Q5T7N3 (KANK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
KN motif and ankyrin repeat domain-containing protein 4

Alternative name(s):
Ankyrin repeat domain-containing protein 38

Gene names

Name:	KANK4
Synonyms:	ANKRD38

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	995 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Coiled coil Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T7N3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T7N3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-628: Missing.
     629-633: SSPPV → MEKTD

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 995	995	KN motif and ankyrin repeat domain-containing protein 4		PRO_0000244364
Regions
	Repeat	823 – 853	31	ANK 1
	Repeat	862 – 890	29	ANK 2
	Repeat	895 – 924	30	ANK 3
	Repeat	928 – 958	31	ANK 4
	Repeat	962 – 992	31	ANK 5
	Coiled coil	343 – 404	62	Potential
	Compositional bias	184 – 315	132	Pro-rich
Amino acid modifications
	Modified residue	164	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	1 – 628	628	Missing in isoform 2.		VSP_019552
	Alternative sequence	629 – 633	5	SSPPV → MEKTD in isoform 2.		VSP_019553
	Natural variant	701	1	G → S. Corresponds to variant rs17123306 [ dbSNP | Ensembl ].		VAR_048306
	Natural variant	768	1	T → A. Corresponds to variant rs11207949 [ dbSNP | Ensembl ].		VAR_048307
	Natural variant	822	1	H → R. Ref.1 Ref.3 Ref.4 Corresponds to variant rs2258470 [ dbSNP | Ensembl ].		VAR_026902
	Natural variant	840	1	V → A. Ref.1 Ref.3 Ref.4 Corresponds to variant rs2666472 [ dbSNP | Ensembl ].		VAR_026903
	Natural variant	935	1	V → L. Ref.1 Ref.3 Ref.4 Corresponds to variant rs2941679 [ dbSNP | Ensembl ].		VAR_026904
	Natural variant	987	1	A → V. Corresponds to variant rs34591898 [ dbSNP | Ensembl ].		VAR_048308
Experimental info
	Sequence conflict	297	1	E → G in CAD89966. Ref.4
	Sequence conflict	786	1	R → H in BAC03774. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 25379EB22B44C760	FASTA	995	107,342
	10 20 30 40 50 60 MEKTDAKDQS SQGDEEKDPP KSHPYSVETP YGFHLDLDFL KYVDDIEKGN TIKRIPIHRR 70 80 90 100 110 120 AKQAKFSTLP RNFSLPDSGA RPPAAPPLQN WSPVVPREAS LGTQEQNQSP PLGNAPQAST 130 140 150 160 170 180 SRSEVSYHRK ALLAEATRQL EAAEPEDAEL TFGSGRPQLL RASSMPATLL HSRASEEPGL 190 200 210 220 230 240 SLGPPAPPAL PPLQGEGSVC DGTFEPAEGL AGFHSSSPRA STRIPELVQE GAEPPEGVVK 250 260 270 280 290 300 VPNHLPLPGP PFSFQNVLVV LEDKEDEHNA REAEVLFTPG SPTPSPPPLP SPIPENELLL 310 320 330 340 350 360 EEIELNISEI PPPPPVEVDM RSIGIRVTEE SLGLARVDPG SISSLKQQVS ALEGELSGRT 370 380 390 400 410 420 EELAQVRTAL QQQEEEIKAR EQRIRELEFT VAQLEGQFHQ ENAKDTQGQT DVMVNTDPVH 430 440 450 460 470 480 GLLTRESCDK GIEVNLLGSM ESESWGHRGE ENGLLWGPDG HKQGNQSPAE RVLLPQLSLP 490 500 510 520 530 540 QGPEQVLTSS VHSFLSTELR IEEAGTEQEG GPQGGTRGAG GFLWGSDRKT PPAGREETSS 550 560 570 580 590 600 NLPGKEHPGR PPSSPTDATI GQYVKKIQEL LQEQWNCLEH GYPELASAIK QPASKLSSIQ 610 620 630 640 650 660 SQLLSSLNLL LSAYSAQAHP PKEPPASSSS PPVEISPSTS LKSIMKKKDY GFRAGGNGTK 670 680 690 700 710 720 KNLQFVGVNG GYETTSSEET SGEDSTPEDL SDSEAEKKCD GPDHKHVKDA HLTCEAGQGI 730 740 750 760 770 780 PEGTCHAAQE SGPGEEVPHS KAERYKPSEE FLNACRALSQ HLPETGTTTD QLLRQSLNTI 790 800 810 820 830 840 SQEWFRVSSR KSSSPAVVAS YLHEVQPHSP HFLKLLVNLA DHNGNTALHY SVSHSNFSIV 850 860 870 880 890 900 KLLLETGVCN VDHQNKAGYT AVMITPLASA ETNEDMAVVW KLLREGNVNI QATQGGQTAL 910 920 930 940 950 960 MLGVSHDRED MVQALLSCQA DVNLQDHDGS SALMVACHHG NVDLVRLLLA HPACDSSLTD 970 980 990 KAGRTALSIA LKSPTHMEIA GLLRAHAEQG RSLGL
	Isoform 2 [UniParc]. Checksum: 5E34B07F149259FB	FASTA	367	39,563
	10 20 30 40 50 60 MEKTDEISPS TSLKSIMKKK DYGFRAGGNG TKKNLQFVGV NGGYETTSSE ETSGEDSTPE 70 80 90 100 110 120 DLSDSEAEKK CDGPDHKHVK DAHLTCEAGQ GIPEGTCHAA QESGPGEEVP HSKAERYKPS 130 140 150 160 170 180 EEFLNACRAL SQHLPETGTT TDQLLRQSLN TISQEWFRVS SRKSSSPAVV ASYLHEVQPH 190 200 210 220 230 240 SPHFLKLLVN LADHNGNTAL HYSVSHSNFS IVKLLLETGV CNVDHQNKAG YTAVMITPLA 250 260 270 280 290 300 SAETNEDMAV VWKLLREGNV NIQATQGGQT ALMLGVSHDR EDMVQALLSC QADVNLQDHD 310 320 330 340 350 360 GSSALMVACH HGNVDLVRLL LAHPACDSSL TDKAGRTALS IALKSPTHME IAGLLRAHAE QGRSLGL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-822; ALA-840 AND LEU-935. Tissue: Kidney.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-822; ALA-840 AND LEU-935. Tissue: Placenta.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-995, VARIANTS ARG-822; ALA-840 AND LEU-935. Tissue: Spinal cord.
[5]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK091941 mRNA. Translation: BAC03774.1. AL139343, AL162739 Genomic DNA. Translation: CAI19093.1. AL139343, AL162739 Genomic DNA. Translation: CAI19094.1. AL162739, AL139343 Genomic DNA. Translation: CAI19297.1. AL162739, AL139343 Genomic DNA. Translation: CAI19298.1. BC041418 mRNA. Translation: AAH41418.1. BC060866 mRNA. Translation: AAH60866.1. AL832644 mRNA. Translation: CAD89966.1.
IPI	IPI00409638. IPI00480105.
RefSeq	NP_859063.3. NM_181712.4.
UniGene	Hs.283398.
3D structure databases
ProteinModelPortal	Q5T7N3.
SMR	Q5T7N3. Positions 792-987.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5T7N3.
PTM databases
PhosphoSite	Q5T7N3.
Polymorphism databases
DMDM	74745407.
Proteomic databases
PRIDE	Q5T7N3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371153; ENSP00000360195; ENSG00000132854.
GeneID	163782.
KEGG	hsa:163782.
NMPDR	fig|9606.3.peg.1269.
UCSC	uc001dah.2. human.
Organism-specific databases
CTD	163782.
GeneCards	GC01M062701.
HGNC	HGNC:27263. KANK4.
HPA	HPA014030.
neXtProt	NX_Q5T7N3.
PharmGKB	PA162392639.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG282993.
HOVERGEN	HBG080220.
OrthoDB	EOG451DQG.
PhylomeDB	Q5T7N3.
Gene expression databases
ArrayExpress	Q5T7N3.
Bgee	Q5T7N3.
CleanEx	HS_KANK4.
Genevestigator	Q5T7N3.
GermOnline	ENSG00000132854. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR021939. KN_motif. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF12796. Ank_2. 2 hits. PF12075. KN_motif. 1 hit. [Graphical view]
SMART	SM00248. ANK. 4 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	88405.

Entry information

Entry name

KANK4_HUMAN

Accession

Primary (citable) accession number: Q5T7N3
Secondary accession number(s): B1ALP7 , Q6P9A0, Q86T71, Q86VE6, Q8NAX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.