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Protein

Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

Gene

TSTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei355 – 3551Cysteine persulfide intermediatePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
Alternative name(s):
Rhodanese domain-containing protein 2
Gene namesi
Name:TSTD2
Synonyms:C9orf97
ORF Names:PP4189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:30087. TSTD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165586365.

Polymorphism and mutation databases

BioMutaiTSTD2.
DMDMi74745447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2PRO_0000230673Add
BLAST

Proteomic databases

MaxQBiQ5T7W7.
PaxDbiQ5T7W7.
PRIDEiQ5T7W7.

PTM databases

PhosphoSiteiQ5T7W7.

Expressioni

Gene expression databases

BgeeiQ5T7W7.
CleanExiHS_C9orf97.
ExpressionAtlasiQ5T7W7. baseline and differential.
GenevisibleiQ5T7W7. HS.

Organism-specific databases

HPAiHPA022537.
HPA024241.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IKZF3Q9UKT93EBI-8994397,EBI-747204
RELQ048643EBI-8994397,EBI-307352
VPS52Q8N1B43EBI-8994397,EBI-2799833

Protein-protein interaction databases

BioGridi127681. 4 interactions.
IntActiQ5T7W7. 16 interactions.
STRINGi9606.ENSP00000342499.

Structurei

3D structure databases

ProteinModelPortaliQ5T7W7.
SMRiQ5T7W7. Positions 198-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini301 – 39696RhodanesePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1054.
GeneTreeiENSGT00390000016307.
HOVERGENiHBG080327.
InParanoidiQ5T7W7.
OMAiVCKEVFQ.
PhylomeDBiQ5T7W7.
TreeFamiTF324329.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T7W7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSSTSPDQG DDLENCILRF SDLDLKDMSL INPSSSLKAE LDGSTKKKYS
60 70 80 90 100
FAKKKAFALF VKTKEVPTKR SFECKEKLWK CCRQLFTDQT SIHRHVATQH
110 120 130 140 150
ADEIYHQTAS ILKQLAVTLS TSKSLSSADE KNPLKECLPH SHDVSAWLPD
160 170 180 190 200
ISCFNPDELI SGQGSEEGEV LLYYCYHDLE DPQWICAWQT ALCQHLHLTG
210 220 230 240 250
KIRIAAEGIN GTVGGSKLAT RLYVEVMLSF PLFKDDLCKD DFKTSKGGAH
260 270 280 290 300
CFPELRVGVF EEIVPMGISP KKISYKKPGI HLSPGEFHKE VEKFLSQANQ
310 320 330 340 350
EQSDTILLDC RNFYESKIGR FQGCLAPDIR KFSYFPSYVD KNLELFREKR
360 370 380 390 400
VLMYCTGGIR CERGSAYLKA KGVCKEVFQL KGGIHKYLEE FPDGFYKGKL
410 420 430 440 450
FVFDERYALS YNSDVVSECS YCGARWDQYK LCSTPQCRQL VLTCPACQGQ
460 470 480 490 500
GFTACCVTCQ DKGSRKVSGP MQDSFKEECE CTARRPRIPR ELLQHVRQPV
510
SPEPGPDADE DGPVLM
Length:516
Mass (Da):58,263
Last modified:December 21, 2004 - v1
Checksum:i8C39781FD73CDA9F
GO
Isoform 2 (identifier: Q5T7W7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.
     261-278: EEIVPMGISPKKISYKKP → MDLCLADSSVSAPAPHRQ
     418-427: ECSYCGARWD → GRSAQAQSPN
     428-516: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):19,001
Checksum:iCBEA9BA49CF22814
GO

Sequence cautioni

The sequence AAH35604.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB71188.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB71271.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301L → F in BAC87530 (PubMed:14702039).Curated
Sequence conflicti304 – 3041D → N in BAB71188 (PubMed:14702039).Curated
Sequence conflicti433 – 4331S → C in BAC87530 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831R → Q.3 Publications
Corresponds to variant rs2773347 [ dbSNP | Ensembl ].
VAR_050842
Natural varianti109 – 1091A → D.
Corresponds to variant rs10817858 [ dbSNP | Ensembl ].
VAR_050843

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 260260Missing in isoform 2. 1 PublicationVSP_017825Add
BLAST
Alternative sequencei261 – 27818EEIVP…SYKKP → MDLCLADSSVSAPAPHRQ in isoform 2. 1 PublicationVSP_017826Add
BLAST
Alternative sequencei418 – 42710ECSYCGARWD → GRSAQAQSPN in isoform 2. 1 PublicationVSP_017827
Alternative sequencei428 – 51689Missing in isoform 2. 1 PublicationVSP_017828Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258575 mRNA. Translation: AAG23778.1.
AK056453 mRNA. Translation: BAB71188.1. Different initiation.
AK056752 mRNA. Translation: BAB71271.1. Different initiation.
AK128615 mRNA. Translation: BAC87530.1.
AK291199 mRNA. Translation: BAF83888.1.
AL162385 Genomic DNA. Translation: CAI12859.1.
AL162385 Genomic DNA. Translation: CAI12860.1.
CH471105 Genomic DNA. Translation: EAW58848.1.
BC035604 mRNA. Translation: AAH35604.1. Different initiation.
CCDSiCCDS6727.2. [Q5T7W7-1]
RefSeqiNP_640339.4. NM_139246.4. [Q5T7W7-1]
UniGeneiHs.723236.

Genome annotation databases

EnsembliENST00000341170; ENSP00000342499; ENSG00000136925. [Q5T7W7-1]
GeneIDi158427.
KEGGihsa:158427.
UCSCiuc004axn.3. human. [Q5T7W7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258575 mRNA. Translation: AAG23778.1.
AK056453 mRNA. Translation: BAB71188.1. Different initiation.
AK056752 mRNA. Translation: BAB71271.1. Different initiation.
AK128615 mRNA. Translation: BAC87530.1.
AK291199 mRNA. Translation: BAF83888.1.
AL162385 Genomic DNA. Translation: CAI12859.1.
AL162385 Genomic DNA. Translation: CAI12860.1.
CH471105 Genomic DNA. Translation: EAW58848.1.
BC035604 mRNA. Translation: AAH35604.1. Different initiation.
CCDSiCCDS6727.2. [Q5T7W7-1]
RefSeqiNP_640339.4. NM_139246.4. [Q5T7W7-1]
UniGeneiHs.723236.

3D structure databases

ProteinModelPortaliQ5T7W7.
SMRiQ5T7W7. Positions 198-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127681. 4 interactions.
IntActiQ5T7W7. 16 interactions.
STRINGi9606.ENSP00000342499.

PTM databases

PhosphoSiteiQ5T7W7.

Polymorphism and mutation databases

BioMutaiTSTD2.
DMDMi74745447.

Proteomic databases

MaxQBiQ5T7W7.
PaxDbiQ5T7W7.
PRIDEiQ5T7W7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341170; ENSP00000342499; ENSG00000136925. [Q5T7W7-1]
GeneIDi158427.
KEGGihsa:158427.
UCSCiuc004axn.3. human. [Q5T7W7-1]

Organism-specific databases

CTDi158427.
GeneCardsiGC09M100363.
H-InvDBHIX0008213.
HGNCiHGNC:30087. TSTD2.
HPAiHPA022537.
HPA024241.
neXtProtiNX_Q5T7W7.
PharmGKBiPA165586365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1054.
GeneTreeiENSGT00390000016307.
HOVERGENiHBG080327.
InParanoidiQ5T7W7.
OMAiVCKEVFQ.
PhylomeDBiQ5T7W7.
TreeFamiTF324329.

Miscellaneous databases

ChiTaRSiTSTD2. human.
GenomeRNAii158427.
NextBioi87734.
PROiQ5T7W7.

Gene expression databases

BgeeiQ5T7W7.
CleanExiHS_C9orf97.
ExpressionAtlasiQ5T7W7. baseline and differential.
GenevisibleiQ5T7W7. HS.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-83.
    Tissue: Trachea.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-83.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-83.
    Tissue: Lymph.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTSTD2_HUMAN
AccessioniPrimary (citable) accession number: Q5T7W7
Secondary accession number(s): A6NMJ4
, A8K584, Q6ZQZ6, Q8IYM3, Q8WY73, Q96ML6, Q96MU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: June 24, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.