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Protein

LINE-1 type transposase domain-containing protein 1

Gene

L1TD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31262-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
LINE-1 type transposase domain-containing protein 1
Alternative name(s):
ES cell-associated protein 11
Gene namesi
Name:L1TD1
Synonyms:ECAT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25595. L1TD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi54596.
OpenTargetsiENSG00000240563.
PharmGKBiPA145008170.

Polymorphism and mutation databases

BioMutaiL1TD1.
DMDMi74745406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003072172 – 865LINE-1 type transposase domain-containing protein 1Add BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei149PhosphothreonineCombined sources1
Modified residuei154PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei561PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5T7N2.
PaxDbiQ5T7N2.
PeptideAtlasiQ5T7N2.
PRIDEiQ5T7N2.

PTM databases

iPTMnetiQ5T7N2.
PhosphoSitePlusiQ5T7N2.

Expressioni

Gene expression databases

BgeeiENSG00000240563.
CleanExiHS_L1TD1.
GenevisibleiQ5T7N2. HS.

Organism-specific databases

HPAiHPA028501.
HPA030064.

Interactioni

Protein-protein interaction databases

BioGridi120072. 20 interactors.
IntActiQ5T7N2. 18 interactors.
MINTiMINT-1198165.
STRINGi9606.ENSP00000419901.

Structurei

Secondary structure

1865
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni248 – 250Combined sources3
Helixi258 – 269Combined sources12
Beta strandi282 – 285Combined sources4
Beta strandi287 – 295Combined sources9
Helixi296 – 304Combined sources9
Helixi307 – 310Combined sources4
Turni314 – 316Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LR6NMR-A/B235-321[»]
3SOOX-ray2.73A/B/C235-321[»]
ProteinModelPortaliQ5T7N2.
SMRiQ5T7N2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5T7N2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili642 – 684Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi369 – 488Glu-richAdd BLAST120
Compositional biasi534 – 537Poly-Glu4

Sequence similaritiesi

Belongs to the transposase 22 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J6GY. Eukaryota.
ENOG410YV4T. LUCA.
GeneTreeiENSGT00840000129838.
HOGENOMiHOG000113335.
HOVERGENiHBG094915.
InParanoidiQ5T7N2.
OMAiKLAFKCD.
OrthoDBiEOG091G0527.
PhylomeDBiQ5T7N2.
TreeFamiTF351152.

Family and domain databases

InterProiIPR004244. Transposase_22.
[Graphical view]
PANTHERiPTHR11505. PTHR11505. 1 hit.
PfamiPF02994. Transposase_22. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5T7N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVSTSVQS KFARLAKKKE NITYMKREQL TETDKDIAPV LDLKCKDVSA
60 70 80 90 100
IMNKFKVLME IQDLMFEEMR ETLKNDLKAV LGGKATIPEV KNSENSSSRT
110 120 130 140 150
EFQQIINLAL QKTGMVGKIE GENSKIGDDN ENLTFKLEVN ELSGKLDNTN
160 170 180 190 200
EYNSNDGKKL PQGESRSYEV MGSMEETLCN IDDRDGNRNV HLEFTERESR
210 220 230 240 250
KDGEDEFVKE MREERKFQKL KNKEEVLKAS REEKVLMDEG AVLTLVADLS
260 270 280 290 300
SATLDISKQW SNVFNILREN DFEPKFLCEV KLAFKCDGEI KTFSDLQSLR
310 320 330 340 350
KFASQKSSVK ELLKDVLPQK EEINQGGRKY GIQEKRDKTL IDSKHRAGEI
360 370 380 390 400
TSDGLSFLFL KEVKVAKPEE MKNLETQEEE FSELEELDEE ASGMEDDEDT
410 420 430 440 450
SGLEEEEEEP SGLEEEEEEE ASGLEEDEAS GLEEEEEQTS EQDSTFQGHT
460 470 480 490 500
LVDAKHEVEI TSDGMETTFI DSVEDSESEE EEEGKSSETG KVKTTSLTEK
510 520 530 540 550
KASRRQKEIP FSYLVGDSGK KKLVKHQVVH KTQEEEETAV PTSQGTGTPC
560 570 580 590 600
LTLCLASPSK SLEMSHDEHK KHSHTNLSIS TGVTKLKKTE EKKHRTLHTE
610 620 630 640 650
ELTSKEADLT EETEENLRSS VINSIREIKE EIGNLKSSHS GVLEIENSVD
660 670 680 690 700
DLSSRMDILE ERIDSLEDQI EEFSKDTMQM TKQIISKERQ RDIEERSRSC
710 720 730 740 750
NIRLIGIPEK ESYENRAEDI IKEIIDENFA ELKKGSSLEI VSACRVPSKI
760 770 780 790 800
DEKRLTPRHI LVKFWNSSDK EKIIRASRER REITYQGTRI RLTADLSLDT
810 820 830 840 850
LDARSKWSNV FKVLLEKGFN PRILYPAKMA FDFRGKTKVF LSIEEFRDYV
860
LHMPTLRELL GNNIP
Length:865
Mass (Da):98,850
Last modified:December 21, 2004 - v1
Checksum:iC7E33893A1E675CC
GO

Sequence cautioni

The sequence BAA91878 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91878 differs from that shown. Reason: Erroneous termination at position 555. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti548T → I in BAA92011 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03537727R → S.Corresponds to variant rs7552335dbSNPEnsembl.1
Natural variantiVAR_035378246V → A.4 PublicationsCorresponds to variant rs7542665dbSNPEnsembl.1
Natural variantiVAR_035379309V → M.4 PublicationsCorresponds to variant rs7533274dbSNPEnsembl.1
Natural variantiVAR_035380329K → N.3 PublicationsCorresponds to variant rs2457828dbSNPEnsembl.1
Natural variantiVAR_035381549P → T.Corresponds to variant rs11207933dbSNPEnsembl.1
Natural variantiVAR_035382613T → I.Corresponds to variant rs2886644dbSNPEnsembl.1
Natural variantiVAR_051094860L → V.Corresponds to variant rs11207934dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211065 mRNA. Translation: BAD95492.1.
AK001746 mRNA. Translation: BAA91878.1. Sequence problems.
AK001973 mRNA. Translation: BAA92011.1.
AL834314 mRNA. Translation: CAD38984.1.
AL162739 Genomic DNA. Translation: CAI19299.1.
BC111559 mRNA. Translation: AAI11560.1.
CCDSiCCDS619.1.
RefSeqiNP_001158307.1. NM_001164835.1.
NP_061952.3. NM_019079.4.
UniGeneiHs.685462.

Genome annotation databases

EnsembliENST00000498273; ENSP00000419901; ENSG00000240563.
GeneIDi54596.
KEGGihsa:54596.
UCSCiuc001dae.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211065 mRNA. Translation: BAD95492.1.
AK001746 mRNA. Translation: BAA91878.1. Sequence problems.
AK001973 mRNA. Translation: BAA92011.1.
AL834314 mRNA. Translation: CAD38984.1.
AL162739 Genomic DNA. Translation: CAI19299.1.
BC111559 mRNA. Translation: AAI11560.1.
CCDSiCCDS619.1.
RefSeqiNP_001158307.1. NM_001164835.1.
NP_061952.3. NM_019079.4.
UniGeneiHs.685462.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LR6NMR-A/B235-321[»]
3SOOX-ray2.73A/B/C235-321[»]
ProteinModelPortaliQ5T7N2.
SMRiQ5T7N2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120072. 20 interactors.
IntActiQ5T7N2. 18 interactors.
MINTiMINT-1198165.
STRINGi9606.ENSP00000419901.

PTM databases

iPTMnetiQ5T7N2.
PhosphoSitePlusiQ5T7N2.

Polymorphism and mutation databases

BioMutaiL1TD1.
DMDMi74745406.

Proteomic databases

EPDiQ5T7N2.
PaxDbiQ5T7N2.
PeptideAtlasiQ5T7N2.
PRIDEiQ5T7N2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000498273; ENSP00000419901; ENSG00000240563.
GeneIDi54596.
KEGGihsa:54596.
UCSCiuc001dae.6. human.

Organism-specific databases

CTDi54596.
DisGeNETi54596.
GeneCardsiL1TD1.
H-InvDBHIX0000653.
HGNCiHGNC:25595. L1TD1.
HPAiHPA028501.
HPA030064.
neXtProtiNX_Q5T7N2.
OpenTargetsiENSG00000240563.
PharmGKBiPA145008170.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6GY. Eukaryota.
ENOG410YV4T. LUCA.
GeneTreeiENSGT00840000129838.
HOGENOMiHOG000113335.
HOVERGENiHBG094915.
InParanoidiQ5T7N2.
OMAiKLAFKCD.
OrthoDBiEOG091G0527.
PhylomeDBiQ5T7N2.
TreeFamiTF351152.

Enzyme and pathway databases

BioCyciZFISH:G66-31262-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5T7N2.
GeneWikiiL1TD1.
GenomeRNAii54596.
PROiQ5T7N2.

Gene expression databases

BgeeiENSG00000240563.
CleanExiHS_L1TD1.
GenevisibleiQ5T7N2. HS.

Family and domain databases

InterProiIPR004244. Transposase_22.
[Graphical view]
PANTHERiPTHR11505. PTHR11505. 1 hit.
PfamiPF02994. Transposase_22. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLITD1_HUMAN
AccessioniPrimary (citable) accession number: Q5T7N2
Secondary accession number(s): Q8NDA1, Q9NUV8, Q9NV78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.