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Protein

Late cornified envelope protein 1E

Gene

LCE1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 1E
Alternative name(s):
Late envelope protein 5
Gene namesi
Name:LCE1E
Synonyms:LEP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29466. LCE1E.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866413.

Polymorphism and mutation databases

BioMutaiLCE1E.
DMDMi74745323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118Late cornified envelope protein 1EPRO_0000235328Add
BLAST

Proteomic databases

PaxDbiQ5T753.
PRIDEiQ5T753.

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Inductioni

By UVB.1 Publication

Gene expression databases

BgeeiQ5T753.
CleanExiHS_LCE1E.
ExpressionAtlasiQ5T753. baseline and differential.
GenevisibleiQ5T753. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357759.

Structurei

3D structure databases

ProteinModelPortaliQ5T753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 118116Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

GeneTreeiENSGT00810000126948.
OMAiQRSNCCS.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG
60 70 80 90 100
CCGSSSGGSC GSSSGGCCSS GGGGCCLSHH RHHRSHRHRP QSSDCCSQPS
110
GGSSCCGGGS GQHSGGCC
Length:118
Mass (Da):11,616
Last modified:December 21, 2004 - v1
Checksum:iA897B2577ADD89A9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591S → G.
Corresponds to variant rs11205106 [ dbSNP | Ensembl ].
VAR_060066
Natural varianti111 – 1111G → S.
Corresponds to variant rs56313719 [ dbSNP | Ensembl ].
VAR_062117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353779 Genomic DNA. Translation: CAI20980.1.
CH471121 Genomic DNA. Translation: EAW53366.1.
CH471121 Genomic DNA. Translation: EAW53367.1.
CCDSiCCDS1024.1.
RefSeqiNP_848130.1. NM_178353.1.
UniGeneiHs.250236.

Genome annotation databases

EnsembliENST00000368770; ENSP00000357759; ENSG00000186226.
ENST00000368771; ENSP00000357760; ENSG00000186226.
GeneIDi353135.
KEGGihsa:353135.
UCSCiuc001fan.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353779 Genomic DNA. Translation: CAI20980.1.
CH471121 Genomic DNA. Translation: EAW53366.1.
CH471121 Genomic DNA. Translation: EAW53367.1.
CCDSiCCDS1024.1.
RefSeqiNP_848130.1. NM_178353.1.
UniGeneiHs.250236.

3D structure databases

ProteinModelPortaliQ5T753.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357759.

Polymorphism and mutation databases

BioMutaiLCE1E.
DMDMi74745323.

Proteomic databases

PaxDbiQ5T753.
PRIDEiQ5T753.

Protocols and materials databases

DNASUi353135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368770; ENSP00000357759; ENSG00000186226.
ENST00000368771; ENSP00000357760; ENSG00000186226.
GeneIDi353135.
KEGGihsa:353135.
UCSCiuc001fan.4. human.

Organism-specific databases

CTDi353135.
GeneCardsiLCE1E.
H-InvDBHIX0028752.
HGNCiHGNC:29466. LCE1E.
MIMi612607. gene.
neXtProtiNX_Q5T753.
PharmGKBiPA134866413.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00810000126948.
OMAiQRSNCCS.

Miscellaneous databases

GenomeRNAii353135.
NextBioi99681.
PROiQ5T753.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T753.
CleanExiHS_LCE1E.
ExpressionAtlasiQ5T753. baseline and differential.
GenevisibleiQ5T753. HS.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Late cornified envelope family in differentiating epithelia --response to calcium and ultraviolet irradiation."
    Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G., Byrne C.
    J. Invest. Dermatol. 124:1062-1070(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION BY UVB.

Entry informationi

Entry nameiLCE1E_HUMAN
AccessioniPrimary (citable) accession number: Q5T753
Secondary accession number(s): D3DV30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: March 16, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Belongs to the LCE cluster present on 1q21.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.