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Q5T7N3

- KANK4_HUMAN

UniProt

Q5T7N3 - KANK4_HUMAN

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Protein
KN motif and ankyrin repeat domain-containing protein 4
Gene
KANK4, ANKRD38
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in the control of cytoskeleton formation by regulating actin polymerization.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
KN motif and ankyrin repeat domain-containing protein 4
Alternative name(s):
Ankyrin repeat domain-containing protein 38
Gene namesi
Name:KANK4
Synonyms:ANKRD38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:27263. KANK4.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392639.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 995995KN motif and ankyrin repeat domain-containing protein 4
PRO_0000244364Add
BLAST

Proteomic databases

MaxQBiQ5T7N3.
PaxDbiQ5T7N3.
PRIDEiQ5T7N3.

PTM databases

PhosphoSiteiQ5T7N3.

Expressioni

Tissue specificityi

Strongly expressed in colon, liver, lung, skeletal muscle and kidney.1 Publication

Gene expression databases

ArrayExpressiQ5T7N3.
BgeeiQ5T7N3.
CleanExiHS_KANK4.
GenevestigatoriQ5T7N3.

Organism-specific databases

HPAiHPA014030.

Interactioni

Protein-protein interaction databases

BioGridi127879. 1 interaction.
STRINGi9606.ENSP00000360195.

Structurei

3D structure databases

ProteinModelPortaliQ5T7N3.
SMRiQ5T7N3. Positions 748-983.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati823 – 85331ANK 1
Add
BLAST
Repeati862 – 89029ANK 2
Add
BLAST
Repeati895 – 92430ANK 3
Add
BLAST
Repeati928 – 95831ANK 4
Add
BLAST
Repeati962 – 99231ANK 5
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili343 – 40462 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi184 – 315132Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000231305.
HOVERGENiHBG080220.
OMAiKRIPIHR.
OrthoDBiEOG7NW687.
PhylomeDBiQ5T7N3.
TreeFamiTF324499.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021939. KN_motif.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF12075. KN_motif. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T7N3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEKTDAKDQS SQGDEEKDPP KSHPYSVETP YGFHLDLDFL KYVDDIEKGN    50
TIKRIPIHRR AKQAKFSTLP RNFSLPDSGA RPPAAPPLQN WSPVVPREAS 100
LGTQEQNQSP PLGNAPQAST SRSEVSYHRK ALLAEATRQL EAAEPEDAEL 150
TFGSGRPQLL RASSMPATLL HSRASEEPGL SLGPPAPPAL PPLQGEGSVC 200
DGTFEPAEGL AGFHSSSPRA STRIPELVQE GAEPPEGVVK VPNHLPLPGP 250
PFSFQNVLVV LEDKEDEHNA REAEVLFTPG SPTPSPPPLP SPIPENELLL 300
EEIELNISEI PPPPPVEVDM RSIGIRVTEE SLGLARVDPG SISSLKQQVS 350
ALEGELSGRT EELAQVRTAL QQQEEEIKAR EQRIRELEFT VAQLEGQFHQ 400
ENAKDTQGQT DVMVNTDPVH GLLTRESCDK GIEVNLLGSM ESESWGHRGE 450
ENGLLWGPDG HKQGNQSPAE RVLLPQLSLP QGPEQVLTSS VHSFLSTELR 500
IEEAGTEQEG GPQGGTRGAG GFLWGSDRKT PPAGREETSS NLPGKEHPGR 550
PPSSPTDATI GQYVKKIQEL LQEQWNCLEH GYPELASAIK QPASKLSSIQ 600
SQLLSSLNLL LSAYSAQAHP PKEPPASSSS PPVEISPSTS LKSIMKKKDY 650
GFRAGGNGTK KNLQFVGVNG GYETTSSEET SGEDSTPEDL SDSEAEKKCD 700
GPDHKHVKDA HLTCEAGQGI PEGTCHAAQE SGPGEEVPHS KAERYKPSEE 750
FLNACRALSQ HLPETGTTTD QLLRQSLNTI SQEWFRVSSR KSSSPAVVAS 800
YLHEVQPHSP HFLKLLVNLA DHNGNTALHY SVSHSNFSIV KLLLETGVCN 850
VDHQNKAGYT AVMITPLASA ETNEDMAVVW KLLREGNVNI QATQGGQTAL 900
MLGVSHDRED MVQALLSCQA DVNLQDHDGS SALMVACHHG NVDLVRLLLA 950
HPACDSSLTD KAGRTALSIA LKSPTHMEIA GLLRAHAEQG RSLGL 995
Length:995
Mass (Da):107,342
Last modified:December 21, 2004 - v1
Checksum:i25379EB22B44C760
GO
Isoform 2 (identifier: Q5T7N3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-628: Missing.
     629-633: SSPPV → MEKTD

Note: No experimental confirmation available.

Show »
Length:367
Mass (Da):39,563
Checksum:i5E34B07F149259FB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti701 – 7011G → S.
Corresponds to variant rs17123306 [ dbSNP | Ensembl ].
VAR_048306
Natural varianti768 – 7681T → A.
Corresponds to variant rs11207949 [ dbSNP | Ensembl ].
VAR_048307
Natural varianti822 – 8221H → R.3 Publications
Corresponds to variant rs2258470 [ dbSNP | Ensembl ].
VAR_026902
Natural varianti840 – 8401V → A.3 Publications
Corresponds to variant rs2666472 [ dbSNP | Ensembl ].
VAR_026903
Natural varianti935 – 9351V → L.3 Publications
Corresponds to variant rs2941679 [ dbSNP | Ensembl ].
VAR_026904
Natural varianti987 – 9871A → V.
Corresponds to variant rs34591898 [ dbSNP | Ensembl ].
VAR_048308

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 628628Missing in isoform 2.
VSP_019552Add
BLAST
Alternative sequencei629 – 6335SSPPV → MEKTD in isoform 2.
VSP_019553

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971E → G in CAD89966. 1 Publication
Sequence conflicti786 – 7861R → H in BAC03774. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK091941 mRNA. Translation: BAC03774.1.
AL139343, AL162739 Genomic DNA. Translation: CAI19093.1.
AL139343, AL162739 Genomic DNA. Translation: CAI19094.1.
AL162739, AL139343 Genomic DNA. Translation: CAI19297.1.
AL162739, AL139343 Genomic DNA. Translation: CAI19298.1.
BC041418 mRNA. Translation: AAH41418.1.
BC060866 mRNA. Translation: AAH60866.1.
AL832644 mRNA. Translation: CAD89966.1.
CCDSiCCDS620.1. [Q5T7N3-1]
RefSeqiNP_859063.3. NM_181712.4. [Q5T7N3-1]
UniGeneiHs.283398.

Genome annotation databases

EnsembliENST00000354381; ENSP00000346352; ENSG00000132854. [Q5T7N3-2]
ENST00000371153; ENSP00000360195; ENSG00000132854. [Q5T7N3-1]
GeneIDi163782.
KEGGihsa:163782.
UCSCiuc001dah.4. human. [Q5T7N3-1]
uc001dai.4. human. [Q5T7N3-2]

Polymorphism databases

DMDMi74745407.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK091941 mRNA. Translation: BAC03774.1 .
AL139343 , AL162739 Genomic DNA. Translation: CAI19093.1 .
AL139343 , AL162739 Genomic DNA. Translation: CAI19094.1 .
AL162739 , AL139343 Genomic DNA. Translation: CAI19297.1 .
AL162739 , AL139343 Genomic DNA. Translation: CAI19298.1 .
BC041418 mRNA. Translation: AAH41418.1 .
BC060866 mRNA. Translation: AAH60866.1 .
AL832644 mRNA. Translation: CAD89966.1 .
CCDSi CCDS620.1. [Q5T7N3-1 ]
RefSeqi NP_859063.3. NM_181712.4. [Q5T7N3-1 ]
UniGenei Hs.283398.

3D structure databases

ProteinModelPortali Q5T7N3.
SMRi Q5T7N3. Positions 748-983.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127879. 1 interaction.
STRINGi 9606.ENSP00000360195.

PTM databases

PhosphoSitei Q5T7N3.

Polymorphism databases

DMDMi 74745407.

Proteomic databases

MaxQBi Q5T7N3.
PaxDbi Q5T7N3.
PRIDEi Q5T7N3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354381 ; ENSP00000346352 ; ENSG00000132854 . [Q5T7N3-2 ]
ENST00000371153 ; ENSP00000360195 ; ENSG00000132854 . [Q5T7N3-1 ]
GeneIDi 163782.
KEGGi hsa:163782.
UCSCi uc001dah.4. human. [Q5T7N3-1 ]
uc001dai.4. human. [Q5T7N3-2 ]

Organism-specific databases

CTDi 163782.
GeneCardsi GC01M062701.
HGNCi HGNC:27263. KANK4.
HPAi HPA014030.
MIMi 614612. gene.
neXtProti NX_Q5T7N3.
PharmGKBi PA162392639.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
HOGENOMi HOG000231305.
HOVERGENi HBG080220.
OMAi KRIPIHR.
OrthoDBi EOG7NW687.
PhylomeDBi Q5T7N3.
TreeFami TF324499.

Miscellaneous databases

ChiTaRSi KANK4. human.
GenomeRNAii 163782.
NextBioi 88405.
PROi Q5T7N3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5T7N3.
Bgeei Q5T7N3.
CleanExi HS_KANK4.
Genevestigatori Q5T7N3.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021939. KN_motif.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
PF12075. KN_motif. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-822; ALA-840 AND LEU-935.
    Tissue: Kidney.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-822; ALA-840 AND LEU-935.
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-995, VARIANTS ARG-822; ALA-840 AND LEU-935.
    Tissue: Spinal cord.
  5. "Kank proteins: a new family of ankyrin-repeat domain-containing proteins."
    Zhu Y., Kakinuma N., Wang Y., Kiyama R.
    Biochim. Biophys. Acta 1780:128-133(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKANK4_HUMAN
AccessioniPrimary (citable) accession number: Q5T7N3
Secondary accession number(s): B1ALP7
, Q6P9A0, Q86T71, Q86VE6, Q8NAX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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