanoidiQ5T848.
KOiK08469.
OMAiETEWFHG.
OrthoDBiEOG71ZP0V.
PhylomeDBiQ5T848.
TreeFamiTF319114.

Miscellaneous databases

GeneWikiiGPR158.
GenomeRNAii57512.
NextBioi63874.
PROiQ5T848.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T848.
CleanExiHS_GPR158.
GenevestigatoriQ5T848.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete coding sequence of GPR158."
    Bonner T.I., Nagle J.W., Kauffman D.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-425.
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1215.
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
    Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
    Proteomics 8:2885-2896(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-774.
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiGP158_HUMAN
AccessioniPrimary (citable) accession number: Q5T848
Secondary accession number(s): Q6QR81, Q9ULT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 21, 2004
Last modified: January 7, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.