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Protein

Interferon-induced protein with tetratricopeptide repeats 1B

Gene

IFIT1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced protein with tetratricopeptide repeats 1B
Alternative name(s):
Interferon-induced protein with tetratricopeptide repeats 1-like protein
Gene namesi
Name:IFIT1B
Synonyms:IFIT1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23442. IFIT1B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165548753.

Polymorphism and mutation databases

BioMutaiIFIT1B.
DMDMi74762241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Interferon-induced protein with tetratricopeptide repeats 1BPRO_0000285728Add
BLAST

Proteomic databases

EPDiQ5T764.
MaxQBiQ5T764.
PaxDbiQ5T764.
PRIDEiQ5T764.

PTM databases

iPTMnetiQ5T764.
PhosphoSiteiQ5T764.

Expressioni

Gene expression databases

BgeeiQ5T764.
CleanExiHS_IFIT1L.

Organism-specific databases

HPAiHPA062924.

Interactioni

Protein-protein interaction databases

BioGridi136196. 6 interactions.
IntActiQ5T764. 2 interactions.
STRINGi9606.ENSP00000360874.

Structurei

3D structure databases

ProteinModelPortaliQ5T764.
SMRiQ5T764. Positions 10-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati52 – 8534TPR 1Add
BLAST
Repeati95 – 12834TPR 2Add
BLAST
Repeati139 – 17436TPR 3Add
BLAST
Repeati182 – 21635TPR 4Add
BLAST
Repeati251 – 28434TPR 5Add
BLAST
Repeati340 – 37334TPR 6Add
BLAST
Repeati378 – 41235TPR 7Add
BLAST
Repeati437 – 47034TPR 8Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili61 – 8525Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the IFIT family.Curated
Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000013876.
HOGENOMiHOG000001558.
HOVERGENiHBG066330.
InParanoidiQ5T764.
KOiK14217.
OMAiFEMAYVC.
OrthoDBiEOG71K62V.
PhylomeDBiQ5T764.
TreeFamiTF342671.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEESDGKLI EDSLIQLRCH FTWKLLIEAP EIPDLENRIW EEIQFLDTKY
60 70 80 90 100
NVGIHNLLAY VKHLKGQNEE ALVSLKKAED LIQKEHANQA DIRSLVTWGN
110 120 130 140 150
FAWVYYHMGR LAEAQTYLDK VENTCKKFAN PSRYRMECPE VDCEEGWALA
160 170 180 190 200
KCGGKNYERA KTCFEKALEG NPENPEFNTG YAITVYRLDK FNTASGRNKA
210 220 230 240 250
FSLHVLKRAV RLNPDDVYIR VLLALKLQDE GQEAEGEKYI EEALTSISSQ
260 270 280 290 300
AYVFQYAAKF YRRKGSVDKA LELLKMALET TPTSAFLHHQ MGLCYRAQMI
310 320 330 340 350
QIKEATNWQP RGQDRETVDR LVQLAICKFE KTIMLKRTFE MAYVDLAETY
360 370 380 390 400
AEIGHHRKAE EHFQKGLRMK IFEDQLKQEI HYHYGRFQEH HGKSQDKAIT
410 420 430 440 450
HYLKGLKIEK MSHSREKLLN ALEKLAKRCI HQNVRVVESV SLLGLIHKLK
460 470
GEVSDALLCY ERALRLAADL NPIF
Length:474
Mass (Da):54,993
Last modified:December 21, 2004 - v1
Checksum:i163BB9DCFFCEF8DE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti188 – 1881L → P.
Corresponds to variant rs7072728 [ dbSNP | Ensembl ].
VAR_052617

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353751 Genomic DNA. Translation: CAI12242.1.
CH471066 Genomic DNA. Translation: EAW50139.1.
BC137368 mRNA. Translation: AAI37369.1.
BC137369 mRNA. Translation: AAI37370.1.
BC150189 mRNA. Translation: AAI50190.1.
CCDSiCCDS31242.1.
RefSeqiNP_001010987.1. NM_001010987.2.
UniGeneiHs.500491.

Genome annotation databases

EnsembliENST00000371809; ENSP00000360874; ENSG00000204010.
GeneIDi439996.
KEGGihsa:439996.
UCSCiuc001kgh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353751 Genomic DNA. Translation: CAI12242.1.
CH471066 Genomic DNA. Translation: EAW50139.1.
BC137368 mRNA. Translation: AAI37369.1.
BC137369 mRNA. Translation: AAI37370.1.
BC150189 mRNA. Translation: AAI50190.1.
CCDSiCCDS31242.1.
RefSeqiNP_001010987.1. NM_001010987.2.
UniGeneiHs.500491.

3D structure databases

ProteinModelPortaliQ5T764.
SMRiQ5T764. Positions 10-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136196. 6 interactions.
IntActiQ5T764. 2 interactions.
STRINGi9606.ENSP00000360874.

PTM databases

iPTMnetiQ5T764.
PhosphoSiteiQ5T764.

Polymorphism and mutation databases

BioMutaiIFIT1B.
DMDMi74762241.

Proteomic databases

EPDiQ5T764.
MaxQBiQ5T764.
PaxDbiQ5T764.
PRIDEiQ5T764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371809; ENSP00000360874; ENSG00000204010.
GeneIDi439996.
KEGGihsa:439996.
UCSCiuc001kgh.3. human.

Organism-specific databases

CTDi439996.
GeneCardsiIFIT1B.
HGNCiHGNC:23442. IFIT1B.
HPAiHPA062924.
neXtProtiNX_Q5T764.
PharmGKBiPA165548753.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000013876.
HOGENOMiHOG000001558.
HOVERGENiHBG066330.
InParanoidiQ5T764.
KOiK14217.
OMAiFEMAYVC.
OrthoDBiEOG71K62V.
PhylomeDBiQ5T764.
TreeFamiTF342671.

Miscellaneous databases

GenomeRNAii439996.
NextBioi108816.
PROiQ5T764.

Gene expression databases

BgeeiQ5T764.
CleanExiHS_IFIT1L.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiIFT1B_HUMAN
AccessioniPrimary (citable) accession number: Q5T764
Secondary accession number(s): A7E245
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.