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Protein

Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

Gene

TSTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei355Cysteine persulfide intermediatePROSITE-ProRule annotation1

Names & Taxonomyi

Protein namesi
Recommended name:
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
Alternative name(s):
Rhodanese domain-containing protein 2
Gene namesi
Name:TSTD2
Synonyms:C9orf97
ORF Names:PP4189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:30087. TSTD2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136925.
PharmGKBiPA165586365.

Polymorphism and mutation databases

BioMutaiTSTD2.
DMDMi74745447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002306731 – 516Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T7W7.
MaxQBiQ5T7W7.
PaxDbiQ5T7W7.
PeptideAtlasiQ5T7W7.
PRIDEiQ5T7W7.

PTM databases

iPTMnetiQ5T7W7.
PhosphoSitePlusiQ5T7W7.

Expressioni

Gene expression databases

BgeeiENSG00000136925.
CleanExiHS_C9orf97.
ExpressionAtlasiQ5T7W7. baseline and differential.
GenevisibleiQ5T7W7. HS.

Organism-specific databases

HPAiHPA022537.
HPA024241.
HPA064304.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IKZF3Q9UKT93EBI-8994397,EBI-747204
RELQ048643EBI-8994397,EBI-307352
VPS52Q8N1B45EBI-8994397,EBI-2799833

Protein-protein interaction databases

BioGridi127681. 4 interactors.
IntActiQ5T7W7. 25 interactors.
STRINGi9606.ENSP00000342499.

Structurei

3D structure databases

ProteinModelPortaliQ5T7W7.
SMRiQ5T7W7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini301 – 396RhodanesePROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410II1G. Eukaryota.
COG1054. LUCA.
GeneTreeiENSGT00390000016307.
HOVERGENiHBG080327.
InParanoidiQ5T7W7.
OMAiTALCQHL.
OrthoDBiEOG091G0FPA.
PhylomeDBiQ5T7W7.
TreeFamiTF324329.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR001763. Rhodanese-like_dom.
IPR022111. Rhodanese_C.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
PF12368. Rhodanese_C. 1 hit.
[Graphical view]
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T7W7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSSTSPDQG DDLENCILRF SDLDLKDMSL INPSSSLKAE LDGSTKKKYS
60 70 80 90 100
FAKKKAFALF VKTKEVPTKR SFECKEKLWK CCRQLFTDQT SIHRHVATQH
110 120 130 140 150
ADEIYHQTAS ILKQLAVTLS TSKSLSSADE KNPLKECLPH SHDVSAWLPD
160 170 180 190 200
ISCFNPDELI SGQGSEEGEV LLYYCYHDLE DPQWICAWQT ALCQHLHLTG
210 220 230 240 250
KIRIAAEGIN GTVGGSKLAT RLYVEVMLSF PLFKDDLCKD DFKTSKGGAH
260 270 280 290 300
CFPELRVGVF EEIVPMGISP KKISYKKPGI HLSPGEFHKE VEKFLSQANQ
310 320 330 340 350
EQSDTILLDC RNFYESKIGR FQGCLAPDIR KFSYFPSYVD KNLELFREKR
360 370 380 390 400
VLMYCTGGIR CERGSAYLKA KGVCKEVFQL KGGIHKYLEE FPDGFYKGKL
410 420 430 440 450
FVFDERYALS YNSDVVSECS YCGARWDQYK LCSTPQCRQL VLTCPACQGQ
460 470 480 490 500
GFTACCVTCQ DKGSRKVSGP MQDSFKEECE CTARRPRIPR ELLQHVRQPV
510
SPEPGPDADE DGPVLM
Length:516
Mass (Da):58,263
Last modified:December 21, 2004 - v1
Checksum:i8C39781FD73CDA9F
GO
Isoform 2 (identifier: Q5T7W7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.
     261-278: EEIVPMGISPKKISYKKP → MDLCLADSSVSAPAPHRQ
     418-427: ECSYCGARWD → GRSAQAQSPN
     428-516: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):19,001
Checksum:iCBEA9BA49CF22814
GO

Sequence cautioni

The sequence AAH35604 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71188 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71271 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30L → F in BAC87530 (PubMed:14702039).Curated1
Sequence conflicti304D → N in BAB71188 (PubMed:14702039).Curated1
Sequence conflicti433S → C in BAC87530 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05084283R → Q.3 PublicationsCorresponds to variant rs2773347dbSNPEnsembl.1
Natural variantiVAR_050843109A → D.Corresponds to variant rs10817858dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0178251 – 260Missing in isoform 2. 1 PublicationAdd BLAST260
Alternative sequenceiVSP_017826261 – 278EEIVP…SYKKP → MDLCLADSSVSAPAPHRQ in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_017827418 – 427ECSYCGARWD → GRSAQAQSPN in isoform 2. 1 Publication10
Alternative sequenceiVSP_017828428 – 516Missing in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258575 mRNA. Translation: AAG23778.1.
AK056453 mRNA. Translation: BAB71188.1. Different initiation.
AK056752 mRNA. Translation: BAB71271.1. Different initiation.
AK128615 mRNA. Translation: BAC87530.1.
AK291199 mRNA. Translation: BAF83888.1.
AL162385 Genomic DNA. Translation: CAI12859.1.
AL162385 Genomic DNA. Translation: CAI12860.1.
CH471105 Genomic DNA. Translation: EAW58848.1.
BC035604 mRNA. Translation: AAH35604.1. Different initiation.
CCDSiCCDS6727.2. [Q5T7W7-1]
RefSeqiNP_640339.4. NM_139246.4. [Q5T7W7-1]
UniGeneiHs.723236.

Genome annotation databases

EnsembliENST00000341170; ENSP00000342499; ENSG00000136925. [Q5T7W7-1]
GeneIDi158427.
KEGGihsa:158427.
UCSCiuc004axn.4. human. [Q5T7W7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258575 mRNA. Translation: AAG23778.1.
AK056453 mRNA. Translation: BAB71188.1. Different initiation.
AK056752 mRNA. Translation: BAB71271.1. Different initiation.
AK128615 mRNA. Translation: BAC87530.1.
AK291199 mRNA. Translation: BAF83888.1.
AL162385 Genomic DNA. Translation: CAI12859.1.
AL162385 Genomic DNA. Translation: CAI12860.1.
CH471105 Genomic DNA. Translation: EAW58848.1.
BC035604 mRNA. Translation: AAH35604.1. Different initiation.
CCDSiCCDS6727.2. [Q5T7W7-1]
RefSeqiNP_640339.4. NM_139246.4. [Q5T7W7-1]
UniGeneiHs.723236.

3D structure databases

ProteinModelPortaliQ5T7W7.
SMRiQ5T7W7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127681. 4 interactors.
IntActiQ5T7W7. 25 interactors.
STRINGi9606.ENSP00000342499.

PTM databases

iPTMnetiQ5T7W7.
PhosphoSitePlusiQ5T7W7.

Polymorphism and mutation databases

BioMutaiTSTD2.
DMDMi74745447.

Proteomic databases

EPDiQ5T7W7.
MaxQBiQ5T7W7.
PaxDbiQ5T7W7.
PeptideAtlasiQ5T7W7.
PRIDEiQ5T7W7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341170; ENSP00000342499; ENSG00000136925. [Q5T7W7-1]
GeneIDi158427.
KEGGihsa:158427.
UCSCiuc004axn.4. human. [Q5T7W7-1]

Organism-specific databases

CTDi158427.
GeneCardsiTSTD2.
H-InvDBHIX0008213.
HGNCiHGNC:30087. TSTD2.
HPAiHPA022537.
HPA024241.
HPA064304.
neXtProtiNX_Q5T7W7.
OpenTargetsiENSG00000136925.
PharmGKBiPA165586365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II1G. Eukaryota.
COG1054. LUCA.
GeneTreeiENSGT00390000016307.
HOVERGENiHBG080327.
InParanoidiQ5T7W7.
OMAiTALCQHL.
OrthoDBiEOG091G0FPA.
PhylomeDBiQ5T7W7.
TreeFamiTF324329.

Miscellaneous databases

ChiTaRSiTSTD2. human.
GenomeRNAii158427.
PROiQ5T7W7.

Gene expression databases

BgeeiENSG00000136925.
CleanExiHS_C9orf97.
ExpressionAtlasiQ5T7W7. baseline and differential.
GenevisibleiQ5T7W7. HS.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR001763. Rhodanese-like_dom.
IPR022111. Rhodanese_C.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
PF12368. Rhodanese_C. 1 hit.
[Graphical view]
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSTD2_HUMAN
AccessioniPrimary (citable) accession number: Q5T7W7
Secondary accession number(s): A6NMJ4
, A8K584, Q6ZQZ6, Q8IYM3, Q8WY73, Q96ML6, Q96MU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.