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Q5T7B8 (KIF24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF24
Gene names
Name:KIF24
Synonyms:C9orf48
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1368 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Ref.6

Subunit structure

Interacts with CCP110 and CEP97. Ref.6

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole. Note: Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole. Ref.6

Developmental stage

Increases as cells progress through G1, peaks during S and G2 phases and decreases as cells enter mitosis during G2/M (at protein level). Ref.6

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Contains 1 kinesin motor domain.

Contains 1 SAM (sterile alpha motif) domain.

Sequence caution

The sequence AAI10504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC86074.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC86329.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAI15917.1 differs from that shown. Reason: Erroneous gene model prediction.

Binary interactions

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5T7B8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5T7B8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     272-405: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q5T7B8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     209-1368: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q5T7B8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1158: SPSPIRQHPADKLPSREADLGEACQSRE → GPGEKTSYKAWLAGVWFVHRPHQVALQQ
     1159-1368: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13681368Kinesin-like protein KIF24
PRO_0000278248

Regions

Domain1 – 6464SAM
Domain223 – 546324Kinesin motor
Nucleotide binding313 – 3208ATP By similarity

Amino acid modifications

Modified residue1021Phosphoserine Ref.4
Modified residue1121Phosphoserine Ref.5
Modified residue4781Phosphoserine Ref.4 Ref.5
Modified residue6461Phosphoserine Ref.5
Modified residue10121Phosphoserine Ref.4

Natural variations

Alternative sequence209 – 13681160Missing in isoform 3.
VSP_023211
Alternative sequence272 – 405134Missing in isoform 2.
VSP_023210
Alternative sequence1131 – 115828SPSPI…CQSRE → GPGEKTSYKAWLAGVWFVHR PHQVALQQ in isoform 4.
VSP_023212
Alternative sequence1159 – 1368210Missing in isoform 4.
VSP_023213
Natural variant501D → E.
Corresponds to variant rs16935508 [ dbSNP | Ensembl ].
VAR_030720
Natural variant1091R → G.
Corresponds to variant rs41274845 [ dbSNP | Ensembl ].
VAR_061284
Natural variant1401M → V.
Corresponds to variant rs10972048 [ dbSNP | Ensembl ].
VAR_030721
Natural variant2181W → L.
Corresponds to variant rs17350674 [ dbSNP | Ensembl ].
VAR_049706
Natural variant8371S → F. Ref.2 Ref.3
Corresponds to variant rs41274041 [ dbSNP | Ensembl ].
VAR_061285
Natural variant10771T → K.
Corresponds to variant rs34101674 [ dbSNP | Ensembl ].
VAR_049707

Experimental info

Mutagenesis263 – 2642VD → AA: Impairs ability to suppress cilia formation.
Mutagenesis483 – 4853KEC → AAA: Impairs ability to suppress cilia formation. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: AE88C9E3A4C9FBFF

FASTA1,368151,903
        10         20         30         40         50         60 
MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND RKRLFQLIKI 

        70         80         90        100        110        120 
IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF DSPADNKDRN ASNDGFEMCS 

       130        140        150        160        170        180 
LSDFSANEQK STYLKVLEHM LPDDSQYHTK TGILNATAGD SYVQTEISTS LFSPNYLSAI 

       190        200        210        220        230        240 
LGDCDIPIIQ RISHVSGYNY GIPHSCIRQN TSEKQNPWTE MEKIRVCVRK RPLGMREVRR 

       250        260        270        280        290        300 
GEINIITVED KETLLVHEKK EAVDLTQYIL QHVFYFDEVF GEACTNQDVY MKTTHPLIQH 

       310        320        330        340        350        360 
IFNGGNATCF AYGQTGAGKT YTMIGTHENP GLYALAAKDI FRQLEVSQPR KHLFVWISFY 

       370        380        390        400        410        420 
EIYCGQLYDL LNRRKRLFAR EDSKHMVQIV GLQELQVDSV ELLLEVILKG SKERSTGATG 

       430        440        450        460        470        480 
VNADSSRSHA VIQIQIKDSA KRTFGRISFI DLAGSERAAD ARDSDRQTKM EGAEINQSLL 

       490        500        510        520        530        540 
ALKECIRALD QEHTHTPFRQ SKLTQVLKDS FIGNAKTCMI ANISPSHVAT EHTLNTLRYA 

       550        560        570        580        590        600 
DRVKELKKGI KCCTSVTSRN RTSGNSSPKR IQSSPGALSE DKCSPKKVKL GFQQSLTVAA 

       610        620        630        640        650        660 
PGSTRGKVHP LTSHPPNIPF TSAPKVSGKR GGSRGSPSQE WVIHASPVKG TVRSGHVAKK 

       670        680        690        700        710        720 
KPEESAPLCS EKNRMGNKTV LGWESRASGP GEGLVRGKLS TKCKKVQTVQ PVQKQLVSRV 

       730        740        750        760        770        780 
ELSFGNAHHR AEYSQDSQRG TPARPASEAW TNIPPHQKER EEHLRFYHQQ FQQPPLLQQK 

       790        800        810        820        830        840 
LKYQPLKRSL RQYRPPEGQL TNETPPLFHS YSENHDGAQV EELDDSDFSE DSFSHISSQR 

       850        860        870        880        890        900 
ATKQRNTLEN SEDSFFLHQT WGQGPEKQVA ERQQSLFSSP RTGDKKDLTK SWVDSRDPIN 

       910        920        930        940        950        960 
HRRAALDHSC SPSKGPVDWS RENSTSSGPS PRDSLAEKPY CSQVDFIYRQ ERGGGSSFDL 

       970        980        990       1000       1010       1020 
RKDASQSEVS GENEGNLPSP EEDGFTISLS HVAVPGSPDQ RDTVTTPLRE VSADGPIQVT 

      1030       1040       1050       1060       1070       1080 
STVKNGHAVP GEDPRGQLGT HAEYASGLMS PLTMSLLENP DNEGSPPSEQ LVQDGATHSL 

      1090       1100       1110       1120       1130       1140 
VAESTGGPVV SHTVPSGDQE AALPVSSATR HLWLSSSPPD NKPGGDLPAL SPSPIRQHPA 

      1150       1160       1170       1180       1190       1200 
DKLPSREADL GEACQSRETV LFSHEHMGSE QYDADAEETG LDGSWGFPGK PFTTIHMGVP 

      1210       1220       1230       1240       1250       1260 
HSGPTLTPRT GSSDVADQLW AQERKHPTRL GWQEFGLSTD PIKLPCNSEN VTWLKPRPIS 

      1270       1280       1290       1300       1310       1320 
RCLARPSSPL VPSCSPKTAG TLRQPTLEQA QQVVIRAHQE QLDEMAELGF KEETLMSQLA 

      1330       1340       1350       1360 
SNDFEDFVTQ LDEIMVLKSK CIQSLRSQLQ LYLTCHGPTA APEGTVPS 

« Hide

Isoform 2 [UniParc].

Checksum: 01797E61137372BB
Show »

FASTA1,234136,423
Isoform 3 [UniParc].

Checksum: C3CBAB7EB7DBA678
Show »

FASTA20823,677
Isoform 4 [UniParc].

Checksum: BF300F8909F152D9
Show »

FASTA1,158128,840

References

« Hide 'large scale' references
[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 503-1368 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-1368 (ISOFORM 3), VARIANT PHE-837.
Tissue: Fetal brain, Ovarian carcinoma and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 509-1368 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 956-1368 (ISOFORM 4), VARIANT PHE-837.
Tissue: Duodenum.
[4]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102; SER-478 AND SER-1012, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112; SER-478 AND SER-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis."
Kobayashi T., Tsang W.Y., Li J., Lane W., Dynlacht B.D.
Cell 145:914-925(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH CCP110 AND CEP97, MUTAGENESIS OF 263-VAL-ASP-264 AND 483-LYS--CYS-485.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL353662 Genomic DNA. Translation: CAI15917.1. Sequence problems.
AL353662 Genomic DNA. Translation: CAI15919.1.
AL353662 Genomic DNA. Translation: CAI15920.3.
AK001795 mRNA. No translation available.
AK125180 mRNA. Translation: BAC86074.1. Different initiation.
AK125872 mRNA. Translation: BAC86329.1. Different initiation.
BC048311 mRNA. Translation: AAH48311.1.
BC110502 mRNA. Translation: AAI10503.2.
BC110503 mRNA. Translation: AAI10504.1. Different initiation.
CCDSCCDS6551.2. [Q5T7B8-1]
RefSeqNP_919289.2. NM_194313.2. [Q5T7B8-1]
UniGeneHs.710246.

3D structure databases

ProteinModelPortalQ5T7B8.
SMRQ5T7B8. Positions 2-63, 223-543.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131415. 3 interactions.
IntActQ5T7B8. 5 interactions.
STRING9606.ENSP00000368464.

PTM databases

PhosphoSiteQ5T7B8.

Polymorphism databases

DMDM126215732.

Proteomic databases

PaxDbQ5T7B8.
PRIDEQ5T7B8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000345050; ENSP00000340179; ENSG00000186638. [Q5T7B8-2]
ENST00000379166; ENSP00000368464; ENSG00000186638. [Q5T7B8-1]
ENST00000379174; ENSP00000368472; ENSG00000186638. [Q5T7B8-2]
ENST00000402558; ENSP00000384433; ENSG00000186638. [Q5T7B8-1]
GeneID347240.
KEGGhsa:347240.
UCSCuc003zua.4. human. [Q5T7B8-1]

Organism-specific databases

CTD347240.
GeneCardsGC09M034252.
H-InvDBHIX0025726.
HGNCHGNC:19916. KIF24.
HPAHPA020643.
MIM613747. gene.
neXtProtNX_Q5T7B8.
PharmGKBPA142671589.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5059.
HOVERGENHBG080392.
InParanoidQ5T7B8.
KOK10393.
OMAQKLKYQP.
OrthoDBEOG7TJ3H2.
PhylomeDBQ5T7B8.
TreeFamTF336001.

Gene expression databases

BgeeQ5T7B8.
CleanExHS_KIF24.
GenevestigatorQ5T7B8.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKIF24.
GenomeRNAi347240.
NextBio99066.
PROQ5T7B8.
SOURCESearch...

Entry information

Entry nameKIF24_HUMAN
AccessionPrimary (citable) accession number: Q5T7B8
Secondary accession number(s): Q2TB93 expand/collapse secondary AC list , Q5T7B5, Q5T7B7, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM