Q5T764 (IFT1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon-induced protein with tetratricopeptide repeats 1B

Alternative name(s):
Interferon-induced protein with tetratricopeptide repeats 1-like protein

Gene names

Name:	IFIT1B
Synonyms:	IFIT1L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the IFIT family. Contains 8 TPR repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil Repeat TPR repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	Interferon-induced protein with tetratricopeptide repeats 1B		PRO_0000285728
Regions
	Repeat	52 – 85	34	TPR 1
	Repeat	95 – 128	34	TPR 2
	Repeat	139 – 174	36	TPR 3
	Repeat	182 – 216	35	TPR 4
	Repeat	251 – 284	34	TPR 5
	Repeat	340 – 373	34	TPR 6
	Repeat	378 – 412	35	TPR 7
	Repeat	437 – 470	34	TPR 8
	Coiled coil	61 – 85	25	Potential
Natural variations
	Natural variant	188	1	L → P. Corresponds to variant rs7072728 [ dbSNP | Ensembl ].		VAR_052617

Sequences

	Sequence		Length	Mass (Da)
	Q5T764 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 163BB9DCFFCEF8DE	FASTA	474	54,993
	10 20 30 40 50 60 MSEESDGKLI EDSLIQLRCH FTWKLLIEAP EIPDLENRIW EEIQFLDTKY NVGIHNLLAY 70 80 90 100 110 120 VKHLKGQNEE ALVSLKKAED LIQKEHANQA DIRSLVTWGN FAWVYYHMGR LAEAQTYLDK 130 140 150 160 170 180 VENTCKKFAN PSRYRMECPE VDCEEGWALA KCGGKNYERA KTCFEKALEG NPENPEFNTG 190 200 210 220 230 240 YAITVYRLDK FNTASGRNKA FSLHVLKRAV RLNPDDVYIR VLLALKLQDE GQEAEGEKYI 250 260 270 280 290 300 EEALTSISSQ AYVFQYAAKF YRRKGSVDKA LELLKMALET TPTSAFLHHQ MGLCYRAQMI 310 320 330 340 350 360 QIKEATNWQP RGQDRETVDR LVQLAICKFE KTIMLKRTFE MAYVDLAETY AEIGHHRKAE 370 380 390 400 410 420 EHFQKGLRMK IFEDQLKQEI HYHYGRFQEH HGKSQDKAIT HYLKGLKIEK MSHSREKLLN 430 440 450 460 470 ALEKLAKRCI HQNVRVVESV SLLGLIHKLK GEVSDALLCY ERALRLAADL NPIF

References

[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL353751 Genomic DNA. Translation: CAI12242.1. CH471066 Genomic DNA. Translation: EAW50139.1. BC137368 mRNA. Translation: AAI37369.1. BC137369 mRNA. Translation: AAI37370.1. BC150189 mRNA. Translation: AAI50190.1.
IPI	IPI00456868.
RefSeq	NP_001010987.1. NM_001010987.2.
UniGene	Hs.500491.
3D structure databases
ProteinModelPortal	Q5T764.
SMR	Q5T764. Positions 24-469.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5T764. 2 interactions.
Polymorphism databases
DMDM	74762241.
Proteomic databases
PRIDE	Q5T764.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371809; ENSP00000360874; ENSG00000204010.
GeneID	439996.
KEGG	hsa:439996.
UCSC	uc001kgh.1. human.
Organism-specific databases
CTD	439996.
GeneCards	GC10P091137.
HGNC	HGNC:23442. IFIT1B.
HPA	HPA041627.
neXtProt	NX_Q5T764.
PharmGKB	PA134937819. PA165548753.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17871.
GeneTree	ENSGT00390000013876.
HOGENOM	HBG447196.
HOVERGEN	HBG066330.
InParanoid	Q5T764.
OMA	QLAICKF.
OrthoDB	EOG4D26PQ.
PhylomeDB	Q5T764.
Gene expression databases
ArrayExpress	Q5T764.
Bgee	Q5T764.
CleanEx	HS_IFIT1L.
Genevestigator	Q5T764.
Family and domain databases
InterPro	IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 2 hits.
KO	K14217.
SMART	SM00028. TPR. 6 hits. [Graphical view]
PROSITE	PS50005. TPR. 4 hits. PS50293. TPR_REGION. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	108816.

Entry information

Entry name

IFT1B_HUMAN

Accession

Primary (citable) accession number: Q5T764
Secondary accession number(s): A7E245

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.