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Q5T7P8

- SYT6_HUMAN

UniProt

Q5T7P8 - SYT6_HUMAN

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Protein
Synaptotagmin-6
Gene
SYT6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. May mediate Ca2+-regulation of exocytosis in acrosomal reaction in sperm By similarity.

Cofactori

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi260 – 2601Calcium 1 By similarity
Metal bindingi260 – 2601Calcium 2 By similarity
Metal bindingi266 – 2661Calcium 1 By similarity
Metal bindingi318 – 3181Calcium 1 By similarity
Metal bindingi318 – 3181Calcium 2 By similarity
Metal bindingi319 – 3191Calcium 1; via carbonyl oxygen By similarity
Metal bindingi320 – 3201Calcium 1 By similarity
Metal bindingi320 – 3201Calcium 2 By similarity
Metal bindingi320 – 3201Calcium 3 By similarity
Metal bindingi323 – 3231Calcium 3 By similarity
Metal bindingi326 – 3261Calcium 2 By similarity
Metal bindingi326 – 3261Calcium 3 By similarity

GO - Molecular functioni

  1. clathrin binding Source: BHF-UCL
  2. metal ion binding Source: UniProtKB-KW
  3. protein homodimerization activity Source: BHF-UCL
  4. syntaxin binding Source: BHF-UCL
  5. transporter activity Source: InterPro

GO - Biological processi

  1. acrosomal vesicle exocytosis Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-6
Alternative name(s):
Synaptotagmin VI
Short name:
SytVI
Gene namesi
Name:SYT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18638. SYT6.

Subcellular locationi

Isoform 1 : Membrane; Single-pass membrane protein By similarity
Note: Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959Vesicular Reviewed prediction
Add
BLAST
Transmembranei60 – 8021Helical; Reviewed prediction
Add
BLAST
Topological domaini81 – 510430Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytosol Source: UniProtKB
  3. extrinsic component of membrane Source: UniProtKB
  4. integral component of membrane Source: UniProtKB
  5. perinuclear endoplasmic reticulum Source: BHF-UCL
  6. plasma membrane Source: UniProtKB
  7. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Synaptotagmin-6
PRO_0000183954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5T7P8.
PRIDEiQ5T7P8.

PTM databases

PhosphoSiteiQ5T7P8.

Expressioni

Gene expression databases

ArrayExpressiQ5T7P8.
BgeeiQ5T7P8.
CleanExiHS_SYT6.
GenevestigatoriQ5T7P8.

Organism-specific databases

HPAiCAB008675.

Interactioni

Subunit structurei

Homodimer (isoform 1). Isoform 1 forms heterodimers with SytIII, SytV and SytX. Interacts with STX1A, STX1B and STX2; the interaction is Ca2+-dependent. Isoform 2 is not able to form homodimer and heterodimers By similarity.

Protein-protein interaction databases

BioGridi127139. 3 interactions.
STRINGi9606.ENSP00000358559.

Structurei

3D structure databases

ProteinModelPortaliQ5T7P8.
SMRiQ5T7P8. Positions 230-500.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini231 – 332102C2 1
Add
BLAST
Domaini363 – 466104C2 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni482 – 51029Necessary for cell membrane association (isoform 2) By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.
Contains 2 C2 domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5038.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ5T7P8.
OMAiWRDIQYA.
OrthoDBiEOG78PV8W.
PhylomeDBiQ5T7P8.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028701. SYT6.
[Graphical view]
PANTHERiPTHR10024:SF45. PTHR10024:SF45. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T7P8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGVWGAGGP RCQEALAVLA SLCRARPPPL GLDVETCRSF ELQPPERSPS    50
AAGAGTSVSL LAVVVIVCGV ALVAVFLFLF WKLCWMPWRN KEASSPSSAN 100
PPLEALQSPS FRGNMADKLK DPSTLGFLEA AVKISHTSPD IPAEVQMSVK 150
EHIMRHTRLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAEQ 200
PTSIGRIKPE LYKQKSVDGE DAKSEATKSC GKINFSLRYD YETETLIVRI 250
LKAFDLPAKD FCGSSDPYVK IYLLPDRKCK LQTRVHRKTL NPTFDENFHF 300
PVPYEELADR KLHLSVFDFD RFSRHDMIGE VILDNLFEAS DLSRETSIWK 350
DIQYATSESV DLGEIMFSLC YLPTAGRLTL TVIKCRNLKA MDITGYSDPY 400
VKVSLLCDGR RLKKKKTTIK KNTLNPVYNE AIIFDIPPEN MDQVSLLISV 450
MDYDRVGHNE IIGVCRVGIT AEGLGRDHWN EMLAYPRKPI AHWHSLVEVK 500
KSFKEGNPRL 510

Note: No experimental confirmation available.

Length:510
Mass (Da):57,325
Last modified:October 14, 2008 - v3
Checksum:iDE5478F5B95693D3
GO
Isoform 2 (identifier: Q5T7P8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:425
Mass (Da):48,442
Checksum:iF41702F895DAC695
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 2.
VSP_036619Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056448 mRNA. Translation: BAG51713.1.
AL162594 Genomic DNA. Translation: CAI18964.1.
AL162594 Genomic DNA. Translation: CAM27152.1.
CH471122 Genomic DNA. Translation: EAW56596.1.
CCDSiCCDS871.1. [Q5T7P8-2]
RefSeqiNP_001257734.1. NM_001270805.1. [Q5T7P8-2]
NP_995320.1. NM_205848.3. [Q5T7P8-2]
XP_006710439.1. XM_006710376.1. [Q5T7P8-2]
UniGeneiHs.370963.
Hs.736999.

Genome annotation databases

EnsembliENST00000369547; ENSP00000358560; ENSG00000134207. [Q5T7P8-2]
ENST00000393296; ENSP00000376974; ENSG00000134207. [Q5T7P8-1]
ENST00000607941; ENSP00000476507; ENSG00000134207. [Q5T7P8-2]
ENST00000609117; ENSP00000477344; ENSG00000134207. [Q5T7P8-2]
ENST00000610222; ENSP00000476396; ENSG00000134207. [Q5T7P8-1]
GeneIDi148281.
KEGGihsa:148281.
UCSCiuc001eev.3. human. [Q5T7P8-1]

Polymorphism databases

DMDMi209572719.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056448 mRNA. Translation: BAG51713.1 .
AL162594 Genomic DNA. Translation: CAI18964.1 .
AL162594 Genomic DNA. Translation: CAM27152.1 .
CH471122 Genomic DNA. Translation: EAW56596.1 .
CCDSi CCDS871.1. [Q5T7P8-2 ]
RefSeqi NP_001257734.1. NM_001270805.1. [Q5T7P8-2 ]
NP_995320.1. NM_205848.3. [Q5T7P8-2 ]
XP_006710439.1. XM_006710376.1. [Q5T7P8-2 ]
UniGenei Hs.370963.
Hs.736999.

3D structure databases

ProteinModelPortali Q5T7P8.
SMRi Q5T7P8. Positions 230-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127139. 3 interactions.
STRINGi 9606.ENSP00000358559.

PTM databases

PhosphoSitei Q5T7P8.

Polymorphism databases

DMDMi 209572719.

Proteomic databases

PaxDbi Q5T7P8.
PRIDEi Q5T7P8.

Protocols and materials databases

DNASUi 148281.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369547 ; ENSP00000358560 ; ENSG00000134207 . [Q5T7P8-2 ]
ENST00000393296 ; ENSP00000376974 ; ENSG00000134207 . [Q5T7P8-1 ]
ENST00000607941 ; ENSP00000476507 ; ENSG00000134207 . [Q5T7P8-2 ]
ENST00000609117 ; ENSP00000477344 ; ENSG00000134207 . [Q5T7P8-2 ]
ENST00000610222 ; ENSP00000476396 ; ENSG00000134207 . [Q5T7P8-1 ]
GeneIDi 148281.
KEGGi hsa:148281.
UCSCi uc001eev.3. human. [Q5T7P8-1 ]

Organism-specific databases

CTDi 148281.
GeneCardsi GC01M114631.
HGNCi HGNC:18638. SYT6.
HPAi CAB008675.
MIMi 607718. gene.
neXtProti NX_Q5T7P8.
PharmGKBi PA38614.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5038.
HOGENOMi HOG000232128.
HOVERGENi HBG005010.
InParanoidi Q5T7P8.
OMAi WRDIQYA.
OrthoDBi EOG78PV8W.
PhylomeDBi Q5T7P8.
TreeFami TF315600.

Miscellaneous databases

GenomeRNAii 148281.
NextBioi 85899.
PROi Q5T7P8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5T7P8.
Bgeei Q5T7P8.
CleanExi HS_SYT6.
Genevestigatori Q5T7P8.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028701. SYT6.
[Graphical view ]
PANTHERi PTHR10024:SF45. PTHR10024:SF45. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
PRINTSi PR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYT6_HUMAN
AccessioniPrimary (citable) accession number: Q5T7P8
Secondary accession number(s): B1AMB8, B3KPK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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