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Q5T848

- GP158_HUMAN

UniProt

Q5T848 - GP158_HUMAN

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Protein
Probable G-protein coupled receptor 158
Gene
GPR158, KIAA1136
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. protein localization to plasma membrane Source: Ensembl
  2. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 158
Gene namesi
Name:GPR158
Synonyms:KIAA1136
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23689. GPR158.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 417394Extracellular Reviewed prediction
Add
BLAST
Transmembranei418 – 43821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini439 – 45113Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei452 – 47221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini473 – 48311Extracellular Reviewed prediction
Add
BLAST
Transmembranei484 – 50623Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini507 – 52822Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei529 – 54921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini550 – 57930Extracellular Reviewed prediction
Add
BLAST
Transmembranei580 – 60021Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini601 – 61313Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei614 – 63421Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini635 – 6439Extracellular Reviewed prediction
Transmembranei644 – 66421Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini665 – 1215551Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 12151192Probable G-protein coupled receptor 158
PRO_0000012969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi215 – 2151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi333 – 3331N-linked (GlcNAc...) Reviewed prediction
Cross-linki774 – 774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5T848.
PRIDEiQ5T848.

PTM databases

PhosphoSiteiQ5T848.

Expressioni

Gene expression databases

BgeeiQ5T848.
CleanExiHS_GPR158.
GenevestigatoriQ5T848.

Organism-specific databases

HPAiHPA013185.

Interactioni

Protein-protein interaction databases

BioGridi121576. 1 interaction.
IntActiQ5T848. 2 interactions.
STRINGi9606.ENSP00000365529.

Structurei

3D structure databases

ProteinModelPortaliQ5T848.
SMRiQ5T848. Positions 421-666.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG328237.
HOGENOMiHOG000049235.
HOVERGENiHBG080352.
InParanoidiQ5T848.
KOiK08469.
OMAiETEWFHG.
OrthoDBiEOG71ZP0V.
PhylomeDBiQ5T848.
TreeFamiTF319114.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5T848-1 [UniParc]FASTAAdd to Basket

« Hide

MGAMAYPLLL CLLLAQLGLG AVGASRDPQG RPDSPRERTP KGKPHAQQPG     50
RASASDSSAP WSRSTDGTIL AQKLAEEVPM DVASYLYTGD SHQLKRANCS 100
GRYELAGLPG KWPALASAHP SLHRALDTLT HATNFLNVML QSNKSREQNL 150
QDDLDWYQAL VWSLLEGEPS ISRAAITFST DSLSAPAPQV FLQATREESR 200
ILLQDLSSSA PHLANATLET EWFHGLRRKW RPHLHRRGPN QGPRGLGHSW 250
RRKDGLGGDK SHFKWSPPYL ECENGSYKPG WLVTLSSAIY GLQPNLVPEF 300
RGVMKVDINL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY 350
ECICKAGFYH PGVLPVNNFR RRGPDQHISG STKDVSEEAY VCLPCREGCP 400
FCADDSPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS 450
GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWARLL GFATVYGTVT 500
LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVILLVVFWF LIGWTSSVCQ 550
NLEKQISLIG QGKTSDHLIF NMCLIDRWDY MTAVAEFLFL LWGVYLCYAV 600
RTVPSAFHEP RYMAVAVHNE LIISAIFHTI RFVLASRLQS DWMLMLYFAH 650
THLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI 700
NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL 750
GRSIMRRITE IPETVSRQCS KEDKEGADHG TAKGTALIRK NPPESSGNTG 800
KSKEETLKNR VFSLKKSHST YDHVRDQTEE SSSLPTESQE EETTENSTLE 850
SLSGKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK TGHPRTSMLQ 900
KSLSVIASAK EKTLGLAGKT QTAGVEERTK SQKPLPKDKE TNRNHSNSDN 950
TETKDPAPQN SNPAEEPRKP QKSGIMKQQR VNPTTANSDL NPGTTQMKDN 1000
FDIGEVCPWE VYDLTPGPVP SESKVQKHVS IVASEMEKNP TFSLKEKSHH 1050
KPKAAEVCQQ SNQKRIDKAE VCLWESQGQS ILEDEKLLIS KTPVLPERAK 1100
EENGGQPRAA NVCAGQSEEL PPKAVASKTE NENLNQIGHQ EKKTSSSEEN 1150
VRGSYNSSNN FQQPLTSRAE VCPWEFETPA QPNAGRSVAL PASSALSANK 1200
IAGPRKEEIW DSFKV 1215
Length:1,215
Mass (Da):135,489
Last modified:December 21, 2004 - v1
Checksum:iE0B565E573B3ADE1
GO

Sequence cautioni

The sequence AAS18315.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti425 – 4251A → G.1 Publication
Corresponds to variant rs2480345 [ dbSNP | Ensembl ].
VAR_049285
Natural varianti1209 – 12091I → V.
Corresponds to variant rs10828833 [ dbSNP | Ensembl ].
VAR_049286

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti620 – 63011ELIISAIFHTI → SWIVNSMNSHF1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY528411 mRNA. Translation: AAS18315.1. Different initiation.
AL161654, AL139821, AL355587 Genomic DNA. Translation: CAI16106.1.
AL355587, AL139821, AL161654 Genomic DNA. Translation: CAI15725.1.
AL139821, AL161654, AL355587 Genomic DNA. Translation: CAI16833.1.
AB032962 mRNA. Translation: BAA86450.2.
CCDSiCCDS31166.1.
RefSeqiNP_065803.2. NM_020752.2.
UniGeneiHs.499108.

Genome annotation databases

EnsembliENST00000376351; ENSP00000365529; ENSG00000151025.
GeneIDi57512.
KEGGihsa:57512.
UCSCiuc001isj.3. human.

Polymorphism databases

DMDMi67461010.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY528411 mRNA. Translation: AAS18315.1 . Different initiation.
AL161654 , AL139821 , AL355587 Genomic DNA. Translation: CAI16106.1 .
AL355587 , AL139821 , AL161654 Genomic DNA. Translation: CAI15725.1 .
AL139821 , AL161654 , AL355587 Genomic DNA. Translation: CAI16833.1 .
AB032962 mRNA. Translation: BAA86450.2 .
CCDSi CCDS31166.1.
RefSeqi NP_065803.2. NM_020752.2.
UniGenei Hs.499108.

3D structure databases

ProteinModelPortali Q5T848.
SMRi Q5T848. Positions 421-666.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121576. 1 interaction.
IntActi Q5T848. 2 interactions.
STRINGi 9606.ENSP00000365529.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q5T848.

Polymorphism databases

DMDMi 67461010.

Proteomic databases

PaxDbi Q5T848.
PRIDEi Q5T848.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376351 ; ENSP00000365529 ; ENSG00000151025 .
GeneIDi 57512.
KEGGi hsa:57512.
UCSCi uc001isj.3. human.

Organism-specific databases

CTDi 57512.
GeneCardsi GC10P025504.
HGNCi HGNC:23689. GPR158.
HPAi HPA013185.
MIMi 614573. gene.
neXtProti NX_Q5T848.
PharmGKBi PA134939018.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG328237.
HOGENOMi HOG000049235.
HOVERGENi HBG080352.
InParanoidi Q5T848.
KOi K08469.
OMAi ETEWFHG.
OrthoDBi EOG71ZP0V.
PhylomeDBi Q5T848.
TreeFami TF319114.

Miscellaneous databases

GeneWikii GPR158.
GenomeRNAii 57512.
NextBioi 63874.
PROi Q5T848.
SOURCEi Search...

Gene expression databases

Bgeei Q5T848.
CleanExi HS_GPR158.
Genevestigatori Q5T848.

Family and domain databases

InterProi IPR017978. GPCR_3_C.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
[Graphical view ]
PROSITEi PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete coding sequence of GPR158."
    Bonner T.I., Nagle J.W., Kauffman D.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-425.
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1215.
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
    Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
    Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-774.
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiGP158_HUMAN
AccessioniPrimary (citable) accession number: Q5T848
Secondary accession number(s): Q6QR81, Q9ULT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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