ID   Q5T7A2_HUMAN            Unreviewed;       492 AA.
AC   Q5T7A2;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   21-DEC-2004, sequence version 1.
DT   24-JAN-2024, entry version 106.
DE   RecName: Full=Atypical kinase COQ8A, mitochondrial {ECO:0000256|ARBA:ARBA00018535};
DE   AltName: Full=Chaperone activity of bc1 complex-like {ECO:0000256|ARBA:ARBA00032726};
DE   AltName: Full=Coenzyme Q protein 8A {ECO:0000256|ARBA:ARBA00033204};
DE   AltName: Full=aarF domain-containing protein kinase 3 {ECO:0000256|ARBA:ARBA00031775};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG52171.1};
RN   [1] {ECO:0000313|EMBL:BAG52171.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adrenal gland {ECO:0000313|EMBL:BAG52171.1};
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M.,
RA   Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S.,
RA   Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S.,
RA   Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H.,
RA   Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M.,
RA   Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M.,
RA   Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y.,
RA   Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N.,
RA   Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S.,
RA   Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T.,
RA   Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M.,
RA   Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y.,
RA   Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y.,
RA   Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T.,
RA   Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004749}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC       kinase family. {ECO:0000256|ARBA:ARBA00009670}.
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DR   EMBL; AK090494; BAG52171.1; -; mRNA.
DR   AlphaFoldDB; Q5T7A2; -.
DR   MaxQB; Q5T7A2; -.
DR   PeptideAtlas; Q5T7A2; -.
DR   ProteomicsDB; 64647; -.
DR   UniPathway; UPA00232; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd13970; ABC1_ADCK3; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR034646; ADCK3_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR43851; -; 1.
DR   PANTHER; PTHR43851:SF1; ATYPICAL KINASE COQ8A, MITOCHONDRIAL; 1.
DR   Pfam; PF03109; ABC1; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          145..383
FT                   /note="ABC1 atypical kinase-like"
FT                   /evidence="ECO:0000259|Pfam:PF03109"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   492 AA;  55981 MW;  002CFE4CACFF3BB3 CRC64;
     MGFQRRFFHQ DQSPVGGLTA EDIEKARQAK ARPENKQHKQ TLSEHARERK VPVTRIGRLA
     NFGGLAVGLG FGALAEVAKK SLRSEDPSGK KAVLGSSPFL SEANAERIVR TLCKVRGAAL
     KLGQMLSIQD DAFINPHLAK IFERVRQSAD FMPLKQMMKT LNNDLGPNWR DKLEYFEERP
     FAAASIGQVH LARMKGGREV AMKIQYPGVA QSINSDVNNL MAVLNMSNML PEGLFPEHLI
     DVLRRELALE CDYQREAACA RKFRDLLKGH PFFYVPEIVD ELCSPHVLTT ELVSGFPLDQ
     AEGLSQEIRN EICYNILVLC LRELFEFHFM QTDPNWSNFF YDPQQHKVAL LDFGATREYD
     RSFTDLYIQI IRAAADRDRE TVRAKSIEMK FLTGYEVKVM EDAHLDAILI LGEAFASDEP
     FDFGTQSTTE KIHNLIPVML RHRLVPPPEE TYSLHRKMGG SFLICSKLKA RFPCKAMFEE
     AYSNYCKRQA QQ
//