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Protein

Interferon-induced protein with tetratricopeptide repeats 1B

Gene

IFIT1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced protein with tetratricopeptide repeats 1B
Alternative name(s):
Interferon-induced protein with tetratricopeptide repeats 1-like protein
Gene namesi
Name:IFIT1B
Synonyms:IFIT1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000204010.3
HGNCiHGNC:23442 IFIT1B
neXtProtiNX_Q5T764

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204010
PharmGKBiPA165548753

Polymorphism and mutation databases

BioMutaiIFIT1B
DMDMi74762241

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002857281 – 474Interferon-induced protein with tetratricopeptide repeats 1BAdd BLAST474

Proteomic databases

EPDiQ5T764
MaxQBiQ5T764
PaxDbiQ5T764
PeptideAtlasiQ5T764
PRIDEiQ5T764

PTM databases

iPTMnetiQ5T764
PhosphoSitePlusiQ5T764

Expressioni

Gene expression databases

BgeeiENSG00000204010
CleanExiHS_IFIT1L

Organism-specific databases

HPAiHPA062924

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IFIT3O148793EBI-3507164,EBI-745127

Protein-protein interaction databases

BioGridi136196, 6 interactors
IntActiQ5T764, 2 interactors
STRINGi9606.ENSP00000360874

Structurei

3D structure databases

ProteinModelPortaliQ5T764
SMRiQ5T764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati52 – 85TPR 1Add BLAST34
Repeati95 – 128TPR 2Add BLAST34
Repeati139 – 174TPR 3Add BLAST36
Repeati182 – 216TPR 4Add BLAST35
Repeati251 – 284TPR 5Add BLAST34
Repeati340 – 373TPR 6Add BLAST34
Repeati378 – 412TPR 7Add BLAST35
Repeati437 – 470TPR 8Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 85Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the IFIT family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000013876
HOGENOMiHOG000001558
HOVERGENiHBG066330
InParanoidiQ5T764
KOiK14217
OMAiRMKIFED
OrthoDBiEOG091G06GX
PhylomeDBiQ5T764
TreeFamiTF342671

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13176 TPR_7, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 3 hits

Sequencei

Sequence statusi: Complete.

Q5T764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEESDGKLI EDSLIQLRCH FTWKLLIEAP EIPDLENRIW EEIQFLDTKY
60 70 80 90 100
NVGIHNLLAY VKHLKGQNEE ALVSLKKAED LIQKEHANQA DIRSLVTWGN
110 120 130 140 150
FAWVYYHMGR LAEAQTYLDK VENTCKKFAN PSRYRMECPE VDCEEGWALA
160 170 180 190 200
KCGGKNYERA KTCFEKALEG NPENPEFNTG YAITVYRLDK FNTASGRNKA
210 220 230 240 250
FSLHVLKRAV RLNPDDVYIR VLLALKLQDE GQEAEGEKYI EEALTSISSQ
260 270 280 290 300
AYVFQYAAKF YRRKGSVDKA LELLKMALET TPTSAFLHHQ MGLCYRAQMI
310 320 330 340 350
QIKEATNWQP RGQDRETVDR LVQLAICKFE KTIMLKRTFE MAYVDLAETY
360 370 380 390 400
AEIGHHRKAE EHFQKGLRMK IFEDQLKQEI HYHYGRFQEH HGKSQDKAIT
410 420 430 440 450
HYLKGLKIEK MSHSREKLLN ALEKLAKRCI HQNVRVVESV SLLGLIHKLK
460 470
GEVSDALLCY ERALRLAADL NPIF
Length:474
Mass (Da):54,993
Last modified:December 21, 2004 - v1
Checksum:i163BB9DCFFCEF8DE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052617188L → P. Corresponds to variant dbSNP:rs7072728Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353751 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50139.1
BC137368 mRNA Translation: AAI37369.1
BC137369 mRNA Translation: AAI37370.1
BC150189 mRNA Translation: AAI50190.1
CCDSiCCDS31242.1
RefSeqiNP_001010987.1, NM_001010987.2
UniGeneiHs.500491

Genome annotation databases

EnsembliENST00000371809; ENSP00000360874; ENSG00000204010
GeneIDi439996
KEGGihsa:439996
UCSCiuc001kgh.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFT1B_HUMAN
AccessioniPrimary (citable) accession number: Q5T764
Secondary accession number(s): A7E245
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 21, 2004
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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