Q5T7N2 (LITD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LINE-1 type transposase domain-containing protein 1

Alternative name(s):
ES cell-associated protein 11

Gene names

Name:	L1TD1
Synonyms:	ECAT11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	865 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the transposase 22 family.
Sequence caution	The sequence BAA91878.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA91878.1 differs from that shown. Reason: Erroneous termination at position 555. Translated as Leu.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 865

865

LINE-1 type transposase domain-containing protein 1

PRO_0000307217

Regions

Coiled coil

642 – 684

43

Potential

Compositional bias

369 – 488

120

Glu-rich

Compositional bias

534 – 537

4

Poly-Glu

Natural variations

Natural variant

27

1

R → S.
Corresponds to variant rs7552335 [ dbSNP | Ensembl ].

VAR_035377

Natural variant

246

1

V → A. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs7542665 [ dbSNP | Ensembl ].

VAR_035378

Natural variant

309

1

V → M. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs7533274 [ dbSNP | Ensembl ].

VAR_035379

Natural variant

329

1

K → N. Ref.1 Ref.3 Ref.5
Corresponds to variant rs2457828 [ dbSNP | Ensembl ].

VAR_035380

Natural variant

549

1

P → T.
Corresponds to variant rs11207933 [ dbSNP | Ensembl ].

VAR_035381

Natural variant

613

1

T → I.
Corresponds to variant rs2886644 [ dbSNP | Ensembl ].

VAR_035382

Natural variant

860

1

L → V.
Corresponds to variant rs11207934 [ dbSNP | Ensembl ].

VAR_051094

Experimental info

Sequence conflict

548

1

T → I in BAA92011. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

865

Helix Strand Turn

Details...

Helix

258 – 269

12

Beta strand

282 – 285

4

Beta strand

287 – 295

9

Helix

296 – 304

9

Helix

307 – 310

4

Turn

314 – 316

3

Sequences

	Sequence		Length	Mass (Da)
	Q5T7N2 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: C7E33893A1E675CC	FASTA	865	98,850
	10 20 30 40 50 60 MSDVSTSVQS KFARLAKKKE NITYMKREQL TETDKDIAPV LDLKCKDVSA IMNKFKVLME 70 80 90 100 110 120 IQDLMFEEMR ETLKNDLKAV LGGKATIPEV KNSENSSSRT EFQQIINLAL QKTGMVGKIE 130 140 150 160 170 180 GENSKIGDDN ENLTFKLEVN ELSGKLDNTN EYNSNDGKKL PQGESRSYEV MGSMEETLCN 190 200 210 220 230 240 IDDRDGNRNV HLEFTERESR KDGEDEFVKE MREERKFQKL KNKEEVLKAS REEKVLMDEG 250 260 270 280 290 300 AVLTLVADLS SATLDISKQW SNVFNILREN DFEPKFLCEV KLAFKCDGEI KTFSDLQSLR 310 320 330 340 350 360 KFASQKSSVK ELLKDVLPQK EEINQGGRKY GIQEKRDKTL IDSKHRAGEI TSDGLSFLFL 370 380 390 400 410 420 KEVKVAKPEE MKNLETQEEE FSELEELDEE ASGMEDDEDT SGLEEEEEEP SGLEEEEEEE 430 440 450 460 470 480 ASGLEEDEAS GLEEEEEQTS EQDSTFQGHT LVDAKHEVEI TSDGMETTFI DSVEDSESEE 490 500 510 520 530 540 EEEGKSSETG KVKTTSLTEK KASRRQKEIP FSYLVGDSGK KKLVKHQVVH KTQEEEETAV 550 560 570 580 590 600 PTSQGTGTPC LTLCLASPSK SLEMSHDEHK KHSHTNLSIS TGVTKLKKTE EKKHRTLHTE 610 620 630 640 650 660 ELTSKEADLT EETEENLRSS VINSIREIKE EIGNLKSSHS GVLEIENSVD DLSSRMDILE 670 680 690 700 710 720 ERIDSLEDQI EEFSKDTMQM TKQIISKERQ RDIEERSRSC NIRLIGIPEK ESYENRAEDI 730 740 750 760 770 780 IKEIIDENFA ELKKGSSLEI VSACRVPSKI DEKRLTPRHI LVKFWNSSDK EKIIRASRER 790 800 810 820 830 840 REITYQGTRI RLTADLSLDT LDARSKWSNV FKVLLEKGFN PRILYPAKMA FDFRGKTKVF 850 860 LSIEEFRDYV LHMPTLRELL GNNIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Yamanaka S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-246; MET-309 AND ASN-329.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-246 AND MET-309. Tissue: Placenta.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-246; MET-309 AND ASN-329. Tissue: Testis.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-246; MET-309 AND ASN-329.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB211065 mRNA. Translation: BAD95492.1.
AK001746 mRNA. Translation: BAA91878.1. Sequence problems.
AK001973 mRNA. Translation: BAA92011.1.
AL834314 mRNA. Translation: CAD38984.1.
AL162739 Genomic DNA. Translation: CAI19299.1.
BC111559 mRNA. Translation: AAI11560.1.

IPI

IPI00253050.

RefSeq

NP_001158307.1. NM_001164835.1.
NP_061952.3. NM_019079.4.

UniGene

Hs.685462.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3SOO	X-ray	2.73	A/B/C	235-321	[»]

ProteinModelPortal

Q5T7N2.

SMR

Q5T7N2. Positions 116-319, 655-863.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-1198165.

STRING

Q5T7N2.

PTM databases

PhosphoSite

Q5T7N2.

Polymorphism databases

DMDM

74745406.

Proteomic databases

PRIDE

Q5T7N2.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000498273; ENSP00000419901; ENSG00000240563.

GeneID

54596.

KEGG

hsa:54596.

NMPDR

fig|9606.3.peg.1267.

UCSC

uc001dae.2. human.

Organism-specific databases

CTD

54596.

GeneCards

GC01P062660.

H-InvDB

HIX0000653.

HGNC

HGNC:25595. L1TD1.

HPA

HPA028501.
HPA030064.

neXtProt

NX_Q5T7N2.

PharmGKB

PA145008170.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG10810.

GeneTree

ENSGT00600000084251.

HOVERGEN

HBG094915.

InParanoid

Q5T7N2.

OrthoDB

EOG49GKG2.

PhylomeDB

Q5T7N2.

Gene expression databases

Bgee

Q5T7N2.

CleanEx

HS_L1TD1.

Genevestigator

Q5T7N2.

Family and domain databases

InterPro

IPR004244. Transposase_22.
[Graphical view]

PANTHER

PTHR11505. Transposase_22. 1 hit.

Pfam

PF02994. Transposase_22. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

57121.

Entry information

Entry name

LITD1_HUMAN

Accession

Primary (citable) accession number: Q5T7N2
Secondary accession number(s): Q8NDA1, Q9NUV8, Q9NV78

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.