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Q5T848

- GP158_HUMAN

UniProt

Q5T848 - GP158_HUMAN

Protein

Probable G-protein coupled receptor 158

Gene

GPR158

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein localization to plasma membrane Source: Ensembl
    2. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 158
    Gene namesi
    Name:GPR158
    Synonyms:KIAA1136
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23689. GPR158.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134939018.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 12151192Probable G-protein coupled receptor 158PRO_0000012969Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
    Cross-linki774 – 774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ5T848.
    PRIDEiQ5T848.

    PTM databases

    PhosphoSiteiQ5T848.

    Expressioni

    Gene expression databases

    BgeeiQ5T848.
    CleanExiHS_GPR158.
    GenevestigatoriQ5T848.

    Organism-specific databases

    HPAiHPA013185.

    Interactioni

    Protein-protein interaction databases

    BioGridi121576. 1 interaction.
    IntActiQ5T848. 2 interactions.
    STRINGi9606.ENSP00000365529.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T848.
    SMRiQ5T848. Positions 421-666.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 417394ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini439 – 45113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini473 – 48311ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini507 – 52822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini550 – 57930ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini601 – 61313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini635 – 6439ExtracellularSequence Analysis
    Topological domaini665 – 1215551CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei418 – 43821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei452 – 47221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei484 – 50623Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei529 – 54921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei580 – 60021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei614 – 63421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei644 – 66421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG328237.
    HOGENOMiHOG000049235.
    HOVERGENiHBG080352.
    InParanoidiQ5T848.
    KOiK08469.
    OMAiETEWFHG.
    OrthoDBiEOG71ZP0V.
    PhylomeDBiQ5T848.
    TreeFamiTF319114.

    Family and domain databases

    InterProiIPR017978. GPCR_3_C.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    [Graphical view]
    PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5T848-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAMAYPLLL CLLLAQLGLG AVGASRDPQG RPDSPRERTP KGKPHAQQPG     50
    RASASDSSAP WSRSTDGTIL AQKLAEEVPM DVASYLYTGD SHQLKRANCS 100
    GRYELAGLPG KWPALASAHP SLHRALDTLT HATNFLNVML QSNKSREQNL 150
    QDDLDWYQAL VWSLLEGEPS ISRAAITFST DSLSAPAPQV FLQATREESR 200
    ILLQDLSSSA PHLANATLET EWFHGLRRKW RPHLHRRGPN QGPRGLGHSW 250
    RRKDGLGGDK SHFKWSPPYL ECENGSYKPG WLVTLSSAIY GLQPNLVPEF 300
    RGVMKVDINL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY 350
    ECICKAGFYH PGVLPVNNFR RRGPDQHISG STKDVSEEAY VCLPCREGCP 400
    FCADDSPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS 450
    GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWARLL GFATVYGTVT 500
    LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVILLVVFWF LIGWTSSVCQ 550
    NLEKQISLIG QGKTSDHLIF NMCLIDRWDY MTAVAEFLFL LWGVYLCYAV 600
    RTVPSAFHEP RYMAVAVHNE LIISAIFHTI RFVLASRLQS DWMLMLYFAH 650
    THLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI 700
    NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL 750
    GRSIMRRITE IPETVSRQCS KEDKEGADHG TAKGTALIRK NPPESSGNTG 800
    KSKEETLKNR VFSLKKSHST YDHVRDQTEE SSSLPTESQE EETTENSTLE 850
    SLSGKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK TGHPRTSMLQ 900
    KSLSVIASAK EKTLGLAGKT QTAGVEERTK SQKPLPKDKE TNRNHSNSDN 950
    TETKDPAPQN SNPAEEPRKP QKSGIMKQQR VNPTTANSDL NPGTTQMKDN 1000
    FDIGEVCPWE VYDLTPGPVP SESKVQKHVS IVASEMEKNP TFSLKEKSHH 1050
    KPKAAEVCQQ SNQKRIDKAE VCLWESQGQS ILEDEKLLIS KTPVLPERAK 1100
    EENGGQPRAA NVCAGQSEEL PPKAVASKTE NENLNQIGHQ EKKTSSSEEN 1150
    VRGSYNSSNN FQQPLTSRAE VCPWEFETPA QPNAGRSVAL PASSALSANK 1200
    IAGPRKEEIW DSFKV 1215
    Length:1,215
    Mass (Da):135,489
    Last modified:December 21, 2004 - v1
    Checksum:iE0B565E573B3ADE1
    GO

    Sequence cautioni

    The sequence AAS18315.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti620 – 63011ELIISAIFHTI → SWIVNSMNSHF(PubMed:10574461)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti425 – 4251A → G.1 Publication
    Corresponds to variant rs2480345 [ dbSNP | Ensembl ].
    VAR_049285
    Natural varianti1209 – 12091I → V.
    Corresponds to variant rs10828833 [ dbSNP | Ensembl ].
    VAR_049286

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY528411 mRNA. Translation: AAS18315.1. Different initiation.
    AL161654, AL139821, AL355587 Genomic DNA. Translation: CAI16106.1.
    AL355587, AL139821, AL161654 Genomic DNA. Translation: CAI15725.1.
    AL139821, AL161654, AL355587 Genomic DNA. Translation: CAI16833.1.
    AB032962 mRNA. Translation: BAA86450.2.
    CCDSiCCDS31166.1.
    RefSeqiNP_065803.2. NM_020752.2.
    UniGeneiHs.499108.

    Genome annotation databases

    EnsembliENST00000376351; ENSP00000365529; ENSG00000151025.
    GeneIDi57512.
    KEGGihsa:57512.
    UCSCiuc001isj.3. human.

    Polymorphism databases

    DMDMi67461010.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY528411 mRNA. Translation: AAS18315.1 . Different initiation.
    AL161654 , AL139821 , AL355587 Genomic DNA. Translation: CAI16106.1 .
    AL355587 , AL139821 , AL161654 Genomic DNA. Translation: CAI15725.1 .
    AL139821 , AL161654 , AL355587 Genomic DNA. Translation: CAI16833.1 .
    AB032962 mRNA. Translation: BAA86450.2 .
    CCDSi CCDS31166.1.
    RefSeqi NP_065803.2. NM_020752.2.
    UniGenei Hs.499108.

    3D structure databases

    ProteinModelPortali Q5T848.
    SMRi Q5T848. Positions 421-666.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121576. 1 interaction.
    IntActi Q5T848. 2 interactions.
    STRINGi 9606.ENSP00000365529.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q5T848.

    Polymorphism databases

    DMDMi 67461010.

    Proteomic databases

    PaxDbi Q5T848.
    PRIDEi Q5T848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376351 ; ENSP00000365529 ; ENSG00000151025 .
    GeneIDi 57512.
    KEGGi hsa:57512.
    UCSCi uc001isj.3. human.

    Organism-specific databases

    CTDi 57512.
    GeneCardsi GC10P025504.
    HGNCi HGNC:23689. GPR158.
    HPAi HPA013185.
    MIMi 614573. gene.
    neXtProti NX_Q5T848.
    PharmGKBi PA134939018.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG328237.
    HOGENOMi HOG000049235.
    HOVERGENi HBG080352.
    InParanoidi Q5T848.
    KOi K08469.
    OMAi ETEWFHG.
    OrthoDBi EOG71ZP0V.
    PhylomeDBi Q5T848.
    TreeFami TF319114.

    Miscellaneous databases

    GeneWikii GPR158.
    GenomeRNAii 57512.
    NextBioi 63874.
    PROi Q5T848.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5T848.
    CleanExi HS_GPR158.
    Genevestigatori Q5T848.

    Family and domain databases

    InterProi IPR017978. GPCR_3_C.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete coding sequence of GPR158."
      Bonner T.I., Nagle J.W., Kauffman D.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-425.
      Tissue: Brain.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1215.
      Tissue: Brain.
    4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
      Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
      Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-774.
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiGP158_HUMAN
    AccessioniPrimary (citable) accession number: Q5T848
    Secondary accession number(s): Q6QR81, Q9ULT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3