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Q5T7N3 (KANK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
KN motif and ankyrin repeat domain-containing protein 4
Alternative name(s):
Ankyrin repeat domain-containing protein 38
Gene names
Name:KANK4
Synonyms:ANKRD38
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length995 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the control of cytoskeleton formation by regulating actin polymerization. Ref.5

Subcellular location

Cytoplasm Ref.5.

Tissue specificity

Strongly expressed in colon, liver, lung, skeletal muscle and kidney. Ref.5

Sequence similarities

Contains 5 ANK repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainANK repeat
Coiled coil
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5T7N3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5T7N3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-628: Missing.
     629-633: SSPPV → MEKTD
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 995995KN motif and ankyrin repeat domain-containing protein 4
PRO_0000244364

Regions

Repeat823 – 85331ANK 1
Repeat862 – 89029ANK 2
Repeat895 – 92430ANK 3
Repeat928 – 95831ANK 4
Repeat962 – 99231ANK 5
Coiled coil343 – 40462 Potential
Compositional bias184 – 315132Pro-rich

Natural variations

Alternative sequence1 – 628628Missing in isoform 2.
VSP_019552
Alternative sequence629 – 6335SSPPV → MEKTD in isoform 2.
VSP_019553
Natural variant7011G → S.
Corresponds to variant rs17123306 [ dbSNP | Ensembl ].
VAR_048306
Natural variant7681T → A.
Corresponds to variant rs11207949 [ dbSNP | Ensembl ].
VAR_048307
Natural variant8221H → R. Ref.1 Ref.3 Ref.4
Corresponds to variant rs2258470 [ dbSNP | Ensembl ].
VAR_026902
Natural variant8401V → A. Ref.1 Ref.3 Ref.4
Corresponds to variant rs2666472 [ dbSNP | Ensembl ].
VAR_026903
Natural variant9351V → L. Ref.1 Ref.3 Ref.4
Corresponds to variant rs2941679 [ dbSNP | Ensembl ].
VAR_026904
Natural variant9871A → V.
Corresponds to variant rs34591898 [ dbSNP | Ensembl ].
VAR_048308

Experimental info

Sequence conflict2971E → G in CAD89966. Ref.4
Sequence conflict7861R → H in BAC03774. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 25379EB22B44C760

FASTA995107,342
        10         20         30         40         50         60 
MEKTDAKDQS SQGDEEKDPP KSHPYSVETP YGFHLDLDFL KYVDDIEKGN TIKRIPIHRR 

        70         80         90        100        110        120 
AKQAKFSTLP RNFSLPDSGA RPPAAPPLQN WSPVVPREAS LGTQEQNQSP PLGNAPQAST 

       130        140        150        160        170        180 
SRSEVSYHRK ALLAEATRQL EAAEPEDAEL TFGSGRPQLL RASSMPATLL HSRASEEPGL 

       190        200        210        220        230        240 
SLGPPAPPAL PPLQGEGSVC DGTFEPAEGL AGFHSSSPRA STRIPELVQE GAEPPEGVVK 

       250        260        270        280        290        300 
VPNHLPLPGP PFSFQNVLVV LEDKEDEHNA REAEVLFTPG SPTPSPPPLP SPIPENELLL 

       310        320        330        340        350        360 
EEIELNISEI PPPPPVEVDM RSIGIRVTEE SLGLARVDPG SISSLKQQVS ALEGELSGRT 

       370        380        390        400        410        420 
EELAQVRTAL QQQEEEIKAR EQRIRELEFT VAQLEGQFHQ ENAKDTQGQT DVMVNTDPVH 

       430        440        450        460        470        480 
GLLTRESCDK GIEVNLLGSM ESESWGHRGE ENGLLWGPDG HKQGNQSPAE RVLLPQLSLP 

       490        500        510        520        530        540 
QGPEQVLTSS VHSFLSTELR IEEAGTEQEG GPQGGTRGAG GFLWGSDRKT PPAGREETSS 

       550        560        570        580        590        600 
NLPGKEHPGR PPSSPTDATI GQYVKKIQEL LQEQWNCLEH GYPELASAIK QPASKLSSIQ 

       610        620        630        640        650        660 
SQLLSSLNLL LSAYSAQAHP PKEPPASSSS PPVEISPSTS LKSIMKKKDY GFRAGGNGTK 

       670        680        690        700        710        720 
KNLQFVGVNG GYETTSSEET SGEDSTPEDL SDSEAEKKCD GPDHKHVKDA HLTCEAGQGI 

       730        740        750        760        770        780 
PEGTCHAAQE SGPGEEVPHS KAERYKPSEE FLNACRALSQ HLPETGTTTD QLLRQSLNTI 

       790        800        810        820        830        840 
SQEWFRVSSR KSSSPAVVAS YLHEVQPHSP HFLKLLVNLA DHNGNTALHY SVSHSNFSIV 

       850        860        870        880        890        900 
KLLLETGVCN VDHQNKAGYT AVMITPLASA ETNEDMAVVW KLLREGNVNI QATQGGQTAL 

       910        920        930        940        950        960 
MLGVSHDRED MVQALLSCQA DVNLQDHDGS SALMVACHHG NVDLVRLLLA HPACDSSLTD 

       970        980        990 
KAGRTALSIA LKSPTHMEIA GLLRAHAEQG RSLGL 

« Hide

Isoform 2 [UniParc].

Checksum: 5E34B07F149259FB
Show »

FASTA36739,563

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-822; ALA-840 AND LEU-935.
Tissue: Kidney.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-822; ALA-840 AND LEU-935.
Tissue: Placenta.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-995, VARIANTS ARG-822; ALA-840 AND LEU-935.
Tissue: Spinal cord.
[5]"Kank proteins: a new family of ankyrin-repeat domain-containing proteins."
Zhu Y., Kakinuma N., Wang Y., Kiyama R.
Biochim. Biophys. Acta 1780:128-133(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK091941 mRNA. Translation: BAC03774.1.
AL139343, AL162739 Genomic DNA. Translation: CAI19093.1.
AL139343, AL162739 Genomic DNA. Translation: CAI19094.1.
AL162739, AL139343 Genomic DNA. Translation: CAI19297.1.
AL162739, AL139343 Genomic DNA. Translation: CAI19298.1.
BC041418 mRNA. Translation: AAH41418.1.
BC060866 mRNA. Translation: AAH60866.1.
AL832644 mRNA. Translation: CAD89966.1.
CCDSCCDS620.1. [Q5T7N3-1]
RefSeqNP_859063.3. NM_181712.4. [Q5T7N3-1]
UniGeneHs.283398.

3D structure databases

ProteinModelPortalQ5T7N3.
SMRQ5T7N3. Positions 748-983.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127879. 1 interaction.
STRING9606.ENSP00000360195.

PTM databases

PhosphoSiteQ5T7N3.

Polymorphism databases

DMDM74745407.

Proteomic databases

MaxQBQ5T7N3.
PaxDbQ5T7N3.
PRIDEQ5T7N3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354381; ENSP00000346352; ENSG00000132854. [Q5T7N3-2]
ENST00000371153; ENSP00000360195; ENSG00000132854. [Q5T7N3-1]
GeneID163782.
KEGGhsa:163782.
UCSCuc001dah.4. human. [Q5T7N3-1]
uc001dai.4. human. [Q5T7N3-2]

Organism-specific databases

CTD163782.
GeneCardsGC01M062701.
HGNCHGNC:27263. KANK4.
HPAHPA014030.
MIM614612. gene.
neXtProtNX_Q5T7N3.
PharmGKBPA162392639.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000231305.
HOVERGENHBG080220.
OMAKRIPIHR.
OrthoDBEOG7NW687.
PhylomeDBQ5T7N3.
TreeFamTF324499.

Gene expression databases

ArrayExpressQ5T7N3.
BgeeQ5T7N3.
CleanExHS_KANK4.
GenevestigatorQ5T7N3.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021939. KN_motif.
[Graphical view]
PfamPF12796. Ank_2. 2 hits.
PF12075. KN_motif. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKANK4. human.
GenomeRNAi163782.
NextBio88405.
PROQ5T7N3.
SOURCESearch...

Entry information

Entry nameKANK4_HUMAN
AccessionPrimary (citable) accession number: Q5T7N3
Secondary accession number(s): B1ALP7 expand/collapse secondary AC list , Q6P9A0, Q86T71, Q86VE6, Q8NAX3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM