Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kinesin-like protein KIF24

Gene

KIF24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi313 – 320ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: UniProtKB

GO - Biological processi

  • ciliary basal body-plasma membrane docking Source: Reactome
  • cilium assembly Source: UniProtKB
  • microtubule-based movement Source: GO_Central
  • microtubule depolymerization Source: UniProtKB

Keywordsi

Molecular functionMotor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-5620912 Anchoring of the basal body to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF24
Gene namesi
Name:KIF24
Synonyms:C9orf48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000186638.15
HGNCiHGNC:19916 KIF24
MIMi613747 gene
neXtProtiNX_Q5T7B8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi263 – 264VD → AA: Impairs ability to suppress cilia formation. 1 Publication2
Mutagenesisi483 – 485KEC → AAA: Impairs ability to suppress cilia formation. 1 Publication3
Mutagenesisi621 – 622TS → AA: Reduces phosphorylation by NEK2 and abolishes ability to suppress cilia formation. 1 Publication2

Organism-specific databases

DisGeNETi347240
OpenTargetsiENSG00000186638
PharmGKBiPA142671589

Polymorphism and mutation databases

BioMutaiKIF24
DMDMi126215732

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782481 – 1368Kinesin-like protein KIF24Add BLAST1368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1
Modified residuei584PhosphoserineBy similarity1
Modified residuei621Phosphothreonine; by NEK21 Publication1
Modified residuei622Phosphoserine; by NEK21 Publication1
Modified residuei646PhosphoserineCombined sources1
Modified residuei826PhosphoserineBy similarity1
Modified residuei829PhosphoserineBy similarity1
Modified residuei1012PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T7B8
MaxQBiQ5T7B8
PaxDbiQ5T7B8
PeptideAtlasiQ5T7B8
PRIDEiQ5T7B8
ProteomicsDBi64650
64651 [Q5T7B8-2]
64652 [Q5T7B8-3]
64653 [Q5T7B8-4]

PTM databases

iPTMnetiQ5T7B8
PhosphoSitePlusiQ5T7B8

Expressioni

Developmental stagei

Increases as cells progress through G1, peaks during S and G2 phases and decreases as cells enter mitosis during G2/M (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000186638
CleanExiHS_KIF24

Organism-specific databases

HPAiHPA020643

Interactioni

Subunit structurei

Interacts with CCP110, CEP97, TALPID3.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • microtubule binding Source: InterPro

Protein-protein interaction databases

BioGridi131415, 10 interactors
IntActiQ5T7B8, 20 interactors
STRINGi9606.ENSP00000368464

Structurei

3D structure databases

ProteinModelPortaliQ5T7B8
SMRiQ5T7B8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 64SAMPROSITE-ProRule annotationAdd BLAST64
Domaini223 – 546Kinesin motorPROSITE-ProRule annotationAdd BLAST324

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0246 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00920000148953
HOVERGENiHBG080392
InParanoidiQ5T7B8
KOiK10393
OMAiQKLKYQP
OrthoDBiEOG091G06V3
PhylomeDBiQ5T7B8
TreeFamiTF336001

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PF00536 SAM_1, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T7B8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND
60 70 80 90 100
RKRLFQLIKI IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF
110 120 130 140 150
DSPADNKDRN ASNDGFEMCS LSDFSANEQK STYLKVLEHM LPDDSQYHTK
160 170 180 190 200
TGILNATAGD SYVQTEISTS LFSPNYLSAI LGDCDIPIIQ RISHVSGYNY
210 220 230 240 250
GIPHSCIRQN TSEKQNPWTE MEKIRVCVRK RPLGMREVRR GEINIITVED
260 270 280 290 300
KETLLVHEKK EAVDLTQYIL QHVFYFDEVF GEACTNQDVY MKTTHPLIQH
310 320 330 340 350
IFNGGNATCF AYGQTGAGKT YTMIGTHENP GLYALAAKDI FRQLEVSQPR
360 370 380 390 400
KHLFVWISFY EIYCGQLYDL LNRRKRLFAR EDSKHMVQIV GLQELQVDSV
410 420 430 440 450
ELLLEVILKG SKERSTGATG VNADSSRSHA VIQIQIKDSA KRTFGRISFI
460 470 480 490 500
DLAGSERAAD ARDSDRQTKM EGAEINQSLL ALKECIRALD QEHTHTPFRQ
510 520 530 540 550
SKLTQVLKDS FIGNAKTCMI ANISPSHVAT EHTLNTLRYA DRVKELKKGI
560 570 580 590 600
KCCTSVTSRN RTSGNSSPKR IQSSPGALSE DKCSPKKVKL GFQQSLTVAA
610 620 630 640 650
PGSTRGKVHP LTSHPPNIPF TSAPKVSGKR GGSRGSPSQE WVIHASPVKG
660 670 680 690 700
TVRSGHVAKK KPEESAPLCS EKNRMGNKTV LGWESRASGP GEGLVRGKLS
710 720 730 740 750
TKCKKVQTVQ PVQKQLVSRV ELSFGNAHHR AEYSQDSQRG TPARPASEAW
760 770 780 790 800
TNIPPHQKER EEHLRFYHQQ FQQPPLLQQK LKYQPLKRSL RQYRPPEGQL
810 820 830 840 850
TNETPPLFHS YSENHDGAQV EELDDSDFSE DSFSHISSQR ATKQRNTLEN
860 870 880 890 900
SEDSFFLHQT WGQGPEKQVA ERQQSLFSSP RTGDKKDLTK SWVDSRDPIN
910 920 930 940 950
HRRAALDHSC SPSKGPVDWS RENSTSSGPS PRDSLAEKPY CSQVDFIYRQ
960 970 980 990 1000
ERGGGSSFDL RKDASQSEVS GENEGNLPSP EEDGFTISLS HVAVPGSPDQ
1010 1020 1030 1040 1050
RDTVTTPLRE VSADGPIQVT STVKNGHAVP GEDPRGQLGT HAEYASGLMS
1060 1070 1080 1090 1100
PLTMSLLENP DNEGSPPSEQ LVQDGATHSL VAESTGGPVV SHTVPSGDQE
1110 1120 1130 1140 1150
AALPVSSATR HLWLSSSPPD NKPGGDLPAL SPSPIRQHPA DKLPSREADL
1160 1170 1180 1190 1200
GEACQSRETV LFSHEHMGSE QYDADAEETG LDGSWGFPGK PFTTIHMGVP
1210 1220 1230 1240 1250
HSGPTLTPRT GSSDVADQLW AQERKHPTRL GWQEFGLSTD PIKLPCNSEN
1260 1270 1280 1290 1300
VTWLKPRPIS RCLARPSSPL VPSCSPKTAG TLRQPTLEQA QQVVIRAHQE
1310 1320 1330 1340 1350
QLDEMAELGF KEETLMSQLA SNDFEDFVTQ LDEIMVLKSK CIQSLRSQLQ
1360
LYLTCHGPTA APEGTVPS
Length:1,368
Mass (Da):151,903
Last modified:February 20, 2007 - v2
Checksum:iAE88C9E3A4C9FBFF
GO
Isoform 2 (identifier: Q5T7B8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-405: Missing.

Note: No experimental confirmation available.
Show »
Length:1,234
Mass (Da):136,423
Checksum:i01797E61137372BB
GO
Isoform 3 (identifier: Q5T7B8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-1368: Missing.

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):23,677
Checksum:iC3CBAB7EB7DBA678
GO
Isoform 4 (identifier: Q5T7B8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1158: SPSPIRQHPADKLPSREADLGEACQSRE → GPGEKTSYKAWLAGVWFVHRPHQVALQQ
     1159-1368: Missing.

Note: No experimental confirmation available.
Show »
Length:1,158
Mass (Da):128,840
Checksum:iBF300F8909F152D9
GO

Sequence cautioni

The sequence AAI10504 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC86074 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC86329 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI15917 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03072050D → E. Corresponds to variant dbSNP:rs16935508Ensembl.1
Natural variantiVAR_061284109R → G. Corresponds to variant dbSNP:rs41274845Ensembl.1
Natural variantiVAR_030721140M → V. Corresponds to variant dbSNP:rs10972048Ensembl.1
Natural variantiVAR_049706218W → L. Corresponds to variant dbSNP:rs17350674Ensembl.1
Natural variantiVAR_061285837S → F2 PublicationsCorresponds to variant dbSNP:rs41274041Ensembl.1
Natural variantiVAR_0497071077T → K. Corresponds to variant dbSNP:rs34101674Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023211209 – 1368Missing in isoform 3. 1 PublicationAdd BLAST1160
Alternative sequenceiVSP_023210272 – 405Missing in isoform 2. CuratedAdd BLAST134
Alternative sequenceiVSP_0232121131 – 1158SPSPI…CQSRE → GPGEKTSYKAWLAGVWFVHR PHQVALQQ in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0232131159 – 1368Missing in isoform 4. 1 PublicationAdd BLAST210

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353662 Genomic DNA Translation: CAI15917.1 Sequence problems.
AL353662 Genomic DNA Translation: CAI15919.1
AL353662 Genomic DNA Translation: CAI15920.3
AK001795 mRNA No translation available.
AK125180 mRNA Translation: BAC86074.1 Different initiation.
AK125872 mRNA Translation: BAC86329.1 Different initiation.
BC048311 mRNA Translation: AAH48311.1
BC110502 mRNA Translation: AAI10503.2
BC110503 mRNA Translation: AAI10504.1 Different initiation.
CCDSiCCDS6551.2 [Q5T7B8-1]
RefSeqiNP_919289.2, NM_194313.2 [Q5T7B8-1]
XP_011516165.1, XM_011517863.2 [Q5T7B8-1]
XP_016870186.1, XM_017014697.1 [Q5T7B8-1]
UniGeneiHs.710246

Genome annotation databases

EnsembliENST00000379174; ENSP00000368472; ENSG00000186638 [Q5T7B8-2]
ENST00000402558; ENSP00000384433; ENSG00000186638 [Q5T7B8-1]
GeneIDi347240
KEGGihsa:347240
UCSCiuc003zua.5 human [Q5T7B8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKIF24_HUMAN
AccessioniPrimary (citable) accession number: Q5T7B8
Secondary accession number(s): Q2TB93
, Q5T7B5, Q5T7B7, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 20, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health