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Q5T7P8

- SYT6_HUMAN

UniProt

Q5T7P8 - SYT6_HUMAN

Protein

Synaptotagmin-6

Gene

SYT6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. May mediate Ca2+-regulation of exocytosis in acrosomal reaction in sperm By similarity.By similarity

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi260 – 2601Calcium 1By similarity
    Metal bindingi260 – 2601Calcium 2By similarity
    Metal bindingi266 – 2661Calcium 1By similarity
    Metal bindingi318 – 3181Calcium 1By similarity
    Metal bindingi318 – 3181Calcium 2By similarity
    Metal bindingi319 – 3191Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi320 – 3201Calcium 1By similarity
    Metal bindingi320 – 3201Calcium 2By similarity
    Metal bindingi320 – 3201Calcium 3By similarity
    Metal bindingi323 – 3231Calcium 3By similarity
    Metal bindingi326 – 3261Calcium 2By similarity
    Metal bindingi326 – 3261Calcium 3By similarity

    GO - Molecular functioni

    1. clathrin binding Source: BHF-UCL
    2. metal ion binding Source: UniProtKB-KW
    3. protein homodimerization activity Source: BHF-UCL
    4. syntaxin binding Source: BHF-UCL
    5. transporter activity Source: InterPro

    GO - Biological processi

    1. acrosomal vesicle exocytosis Source: BHF-UCL

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-6
    Alternative name(s):
    Synaptotagmin VI
    Short name:
    SytVI
    Gene namesi
    Name:SYT6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18638. SYT6.

    Subcellular locationi

    Isoform 1 : Membrane By similarity; Single-pass membrane protein By similarity
    Note: Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment.By similarity
    Isoform 2 : Cytoplasmcytosol By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytosol Source: UniProtKB
    3. extrinsic component of membrane Source: UniProtKB
    4. integral component of membrane Source: UniProtKB
    5. perinuclear endoplasmic reticulum Source: BHF-UCL
    6. plasma membrane Source: UniProtKB
    7. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38614.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Synaptotagmin-6PRO_0000183954Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei216 – 2161Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5T7P8.
    PRIDEiQ5T7P8.

    PTM databases

    PhosphoSiteiQ5T7P8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5T7P8.
    BgeeiQ5T7P8.
    CleanExiHS_SYT6.
    GenevestigatoriQ5T7P8.

    Organism-specific databases

    HPAiCAB008675.

    Interactioni

    Subunit structurei

    Homodimer (isoform 1). Isoform 1 forms heterodimers with SytIII, SytV and SytX. Interacts with STX1A, STX1B and STX2; the interaction is Ca2+-dependent. Isoform 2 is not able to form homodimer and heterodimers By similarity.By similarity

    Protein-protein interaction databases

    BioGridi127139. 3 interactions.
    STRINGi9606.ENSP00000358559.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T7P8.
    SMRiQ5T7P8. Positions 230-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5959VesicularSequence AnalysisAdd
    BLAST
    Topological domaini81 – 510430CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini231 – 332102C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini363 – 466104C2 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni482 – 51029Necessary for cell membrane association (isoform 2)By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5038.
    HOGENOMiHOG000232128.
    HOVERGENiHBG005010.
    InParanoidiQ5T7P8.
    OMAiWRDIQYA.
    OrthoDBiEOG78PV8W.
    PhylomeDBiQ5T7P8.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028701. SYT6.
    [Graphical view]
    PANTHERiPTHR10024:SF45. PTHR10024:SF45. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    PRINTSiPR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T7P8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGVWGAGGP RCQEALAVLA SLCRARPPPL GLDVETCRSF ELQPPERSPS    50
    AAGAGTSVSL LAVVVIVCGV ALVAVFLFLF WKLCWMPWRN KEASSPSSAN 100
    PPLEALQSPS FRGNMADKLK DPSTLGFLEA AVKISHTSPD IPAEVQMSVK 150
    EHIMRHTRLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAEQ 200
    PTSIGRIKPE LYKQKSVDGE DAKSEATKSC GKINFSLRYD YETETLIVRI 250
    LKAFDLPAKD FCGSSDPYVK IYLLPDRKCK LQTRVHRKTL NPTFDENFHF 300
    PVPYEELADR KLHLSVFDFD RFSRHDMIGE VILDNLFEAS DLSRETSIWK 350
    DIQYATSESV DLGEIMFSLC YLPTAGRLTL TVIKCRNLKA MDITGYSDPY 400
    VKVSLLCDGR RLKKKKTTIK KNTLNPVYNE AIIFDIPPEN MDQVSLLISV 450
    MDYDRVGHNE IIGVCRVGIT AEGLGRDHWN EMLAYPRKPI AHWHSLVEVK 500
    KSFKEGNPRL 510

    Note: No experimental confirmation available.

    Length:510
    Mass (Da):57,325
    Last modified:October 14, 2008 - v3
    Checksum:iDE5478F5B95693D3
    GO
    Isoform 2 (identifier: Q5T7P8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-85: Missing.

    Show »
    Length:425
    Mass (Da):48,442
    Checksum:iF41702F895DAC695
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8585Missing in isoform 2. 1 PublicationVSP_036619Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056448 mRNA. Translation: BAG51713.1.
    AL162594 Genomic DNA. Translation: CAI18964.1.
    AL162594 Genomic DNA. Translation: CAM27152.1.
    CH471122 Genomic DNA. Translation: EAW56596.1.
    CCDSiCCDS871.1. [Q5T7P8-2]
    RefSeqiNP_001257734.1. NM_001270805.1. [Q5T7P8-2]
    NP_995320.1. NM_205848.3. [Q5T7P8-2]
    XP_006710439.1. XM_006710376.1. [Q5T7P8-2]
    UniGeneiHs.370963.
    Hs.736999.

    Genome annotation databases

    EnsembliENST00000369547; ENSP00000358560; ENSG00000134207. [Q5T7P8-2]
    ENST00000607941; ENSP00000476507; ENSG00000134207. [Q5T7P8-2]
    ENST00000609117; ENSP00000477344; ENSG00000134207. [Q5T7P8-2]
    ENST00000610222; ENSP00000476396; ENSG00000134207. [Q5T7P8-1]
    GeneIDi148281.
    KEGGihsa:148281.
    UCSCiuc001eev.3. human. [Q5T7P8-1]

    Polymorphism databases

    DMDMi209572719.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056448 mRNA. Translation: BAG51713.1 .
    AL162594 Genomic DNA. Translation: CAI18964.1 .
    AL162594 Genomic DNA. Translation: CAM27152.1 .
    CH471122 Genomic DNA. Translation: EAW56596.1 .
    CCDSi CCDS871.1. [Q5T7P8-2 ]
    RefSeqi NP_001257734.1. NM_001270805.1. [Q5T7P8-2 ]
    NP_995320.1. NM_205848.3. [Q5T7P8-2 ]
    XP_006710439.1. XM_006710376.1. [Q5T7P8-2 ]
    UniGenei Hs.370963.
    Hs.736999.

    3D structure databases

    ProteinModelPortali Q5T7P8.
    SMRi Q5T7P8. Positions 230-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127139. 3 interactions.
    STRINGi 9606.ENSP00000358559.

    PTM databases

    PhosphoSitei Q5T7P8.

    Polymorphism databases

    DMDMi 209572719.

    Proteomic databases

    PaxDbi Q5T7P8.
    PRIDEi Q5T7P8.

    Protocols and materials databases

    DNASUi 148281.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369547 ; ENSP00000358560 ; ENSG00000134207 . [Q5T7P8-2 ]
    ENST00000607941 ; ENSP00000476507 ; ENSG00000134207 . [Q5T7P8-2 ]
    ENST00000609117 ; ENSP00000477344 ; ENSG00000134207 . [Q5T7P8-2 ]
    ENST00000610222 ; ENSP00000476396 ; ENSG00000134207 . [Q5T7P8-1 ]
    GeneIDi 148281.
    KEGGi hsa:148281.
    UCSCi uc001eev.3. human. [Q5T7P8-1 ]

    Organism-specific databases

    CTDi 148281.
    GeneCardsi GC01M114631.
    HGNCi HGNC:18638. SYT6.
    HPAi CAB008675.
    MIMi 607718. gene.
    neXtProti NX_Q5T7P8.
    PharmGKBi PA38614.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5038.
    HOGENOMi HOG000232128.
    HOVERGENi HBG005010.
    InParanoidi Q5T7P8.
    OMAi WRDIQYA.
    OrthoDBi EOG78PV8W.
    PhylomeDBi Q5T7P8.
    TreeFami TF315600.

    Miscellaneous databases

    GenomeRNAii 148281.
    NextBioi 85899.
    PROi Q5T7P8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5T7P8.
    Bgeei Q5T7P8.
    CleanExi HS_SYT6.
    Genevestigatori Q5T7P8.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028701. SYT6.
    [Graphical view ]
    PANTHERi PTHR10024:SF45. PTHR10024:SF45. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    PRINTSi PR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Teratocarcinoma.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSYT6_HUMAN
    AccessioniPrimary (citable) accession number: Q5T7P8
    Secondary accession number(s): B1AMB8, B3KPK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3