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Protein

KN motif and ankyrin repeat domain-containing protein 4

Gene

KANK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the control of cytoskeleton formation by regulating actin polymerization.

Names & Taxonomyi

Protein namesi
Recommended name:
KN motif and ankyrin repeat domain-containing protein 4
Alternative name(s):
Ankyrin repeat domain-containing protein 38
Gene namesi
Name:KANK4
Synonyms:ANKRD38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27263. KANK4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392639.

Polymorphism and mutation databases

BioMutaiKANK4.
DMDMi74745407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 995995KN motif and ankyrin repeat domain-containing protein 4PRO_0000244364Add
BLAST

Proteomic databases

MaxQBiQ5T7N3.
PaxDbiQ5T7N3.
PRIDEiQ5T7N3.

PTM databases

PhosphoSiteiQ5T7N3.

Expressioni

Tissue specificityi

Strongly expressed in colon, liver, lung, skeletal muscle and kidney.1 Publication

Gene expression databases

BgeeiQ5T7N3.
CleanExiHS_KANK4.
ExpressionAtlasiQ5T7N3. baseline and differential.
GenevestigatoriQ5T7N3.

Organism-specific databases

HPAiHPA014030.

Interactioni

Protein-protein interaction databases

BioGridi127879. 1 interaction.
IntActiQ5T7N3. 1 interaction.
STRINGi9606.ENSP00000360195.

Structurei

3D structure databases

ProteinModelPortaliQ5T7N3.
SMRiQ5T7N3. Positions 748-983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati823 – 85331ANK 1Add
BLAST
Repeati862 – 89029ANK 2Add
BLAST
Repeati895 – 92430ANK 3Add
BLAST
Repeati928 – 95831ANK 4Add
BLAST
Repeati962 – 99231ANK 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili343 – 40462Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi184 – 315132Pro-richAdd
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00530000063448.
HOGENOMiHOG000231305.
HOVERGENiHBG080220.
InParanoidiQ5T7N3.
OMAiKRIPIHR.
OrthoDBiEOG7NW687.
PhylomeDBiQ5T7N3.
TreeFamiTF324499.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021939. KN_motif.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF12075. KN_motif. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T7N3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKTDAKDQS SQGDEEKDPP KSHPYSVETP YGFHLDLDFL KYVDDIEKGN
60 70 80 90 100
TIKRIPIHRR AKQAKFSTLP RNFSLPDSGA RPPAAPPLQN WSPVVPREAS
110 120 130 140 150
LGTQEQNQSP PLGNAPQAST SRSEVSYHRK ALLAEATRQL EAAEPEDAEL
160 170 180 190 200
TFGSGRPQLL RASSMPATLL HSRASEEPGL SLGPPAPPAL PPLQGEGSVC
210 220 230 240 250
DGTFEPAEGL AGFHSSSPRA STRIPELVQE GAEPPEGVVK VPNHLPLPGP
260 270 280 290 300
PFSFQNVLVV LEDKEDEHNA REAEVLFTPG SPTPSPPPLP SPIPENELLL
310 320 330 340 350
EEIELNISEI PPPPPVEVDM RSIGIRVTEE SLGLARVDPG SISSLKQQVS
360 370 380 390 400
ALEGELSGRT EELAQVRTAL QQQEEEIKAR EQRIRELEFT VAQLEGQFHQ
410 420 430 440 450
ENAKDTQGQT DVMVNTDPVH GLLTRESCDK GIEVNLLGSM ESESWGHRGE
460 470 480 490 500
ENGLLWGPDG HKQGNQSPAE RVLLPQLSLP QGPEQVLTSS VHSFLSTELR
510 520 530 540 550
IEEAGTEQEG GPQGGTRGAG GFLWGSDRKT PPAGREETSS NLPGKEHPGR
560 570 580 590 600
PPSSPTDATI GQYVKKIQEL LQEQWNCLEH GYPELASAIK QPASKLSSIQ
610 620 630 640 650
SQLLSSLNLL LSAYSAQAHP PKEPPASSSS PPVEISPSTS LKSIMKKKDY
660 670 680 690 700
GFRAGGNGTK KNLQFVGVNG GYETTSSEET SGEDSTPEDL SDSEAEKKCD
710 720 730 740 750
GPDHKHVKDA HLTCEAGQGI PEGTCHAAQE SGPGEEVPHS KAERYKPSEE
760 770 780 790 800
FLNACRALSQ HLPETGTTTD QLLRQSLNTI SQEWFRVSSR KSSSPAVVAS
810 820 830 840 850
YLHEVQPHSP HFLKLLVNLA DHNGNTALHY SVSHSNFSIV KLLLETGVCN
860 870 880 890 900
VDHQNKAGYT AVMITPLASA ETNEDMAVVW KLLREGNVNI QATQGGQTAL
910 920 930 940 950
MLGVSHDRED MVQALLSCQA DVNLQDHDGS SALMVACHHG NVDLVRLLLA
960 970 980 990
HPACDSSLTD KAGRTALSIA LKSPTHMEIA GLLRAHAEQG RSLGL
Length:995
Mass (Da):107,342
Last modified:December 21, 2004 - v1
Checksum:i25379EB22B44C760
GO
Isoform 2 (identifier: Q5T7N3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-628: Missing.
     629-633: SSPPV → MEKTD

Note: No experimental confirmation available.

Show »
Length:367
Mass (Da):39,563
Checksum:i5E34B07F149259FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971E → G in CAD89966 (PubMed:17974005).Curated
Sequence conflicti786 – 7861R → H in BAC03774 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti701 – 7011G → S.
Corresponds to variant rs17123306 [ dbSNP | Ensembl ].
VAR_048306
Natural varianti768 – 7681T → A.
Corresponds to variant rs11207949 [ dbSNP | Ensembl ].
VAR_048307
Natural varianti822 – 8221H → R.3 Publications
Corresponds to variant rs2258470 [ dbSNP | Ensembl ].
VAR_026902
Natural varianti840 – 8401V → A.3 Publications
Corresponds to variant rs2666472 [ dbSNP | Ensembl ].
VAR_026903
Natural varianti935 – 9351V → L.3 Publications
Corresponds to variant rs2941679 [ dbSNP | Ensembl ].
VAR_026904
Natural varianti987 – 9871A → V.
Corresponds to variant rs34591898 [ dbSNP | Ensembl ].
VAR_048308

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 628628Missing in isoform 2. 1 PublicationVSP_019552Add
BLAST
Alternative sequencei629 – 6335SSPPV → MEKTD in isoform 2. 1 PublicationVSP_019553

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091941 mRNA. Translation: BAC03774.1.
AL139343, AL162739 Genomic DNA. Translation: CAI19093.1.
AL139343, AL162739 Genomic DNA. Translation: CAI19094.1.
AL162739, AL139343 Genomic DNA. Translation: CAI19297.1.
AL162739, AL139343 Genomic DNA. Translation: CAI19298.1.
BC041418 mRNA. Translation: AAH41418.1.
BC060866 mRNA. Translation: AAH60866.1.
AL832644 mRNA. Translation: CAD89966.1.
CCDSiCCDS620.1. [Q5T7N3-1]
RefSeqiNP_859063.3. NM_181712.4. [Q5T7N3-1]
UniGeneiHs.283398.

Genome annotation databases

EnsembliENST00000354381; ENSP00000346352; ENSG00000132854. [Q5T7N3-2]
ENST00000371153; ENSP00000360195; ENSG00000132854. [Q5T7N3-1]
GeneIDi163782.
KEGGihsa:163782.
UCSCiuc001dah.4. human. [Q5T7N3-1]
uc001dai.4. human. [Q5T7N3-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091941 mRNA. Translation: BAC03774.1.
AL139343, AL162739 Genomic DNA. Translation: CAI19093.1.
AL139343, AL162739 Genomic DNA. Translation: CAI19094.1.
AL162739, AL139343 Genomic DNA. Translation: CAI19297.1.
AL162739, AL139343 Genomic DNA. Translation: CAI19298.1.
BC041418 mRNA. Translation: AAH41418.1.
BC060866 mRNA. Translation: AAH60866.1.
AL832644 mRNA. Translation: CAD89966.1.
CCDSiCCDS620.1. [Q5T7N3-1]
RefSeqiNP_859063.3. NM_181712.4. [Q5T7N3-1]
UniGeneiHs.283398.

3D structure databases

ProteinModelPortaliQ5T7N3.
SMRiQ5T7N3. Positions 748-983.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127879. 1 interaction.
IntActiQ5T7N3. 1 interaction.
STRINGi9606.ENSP00000360195.

PTM databases

PhosphoSiteiQ5T7N3.

Polymorphism and mutation databases

BioMutaiKANK4.
DMDMi74745407.

Proteomic databases

MaxQBiQ5T7N3.
PaxDbiQ5T7N3.
PRIDEiQ5T7N3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354381; ENSP00000346352; ENSG00000132854. [Q5T7N3-2]
ENST00000371153; ENSP00000360195; ENSG00000132854. [Q5T7N3-1]
GeneIDi163782.
KEGGihsa:163782.
UCSCiuc001dah.4. human. [Q5T7N3-1]
uc001dai.4. human. [Q5T7N3-2]

Organism-specific databases

CTDi163782.
GeneCardsiGC01M062701.
HGNCiHGNC:27263. KANK4.
HPAiHPA014030.
MIMi614612. gene.
neXtProtiNX_Q5T7N3.
PharmGKBiPA162392639.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00530000063448.
HOGENOMiHOG000231305.
HOVERGENiHBG080220.
InParanoidiQ5T7N3.
OMAiKRIPIHR.
OrthoDBiEOG7NW687.
PhylomeDBiQ5T7N3.
TreeFamiTF324499.

Miscellaneous databases

ChiTaRSiKANK4. human.
GenomeRNAii163782.
NextBioi88405.
PROiQ5T7N3.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T7N3.
CleanExiHS_KANK4.
ExpressionAtlasiQ5T7N3. baseline and differential.
GenevestigatoriQ5T7N3.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021939. KN_motif.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF12075. KN_motif. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-822; ALA-840 AND LEU-935.
    Tissue: Kidney.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-822; ALA-840 AND LEU-935.
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-995, VARIANTS ARG-822; ALA-840 AND LEU-935.
    Tissue: Spinal cord.
  5. "Kank proteins: a new family of ankyrin-repeat domain-containing proteins."
    Zhu Y., Kakinuma N., Wang Y., Kiyama R.
    Biochim. Biophys. Acta 1780:128-133(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKANK4_HUMAN
AccessioniPrimary (citable) accession number: Q5T7N3
Secondary accession number(s): B1ALP7
, Q6P9A0, Q86T71, Q86VE6, Q8NAX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: April 29, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.