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Q5T7B8

- KIF24_HUMAN

UniProt

Q5T7B8 - KIF24_HUMAN

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Protein

Kinesin-like protein KIF24

Gene

KIF24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi313 – 3208ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. cilium assembly Source: UniProtKB
  3. metabolic process Source: GOC
  4. microtubule-based movement Source: RefGenome
  5. microtubule depolymerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF24
Gene namesi
Name:KIF24
Synonyms:C9orf48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:19916. KIF24.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole 1 Publication
Note: Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. kinesin complex Source: RefGenome
  3. microtubule Source: UniProtKB-KW
  4. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi263 – 2642VD → AA: Impairs ability to suppress cilia formation. 1 Publication
Mutagenesisi483 – 4853KEC → AAA: Impairs ability to suppress cilia formation. 1 Publication

Organism-specific databases

PharmGKBiPA142671589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13681368Kinesin-like protein KIF24PRO_0000278248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021Phosphoserine1 Publication
Modified residuei112 – 1121Phosphoserine1 Publication
Modified residuei478 – 4781Phosphoserine2 Publications
Modified residuei646 – 6461Phosphoserine1 Publication
Modified residuei1012 – 10121Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5T7B8.
PaxDbiQ5T7B8.
PRIDEiQ5T7B8.

PTM databases

PhosphoSiteiQ5T7B8.

Expressioni

Developmental stagei

Increases as cells progress through G1, peaks during S and G2 phases and decreases as cells enter mitosis during G2/M (at protein level).1 Publication

Gene expression databases

BgeeiQ5T7B8.
CleanExiHS_KIF24.
GenevestigatoriQ5T7B8.

Organism-specific databases

HPAiHPA020643.

Interactioni

Subunit structurei

Interacts with CCP110 and CEP97.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCP110O433039EBI-2556811,EBI-1566217
CEP97Q8IW359EBI-2556811,EBI-1566210

Protein-protein interaction databases

BioGridi131415. 3 interactions.
IntActiQ5T7B8. 5 interactions.
STRINGi9606.ENSP00000368464.

Structurei

3D structure databases

ProteinModelPortaliQ5T7B8.
SMRiQ5T7B8. Positions 223-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6464SAMPROSITE-ProRule annotationAdd
BLAST
Domaini223 – 546324Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120451.
HOVERGENiHBG080392.
InParanoidiQ5T7B8.
KOiK10393.
OMAiQKLKYQP.
OrthoDBiEOG7TJ3H2.
PhylomeDBiQ5T7B8.
TreeFamiTF336001.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T7B8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND
60 70 80 90 100
RKRLFQLIKI IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF
110 120 130 140 150
DSPADNKDRN ASNDGFEMCS LSDFSANEQK STYLKVLEHM LPDDSQYHTK
160 170 180 190 200
TGILNATAGD SYVQTEISTS LFSPNYLSAI LGDCDIPIIQ RISHVSGYNY
210 220 230 240 250
GIPHSCIRQN TSEKQNPWTE MEKIRVCVRK RPLGMREVRR GEINIITVED
260 270 280 290 300
KETLLVHEKK EAVDLTQYIL QHVFYFDEVF GEACTNQDVY MKTTHPLIQH
310 320 330 340 350
IFNGGNATCF AYGQTGAGKT YTMIGTHENP GLYALAAKDI FRQLEVSQPR
360 370 380 390 400
KHLFVWISFY EIYCGQLYDL LNRRKRLFAR EDSKHMVQIV GLQELQVDSV
410 420 430 440 450
ELLLEVILKG SKERSTGATG VNADSSRSHA VIQIQIKDSA KRTFGRISFI
460 470 480 490 500
DLAGSERAAD ARDSDRQTKM EGAEINQSLL ALKECIRALD QEHTHTPFRQ
510 520 530 540 550
SKLTQVLKDS FIGNAKTCMI ANISPSHVAT EHTLNTLRYA DRVKELKKGI
560 570 580 590 600
KCCTSVTSRN RTSGNSSPKR IQSSPGALSE DKCSPKKVKL GFQQSLTVAA
610 620 630 640 650
PGSTRGKVHP LTSHPPNIPF TSAPKVSGKR GGSRGSPSQE WVIHASPVKG
660 670 680 690 700
TVRSGHVAKK KPEESAPLCS EKNRMGNKTV LGWESRASGP GEGLVRGKLS
710 720 730 740 750
TKCKKVQTVQ PVQKQLVSRV ELSFGNAHHR AEYSQDSQRG TPARPASEAW
760 770 780 790 800
TNIPPHQKER EEHLRFYHQQ FQQPPLLQQK LKYQPLKRSL RQYRPPEGQL
810 820 830 840 850
TNETPPLFHS YSENHDGAQV EELDDSDFSE DSFSHISSQR ATKQRNTLEN
860 870 880 890 900
SEDSFFLHQT WGQGPEKQVA ERQQSLFSSP RTGDKKDLTK SWVDSRDPIN
910 920 930 940 950
HRRAALDHSC SPSKGPVDWS RENSTSSGPS PRDSLAEKPY CSQVDFIYRQ
960 970 980 990 1000
ERGGGSSFDL RKDASQSEVS GENEGNLPSP EEDGFTISLS HVAVPGSPDQ
1010 1020 1030 1040 1050
RDTVTTPLRE VSADGPIQVT STVKNGHAVP GEDPRGQLGT HAEYASGLMS
1060 1070 1080 1090 1100
PLTMSLLENP DNEGSPPSEQ LVQDGATHSL VAESTGGPVV SHTVPSGDQE
1110 1120 1130 1140 1150
AALPVSSATR HLWLSSSPPD NKPGGDLPAL SPSPIRQHPA DKLPSREADL
1160 1170 1180 1190 1200
GEACQSRETV LFSHEHMGSE QYDADAEETG LDGSWGFPGK PFTTIHMGVP
1210 1220 1230 1240 1250
HSGPTLTPRT GSSDVADQLW AQERKHPTRL GWQEFGLSTD PIKLPCNSEN
1260 1270 1280 1290 1300
VTWLKPRPIS RCLARPSSPL VPSCSPKTAG TLRQPTLEQA QQVVIRAHQE
1310 1320 1330 1340 1350
QLDEMAELGF KEETLMSQLA SNDFEDFVTQ LDEIMVLKSK CIQSLRSQLQ
1360
LYLTCHGPTA APEGTVPS
Length:1,368
Mass (Da):151,903
Last modified:February 20, 2007 - v2
Checksum:iAE88C9E3A4C9FBFF
GO
Isoform 2 (identifier: Q5T7B8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-405: Missing.

Note: No experimental confirmation available.

Show »
Length:1,234
Mass (Da):136,423
Checksum:i01797E61137372BB
GO
Isoform 3 (identifier: Q5T7B8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-1368: Missing.

Note: No experimental confirmation available.

Show »
Length:208
Mass (Da):23,677
Checksum:iC3CBAB7EB7DBA678
GO
Isoform 4 (identifier: Q5T7B8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1158: SPSPIRQHPADKLPSREADLGEACQSRE → GPGEKTSYKAWLAGVWFVHRPHQVALQQ
     1159-1368: Missing.

Note: No experimental confirmation available.

Show »
Length:1,158
Mass (Da):128,840
Checksum:iBF300F8909F152D9
GO

Sequence cautioni

The sequence AAI10504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC86074.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC86329.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI15917.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501D → E.
Corresponds to variant rs16935508 [ dbSNP | Ensembl ].
VAR_030720
Natural varianti109 – 1091R → G.
Corresponds to variant rs41274845 [ dbSNP | Ensembl ].
VAR_061284
Natural varianti140 – 1401M → V.
Corresponds to variant rs10972048 [ dbSNP | Ensembl ].
VAR_030721
Natural varianti218 – 2181W → L.
Corresponds to variant rs17350674 [ dbSNP | Ensembl ].
VAR_049706
Natural varianti837 – 8371S → F.2 Publications
Corresponds to variant rs41274041 [ dbSNP | Ensembl ].
VAR_061285
Natural varianti1077 – 10771T → K.
Corresponds to variant rs34101674 [ dbSNP | Ensembl ].
VAR_049707

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei209 – 13681160Missing in isoform 3. 1 PublicationVSP_023211Add
BLAST
Alternative sequencei272 – 405134Missing in isoform 2. CuratedVSP_023210Add
BLAST
Alternative sequencei1131 – 115828SPSPI…CQSRE → GPGEKTSYKAWLAGVWFVHR PHQVALQQ in isoform 4. 1 PublicationVSP_023212Add
BLAST
Alternative sequencei1159 – 1368210Missing in isoform 4. 1 PublicationVSP_023213Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353662 Genomic DNA. Translation: CAI15917.1. Sequence problems.
AL353662 Genomic DNA. Translation: CAI15919.1.
AL353662 Genomic DNA. Translation: CAI15920.3.
AK001795 mRNA. No translation available.
AK125180 mRNA. Translation: BAC86074.1. Different initiation.
AK125872 mRNA. Translation: BAC86329.1. Different initiation.
BC048311 mRNA. Translation: AAH48311.1.
BC110502 mRNA. Translation: AAI10503.2.
BC110503 mRNA. Translation: AAI10504.1. Different initiation.
CCDSiCCDS6551.2. [Q5T7B8-1]
RefSeqiNP_919289.2. NM_194313.2. [Q5T7B8-1]
UniGeneiHs.710246.

Genome annotation databases

EnsembliENST00000379166; ENSP00000368464; ENSG00000186638. [Q5T7B8-1]
ENST00000379174; ENSP00000368472; ENSG00000186638. [Q5T7B8-2]
ENST00000402558; ENSP00000384433; ENSG00000186638. [Q5T7B8-1]
GeneIDi347240.
KEGGihsa:347240.
UCSCiuc003zua.4. human. [Q5T7B8-1]

Polymorphism databases

DMDMi126215732.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353662 Genomic DNA. Translation: CAI15917.1 . Sequence problems.
AL353662 Genomic DNA. Translation: CAI15919.1 .
AL353662 Genomic DNA. Translation: CAI15920.3 .
AK001795 mRNA. No translation available.
AK125180 mRNA. Translation: BAC86074.1 . Different initiation.
AK125872 mRNA. Translation: BAC86329.1 . Different initiation.
BC048311 mRNA. Translation: AAH48311.1 .
BC110502 mRNA. Translation: AAI10503.2 .
BC110503 mRNA. Translation: AAI10504.1 . Different initiation.
CCDSi CCDS6551.2. [Q5T7B8-1 ]
RefSeqi NP_919289.2. NM_194313.2. [Q5T7B8-1 ]
UniGenei Hs.710246.

3D structure databases

ProteinModelPortali Q5T7B8.
SMRi Q5T7B8. Positions 223-543.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131415. 3 interactions.
IntActi Q5T7B8. 5 interactions.
STRINGi 9606.ENSP00000368464.

PTM databases

PhosphoSitei Q5T7B8.

Polymorphism databases

DMDMi 126215732.

Proteomic databases

MaxQBi Q5T7B8.
PaxDbi Q5T7B8.
PRIDEi Q5T7B8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379166 ; ENSP00000368464 ; ENSG00000186638 . [Q5T7B8-1 ]
ENST00000379174 ; ENSP00000368472 ; ENSG00000186638 . [Q5T7B8-2 ]
ENST00000402558 ; ENSP00000384433 ; ENSG00000186638 . [Q5T7B8-1 ]
GeneIDi 347240.
KEGGi hsa:347240.
UCSCi uc003zua.4. human. [Q5T7B8-1 ]

Organism-specific databases

CTDi 347240.
GeneCardsi GC09M034252.
H-InvDB HIX0025726.
HGNCi HGNC:19916. KIF24.
HPAi HPA020643.
MIMi 613747. gene.
neXtProti NX_Q5T7B8.
PharmGKBi PA142671589.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00770000120451.
HOVERGENi HBG080392.
InParanoidi Q5T7B8.
KOi K10393.
OMAi QKLKYQP.
OrthoDBi EOG7TJ3H2.
PhylomeDBi Q5T7B8.
TreeFami TF336001.

Miscellaneous databases

GeneWikii KIF24.
GenomeRNAii 347240.
NextBioi 99066.
PROi Q5T7B8.
SOURCEi Search...

Gene expression databases

Bgeei Q5T7B8.
CleanExi HS_KIF24.
Genevestigatori Q5T7B8.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 503-1368 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-1368 (ISOFORM 3), VARIANT PHE-837.
    Tissue: Fetal brain, Ovarian carcinoma and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 509-1368 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 956-1368 (ISOFORM 4), VARIANT PHE-837.
    Tissue: Duodenum.
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102; SER-478 AND SER-1012, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112; SER-478 AND SER-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis."
    Kobayashi T., Tsang W.Y., Li J., Lane W., Dynlacht B.D.
    Cell 145:914-925(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH CCP110 AND CEP97, MUTAGENESIS OF 263-VAL-ASP-264 AND 483-LYS--CYS-485.

Entry informationi

Entry nameiKIF24_HUMAN
AccessioniPrimary (citable) accession number: Q5T7B8
Secondary accession number(s): Q2TB93
, Q5T7B5, Q5T7B7, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 26, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3