Q5T752 (LCE1D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Late cornified envelope protein 1D

Alternative name(s):
Late envelope protein 4

Gene names

Name:	LCE1D
Synonyms:	LEP4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Precursors of the cornified envelope of the stratum corneum.
Tissue specificity	Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta. Ref.2
Induction	By UVB. Ref.2
Miscellaneous	Belongs to the LCE cluster present on 1q21.
Sequence similarities	Belongs to the LCE family.

Ontologies

Keywords
Biological process	Keratinization
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to calcium ion Inferred from direct assay PubMed 11698679. Source: MGI keratinization Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cornified envelope Inferred from direct assay PubMed 11698679. Source: MGI perinuclear region of cytoplasm Inferred from direct assay PubMed 11698679. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 114	114	Late cornified envelope protein 1D		PRO_0000235327
Regions
	Compositional bias	3 – 114	112	Cys-rich
Natural variations
	Natural variant	59	1	N → S. Corresponds to variant rs7527180 [ dbSNP | Ensembl ].		VAR_060065
	Natural variant	78	1	R → H. Corresponds to variant rs41268490 [ dbSNP | Ensembl ].		VAR_062116

Sequences

	Sequence		Length	Mass (Da)
	Q5T752 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 809EE3813C377446	FASTA	114	11,230
	10 20 30 40 50 60 MSCQQSQQQC QPPPKCTPKC TPKCPAPKCP PKCPPVSSCC SVSSGGCCGS SSGGGCGSNS 70 80 90 100 110 GGCCSSGGGG CCLSHHRRHR SHRRRPQSSD CCSQPSGGSS CCGGGSSQHS GGCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Late cornified envelope family in differentiating epithelia --response to calcium and ultraviolet irradiation." Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G., Byrne C. J. Invest. Dermatol. 124:1062-1070(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION BY UVB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL353779 Genomic DNA. Translation: CAI20981.1.
IPI	IPI00374333.
RefSeq	NP_848129.1. NM_178352.2.
UniGene	Hs.490235.
3D structure databases
ProteinModelPortal	Q5T752.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000316737.
Polymorphism databases
DMDM	74745322.
Proteomic databases
PaxDb	Q5T752.
PRIDE	Q5T752.
Protocols and materials databases
DNASU	353134.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326233; ENSP00000316737; ENSG00000172155.
GeneID	353134.
KEGG	hsa:353134.
UCSC	uc009wnp.3. human.
Organism-specific databases
CTD	353134.
GeneCards	GC01P152769.
HGNC	HGNC:29465. LCE1D.
MIM	612606. gene.
neXtProt	NX_Q5T752.
PharmGKB	PA134906518.
GenAtlas	Search...
Phylogenomic databases
OMA	GCCERSG.
Gene expression databases
Bgee	Q5T752.
CleanEx	HS_LCE1D.
Genevestigator	Q5T752.
GermOnline	ENSG00000172155. Homo sapiens.
Family and domain databases
InterPro	IPR026075. SPRR/LCE. [Graphical view]
PANTHER	PTHR23263. PTHR23263. 1 hit.
ProtoNet	Search...
Other
NextBio	99677.
SOURCE	Search...

Entry information

Entry name

LCE1D_HUMAN

Accession

Primary (citable) accession number: Q5T752

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.