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Q5T7W7

- TSTD2_HUMAN

UniProt

Q5T7W7 - TSTD2_HUMAN

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Protein

Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

Gene
TSTD2, C9orf97, PP4189
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei355 – 3551Cysteine persulfide intermediate By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
Alternative name(s):
Rhodanese domain-containing protein 2
Gene namesi
Name:TSTD2
Synonyms:C9orf97
ORF Names:PP4189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:30087. TSTD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165586365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2PRO_0000230673Add
BLAST

Proteomic databases

MaxQBiQ5T7W7.
PaxDbiQ5T7W7.
PRIDEiQ5T7W7.

PTM databases

PhosphoSiteiQ5T7W7.

Expressioni

Gene expression databases

ArrayExpressiQ5T7W7.
BgeeiQ5T7W7.
CleanExiHS_C9orf97.
GenevestigatoriQ5T7W7.

Organism-specific databases

HPAiHPA022537.
HPA024241.

Interactioni

Protein-protein interaction databases

BioGridi127681. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5T7W7.
SMRiQ5T7W7. Positions 198-416.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini301 – 39696RhodaneseAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.

Phylogenomic databases

eggNOGiCOG1054.
HOVERGENiHBG080327.
InParanoidiQ5T7W7.
PhylomeDBiQ5T7W7.
TreeFamiTF324329.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T7W7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPSSTSPDQG DDLENCILRF SDLDLKDMSL INPSSSLKAE LDGSTKKKYS    50
FAKKKAFALF VKTKEVPTKR SFECKEKLWK CCRQLFTDQT SIHRHVATQH 100
ADEIYHQTAS ILKQLAVTLS TSKSLSSADE KNPLKECLPH SHDVSAWLPD 150
ISCFNPDELI SGQGSEEGEV LLYYCYHDLE DPQWICAWQT ALCQHLHLTG 200
KIRIAAEGIN GTVGGSKLAT RLYVEVMLSF PLFKDDLCKD DFKTSKGGAH 250
CFPELRVGVF EEIVPMGISP KKISYKKPGI HLSPGEFHKE VEKFLSQANQ 300
EQSDTILLDC RNFYESKIGR FQGCLAPDIR KFSYFPSYVD KNLELFREKR 350
VLMYCTGGIR CERGSAYLKA KGVCKEVFQL KGGIHKYLEE FPDGFYKGKL 400
FVFDERYALS YNSDVVSECS YCGARWDQYK LCSTPQCRQL VLTCPACQGQ 450
GFTACCVTCQ DKGSRKVSGP MQDSFKEECE CTARRPRIPR ELLQHVRQPV 500
SPEPGPDADE DGPVLM 516
Length:516
Mass (Da):58,263
Last modified:December 21, 2004 - v1
Checksum:i8C39781FD73CDA9F
GO
Isoform 2 (identifier: Q5T7W7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.
     261-278: EEIVPMGISPKKISYKKP → MDLCLADSSVSAPAPHRQ
     418-427: ECSYCGARWD → GRSAQAQSPN
     428-516: Missing.

Note: No experimental confirmation available.

Show »
Length:167
Mass (Da):19,001
Checksum:iCBEA9BA49CF22814
GO

Sequence cautioni

The sequence AAH35604.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB71188.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB71271.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831R → Q.3 Publications
Corresponds to variant rs2773347 [ dbSNP | Ensembl ].
VAR_050842
Natural varianti109 – 1091A → D.
Corresponds to variant rs10817858 [ dbSNP | Ensembl ].
VAR_050843

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 260260Missing in isoform 2. VSP_017825Add
BLAST
Alternative sequencei261 – 27818EEIVP…SYKKP → MDLCLADSSVSAPAPHRQ in isoform 2. VSP_017826Add
BLAST
Alternative sequencei418 – 42710ECSYCGARWD → GRSAQAQSPN in isoform 2. VSP_017827
Alternative sequencei428 – 51689Missing in isoform 2. VSP_017828Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301L → F in BAC87530. 1 Publication
Sequence conflicti304 – 3041D → N in BAB71188. 1 Publication
Sequence conflicti433 – 4331S → C in BAC87530. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF258575 mRNA. Translation: AAG23778.1.
AK056453 mRNA. Translation: BAB71188.1. Different initiation.
AK056752 mRNA. Translation: BAB71271.1. Different initiation.
AK128615 mRNA. Translation: BAC87530.1.
AK291199 mRNA. Translation: BAF83888.1.
AL162385 Genomic DNA. Translation: CAI12859.1.
AL162385 Genomic DNA. Translation: CAI12860.1.
CH471105 Genomic DNA. Translation: EAW58848.1.
BC035604 mRNA. Translation: AAH35604.1. Different initiation.
CCDSiCCDS6727.2. [Q5T7W7-1]
RefSeqiNP_640339.4. NM_139246.4. [Q5T7W7-1]
UniGeneiHs.723236.

Genome annotation databases

EnsembliENST00000341170; ENSP00000342499; ENSG00000136925. [Q5T7W7-1]
ENST00000354801; ENSP00000346856; ENSG00000136925. [Q5T7W7-2]
GeneIDi158427.
KEGGihsa:158427.
UCSCiuc004axn.3. human. [Q5T7W7-1]

Polymorphism databases

DMDMi74745447.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF258575 mRNA. Translation: AAG23778.1 .
AK056453 mRNA. Translation: BAB71188.1 . Different initiation.
AK056752 mRNA. Translation: BAB71271.1 . Different initiation.
AK128615 mRNA. Translation: BAC87530.1 .
AK291199 mRNA. Translation: BAF83888.1 .
AL162385 Genomic DNA. Translation: CAI12859.1 .
AL162385 Genomic DNA. Translation: CAI12860.1 .
CH471105 Genomic DNA. Translation: EAW58848.1 .
BC035604 mRNA. Translation: AAH35604.1 . Different initiation.
CCDSi CCDS6727.2. [Q5T7W7-1 ]
RefSeqi NP_640339.4. NM_139246.4. [Q5T7W7-1 ]
UniGenei Hs.723236.

3D structure databases

ProteinModelPortali Q5T7W7.
SMRi Q5T7W7. Positions 198-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127681. 1 interaction.

PTM databases

PhosphoSitei Q5T7W7.

Polymorphism databases

DMDMi 74745447.

Proteomic databases

MaxQBi Q5T7W7.
PaxDbi Q5T7W7.
PRIDEi Q5T7W7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341170 ; ENSP00000342499 ; ENSG00000136925 . [Q5T7W7-1 ]
ENST00000354801 ; ENSP00000346856 ; ENSG00000136925 . [Q5T7W7-2 ]
GeneIDi 158427.
KEGGi hsa:158427.
UCSCi uc004axn.3. human. [Q5T7W7-1 ]

Organism-specific databases

CTDi 158427.
GeneCardsi GC09M100363.
H-InvDB HIX0008213.
HGNCi HGNC:30087. TSTD2.
HPAi HPA022537.
HPA024241.
neXtProti NX_Q5T7W7.
PharmGKBi PA165586365.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1054.
HOVERGENi HBG080327.
InParanoidi Q5T7W7.
PhylomeDBi Q5T7W7.
TreeFami TF324329.

Miscellaneous databases

ChiTaRSi TSTD2. human.
GenomeRNAii 158427.
NextBioi 87734.
PROi Q5T7W7.

Gene expression databases

ArrayExpressi Q5T7W7.
Bgeei Q5T7W7.
CleanExi HS_C9orf97.
Genevestigatori Q5T7W7.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
InterProi IPR001763. Rhodanese-like_dom.
[Graphical view ]
Pfami PF00581. Rhodanese. 1 hit.
[Graphical view ]
SMARTi SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-83.
    Tissue: Trachea.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-83.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-83.
    Tissue: Lymph.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTSTD2_HUMAN
AccessioniPrimary (citable) accession number: Q5T7W7
Secondary accession number(s): A6NMJ4
, A8K584, Q6ZQZ6, Q8IYM3, Q8WY73, Q96ML6, Q96MU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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