Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5T7B8

- KIF24_HUMAN

UniProt

Q5T7B8 - KIF24_HUMAN

Protein

Kinesin-like protein KIF24

Gene

KIF24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi313 – 3208ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. metabolic process Source: GOC
    3. microtubule-based movement Source: InterPro
    4. microtubule depolymerization Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF24
    Gene namesi
    Name:KIF24
    Synonyms:C9orf48
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:19916. KIF24.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole 1 Publication
    Note: Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.

    GO - Cellular componenti

    1. centriole Source: UniProtKB
    2. kinesin complex Source: InterPro
    3. microtubule Source: UniProtKB-KW
    4. protein complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi263 – 2642VD → AA: Impairs ability to suppress cilia formation. 1 Publication
    Mutagenesisi483 – 4853KEC → AAA: Impairs ability to suppress cilia formation. 1 Publication

    Organism-specific databases

    PharmGKBiPA142671589.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13681368Kinesin-like protein KIF24PRO_0000278248Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021Phosphoserine1 Publication
    Modified residuei112 – 1121Phosphoserine1 Publication
    Modified residuei478 – 4781Phosphoserine2 Publications
    Modified residuei646 – 6461Phosphoserine1 Publication
    Modified residuei1012 – 10121Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5T7B8.
    PRIDEiQ5T7B8.

    PTM databases

    PhosphoSiteiQ5T7B8.

    Expressioni

    Developmental stagei

    Increases as cells progress through G1, peaks during S and G2 phases and decreases as cells enter mitosis during G2/M (at protein level).1 Publication

    Gene expression databases

    BgeeiQ5T7B8.
    CleanExiHS_KIF24.
    GenevestigatoriQ5T7B8.

    Organism-specific databases

    HPAiHPA020643.

    Interactioni

    Subunit structurei

    Interacts with CCP110 and CEP97.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CCP110O433039EBI-2556811,EBI-1566217
    CEP97Q8IW359EBI-2556811,EBI-1566210

    Protein-protein interaction databases

    BioGridi131415. 3 interactions.
    IntActiQ5T7B8. 5 interactions.
    STRINGi9606.ENSP00000368464.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T7B8.
    SMRiQ5T7B8. Positions 2-63, 223-543.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6464SAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini223 – 546324Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5059.
    HOVERGENiHBG080392.
    InParanoidiQ5T7B8.
    KOiK10393.
    OMAiQKLKYQP.
    OrthoDBiEOG7TJ3H2.
    PhylomeDBiQ5T7B8.
    TreeFamiTF336001.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T7B8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND     50
    RKRLFQLIKI IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF 100
    DSPADNKDRN ASNDGFEMCS LSDFSANEQK STYLKVLEHM LPDDSQYHTK 150
    TGILNATAGD SYVQTEISTS LFSPNYLSAI LGDCDIPIIQ RISHVSGYNY 200
    GIPHSCIRQN TSEKQNPWTE MEKIRVCVRK RPLGMREVRR GEINIITVED 250
    KETLLVHEKK EAVDLTQYIL QHVFYFDEVF GEACTNQDVY MKTTHPLIQH 300
    IFNGGNATCF AYGQTGAGKT YTMIGTHENP GLYALAAKDI FRQLEVSQPR 350
    KHLFVWISFY EIYCGQLYDL LNRRKRLFAR EDSKHMVQIV GLQELQVDSV 400
    ELLLEVILKG SKERSTGATG VNADSSRSHA VIQIQIKDSA KRTFGRISFI 450
    DLAGSERAAD ARDSDRQTKM EGAEINQSLL ALKECIRALD QEHTHTPFRQ 500
    SKLTQVLKDS FIGNAKTCMI ANISPSHVAT EHTLNTLRYA DRVKELKKGI 550
    KCCTSVTSRN RTSGNSSPKR IQSSPGALSE DKCSPKKVKL GFQQSLTVAA 600
    PGSTRGKVHP LTSHPPNIPF TSAPKVSGKR GGSRGSPSQE WVIHASPVKG 650
    TVRSGHVAKK KPEESAPLCS EKNRMGNKTV LGWESRASGP GEGLVRGKLS 700
    TKCKKVQTVQ PVQKQLVSRV ELSFGNAHHR AEYSQDSQRG TPARPASEAW 750
    TNIPPHQKER EEHLRFYHQQ FQQPPLLQQK LKYQPLKRSL RQYRPPEGQL 800
    TNETPPLFHS YSENHDGAQV EELDDSDFSE DSFSHISSQR ATKQRNTLEN 850
    SEDSFFLHQT WGQGPEKQVA ERQQSLFSSP RTGDKKDLTK SWVDSRDPIN 900
    HRRAALDHSC SPSKGPVDWS RENSTSSGPS PRDSLAEKPY CSQVDFIYRQ 950
    ERGGGSSFDL RKDASQSEVS GENEGNLPSP EEDGFTISLS HVAVPGSPDQ 1000
    RDTVTTPLRE VSADGPIQVT STVKNGHAVP GEDPRGQLGT HAEYASGLMS 1050
    PLTMSLLENP DNEGSPPSEQ LVQDGATHSL VAESTGGPVV SHTVPSGDQE 1100
    AALPVSSATR HLWLSSSPPD NKPGGDLPAL SPSPIRQHPA DKLPSREADL 1150
    GEACQSRETV LFSHEHMGSE QYDADAEETG LDGSWGFPGK PFTTIHMGVP 1200
    HSGPTLTPRT GSSDVADQLW AQERKHPTRL GWQEFGLSTD PIKLPCNSEN 1250
    VTWLKPRPIS RCLARPSSPL VPSCSPKTAG TLRQPTLEQA QQVVIRAHQE 1300
    QLDEMAELGF KEETLMSQLA SNDFEDFVTQ LDEIMVLKSK CIQSLRSQLQ 1350
    LYLTCHGPTA APEGTVPS 1368
    Length:1,368
    Mass (Da):151,903
    Last modified:February 20, 2007 - v2
    Checksum:iAE88C9E3A4C9FBFF
    GO
    Isoform 2 (identifier: Q5T7B8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         272-405: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,234
    Mass (Da):136,423
    Checksum:i01797E61137372BB
    GO
    Isoform 3 (identifier: Q5T7B8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         209-1368: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:208
    Mass (Da):23,677
    Checksum:iC3CBAB7EB7DBA678
    GO
    Isoform 4 (identifier: Q5T7B8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1131-1158: SPSPIRQHPADKLPSREADLGEACQSRE → GPGEKTSYKAWLAGVWFVHRPHQVALQQ
         1159-1368: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,158
    Mass (Da):128,840
    Checksum:iBF300F8909F152D9
    GO

    Sequence cautioni

    The sequence AAI10504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC86074.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC86329.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAI15917.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501D → E.
    Corresponds to variant rs16935508 [ dbSNP | Ensembl ].
    VAR_030720
    Natural varianti109 – 1091R → G.
    Corresponds to variant rs41274845 [ dbSNP | Ensembl ].
    VAR_061284
    Natural varianti140 – 1401M → V.
    Corresponds to variant rs10972048 [ dbSNP | Ensembl ].
    VAR_030721
    Natural varianti218 – 2181W → L.
    Corresponds to variant rs17350674 [ dbSNP | Ensembl ].
    VAR_049706
    Natural varianti837 – 8371S → F.2 Publications
    Corresponds to variant rs41274041 [ dbSNP | Ensembl ].
    VAR_061285
    Natural varianti1077 – 10771T → K.
    Corresponds to variant rs34101674 [ dbSNP | Ensembl ].
    VAR_049707

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei209 – 13681160Missing in isoform 3. 1 PublicationVSP_023211Add
    BLAST
    Alternative sequencei272 – 405134Missing in isoform 2. CuratedVSP_023210Add
    BLAST
    Alternative sequencei1131 – 115828SPSPI…CQSRE → GPGEKTSYKAWLAGVWFVHR PHQVALQQ in isoform 4. 1 PublicationVSP_023212Add
    BLAST
    Alternative sequencei1159 – 1368210Missing in isoform 4. 1 PublicationVSP_023213Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353662 Genomic DNA. Translation: CAI15917.1. Sequence problems.
    AL353662 Genomic DNA. Translation: CAI15919.1.
    AL353662 Genomic DNA. Translation: CAI15920.3.
    AK001795 mRNA. No translation available.
    AK125180 mRNA. Translation: BAC86074.1. Different initiation.
    AK125872 mRNA. Translation: BAC86329.1. Different initiation.
    BC048311 mRNA. Translation: AAH48311.1.
    BC110502 mRNA. Translation: AAI10503.2.
    BC110503 mRNA. Translation: AAI10504.1. Different initiation.
    CCDSiCCDS6551.2. [Q5T7B8-1]
    RefSeqiNP_919289.2. NM_194313.2. [Q5T7B8-1]
    UniGeneiHs.710246.

    Genome annotation databases

    EnsembliENST00000379166; ENSP00000368464; ENSG00000186638. [Q5T7B8-1]
    ENST00000379174; ENSP00000368472; ENSG00000186638. [Q5T7B8-2]
    ENST00000402558; ENSP00000384433; ENSG00000186638. [Q5T7B8-1]
    GeneIDi347240.
    KEGGihsa:347240.
    UCSCiuc003zua.4. human. [Q5T7B8-1]

    Polymorphism databases

    DMDMi126215732.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353662 Genomic DNA. Translation: CAI15917.1 . Sequence problems.
    AL353662 Genomic DNA. Translation: CAI15919.1 .
    AL353662 Genomic DNA. Translation: CAI15920.3 .
    AK001795 mRNA. No translation available.
    AK125180 mRNA. Translation: BAC86074.1 . Different initiation.
    AK125872 mRNA. Translation: BAC86329.1 . Different initiation.
    BC048311 mRNA. Translation: AAH48311.1 .
    BC110502 mRNA. Translation: AAI10503.2 .
    BC110503 mRNA. Translation: AAI10504.1 . Different initiation.
    CCDSi CCDS6551.2. [Q5T7B8-1 ]
    RefSeqi NP_919289.2. NM_194313.2. [Q5T7B8-1 ]
    UniGenei Hs.710246.

    3D structure databases

    ProteinModelPortali Q5T7B8.
    SMRi Q5T7B8. Positions 2-63, 223-543.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131415. 3 interactions.
    IntActi Q5T7B8. 5 interactions.
    STRINGi 9606.ENSP00000368464.

    PTM databases

    PhosphoSitei Q5T7B8.

    Polymorphism databases

    DMDMi 126215732.

    Proteomic databases

    PaxDbi Q5T7B8.
    PRIDEi Q5T7B8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379166 ; ENSP00000368464 ; ENSG00000186638 . [Q5T7B8-1 ]
    ENST00000379174 ; ENSP00000368472 ; ENSG00000186638 . [Q5T7B8-2 ]
    ENST00000402558 ; ENSP00000384433 ; ENSG00000186638 . [Q5T7B8-1 ]
    GeneIDi 347240.
    KEGGi hsa:347240.
    UCSCi uc003zua.4. human. [Q5T7B8-1 ]

    Organism-specific databases

    CTDi 347240.
    GeneCardsi GC09M034252.
    H-InvDB HIX0025726.
    HGNCi HGNC:19916. KIF24.
    HPAi HPA020643.
    MIMi 613747. gene.
    neXtProti NX_Q5T7B8.
    PharmGKBi PA142671589.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOVERGENi HBG080392.
    InParanoidi Q5T7B8.
    KOi K10393.
    OMAi QKLKYQP.
    OrthoDBi EOG7TJ3H2.
    PhylomeDBi Q5T7B8.
    TreeFami TF336001.

    Miscellaneous databases

    GeneWikii KIF24.
    GenomeRNAii 347240.
    NextBioi 99066.
    PROi Q5T7B8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5T7B8.
    CleanExi HS_KIF24.
    Genevestigatori Q5T7B8.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 503-1368 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-1368 (ISOFORM 3), VARIANT PHE-837.
      Tissue: Fetal brain, Ovarian carcinoma and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 509-1368 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 956-1368 (ISOFORM 4), VARIANT PHE-837.
      Tissue: Duodenum.
    4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102; SER-478 AND SER-1012, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112; SER-478 AND SER-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis."
      Kobayashi T., Tsang W.Y., Li J., Lane W., Dynlacht B.D.
      Cell 145:914-925(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH CCP110 AND CEP97, MUTAGENESIS OF 263-VAL-ASP-264 AND 483-LYS--CYS-485.

    Entry informationi

    Entry nameiKIF24_HUMAN
    AccessioniPrimary (citable) accession number: Q5T7B8
    Secondary accession number(s): Q2TB93
    , Q5T7B5, Q5T7B7, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3