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Q5T7P8 (SYT6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-6
Alternative name(s):
Synaptotagmin VI
Short name=SytVI
Gene names
Name:SYT6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. May mediate Ca2+-regulation of exocytosis in acrosomal reaction in sperm By similarity.

Cofactor

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Subunit structure

Homodimer (isoform 1) Isoform 1 forms heterodimers with SytIII, SytV and SytX. Interacts with STX1A, STX1B and STX2; the interaction is Ca2+-dependent. Isoform 2 is not able to form homodimer and heterodimers By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Single-pass membrane protein By similarity.

Isoform 1: Membrane; Single-pass membrane protein By similarity. Note: Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment By similarity.

Isoform 2: Cytoplasmcytosol By similarity. Cell membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Ontologies

Keywords
   Cellular componentCell junction
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Membrane
Synapse
   Coding sequence diversityAlternative splicing
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandCalcium
Metal-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacrosomal vesicle exocytosis

Inferred from mutant phenotype PubMed 11437455. Source: BHF-UCL

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

extrinsic component of membrane

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Inferred from sequence or structural similarity. Source: UniProtKB

perinuclear endoplasmic reticulum

Inferred from sequence or structural similarity. Source: BHF-UCL

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

synaptic vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionclathrin binding

Inferred from direct assay PubMed 7791877. Source: BHF-UCL

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein homodimerization activity

Inferred from sequence or structural similarity. Source: BHF-UCL

syntaxin binding

Inferred from direct assay PubMed 7791877. Source: BHF-UCL

transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5T7P8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q5T7P8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 510510Synaptotagmin-6
PRO_0000183954

Regions

Topological domain1 – 5959Vesicular Potential
Transmembrane60 – 8021Helical; Potential
Topological domain81 – 510430Cytoplasmic Potential
Domain231 – 332102C2 1
Domain363 – 466104C2 2
Region482 – 51029Necessary for cell membrane association (isoform 2) By similarity

Sites

Metal binding2601Calcium 1 By similarity
Metal binding2601Calcium 2 By similarity
Metal binding2661Calcium 1 By similarity
Metal binding3181Calcium 1 By similarity
Metal binding3181Calcium 2 By similarity
Metal binding3191Calcium 1; via carbonyl oxygen By similarity
Metal binding3201Calcium 1 By similarity
Metal binding3201Calcium 2 By similarity
Metal binding3201Calcium 3 By similarity
Metal binding3231Calcium 3 By similarity
Metal binding3261Calcium 2 By similarity
Metal binding3261Calcium 3 By similarity

Amino acid modifications

Modified residue2161Phosphoserine Ref.4

Natural variations

Alternative sequence1 – 8585Missing in isoform 2.
VSP_036619

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 14, 2008. Version 3.
Checksum: DE5478F5B95693D3

FASTA51057,325
        10         20         30         40         50         60 
MSGVWGAGGP RCQEALAVLA SLCRARPPPL GLDVETCRSF ELQPPERSPS AAGAGTSVSL 

        70         80         90        100        110        120 
LAVVVIVCGV ALVAVFLFLF WKLCWMPWRN KEASSPSSAN PPLEALQSPS FRGNMADKLK 

       130        140        150        160        170        180 
DPSTLGFLEA AVKISHTSPD IPAEVQMSVK EHIMRHTRLQ RQTTEPASST RHTSFKRHLP 

       190        200        210        220        230        240 
RQMHVSSVDY GNELPPAAEQ PTSIGRIKPE LYKQKSVDGE DAKSEATKSC GKINFSLRYD 

       250        260        270        280        290        300 
YETETLIVRI LKAFDLPAKD FCGSSDPYVK IYLLPDRKCK LQTRVHRKTL NPTFDENFHF 

       310        320        330        340        350        360 
PVPYEELADR KLHLSVFDFD RFSRHDMIGE VILDNLFEAS DLSRETSIWK DIQYATSESV 

       370        380        390        400        410        420 
DLGEIMFSLC YLPTAGRLTL TVIKCRNLKA MDITGYSDPY VKVSLLCDGR RLKKKKTTIK 

       430        440        450        460        470        480 
KNTLNPVYNE AIIFDIPPEN MDQVSLLISV MDYDRVGHNE IIGVCRVGIT AEGLGRDHWN 

       490        500        510 
EMLAYPRKPI AHWHSLVEVK KSFKEGNPRL 

« Hide

Isoform 2 [UniParc].

Checksum: F41702F895DAC695
Show »

FASTA42548,442

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Teratocarcinoma.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK056448 mRNA. Translation: BAG51713.1.
AL162594 Genomic DNA. Translation: CAI18964.1.
AL162594 Genomic DNA. Translation: CAM27152.1.
CH471122 Genomic DNA. Translation: EAW56596.1.
RefSeqNP_001257734.1. NM_001270805.1.
NP_995320.1. NM_205848.3.
UniGeneHs.370963.
Hs.736999.

3D structure databases

ProteinModelPortalQ5T7P8.
SMRQ5T7P8. Positions 230-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127139. 3 interactions.
STRING9606.ENSP00000358559.

PTM databases

PhosphoSiteQ5T7P8.

Polymorphism databases

DMDM209572719.

Proteomic databases

PaxDbQ5T7P8.
PRIDEQ5T7P8.

Protocols and materials databases

DNASU148281.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369547; ENSP00000358560; ENSG00000134207. [Q5T7P8-2]
ENST00000393296; ENSP00000376974; ENSG00000134207. [Q5T7P8-1]
ENST00000607941; ENSP00000476507; ENSG00000134207. [Q5T7P8-2]
ENST00000609117; ENSP00000477344; ENSG00000134207. [Q5T7P8-2]
ENST00000610222; ENSP00000476396; ENSG00000134207. [Q5T7P8-1]
GeneID148281.
KEGGhsa:148281.
UCSCuc001eev.3. human. [Q5T7P8-1]

Organism-specific databases

CTD148281.
GeneCardsGC01M114631.
HGNCHGNC:18638. SYT6.
HPACAB008675.
MIM607718. gene.
neXtProtNX_Q5T7P8.
PharmGKBPA38614.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5038.
HOGENOMHOG000232128.
HOVERGENHBG005010.
InParanoidQ5T7P8.
OMAEHFLRRT.
OrthoDBEOG78PV8W.
PhylomeDBQ5T7P8.
TreeFamTF315600.

Gene expression databases

ArrayExpressQ5T7P8.
BgeeQ5T7P8.
CleanExHS_SYT6.
GenevestigatorQ5T7P8.

Family and domain databases

Gene3D2.60.40.150. 2 hits.
InterProIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028701. SYT6.
[Graphical view]
PANTHERPTHR10024:SF45. PTHR10024:SF45. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
PRINTSPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. SSF49562. 2 hits.
PROSITEPS50004. C2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi148281.
NextBio85899.
PROQ5T7P8.
SOURCESearch...

Entry information

Entry nameSYT6_HUMAN
AccessionPrimary (citable) accession number: Q5T7P8
Secondary accession number(s): B1AMB8, B3KPK1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM