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Q5T7B8

- KIF24_HUMAN

UniProt

Q5T7B8 - KIF24_HUMAN

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Protein
Kinesin-like protein KIF24
Gene
KIF24, C9orf48
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi313 – 3208ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: UniProtKB
  3. protein binding Source: IntAct

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. metabolic process Source: GOC
  3. microtubule depolymerization Source: UniProtKB
  4. microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF24
Gene namesi
Name:KIF24
Synonyms:C9orf48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:19916. KIF24.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole
Note: Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.1 Publication

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. kinesin complex Source: InterPro
  3. microtubule Source: UniProtKB-KW
  4. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi263 – 2642VD → AA: Impairs ability to suppress cilia formation.
Mutagenesisi483 – 4853KEC → AAA: Impairs ability to suppress cilia formation. 1 Publication

Organism-specific databases

PharmGKBiPA142671589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13681368Kinesin-like protein KIF24
PRO_0000278248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021Phosphoserine1 Publication
Modified residuei112 – 1121Phosphoserine1 Publication
Modified residuei478 – 4781Phosphoserine2 Publications
Modified residuei646 – 6461Phosphoserine1 Publication
Modified residuei1012 – 10121Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5T7B8.
PRIDEiQ5T7B8.

PTM databases

PhosphoSiteiQ5T7B8.

Expressioni

Developmental stagei

Increases as cells progress through G1, peaks during S and G2 phases and decreases as cells enter mitosis during G2/M (at protein level).1 Publication

Gene expression databases

BgeeiQ5T7B8.
CleanExiHS_KIF24.
GenevestigatoriQ5T7B8.

Organism-specific databases

HPAiHPA020643.

Interactioni

Subunit structurei

Interacts with CCP110 and CEP97.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCP110O433039EBI-2556811,EBI-1566217
CEP97Q8IW359EBI-2556811,EBI-1566210

Protein-protein interaction databases

BioGridi131415. 3 interactions.
IntActiQ5T7B8. 5 interactions.
STRINGi9606.ENSP00000368464.

Structurei

3D structure databases

ProteinModelPortaliQ5T7B8.
SMRiQ5T7B8. Positions 2-63, 223-543.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6464SAM
Add
BLAST
Domaini223 – 546324Kinesin motor
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5059.
HOVERGENiHBG080392.
InParanoidiQ5T7B8.
KOiK10393.
OMAiQKLKYQP.
OrthoDBiEOG7TJ3H2.
PhylomeDBiQ5T7B8.
TreeFamiTF336001.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T7B8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND     50
RKRLFQLIKI IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF 100
DSPADNKDRN ASNDGFEMCS LSDFSANEQK STYLKVLEHM LPDDSQYHTK 150
TGILNATAGD SYVQTEISTS LFSPNYLSAI LGDCDIPIIQ RISHVSGYNY 200
GIPHSCIRQN TSEKQNPWTE MEKIRVCVRK RPLGMREVRR GEINIITVED 250
KETLLVHEKK EAVDLTQYIL QHVFYFDEVF GEACTNQDVY MKTTHPLIQH 300
IFNGGNATCF AYGQTGAGKT YTMIGTHENP GLYALAAKDI FRQLEVSQPR 350
KHLFVWISFY EIYCGQLYDL LNRRKRLFAR EDSKHMVQIV GLQELQVDSV 400
ELLLEVILKG SKERSTGATG VNADSSRSHA VIQIQIKDSA KRTFGRISFI 450
DLAGSERAAD ARDSDRQTKM EGAEINQSLL ALKECIRALD QEHTHTPFRQ 500
SKLTQVLKDS FIGNAKTCMI ANISPSHVAT EHTLNTLRYA DRVKELKKGI 550
KCCTSVTSRN RTSGNSSPKR IQSSPGALSE DKCSPKKVKL GFQQSLTVAA 600
PGSTRGKVHP LTSHPPNIPF TSAPKVSGKR GGSRGSPSQE WVIHASPVKG 650
TVRSGHVAKK KPEESAPLCS EKNRMGNKTV LGWESRASGP GEGLVRGKLS 700
TKCKKVQTVQ PVQKQLVSRV ELSFGNAHHR AEYSQDSQRG TPARPASEAW 750
TNIPPHQKER EEHLRFYHQQ FQQPPLLQQK LKYQPLKRSL RQYRPPEGQL 800
TNETPPLFHS YSENHDGAQV EELDDSDFSE DSFSHISSQR ATKQRNTLEN 850
SEDSFFLHQT WGQGPEKQVA ERQQSLFSSP RTGDKKDLTK SWVDSRDPIN 900
HRRAALDHSC SPSKGPVDWS RENSTSSGPS PRDSLAEKPY CSQVDFIYRQ 950
ERGGGSSFDL RKDASQSEVS GENEGNLPSP EEDGFTISLS HVAVPGSPDQ 1000
RDTVTTPLRE VSADGPIQVT STVKNGHAVP GEDPRGQLGT HAEYASGLMS 1050
PLTMSLLENP DNEGSPPSEQ LVQDGATHSL VAESTGGPVV SHTVPSGDQE 1100
AALPVSSATR HLWLSSSPPD NKPGGDLPAL SPSPIRQHPA DKLPSREADL 1150
GEACQSRETV LFSHEHMGSE QYDADAEETG LDGSWGFPGK PFTTIHMGVP 1200
HSGPTLTPRT GSSDVADQLW AQERKHPTRL GWQEFGLSTD PIKLPCNSEN 1250
VTWLKPRPIS RCLARPSSPL VPSCSPKTAG TLRQPTLEQA QQVVIRAHQE 1300
QLDEMAELGF KEETLMSQLA SNDFEDFVTQ LDEIMVLKSK CIQSLRSQLQ 1350
LYLTCHGPTA APEGTVPS 1368
Length:1,368
Mass (Da):151,903
Last modified:February 20, 2007 - v2
Checksum:iAE88C9E3A4C9FBFF
GO
Isoform 2 (identifier: Q5T7B8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-405: Missing.

Note: No experimental confirmation available.

Show »
Length:1,234
Mass (Da):136,423
Checksum:i01797E61137372BB
GO
Isoform 3 (identifier: Q5T7B8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-1368: Missing.

Note: No experimental confirmation available.

Show »
Length:208
Mass (Da):23,677
Checksum:iC3CBAB7EB7DBA678
GO
Isoform 4 (identifier: Q5T7B8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1158: SPSPIRQHPADKLPSREADLGEACQSRE → GPGEKTSYKAWLAGVWFVHRPHQVALQQ
     1159-1368: Missing.

Note: No experimental confirmation available.

Show »
Length:1,158
Mass (Da):128,840
Checksum:iBF300F8909F152D9
GO

Sequence cautioni

The sequence AAI10504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC86074.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC86329.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAI15917.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501D → E.
Corresponds to variant rs16935508 [ dbSNP | Ensembl ].
VAR_030720
Natural varianti109 – 1091R → G.
Corresponds to variant rs41274845 [ dbSNP | Ensembl ].
VAR_061284
Natural varianti140 – 1401M → V.
Corresponds to variant rs10972048 [ dbSNP | Ensembl ].
VAR_030721
Natural varianti218 – 2181W → L.
Corresponds to variant rs17350674 [ dbSNP | Ensembl ].
VAR_049706
Natural varianti837 – 8371S → F.2 Publications
Corresponds to variant rs41274041 [ dbSNP | Ensembl ].
VAR_061285
Natural varianti1077 – 10771T → K.
Corresponds to variant rs34101674 [ dbSNP | Ensembl ].
VAR_049707

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei209 – 13681160Missing in isoform 3.
VSP_023211Add
BLAST
Alternative sequencei272 – 405134Missing in isoform 2.
VSP_023210Add
BLAST
Alternative sequencei1131 – 115828SPSPI…CQSRE → GPGEKTSYKAWLAGVWFVHR PHQVALQQ in isoform 4.
VSP_023212Add
BLAST
Alternative sequencei1159 – 1368210Missing in isoform 4.
VSP_023213Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL353662 Genomic DNA. Translation: CAI15917.1. Sequence problems.
AL353662 Genomic DNA. Translation: CAI15919.1.
AL353662 Genomic DNA. Translation: CAI15920.3.
AK001795 mRNA. No translation available.
AK125180 mRNA. Translation: BAC86074.1. Different initiation.
AK125872 mRNA. Translation: BAC86329.1. Different initiation.
BC048311 mRNA. Translation: AAH48311.1.
BC110502 mRNA. Translation: AAI10503.2.
BC110503 mRNA. Translation: AAI10504.1. Different initiation.
CCDSiCCDS6551.2. [Q5T7B8-1]
RefSeqiNP_919289.2. NM_194313.2. [Q5T7B8-1]
UniGeneiHs.710246.

Genome annotation databases

EnsembliENST00000345050; ENSP00000340179; ENSG00000186638. [Q5T7B8-2]
ENST00000379166; ENSP00000368464; ENSG00000186638. [Q5T7B8-1]
ENST00000379174; ENSP00000368472; ENSG00000186638. [Q5T7B8-2]
ENST00000402558; ENSP00000384433; ENSG00000186638. [Q5T7B8-1]
GeneIDi347240.
KEGGihsa:347240.
UCSCiuc003zua.4. human. [Q5T7B8-1]

Polymorphism databases

DMDMi126215732.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL353662 Genomic DNA. Translation: CAI15917.1 . Sequence problems.
AL353662 Genomic DNA. Translation: CAI15919.1 .
AL353662 Genomic DNA. Translation: CAI15920.3 .
AK001795 mRNA. No translation available.
AK125180 mRNA. Translation: BAC86074.1 . Different initiation.
AK125872 mRNA. Translation: BAC86329.1 . Different initiation.
BC048311 mRNA. Translation: AAH48311.1 .
BC110502 mRNA. Translation: AAI10503.2 .
BC110503 mRNA. Translation: AAI10504.1 . Different initiation.
CCDSi CCDS6551.2. [Q5T7B8-1 ]
RefSeqi NP_919289.2. NM_194313.2. [Q5T7B8-1 ]
UniGenei Hs.710246.

3D structure databases

ProteinModelPortali Q5T7B8.
SMRi Q5T7B8. Positions 2-63, 223-543.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131415. 3 interactions.
IntActi Q5T7B8. 5 interactions.
STRINGi 9606.ENSP00000368464.

PTM databases

PhosphoSitei Q5T7B8.

Polymorphism databases

DMDMi 126215732.

Proteomic databases

PaxDbi Q5T7B8.
PRIDEi Q5T7B8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345050 ; ENSP00000340179 ; ENSG00000186638 . [Q5T7B8-2 ]
ENST00000379166 ; ENSP00000368464 ; ENSG00000186638 . [Q5T7B8-1 ]
ENST00000379174 ; ENSP00000368472 ; ENSG00000186638 . [Q5T7B8-2 ]
ENST00000402558 ; ENSP00000384433 ; ENSG00000186638 . [Q5T7B8-1 ]
GeneIDi 347240.
KEGGi hsa:347240.
UCSCi uc003zua.4. human. [Q5T7B8-1 ]

Organism-specific databases

CTDi 347240.
GeneCardsi GC09M034252.
H-InvDB HIX0025726.
HGNCi HGNC:19916. KIF24.
HPAi HPA020643.
MIMi 613747. gene.
neXtProti NX_Q5T7B8.
PharmGKBi PA142671589.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
HOVERGENi HBG080392.
InParanoidi Q5T7B8.
KOi K10393.
OMAi QKLKYQP.
OrthoDBi EOG7TJ3H2.
PhylomeDBi Q5T7B8.
TreeFami TF336001.

Miscellaneous databases

GeneWikii KIF24.
GenomeRNAii 347240.
NextBioi 99066.
PROi Q5T7B8.
SOURCEi Search...

Gene expression databases

Bgeei Q5T7B8.
CleanExi HS_KIF24.
Genevestigatori Q5T7B8.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 503-1368 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-1368 (ISOFORM 3), VARIANT PHE-837.
    Tissue: Fetal brain, Ovarian carcinoma and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 509-1368 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 956-1368 (ISOFORM 4), VARIANT PHE-837.
    Tissue: Duodenum.
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102; SER-478 AND SER-1012, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112; SER-478 AND SER-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis."
    Kobayashi T., Tsang W.Y., Li J., Lane W., Dynlacht B.D.
    Cell 145:914-925(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH CCP110 AND CEP97, MUTAGENESIS OF 263-VAL-ASP-264 AND 483-LYS--CYS-485.

Entry informationi

Entry nameiKIF24_HUMAN
AccessioniPrimary (citable) accession number: Q5T7B8
Secondary accession number(s): Q2TB93
, Q5T7B5, Q5T7B7, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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