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Q5T7W7

- TSTD2_HUMAN

UniProt

Q5T7W7 - TSTD2_HUMAN

Protein

Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

Gene

TSTD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei355 – 3551Cysteine persulfide intermediatePROSITE-ProRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
    Alternative name(s):
    Rhodanese domain-containing protein 2
    Gene namesi
    Name:TSTD2
    Synonyms:C9orf97
    ORF Names:PP4189
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:30087. TSTD2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165586365.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 516516Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2PRO_0000230673Add
    BLAST

    Proteomic databases

    MaxQBiQ5T7W7.
    PaxDbiQ5T7W7.
    PRIDEiQ5T7W7.

    PTM databases

    PhosphoSiteiQ5T7W7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5T7W7.
    BgeeiQ5T7W7.
    CleanExiHS_C9orf97.
    GenevestigatoriQ5T7W7.

    Organism-specific databases

    HPAiHPA022537.
    HPA024241.

    Interactioni

    Protein-protein interaction databases

    BioGridi127681. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T7W7.
    SMRiQ5T7W7. Positions 198-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini301 – 39696RhodanesePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1054.
    HOVERGENiHBG080327.
    InParanoidiQ5T7W7.
    PhylomeDBiQ5T7W7.
    TreeFamiTF324329.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    InterProiIPR001763. Rhodanese-like_dom.
    [Graphical view]
    PfamiPF00581. Rhodanese. 1 hit.
    [Graphical view]
    SMARTiSM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T7W7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPSSTSPDQG DDLENCILRF SDLDLKDMSL INPSSSLKAE LDGSTKKKYS    50
    FAKKKAFALF VKTKEVPTKR SFECKEKLWK CCRQLFTDQT SIHRHVATQH 100
    ADEIYHQTAS ILKQLAVTLS TSKSLSSADE KNPLKECLPH SHDVSAWLPD 150
    ISCFNPDELI SGQGSEEGEV LLYYCYHDLE DPQWICAWQT ALCQHLHLTG 200
    KIRIAAEGIN GTVGGSKLAT RLYVEVMLSF PLFKDDLCKD DFKTSKGGAH 250
    CFPELRVGVF EEIVPMGISP KKISYKKPGI HLSPGEFHKE VEKFLSQANQ 300
    EQSDTILLDC RNFYESKIGR FQGCLAPDIR KFSYFPSYVD KNLELFREKR 350
    VLMYCTGGIR CERGSAYLKA KGVCKEVFQL KGGIHKYLEE FPDGFYKGKL 400
    FVFDERYALS YNSDVVSECS YCGARWDQYK LCSTPQCRQL VLTCPACQGQ 450
    GFTACCVTCQ DKGSRKVSGP MQDSFKEECE CTARRPRIPR ELLQHVRQPV 500
    SPEPGPDADE DGPVLM 516
    Length:516
    Mass (Da):58,263
    Last modified:December 21, 2004 - v1
    Checksum:i8C39781FD73CDA9F
    GO
    Isoform 2 (identifier: Q5T7W7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-260: Missing.
         261-278: EEIVPMGISPKKISYKKP → MDLCLADSSVSAPAPHRQ
         418-427: ECSYCGARWD → GRSAQAQSPN
         428-516: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:167
    Mass (Da):19,001
    Checksum:iCBEA9BA49CF22814
    GO

    Sequence cautioni

    The sequence AAH35604.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB71188.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB71271.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301L → F in BAC87530. (PubMed:14702039)Curated
    Sequence conflicti304 – 3041D → N in BAB71188. (PubMed:14702039)Curated
    Sequence conflicti433 – 4331S → C in BAC87530. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831R → Q.3 Publications
    Corresponds to variant rs2773347 [ dbSNP | Ensembl ].
    VAR_050842
    Natural varianti109 – 1091A → D.
    Corresponds to variant rs10817858 [ dbSNP | Ensembl ].
    VAR_050843

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 260260Missing in isoform 2. 1 PublicationVSP_017825Add
    BLAST
    Alternative sequencei261 – 27818EEIVP…SYKKP → MDLCLADSSVSAPAPHRQ in isoform 2. 1 PublicationVSP_017826Add
    BLAST
    Alternative sequencei418 – 42710ECSYCGARWD → GRSAQAQSPN in isoform 2. 1 PublicationVSP_017827
    Alternative sequencei428 – 51689Missing in isoform 2. 1 PublicationVSP_017828Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF258575 mRNA. Translation: AAG23778.1.
    AK056453 mRNA. Translation: BAB71188.1. Different initiation.
    AK056752 mRNA. Translation: BAB71271.1. Different initiation.
    AK128615 mRNA. Translation: BAC87530.1.
    AK291199 mRNA. Translation: BAF83888.1.
    AL162385 Genomic DNA. Translation: CAI12859.1.
    AL162385 Genomic DNA. Translation: CAI12860.1.
    CH471105 Genomic DNA. Translation: EAW58848.1.
    BC035604 mRNA. Translation: AAH35604.1. Different initiation.
    CCDSiCCDS6727.2. [Q5T7W7-1]
    RefSeqiNP_640339.4. NM_139246.4. [Q5T7W7-1]
    UniGeneiHs.723236.

    Genome annotation databases

    EnsembliENST00000341170; ENSP00000342499; ENSG00000136925. [Q5T7W7-1]
    GeneIDi158427.
    KEGGihsa:158427.
    UCSCiuc004axn.3. human. [Q5T7W7-1]

    Polymorphism databases

    DMDMi74745447.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF258575 mRNA. Translation: AAG23778.1 .
    AK056453 mRNA. Translation: BAB71188.1 . Different initiation.
    AK056752 mRNA. Translation: BAB71271.1 . Different initiation.
    AK128615 mRNA. Translation: BAC87530.1 .
    AK291199 mRNA. Translation: BAF83888.1 .
    AL162385 Genomic DNA. Translation: CAI12859.1 .
    AL162385 Genomic DNA. Translation: CAI12860.1 .
    CH471105 Genomic DNA. Translation: EAW58848.1 .
    BC035604 mRNA. Translation: AAH35604.1 . Different initiation.
    CCDSi CCDS6727.2. [Q5T7W7-1 ]
    RefSeqi NP_640339.4. NM_139246.4. [Q5T7W7-1 ]
    UniGenei Hs.723236.

    3D structure databases

    ProteinModelPortali Q5T7W7.
    SMRi Q5T7W7. Positions 198-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127681. 1 interaction.

    PTM databases

    PhosphoSitei Q5T7W7.

    Polymorphism databases

    DMDMi 74745447.

    Proteomic databases

    MaxQBi Q5T7W7.
    PaxDbi Q5T7W7.
    PRIDEi Q5T7W7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341170 ; ENSP00000342499 ; ENSG00000136925 . [Q5T7W7-1 ]
    GeneIDi 158427.
    KEGGi hsa:158427.
    UCSCi uc004axn.3. human. [Q5T7W7-1 ]

    Organism-specific databases

    CTDi 158427.
    GeneCardsi GC09M100363.
    H-InvDB HIX0008213.
    HGNCi HGNC:30087. TSTD2.
    HPAi HPA022537.
    HPA024241.
    neXtProti NX_Q5T7W7.
    PharmGKBi PA165586365.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1054.
    HOVERGENi HBG080327.
    InParanoidi Q5T7W7.
    PhylomeDBi Q5T7W7.
    TreeFami TF324329.

    Miscellaneous databases

    ChiTaRSi TSTD2. human.
    GenomeRNAii 158427.
    NextBioi 87734.
    PROi Q5T7W7.

    Gene expression databases

    ArrayExpressi Q5T7W7.
    Bgeei Q5T7W7.
    CleanExi HS_C9orf97.
    Genevestigatori Q5T7W7.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    InterProi IPR001763. Rhodanese-like_dom.
    [Graphical view ]
    Pfami PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    SMARTi SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-83.
      Tissue: Trachea.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-83.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-83.
      Tissue: Lymph.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiTSTD2_HUMAN
    AccessioniPrimary (citable) accession number: Q5T7W7
    Secondary accession number(s): A6NMJ4
    , A8K584, Q6ZQZ6, Q8IYM3, Q8WY73, Q96ML6, Q96MU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3