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Protein

LINE-1 type transposase domain-containing protein 1

Gene

L1TD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LINE-1 type transposase domain-containing protein 1
Alternative name(s):
ES cell-associated protein 11
Gene namesi
Name:L1TD1
Synonyms:ECAT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25595. L1TD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008170.

Polymorphism and mutation databases

BioMutaiL1TD1.
DMDMi74745406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 865864LINE-1 type transposase domain-containing protein 1PRO_0000307217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei2 – 21PhosphoserineCombined sources
Modified residuei149 – 1491PhosphothreonineCombined sources
Modified residuei154 – 1541PhosphoserineCombined sources
Modified residuei472 – 4721PhosphoserineCombined sources
Modified residuei476 – 4761PhosphoserineCombined sources
Modified residuei478 – 4781PhosphoserineCombined sources
Modified residuei518 – 5181PhosphoserineCombined sources
Modified residuei561 – 5611PhosphoserineCombined sources
Modified residuei573 – 5731PhosphoserineCombined sources
Modified residuei640 – 6401PhosphoserineCombined sources
Modified residuei648 – 6481PhosphoserineCombined sources
Modified residuei665 – 6651PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5T7N2.
PRIDEiQ5T7N2.

PTM databases

iPTMnetiQ5T7N2.
PhosphoSiteiQ5T7N2.

Expressioni

Gene expression databases

BgeeiQ5T7N2.
CleanExiHS_L1TD1.
GenevisibleiQ5T7N2. HS.

Organism-specific databases

HPAiHPA028501.
HPA030064.

Interactioni

Protein-protein interaction databases

BioGridi120072. 20 interactions.
IntActiQ5T7N2. 18 interactions.
MINTiMINT-1198165.
STRINGi9606.ENSP00000419901.

Structurei

Secondary structure

1
865
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni248 – 2503Combined sources
Helixi258 – 26912Combined sources
Beta strandi282 – 2854Combined sources
Beta strandi287 – 2959Combined sources
Helixi296 – 3049Combined sources
Helixi307 – 3104Combined sources
Turni314 – 3163Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LR6NMR-A/B235-321[»]
3SOOX-ray2.73A/B/C235-321[»]
ProteinModelPortaliQ5T7N2.
SMRiQ5T7N2. Positions 235-321, 655-860.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5T7N2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili642 – 68443Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi369 – 488120Glu-richAdd
BLAST
Compositional biasi534 – 5374Poly-Glu

Sequence similaritiesi

Belongs to the transposase 22 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J6GY. Eukaryota.
ENOG410YV4T. LUCA.
GeneTreeiENSGT00840000129838.
HOGENOMiHOG000113335.
HOVERGENiHBG094915.
InParanoidiQ5T7N2.
OMAiKLAFKCD.
OrthoDBiEOG7N8ZV4.
PhylomeDBiQ5T7N2.
TreeFamiTF351152.

Family and domain databases

InterProiIPR004244. Transposase_22.
[Graphical view]
PANTHERiPTHR11505. PTHR11505. 1 hit.
PfamiPF02994. Transposase_22. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5T7N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVSTSVQS KFARLAKKKE NITYMKREQL TETDKDIAPV LDLKCKDVSA
60 70 80 90 100
IMNKFKVLME IQDLMFEEMR ETLKNDLKAV LGGKATIPEV KNSENSSSRT
110 120 130 140 150
EFQQIINLAL QKTGMVGKIE GENSKIGDDN ENLTFKLEVN ELSGKLDNTN
160 170 180 190 200
EYNSNDGKKL PQGESRSYEV MGSMEETLCN IDDRDGNRNV HLEFTERESR
210 220 230 240 250
KDGEDEFVKE MREERKFQKL KNKEEVLKAS REEKVLMDEG AVLTLVADLS
260 270 280 290 300
SATLDISKQW SNVFNILREN DFEPKFLCEV KLAFKCDGEI KTFSDLQSLR
310 320 330 340 350
KFASQKSSVK ELLKDVLPQK EEINQGGRKY GIQEKRDKTL IDSKHRAGEI
360 370 380 390 400
TSDGLSFLFL KEVKVAKPEE MKNLETQEEE FSELEELDEE ASGMEDDEDT
410 420 430 440 450
SGLEEEEEEP SGLEEEEEEE ASGLEEDEAS GLEEEEEQTS EQDSTFQGHT
460 470 480 490 500
LVDAKHEVEI TSDGMETTFI DSVEDSESEE EEEGKSSETG KVKTTSLTEK
510 520 530 540 550
KASRRQKEIP FSYLVGDSGK KKLVKHQVVH KTQEEEETAV PTSQGTGTPC
560 570 580 590 600
LTLCLASPSK SLEMSHDEHK KHSHTNLSIS TGVTKLKKTE EKKHRTLHTE
610 620 630 640 650
ELTSKEADLT EETEENLRSS VINSIREIKE EIGNLKSSHS GVLEIENSVD
660 670 680 690 700
DLSSRMDILE ERIDSLEDQI EEFSKDTMQM TKQIISKERQ RDIEERSRSC
710 720 730 740 750
NIRLIGIPEK ESYENRAEDI IKEIIDENFA ELKKGSSLEI VSACRVPSKI
760 770 780 790 800
DEKRLTPRHI LVKFWNSSDK EKIIRASRER REITYQGTRI RLTADLSLDT
810 820 830 840 850
LDARSKWSNV FKVLLEKGFN PRILYPAKMA FDFRGKTKVF LSIEEFRDYV
860
LHMPTLRELL GNNIP
Length:865
Mass (Da):98,850
Last modified:December 21, 2004 - v1
Checksum:iC7E33893A1E675CC
GO

Sequence cautioni

The sequence BAA91878.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91878.1 differs from that shown. Reason: Erroneous termination at position 555. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti548 – 5481T → I in BAA92011 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271R → S.
Corresponds to variant rs7552335 [ dbSNP | Ensembl ].
VAR_035377
Natural varianti246 – 2461V → A.4 Publications
Corresponds to variant rs7542665 [ dbSNP | Ensembl ].
VAR_035378
Natural varianti309 – 3091V → M.4 Publications
Corresponds to variant rs7533274 [ dbSNP | Ensembl ].
VAR_035379
Natural varianti329 – 3291K → N.3 Publications
Corresponds to variant rs2457828 [ dbSNP | Ensembl ].
VAR_035380
Natural varianti549 – 5491P → T.
Corresponds to variant rs11207933 [ dbSNP | Ensembl ].
VAR_035381
Natural varianti613 – 6131T → I.
Corresponds to variant rs2886644 [ dbSNP | Ensembl ].
VAR_035382
Natural varianti860 – 8601L → V.
Corresponds to variant rs11207934 [ dbSNP | Ensembl ].
VAR_051094

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211065 mRNA. Translation: BAD95492.1.
AK001746 mRNA. Translation: BAA91878.1. Sequence problems.
AK001973 mRNA. Translation: BAA92011.1.
AL834314 mRNA. Translation: CAD38984.1.
AL162739 Genomic DNA. Translation: CAI19299.1.
BC111559 mRNA. Translation: AAI11560.1.
CCDSiCCDS619.1.
RefSeqiNP_001158307.1. NM_001164835.1.
NP_061952.3. NM_019079.4.
UniGeneiHs.685462.

Genome annotation databases

EnsembliENST00000498273; ENSP00000419901; ENSG00000240563.
GeneIDi54596.
KEGGihsa:54596.
UCSCiuc001dae.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211065 mRNA. Translation: BAD95492.1.
AK001746 mRNA. Translation: BAA91878.1. Sequence problems.
AK001973 mRNA. Translation: BAA92011.1.
AL834314 mRNA. Translation: CAD38984.1.
AL162739 Genomic DNA. Translation: CAI19299.1.
BC111559 mRNA. Translation: AAI11560.1.
CCDSiCCDS619.1.
RefSeqiNP_001158307.1. NM_001164835.1.
NP_061952.3. NM_019079.4.
UniGeneiHs.685462.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LR6NMR-A/B235-321[»]
3SOOX-ray2.73A/B/C235-321[»]
ProteinModelPortaliQ5T7N2.
SMRiQ5T7N2. Positions 235-321, 655-860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120072. 20 interactions.
IntActiQ5T7N2. 18 interactions.
MINTiMINT-1198165.
STRINGi9606.ENSP00000419901.

PTM databases

iPTMnetiQ5T7N2.
PhosphoSiteiQ5T7N2.

Polymorphism and mutation databases

BioMutaiL1TD1.
DMDMi74745406.

Proteomic databases

PaxDbiQ5T7N2.
PRIDEiQ5T7N2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000498273; ENSP00000419901; ENSG00000240563.
GeneIDi54596.
KEGGihsa:54596.
UCSCiuc001dae.6. human.

Organism-specific databases

CTDi54596.
GeneCardsiL1TD1.
H-InvDBHIX0000653.
HGNCiHGNC:25595. L1TD1.
HPAiHPA028501.
HPA030064.
neXtProtiNX_Q5T7N2.
PharmGKBiPA145008170.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6GY. Eukaryota.
ENOG410YV4T. LUCA.
GeneTreeiENSGT00840000129838.
HOGENOMiHOG000113335.
HOVERGENiHBG094915.
InParanoidiQ5T7N2.
OMAiKLAFKCD.
OrthoDBiEOG7N8ZV4.
PhylomeDBiQ5T7N2.
TreeFamiTF351152.

Miscellaneous databases

EvolutionaryTraceiQ5T7N2.
GeneWikiiL1TD1.
GenomeRNAii54596.
NextBioi57121.
PROiQ5T7N2.

Gene expression databases

BgeeiQ5T7N2.
CleanExiHS_L1TD1.
GenevisibleiQ5T7N2. HS.

Family and domain databases

InterProiIPR004244. Transposase_22.
[Graphical view]
PANTHERiPTHR11505. PTHR11505. 1 hit.
PfamiPF02994. Transposase_22. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Yamanaka S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-246; MET-309 AND ASN-329.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-246 AND MET-309.
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-246; MET-309 AND ASN-329.
    Tissue: Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-246; MET-309 AND ASN-329.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; THR-149; SER-154; SER-472; SER-476; SER-478; SER-518; SER-561; SER-573; SER-640; SER-648 AND SER-665, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLITD1_HUMAN
AccessioniPrimary (citable) accession number: Q5T7N2
Secondary accession number(s): Q8NDA1, Q9NUV8, Q9NV78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.