Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5T7N3

- KANK4_HUMAN

UniProt

Q5T7N3 - KANK4_HUMAN

Protein

KN motif and ankyrin repeat domain-containing protein 4

Gene

KANK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in the control of cytoskeleton formation by regulating actin polymerization.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KN motif and ankyrin repeat domain-containing protein 4
    Alternative name(s):
    Ankyrin repeat domain-containing protein 38
    Gene namesi
    Name:KANK4
    Synonyms:ANKRD38
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:27263. KANK4.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162392639.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 995995KN motif and ankyrin repeat domain-containing protein 4PRO_0000244364Add
    BLAST

    Proteomic databases

    MaxQBiQ5T7N3.
    PaxDbiQ5T7N3.
    PRIDEiQ5T7N3.

    PTM databases

    PhosphoSiteiQ5T7N3.

    Expressioni

    Tissue specificityi

    Strongly expressed in colon, liver, lung, skeletal muscle and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ5T7N3.
    BgeeiQ5T7N3.
    CleanExiHS_KANK4.
    GenevestigatoriQ5T7N3.

    Organism-specific databases

    HPAiHPA014030.

    Interactioni

    Protein-protein interaction databases

    BioGridi127879. 1 interaction.
    IntActiQ5T7N3. 1 interaction.
    STRINGi9606.ENSP00000360195.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T7N3.
    SMRiQ5T7N3. Positions 748-983.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati823 – 85331ANK 1Add
    BLAST
    Repeati862 – 89029ANK 2Add
    BLAST
    Repeati895 – 92430ANK 3Add
    BLAST
    Repeati928 – 95831ANK 4Add
    BLAST
    Repeati962 – 99231ANK 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili343 – 40462Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi184 – 315132Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 5 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000231305.
    HOVERGENiHBG080220.
    OMAiKRIPIHR.
    OrthoDBiEOG7NW687.
    PhylomeDBiQ5T7N3.
    TreeFamiTF324499.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR021939. KN_motif.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    PF12075. KN_motif. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T7N3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEKTDAKDQS SQGDEEKDPP KSHPYSVETP YGFHLDLDFL KYVDDIEKGN    50
    TIKRIPIHRR AKQAKFSTLP RNFSLPDSGA RPPAAPPLQN WSPVVPREAS 100
    LGTQEQNQSP PLGNAPQAST SRSEVSYHRK ALLAEATRQL EAAEPEDAEL 150
    TFGSGRPQLL RASSMPATLL HSRASEEPGL SLGPPAPPAL PPLQGEGSVC 200
    DGTFEPAEGL AGFHSSSPRA STRIPELVQE GAEPPEGVVK VPNHLPLPGP 250
    PFSFQNVLVV LEDKEDEHNA REAEVLFTPG SPTPSPPPLP SPIPENELLL 300
    EEIELNISEI PPPPPVEVDM RSIGIRVTEE SLGLARVDPG SISSLKQQVS 350
    ALEGELSGRT EELAQVRTAL QQQEEEIKAR EQRIRELEFT VAQLEGQFHQ 400
    ENAKDTQGQT DVMVNTDPVH GLLTRESCDK GIEVNLLGSM ESESWGHRGE 450
    ENGLLWGPDG HKQGNQSPAE RVLLPQLSLP QGPEQVLTSS VHSFLSTELR 500
    IEEAGTEQEG GPQGGTRGAG GFLWGSDRKT PPAGREETSS NLPGKEHPGR 550
    PPSSPTDATI GQYVKKIQEL LQEQWNCLEH GYPELASAIK QPASKLSSIQ 600
    SQLLSSLNLL LSAYSAQAHP PKEPPASSSS PPVEISPSTS LKSIMKKKDY 650
    GFRAGGNGTK KNLQFVGVNG GYETTSSEET SGEDSTPEDL SDSEAEKKCD 700
    GPDHKHVKDA HLTCEAGQGI PEGTCHAAQE SGPGEEVPHS KAERYKPSEE 750
    FLNACRALSQ HLPETGTTTD QLLRQSLNTI SQEWFRVSSR KSSSPAVVAS 800
    YLHEVQPHSP HFLKLLVNLA DHNGNTALHY SVSHSNFSIV KLLLETGVCN 850
    VDHQNKAGYT AVMITPLASA ETNEDMAVVW KLLREGNVNI QATQGGQTAL 900
    MLGVSHDRED MVQALLSCQA DVNLQDHDGS SALMVACHHG NVDLVRLLLA 950
    HPACDSSLTD KAGRTALSIA LKSPTHMEIA GLLRAHAEQG RSLGL 995
    Length:995
    Mass (Da):107,342
    Last modified:December 21, 2004 - v1
    Checksum:i25379EB22B44C760
    GO
    Isoform 2 (identifier: Q5T7N3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-628: Missing.
         629-633: SSPPV → MEKTD

    Note: No experimental confirmation available.

    Show »
    Length:367
    Mass (Da):39,563
    Checksum:i5E34B07F149259FB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti297 – 2971E → G in CAD89966. (PubMed:17974005)Curated
    Sequence conflicti786 – 7861R → H in BAC03774. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti701 – 7011G → S.
    Corresponds to variant rs17123306 [ dbSNP | Ensembl ].
    VAR_048306
    Natural varianti768 – 7681T → A.
    Corresponds to variant rs11207949 [ dbSNP | Ensembl ].
    VAR_048307
    Natural varianti822 – 8221H → R.3 Publications
    Corresponds to variant rs2258470 [ dbSNP | Ensembl ].
    VAR_026902
    Natural varianti840 – 8401V → A.3 Publications
    Corresponds to variant rs2666472 [ dbSNP | Ensembl ].
    VAR_026903
    Natural varianti935 – 9351V → L.3 Publications
    Corresponds to variant rs2941679 [ dbSNP | Ensembl ].
    VAR_026904
    Natural varianti987 – 9871A → V.
    Corresponds to variant rs34591898 [ dbSNP | Ensembl ].
    VAR_048308

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 628628Missing in isoform 2. 1 PublicationVSP_019552Add
    BLAST
    Alternative sequencei629 – 6335SSPPV → MEKTD in isoform 2. 1 PublicationVSP_019553

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091941 mRNA. Translation: BAC03774.1.
    AL139343, AL162739 Genomic DNA. Translation: CAI19093.1.
    AL139343, AL162739 Genomic DNA. Translation: CAI19094.1.
    AL162739, AL139343 Genomic DNA. Translation: CAI19297.1.
    AL162739, AL139343 Genomic DNA. Translation: CAI19298.1.
    BC041418 mRNA. Translation: AAH41418.1.
    BC060866 mRNA. Translation: AAH60866.1.
    AL832644 mRNA. Translation: CAD89966.1.
    CCDSiCCDS620.1. [Q5T7N3-1]
    RefSeqiNP_859063.3. NM_181712.4. [Q5T7N3-1]
    UniGeneiHs.283398.

    Genome annotation databases

    EnsembliENST00000354381; ENSP00000346352; ENSG00000132854. [Q5T7N3-2]
    ENST00000371153; ENSP00000360195; ENSG00000132854. [Q5T7N3-1]
    GeneIDi163782.
    KEGGihsa:163782.
    UCSCiuc001dah.4. human. [Q5T7N3-1]
    uc001dai.4. human. [Q5T7N3-2]

    Polymorphism databases

    DMDMi74745407.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091941 mRNA. Translation: BAC03774.1 .
    AL139343 , AL162739 Genomic DNA. Translation: CAI19093.1 .
    AL139343 , AL162739 Genomic DNA. Translation: CAI19094.1 .
    AL162739 , AL139343 Genomic DNA. Translation: CAI19297.1 .
    AL162739 , AL139343 Genomic DNA. Translation: CAI19298.1 .
    BC041418 mRNA. Translation: AAH41418.1 .
    BC060866 mRNA. Translation: AAH60866.1 .
    AL832644 mRNA. Translation: CAD89966.1 .
    CCDSi CCDS620.1. [Q5T7N3-1 ]
    RefSeqi NP_859063.3. NM_181712.4. [Q5T7N3-1 ]
    UniGenei Hs.283398.

    3D structure databases

    ProteinModelPortali Q5T7N3.
    SMRi Q5T7N3. Positions 748-983.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127879. 1 interaction.
    IntActi Q5T7N3. 1 interaction.
    STRINGi 9606.ENSP00000360195.

    PTM databases

    PhosphoSitei Q5T7N3.

    Polymorphism databases

    DMDMi 74745407.

    Proteomic databases

    MaxQBi Q5T7N3.
    PaxDbi Q5T7N3.
    PRIDEi Q5T7N3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354381 ; ENSP00000346352 ; ENSG00000132854 . [Q5T7N3-2 ]
    ENST00000371153 ; ENSP00000360195 ; ENSG00000132854 . [Q5T7N3-1 ]
    GeneIDi 163782.
    KEGGi hsa:163782.
    UCSCi uc001dah.4. human. [Q5T7N3-1 ]
    uc001dai.4. human. [Q5T7N3-2 ]

    Organism-specific databases

    CTDi 163782.
    GeneCardsi GC01M062701.
    HGNCi HGNC:27263. KANK4.
    HPAi HPA014030.
    MIMi 614612. gene.
    neXtProti NX_Q5T7N3.
    PharmGKBi PA162392639.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000231305.
    HOVERGENi HBG080220.
    OMAi KRIPIHR.
    OrthoDBi EOG7NW687.
    PhylomeDBi Q5T7N3.
    TreeFami TF324499.

    Miscellaneous databases

    ChiTaRSi KANK4. human.
    GenomeRNAii 163782.
    NextBioi 88405.
    PROi Q5T7N3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5T7N3.
    Bgeei Q5T7N3.
    CleanExi HS_KANK4.
    Genevestigatori Q5T7N3.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR021939. KN_motif.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    PF12075. KN_motif. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-822; ALA-840 AND LEU-935.
      Tissue: Kidney.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-822; ALA-840 AND LEU-935.
      Tissue: Placenta.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-995, VARIANTS ARG-822; ALA-840 AND LEU-935.
      Tissue: Spinal cord.
    5. "Kank proteins: a new family of ankyrin-repeat domain-containing proteins."
      Zhu Y., Kakinuma N., Wang Y., Kiyama R.
      Biochim. Biophys. Acta 1780:128-133(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKANK4_HUMAN
    AccessioniPrimary (citable) accession number: Q5T7N3
    Secondary accession number(s): B1ALP7
    , Q6P9A0, Q86T71, Q86VE6, Q8NAX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3