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Q5T7W7 (TSTD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
Alternative name(s):
Rhodanese domain-containing protein 2
Gene names
Name:TSTD2
Synonyms:C9orf97
ORF Names:PP4189
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 rhodanese domain.

Sequence caution

The sequence AAH35604.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB71188.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB71271.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5T7W7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5T7W7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.
     261-278: EEIVPMGISPKKISYKKP → MDLCLADSSVSAPAPHRQ
     418-427: ECSYCGARWD → GRSAQAQSPN
     428-516: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 516516Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
PRO_0000230673

Regions

Domain301 – 39696Rhodanese

Sites

Active site3551Cysteine persulfide intermediate By similarity

Natural variations

Alternative sequence1 – 260260Missing in isoform 2.
VSP_017825
Alternative sequence261 – 27818EEIVP…SYKKP → MDLCLADSSVSAPAPHRQ in isoform 2.
VSP_017826
Alternative sequence418 – 42710ECSYCGARWD → GRSAQAQSPN in isoform 2.
VSP_017827
Alternative sequence428 – 51689Missing in isoform 2.
VSP_017828
Natural variant831R → Q. Ref.2 Ref.4 Ref.5
Corresponds to variant rs2773347 [ dbSNP | Ensembl ].
VAR_050842
Natural variant1091A → D.
Corresponds to variant rs10817858 [ dbSNP | Ensembl ].
VAR_050843

Experimental info

Sequence conflict301L → F in BAC87530. Ref.2
Sequence conflict3041D → N in BAB71188. Ref.2
Sequence conflict4331S → C in BAC87530. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 8C39781FD73CDA9F

FASTA51658,263
        10         20         30         40         50         60 
MPSSTSPDQG DDLENCILRF SDLDLKDMSL INPSSSLKAE LDGSTKKKYS FAKKKAFALF 

        70         80         90        100        110        120 
VKTKEVPTKR SFECKEKLWK CCRQLFTDQT SIHRHVATQH ADEIYHQTAS ILKQLAVTLS 

       130        140        150        160        170        180 
TSKSLSSADE KNPLKECLPH SHDVSAWLPD ISCFNPDELI SGQGSEEGEV LLYYCYHDLE 

       190        200        210        220        230        240 
DPQWICAWQT ALCQHLHLTG KIRIAAEGIN GTVGGSKLAT RLYVEVMLSF PLFKDDLCKD 

       250        260        270        280        290        300 
DFKTSKGGAH CFPELRVGVF EEIVPMGISP KKISYKKPGI HLSPGEFHKE VEKFLSQANQ 

       310        320        330        340        350        360 
EQSDTILLDC RNFYESKIGR FQGCLAPDIR KFSYFPSYVD KNLELFREKR VLMYCTGGIR 

       370        380        390        400        410        420 
CERGSAYLKA KGVCKEVFQL KGGIHKYLEE FPDGFYKGKL FVFDERYALS YNSDVVSECS 

       430        440        450        460        470        480 
YCGARWDQYK LCSTPQCRQL VLTCPACQGQ GFTACCVTCQ DKGSRKVSGP MQDSFKEECE 

       490        500        510 
CTARRPRIPR ELLQHVRQPV SPEPGPDADE DGPVLM 

« Hide

Isoform 2 [UniParc].

Checksum: CBEA9BA49CF22814
Show »

FASTA16719,001

References

[1]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-83.
Tissue: Trachea.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-83.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-83.
Tissue: Lymph.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF258575 mRNA. Translation: AAG23778.1.
AK056453 mRNA. Translation: BAB71188.1. Different initiation.
AK056752 mRNA. Translation: BAB71271.1. Different initiation.
AK128615 mRNA. Translation: BAC87530.1.
AK291199 mRNA. Translation: BAF83888.1.
AL162385 Genomic DNA. Translation: CAI12859.1.
AL162385 Genomic DNA. Translation: CAI12860.1.
CH471105 Genomic DNA. Translation: EAW58848.1.
BC035604 mRNA. Translation: AAH35604.1. Different initiation.
CCDSCCDS6727.2. [Q5T7W7-1]
RefSeqNP_640339.4. NM_139246.4. [Q5T7W7-1]
UniGeneHs.723236.

3D structure databases

ProteinModelPortalQ5T7W7.
SMRQ5T7W7. Positions 198-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127681. 1 interaction.

PTM databases

PhosphoSiteQ5T7W7.

Polymorphism databases

DMDM74745447.

Proteomic databases

MaxQBQ5T7W7.
PaxDbQ5T7W7.
PRIDEQ5T7W7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341170; ENSP00000342499; ENSG00000136925. [Q5T7W7-1]
ENST00000354801; ENSP00000346856; ENSG00000136925. [Q5T7W7-2]
GeneID158427.
KEGGhsa:158427.
UCSCuc004axn.3. human. [Q5T7W7-1]

Organism-specific databases

CTD158427.
GeneCardsGC09M100363.
H-InvDBHIX0008213.
HGNCHGNC:30087. TSTD2.
HPAHPA022537.
HPA024241.
neXtProtNX_Q5T7W7.
PharmGKBPA165586365.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1054.
HOVERGENHBG080327.
InParanoidQ5T7W7.
PhylomeDBQ5T7W7.
TreeFamTF324329.

Gene expression databases

ArrayExpressQ5T7W7.
BgeeQ5T7W7.
CleanExHS_C9orf97.
GenevestigatorQ5T7W7.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR001763. Rhodanese-like_dom.
[Graphical view]
PfamPF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTSTD2. human.
GenomeRNAi158427.
NextBio87734.
PROQ5T7W7.

Entry information

Entry nameTSTD2_HUMAN
AccessionPrimary (citable) accession number: Q5T7W7
Secondary accession number(s): A6NMJ4 expand/collapse secondary AC list , A8K584, Q6ZQZ6, Q8IYM3, Q8WY73, Q96ML6, Q96MU1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM