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Protein

Protein FAM69A

Gene

FAM69A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM69A
Gene namesi
Name:FAM69A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32213. FAM69A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727CytoplasmicSequence analysisAdd
BLAST
Transmembranei28 – 4821HelicalSequence analysisAdd
BLAST
Topological domaini49 – 428380LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671883.

Polymorphism and mutation databases

BioMutaiFAM69A.
DMDMi74745404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Protein FAM69APRO_0000282423Add
BLAST

Post-translational modificationi

Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ5T7M9.
PaxDbiQ5T7M9.
PRIDEiQ5T7M9.

PTM databases

iPTMnetiQ5T7M9.
PhosphoSiteiQ5T7M9.
SwissPalmiQ5T7M9.

Expressioni

Gene expression databases

BgeeiQ5T7M9.
ExpressionAtlasiQ5T7M9. baseline and differential.
GenevisibleiQ5T7M9. HS.

Organism-specific databases

HPAiHPA015718.
HPA017281.

Interactioni

Protein-protein interaction databases

BioGridi132793. 25 interactions.
IntActiQ5T7M9. 1 interaction.
STRINGi9606.ENSP00000359333.

Structurei

3D structure databases

ProteinModelPortaliQ5T7M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM69 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE6T. Eukaryota.
ENOG4110ANJ. LUCA.
GeneTreeiENSGT00390000006452.
HOGENOMiHOG000253951.
HOVERGENiHBG057071.
InParanoidiQ5T7M9.
OMAiVIKCQME.
OrthoDBiEOG7PGDQK.
PhylomeDBiQ5T7M9.
TreeFamiTF313319.

Family and domain databases

InterProiIPR022049. FAM69_kinase_dom.
IPR029244. FAM69_N.
[Graphical view]
PfamiPF12260. PIP49_C. 1 hit.
PF14875. PIP49_N. 1 hit.
[Graphical view]
SMARTiSM01299. PIP49_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T7M9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARSLCPGAW LRKPYYLQAR FSYVRMKYLF FSWLVVFVGS WIIYVQYSTY
60 70 80 90 100
TELCRGKDCK KIICDKYKTG VIDGPACNSL CVTETLYFGK CLSTKPNNQM
110 120 130 140 150
YLGIWDNLPG VVKCQMEQAL HLDFGTELEP RKEIVLFDKP TRGTTVQKFK
160 170 180 190 200
EMVYSLFKAK LGDQGNLSEL VNLILTVADG DKDGQVSLGE AKSAWALLQL
210 220 230 240 250
NEFLLMVILQ DKEHTPKLMG FCGDLYVMES VEYTSLYGIS LPWVIELFIP
260 270 280 290 300
SGFRRSMDQL FTPSWPRKAK IAIGLLEFVE DVFHGPYGNF LMCDTSAKNL
310 320 330 340 350
GYNDKYDLKM VDMRKIVPET NLKELIKDRH CESDLDCVYG TDCRTSCDQS
360 370 380 390 400
TMKCTSEVIQ PNLAKACQLL KDYLLRGAPS EIREELEKQL YSCIALKVTA
410 420
NQMEMEHSLI LNNLKTLLWK KISYTNDS
Length:428
Mass (Da):49,024
Last modified:December 21, 2004 - v1
Checksum:i1A348DD44643AA4C
GO
Isoform 2 (identifier: Q5T7M9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-162: KAKLG → KDQHR
     163-428: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,978
Checksum:i7CBFB6FD9182C318
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei158 – 1625KAKLG → KDQHR in isoform 2. 1 PublicationVSP_024140
Alternative sequencei163 – 428266Missing in isoform 2. 1 PublicationVSP_024141Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162740, AC093577 Genomic DNA. Translation: CAI22507.1.
BC070342 mRNA. Translation: AAH70342.1.
CCDSiCCDS44173.1. [Q5T7M9-1]
CCDS72825.1. [Q5T7M9-2]
RefSeqiNP_001006606.2. NM_001006605.4. [Q5T7M9-1]
NP_001239202.1. NM_001252273.1. [Q5T7M9-2]
UniGeneiHs.180946.

Genome annotation databases

EnsembliENST00000370310; ENSP00000359333; ENSG00000154511. [Q5T7M9-1]
ENST00000615519; ENSP00000483279; ENSG00000154511. [Q5T7M9-2]
GeneIDi388650.
KEGGihsa:388650.
UCSCiuc001dpc.4. human. [Q5T7M9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162740, AC093577 Genomic DNA. Translation: CAI22507.1.
BC070342 mRNA. Translation: AAH70342.1.
CCDSiCCDS44173.1. [Q5T7M9-1]
CCDS72825.1. [Q5T7M9-2]
RefSeqiNP_001006606.2. NM_001006605.4. [Q5T7M9-1]
NP_001239202.1. NM_001252273.1. [Q5T7M9-2]
UniGeneiHs.180946.

3D structure databases

ProteinModelPortaliQ5T7M9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132793. 25 interactions.
IntActiQ5T7M9. 1 interaction.
STRINGi9606.ENSP00000359333.

PTM databases

iPTMnetiQ5T7M9.
PhosphoSiteiQ5T7M9.
SwissPalmiQ5T7M9.

Polymorphism and mutation databases

BioMutaiFAM69A.
DMDMi74745404.

Proteomic databases

MaxQBiQ5T7M9.
PaxDbiQ5T7M9.
PRIDEiQ5T7M9.

Protocols and materials databases

DNASUi388650.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370310; ENSP00000359333; ENSG00000154511. [Q5T7M9-1]
ENST00000615519; ENSP00000483279; ENSG00000154511. [Q5T7M9-2]
GeneIDi388650.
KEGGihsa:388650.
UCSCiuc001dpc.4. human. [Q5T7M9-1]

Organism-specific databases

CTDi388650.
GeneCardsiFAM69A.
HGNCiHGNC:32213. FAM69A.
HPAiHPA015718.
HPA017281.
MIMi614542. gene.
neXtProtiNX_Q5T7M9.
PharmGKBiPA142671883.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE6T. Eukaryota.
ENOG4110ANJ. LUCA.
GeneTreeiENSGT00390000006452.
HOGENOMiHOG000253951.
HOVERGENiHBG057071.
InParanoidiQ5T7M9.
OMAiVIKCQME.
OrthoDBiEOG7PGDQK.
PhylomeDBiQ5T7M9.
TreeFamiTF313319.

Miscellaneous databases

ChiTaRSiFAM69A. human.
GenomeRNAii388650.
NextBioi102261.
PROiQ5T7M9.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T7M9.
ExpressionAtlasiQ5T7M9. baseline and differential.
GenevisibleiQ5T7M9. HS.

Family and domain databases

InterProiIPR022049. FAM69_kinase_dom.
IPR029244. FAM69_N.
[Graphical view]
PfamiPF12260. PIP49_C. 1 hit.
PF14875. PIP49_N. 1 hit.
[Graphical view]
SMARTiSM01299. PIP49_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiFA69A_HUMAN
AccessioniPrimary (citable) accession number: Q5T7M9
Secondary accession number(s): Q6IRV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.