Q5T7B8 (KIF24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF24

Gene names

Name:	KIF24
Synonyms:	C9orf48

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1368 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress abberrant cilia formation. Ref.6
Subunit structure	Interacts with CCP110 and CEP97. Ref.6
Subcellular location	Cytoplasm › cytoskeleton › centrosome › centriole. Note: Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole. Ref.6
Developmental stage	Increases as cells progress through G1, peaks during S and G2 phases and decreases as cells enter mitosis during G2/M (at protein level). Ref.6
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain. Contains 1 SAM (sterile alpha motif) domain.
Sequence caution	The sequence AAI10504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC86074.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC86329.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAI15917.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cilium assembly Inferred from mutant phenotype Ref.6. Source: UniProtKB microtubule depolymerization Inferred from direct assay Ref.6. Source: UniProtKB microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	centriole Inferred from direct assay Ref.6. Source: UniProtKB microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CCP110	O43303	9	EBI-2556811,EBI-1566217
CEP97	Q8IW35	9	EBI-2556811,EBI-1566210

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T7B8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T7B8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     272-405: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5T7B8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     209-1368: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q5T7B8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1158: SPSPIRQHPADKLPSREADLGEACQSRE → GPGEKTSYKAWLAGVWFVHRPHQVALQQ
     1159-1368: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1368	1368	Kinesin-like protein KIF24		PRO_0000278248
Regions
	Domain	1 – 64	64	SAM
	Domain	220 – 477	258	Kinesin-motor
	Nucleotide binding	313 – 320	8	ATP Potential
Amino acid modifications
	Modified residue	102	1	Phosphoserine Ref.4
	Modified residue	112	1	Phosphoserine Ref.5
	Modified residue	478	1	Phosphoserine Ref.4 Ref.5
	Modified residue	646	1	Phosphoserine Ref.5
	Modified residue	1012	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	209 – 1368	1160	Missing in isoform 3.		VSP_023211
	Alternative sequence	272 – 405	134	Missing in isoform 2.		VSP_023210
	Alternative sequence	1131 – 1158	28	SPSPI…CQSRE → GPGEKTSYKAWLAGVWFVHR PHQVALQQ in isoform 4.		VSP_023212
	Alternative sequence	1159 – 1368	210	Missing in isoform 4.		VSP_023213
	Natural variant	50	1	D → E. Corresponds to variant rs16935508 [ dbSNP | Ensembl ].		VAR_030720
	Natural variant	109	1	R → G. Corresponds to variant rs41274845 [ dbSNP | Ensembl ].		VAR_061284
	Natural variant	140	1	M → V. Corresponds to variant rs10972048 [ dbSNP | Ensembl ].		VAR_030721
	Natural variant	218	1	W → L. Corresponds to variant rs17350674 [ dbSNP | Ensembl ].		VAR_049706
	Natural variant	837	1	S → F. Ref.2 Ref.3 Corresponds to variant rs41274041 [ dbSNP | Ensembl ].		VAR_061285
	Natural variant	1077	1	T → K. Corresponds to variant rs34101674 [ dbSNP | Ensembl ].		VAR_049707
Experimental info
	Mutagenesis	263 – 264	2	VD → AA: Impairs ability to suppress cilia formation.
	Mutagenesis	483 – 485	3	KEC → AAA: Impairs ability to suppress cilia formation. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: AE88C9E3A4C9FBFF	FASTA	1,368	151,903
	10 20 30 40 50 60 MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND RKRLFQLIKI 70 80 90 100 110 120 IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF DSPADNKDRN ASNDGFEMCS 130 140 150 160 170 180 LSDFSANEQK STYLKVLEHM LPDDSQYHTK TGILNATAGD SYVQTEISTS LFSPNYLSAI 190 200 210 220 230 240 LGDCDIPIIQ RISHVSGYNY GIPHSCIRQN TSEKQNPWTE MEKIRVCVRK RPLGMREVRR 250 260 270 280 290 300 GEINIITVED KETLLVHEKK EAVDLTQYIL QHVFYFDEVF GEACTNQDVY MKTTHPLIQH 310 320 330 340 350 360 IFNGGNATCF AYGQTGAGKT YTMIGTHENP GLYALAAKDI FRQLEVSQPR KHLFVWISFY 370 380 390 400 410 420 EIYCGQLYDL LNRRKRLFAR EDSKHMVQIV GLQELQVDSV ELLLEVILKG SKERSTGATG 430 440 450 460 470 480 VNADSSRSHA VIQIQIKDSA KRTFGRISFI DLAGSERAAD ARDSDRQTKM EGAEINQSLL 490 500 510 520 530 540 ALKECIRALD QEHTHTPFRQ SKLTQVLKDS FIGNAKTCMI ANISPSHVAT EHTLNTLRYA 550 560 570 580 590 600 DRVKELKKGI KCCTSVTSRN RTSGNSSPKR IQSSPGALSE DKCSPKKVKL GFQQSLTVAA 610 620 630 640 650 660 PGSTRGKVHP LTSHPPNIPF TSAPKVSGKR GGSRGSPSQE WVIHASPVKG TVRSGHVAKK 670 680 690 700 710 720 KPEESAPLCS EKNRMGNKTV LGWESRASGP GEGLVRGKLS TKCKKVQTVQ PVQKQLVSRV 730 740 750 760 770 780 ELSFGNAHHR AEYSQDSQRG TPARPASEAW TNIPPHQKER EEHLRFYHQQ FQQPPLLQQK 790 800 810 820 830 840 LKYQPLKRSL RQYRPPEGQL TNETPPLFHS YSENHDGAQV EELDDSDFSE DSFSHISSQR 850 860 870 880 890 900 ATKQRNTLEN SEDSFFLHQT WGQGPEKQVA ERQQSLFSSP RTGDKKDLTK SWVDSRDPIN 910 920 930 940 950 960 HRRAALDHSC SPSKGPVDWS RENSTSSGPS PRDSLAEKPY CSQVDFIYRQ ERGGGSSFDL 970 980 990 1000 1010 1020 RKDASQSEVS GENEGNLPSP EEDGFTISLS HVAVPGSPDQ RDTVTTPLRE VSADGPIQVT 1030 1040 1050 1060 1070 1080 STVKNGHAVP GEDPRGQLGT HAEYASGLMS PLTMSLLENP DNEGSPPSEQ LVQDGATHSL 1090 1100 1110 1120 1130 1140 VAESTGGPVV SHTVPSGDQE AALPVSSATR HLWLSSSPPD NKPGGDLPAL SPSPIRQHPA 1150 1160 1170 1180 1190 1200 DKLPSREADL GEACQSRETV LFSHEHMGSE QYDADAEETG LDGSWGFPGK PFTTIHMGVP 1210 1220 1230 1240 1250 1260 HSGPTLTPRT GSSDVADQLW AQERKHPTRL GWQEFGLSTD PIKLPCNSEN VTWLKPRPIS 1270 1280 1290 1300 1310 1320 RCLARPSSPL VPSCSPKTAG TLRQPTLEQA QQVVIRAHQE QLDEMAELGF KEETLMSQLA 1330 1340 1350 1360 SNDFEDFVTQ LDEIMVLKSK CIQSLRSQLQ LYLTCHGPTA APEGTVPS
	Isoform 2 [UniParc]. Checksum: 01797E61137372BB	FASTA	1,234	136,423
	10 20 30 40 50 60 MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND RKRLFQLIKI 70 80 90 100 110 120 IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF DSPADNKDRN ASNDGFEMCS 130 140 150 160 170 180 LSDFSANEQK STYLKVLEHM LPDDSQYHTK TGILNATAGD SYVQTEISTS LFSPNYLSAI 190 200 210 220 230 240 LGDCDIPIIQ RISHVSGYNY GIPHSCIRQN TSEKQNPWTE MEKIRVCVRK RPLGMREVRR 250 260 270 280 290 300 GEINIITVED KETLLVHEKK EAVDLTQYIL QVILKGSKER STGATGVNAD SSRSHAVIQI 310 320 330 340 350 360 QIKDSAKRTF GRISFIDLAG SERAADARDS DRQTKMEGAE INQSLLALKE CIRALDQEHT 370 380 390 400 410 420 HTPFRQSKLT QVLKDSFIGN AKTCMIANIS PSHVATEHTL NTLRYADRVK ELKKGIKCCT 430 440 450 460 470 480 SVTSRNRTSG NSSPKRIQSS PGALSEDKCS PKKVKLGFQQ SLTVAAPGST RGKVHPLTSH 490 500 510 520 530 540 PPNIPFTSAP KVSGKRGGSR GSPSQEWVIH ASPVKGTVRS GHVAKKKPEE SAPLCSEKNR 550 560 570 580 590 600 MGNKTVLGWE SRASGPGEGL VRGKLSTKCK KVQTVQPVQK QLVSRVELSF GNAHHRAEYS 610 620 630 640 650 660 QDSQRGTPAR PASEAWTNIP PHQKEREEHL RFYHQQFQQP PLLQQKLKYQ PLKRSLRQYR 670 680 690 700 710 720 PPEGQLTNET PPLFHSYSEN HDGAQVEELD DSDFSEDSFS HISSQRATKQ RNTLENSEDS 730 740 750 760 770 780 FFLHQTWGQG PEKQVAERQQ SLFSSPRTGD KKDLTKSWVD SRDPINHRRA ALDHSCSPSK 790 800 810 820 830 840 GPVDWSRENS TSSGPSPRDS LAEKPYCSQV DFIYRQERGG GSSFDLRKDA SQSEVSGENE 850 860 870 880 890 900 GNLPSPEEDG FTISLSHVAV PGSPDQRDTV TTPLREVSAD GPIQVTSTVK NGHAVPGEDP 910 920 930 940 950 960 RGQLGTHAEY ASGLMSPLTM SLLENPDNEG SPPSEQLVQD GATHSLVAES TGGPVVSHTV 970 980 990 1000 1010 1020 PSGDQEAALP VSSATRHLWL SSSPPDNKPG GDLPALSPSP IRQHPADKLP SREADLGEAC 1030 1040 1050 1060 1070 1080 QSRETVLFSH EHMGSEQYDA DAEETGLDGS WGFPGKPFTT IHMGVPHSGP TLTPRTGSSD 1090 1100 1110 1120 1130 1140 VADQLWAQER KHPTRLGWQE FGLSTDPIKL PCNSENVTWL KPRPISRCLA RPSSPLVPSC 1150 1160 1170 1180 1190 1200 SPKTAGTLRQ PTLEQAQQVV IRAHQEQLDE MAELGFKEET LMSQLASNDF EDFVTQLDEI 1210 1220 1230 MVLKSKCIQS LRSQLQLYLT CHGPTAAPEG TVPS
	Isoform 3 [UniParc]. Checksum: C3CBAB7EB7DBA678	FASTA	208	23,677
	10 20 30 40 50 60 MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND RKRLFQLIKI 70 80 90 100 110 120 IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF DSPADNKDRN ASNDGFEMCS 130 140 150 160 170 180 LSDFSANEQK STYLKVLEHM LPDDSQYHTK TGILNATAGD SYVQTEISTS LFSPNYLSAI 190 200 LGDCDIPIIQ RISHVSGYNY GIPHSCIR
	Isoform 4 [UniParc]. Checksum: BF300F8909F152D9	FASTA	1,158	128,840
	10 20 30 40 50 60 MASWLYECLC EAELAQYYSH FTALGLQKID ELAKITMKDY SKLGVHDMND RKRLFQLIKI 70 80 90 100 110 120 IKIMQEEDKA VSIPERHLQT SSLRIKSQEL RSGPRRQLNF DSPADNKDRN ASNDGFEMCS 130 140 150 160 170 180 LSDFSANEQK STYLKVLEHM LPDDSQYHTK TGILNATAGD SYVQTEISTS LFSPNYLSAI 190 200 210 220 230 240 LGDCDIPIIQ RISHVSGYNY GIPHSCIRQN TSEKQNPWTE MEKIRVCVRK RPLGMREVRR 250 260 270 280 290 300 GEINIITVED KETLLVHEKK EAVDLTQYIL QHVFYFDEVF GEACTNQDVY MKTTHPLIQH 310 320 330 340 350 360 IFNGGNATCF AYGQTGAGKT YTMIGTHENP GLYALAAKDI FRQLEVSQPR KHLFVWISFY 370 380 390 400 410 420 EIYCGQLYDL LNRRKRLFAR EDSKHMVQIV GLQELQVDSV ELLLEVILKG SKERSTGATG 430 440 450 460 470 480 VNADSSRSHA VIQIQIKDSA KRTFGRISFI DLAGSERAAD ARDSDRQTKM EGAEINQSLL 490 500 510 520 530 540 ALKECIRALD QEHTHTPFRQ SKLTQVLKDS FIGNAKTCMI ANISPSHVAT EHTLNTLRYA 550 560 570 580 590 600 DRVKELKKGI KCCTSVTSRN RTSGNSSPKR IQSSPGALSE DKCSPKKVKL GFQQSLTVAA 610 620 630 640 650 660 PGSTRGKVHP LTSHPPNIPF TSAPKVSGKR GGSRGSPSQE WVIHASPVKG TVRSGHVAKK 670 680 690 700 710 720 KPEESAPLCS EKNRMGNKTV LGWESRASGP GEGLVRGKLS TKCKKVQTVQ PVQKQLVSRV 730 740 750 760 770 780 ELSFGNAHHR AEYSQDSQRG TPARPASEAW TNIPPHQKER EEHLRFYHQQ FQQPPLLQQK 790 800 810 820 830 840 LKYQPLKRSL RQYRPPEGQL TNETPPLFHS YSENHDGAQV EELDDSDFSE DSFSHISSQR 850 860 870 880 890 900 ATKQRNTLEN SEDSFFLHQT WGQGPEKQVA ERQQSLFSSP RTGDKKDLTK SWVDSRDPIN 910 920 930 940 950 960 HRRAALDHSC SPSKGPVDWS RENSTSSGPS PRDSLAEKPY CSQVDFIYRQ ERGGGSSFDL 970 980 990 1000 1010 1020 RKDASQSEVS GENEGNLPSP EEDGFTISLS HVAVPGSPDQ RDTVTTPLRE VSADGPIQVT 1030 1040 1050 1060 1070 1080 STVKNGHAVP GEDPRGQLGT HAEYASGLMS PLTMSLLENP DNEGSPPSEQ LVQDGATHSL 1090 1100 1110 1120 1130 1140 VAESTGGPVV SHTVPSGDQE AALPVSSATR HLWLSSSPPD NKPGGDLPAL GPGEKTSYKA 1150 WLAGVWFVHR PHQVALQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 503-1368 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-1368 (ISOFORM 3), VARIANT PHE-837. Tissue: Fetal brain, Ovarian carcinoma and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 509-1368 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 956-1368 (ISOFORM 4), VARIANT PHE-837. Tissue: Duodenum.
[4]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102; SER-478 AND SER-1012, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112; SER-478 AND SER-646, MASS SPECTROMETRY.
[6]	"Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis." Kobayashi T., Tsang W.Y., Li J., Lane W., Dynlacht B.D. Cell 145:914-925(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH CCP110 AND CEP97, MUTAGENESIS OF 263-VAL-ASP-264 AND 483-LYS--CYS-485.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL353662 Genomic DNA. Translation: CAI15917.1. Sequence problems. AL353662 Genomic DNA. Translation: CAI15919.1. AL353662 Genomic DNA. Translation: CAI15920.3. AK001795 mRNA. No translation available. AK125180 mRNA. Translation: BAC86074.1. Different initiation. AK125872 mRNA. Translation: BAC86329.1. Different initiation. BC048311 mRNA. Translation: AAH48311.1. BC110502 mRNA. Translation: AAI10503.2. BC110503 mRNA. Translation: AAI10504.1. Different initiation.
IPI	IPI00419014. IPI00828028. IPI00828144. IPI00847428.
RefSeq	NP_919289.2. NM_194313.2.
UniGene	Hs.710246.
3D structure databases
HSSP	HSSP built from PDB template 1V8J based on UniProtKB Q922S8.
ProteinModelPortal	Q5T7B8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5T7B8. 5 interactions.
STRING	9606.ENSP00000368464.
PTM databases
PhosphoSite	Q5T7B8.
Polymorphism databases
DMDM	126215732.
Proteomic databases
PaxDb	Q5T7B8.
PRIDE	Q5T7B8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000345050; ENSP00000340179; ENSG00000186638. ENST00000379166; ENSP00000368464; ENSG00000186638. ENST00000379174; ENSP00000368472; ENSG00000186638. ENST00000402558; ENSP00000384433; ENSG00000186638.
GeneID	347240.
KEGG	hsa:347240.
UCSC	uc003zua.4. human.
Organism-specific databases
CTD	347240.
GeneCards	GC09M034252.
H-InvDB	HIX0025726.
HGNC	HGNC:19916. KIF24.
HPA	HPA020643.
MIM	613747. gene.
neXtProt	NX_Q5T7B8.
PharmGKB	PA142671589.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5059.
HOVERGEN	HBG080392.
InParanoid	Q5T7B8.
KO	K10393.
OMA	QKLKYQP.
OrthoDB	EOG4SJ5CZ.
Gene expression databases
Bgee	Q5T7B8.
CleanEx	HS_KIF24.
Genevestigator	Q5T7B8.
Family and domain databases
Gene3D	1.10.150.50. 1 hit. 3.40.850.10. 1 hit.
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR001660. SAM. IPR013761. SAM/pointed. IPR021129. SAM_type1. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. PF00536. SAM_1. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
SUPFAM	SSF47769. SAM_homology. 1 hit.
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	347240.
NextBio	99066.
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Entry information

Entry name

KIF24_HUMAN

Accession

Primary (citable) accession number: Q5T7B8
Secondary accession number(s): Q2TB93 , Q5T7B5, Q5T7B7, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.