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Protein

Late cornified envelope protein 1F

Gene

LCE1F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

Miscellaneous

Belongs to the LCE cluster present on 1q21.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 1F
Alternative name(s):
Late envelope protein 6
Gene namesi
Name:LCE1F
Synonyms:LEP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000240386.3.
HGNCiHGNC:29467. LCE1F.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000240386.
PharmGKBiPA134962947.

Polymorphism and mutation databases

BioMutaiLCE1F.
DMDMi74745324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002353291 – 118Late cornified envelope protein 1FAdd BLAST118

Proteomic databases

PaxDbiQ5T754.
PeptideAtlasiQ5T754.
PRIDEiQ5T754.

PTM databases

iPTMnetiQ5T754.
PhosphoSitePlusiQ5T754.

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta. Expression is observed in the fibroblasts.1 Publication

Inductioni

By UVB.1 Publication

Gene expression databases

BgeeiENSG00000240386.
CleanExiHS_LCE1F.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ5T754. 66 interactors.
STRINGi9606.ENSP00000334187.

Structurei

3D structure databases

ProteinModelPortaliQ5T754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 39Pro-richAdd BLAST28
Compositional biasi63 – 66Poly-Gly4
Compositional biasi71 – 74Poly-Gly4
Compositional biasi81 – 84Poly-Arg4

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

GeneTreeiENSGT00810000126956.
OMAiPRRSHHF.

Family and domain databases

InterProiView protein in InterPro
IPR028205. LCE.
IPR026075. SPRR/LCE.
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiView protein in Pfam
PF14672. LCE. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5T754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG
60 70 80 90 100
CCGSSSGGCC SSGGGGCCSS GGGGCCLSHH RRRRSHRHRP QSSDCCSQPS
110
AGSSCCGGGS GQHSGGCC
Length:118
Mass (Da):11,654
Last modified:December 21, 2004 - v1
Checksum:i4C937D67D53D2934
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353779 Genomic DNA. No translation available.
CCDSiCCDS1023.1.
RefSeqiNP_848131.1. NM_178354.2.
UniGeneiHs.553712.

Genome annotation databases

EnsembliENST00000334371; ENSP00000334187; ENSG00000240386.
GeneIDi353137.
KEGGihsa:353137.
UCSCiuc010pdv.3. human.

Similar proteinsi

Entry informationi

Entry nameiLCE1F_HUMAN
AccessioniPrimary (citable) accession number: Q5T754
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families