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Protein

Late cornified envelope protein 1D

Gene

LCE1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

Miscellaneous

Belongs to the LCE cluster present on 1q21.

GO - Molecular functioni

GO - Biological processi

  • cellular response to calcium ion Source: MGI
  • cognition Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: GO_Central
  • peptide cross-linking Source: GO_Central

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 1D
Alternative name(s):
Late envelope protein 4
Gene namesi
Name:LCE1D
Synonyms:LEP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000172155.9.
HGNCiHGNC:29465. LCE1D.
MIMi612606. gene.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172155.
PharmGKBiPA134906518.

Polymorphism and mutation databases

BioMutaiLCE1D.
DMDMi74745322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002353271 – 114Late cornified envelope protein 1DAdd BLAST114

Proteomic databases

PaxDbiQ5T752.
PeptideAtlasiQ5T752.
PRIDEiQ5T752.

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Inductioni

By UVB.1 Publication

Gene expression databases

BgeeiENSG00000172155.
CleanExiHS_LCE1D.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ5T752. 53 interactors.
STRINGi9606.ENSP00000316737.

Structurei

3D structure databases

ProteinModelPortaliQ5T752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 114Cys-richAdd BLAST112

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000113489.
OMAiEGCCLSH.

Family and domain databases

InterProiView protein in InterPro
IPR028205. LCE.
IPR026075. SPRR/LCE.
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiView protein in Pfam
PF14672. LCE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5T752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQSQQQC QPPPKCTPKC TPKCPAPKCP PKCPPVSSCC SVSSGGCCGS
60 70 80 90 100
SSGGGCGSNS GGCCSSGGGG CCLSHHRRHR SHRRRPQSSD CCSQPSGGSS
110
CCGGGSSQHS GGCC
Length:114
Mass (Da):11,230
Last modified:December 21, 2004 - v1
Checksum:i809EE3813C377446
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06006559N → S. Corresponds to variant dbSNP:rs7527180Ensembl.1
Natural variantiVAR_06211678R → H. Corresponds to variant dbSNP:rs41268490Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353779 Genomic DNA. No translation available.
CCDSiCCDS1025.1.
RefSeqiNP_848129.1. NM_178352.2.
UniGeneiHs.490235.

Genome annotation databases

EnsembliENST00000326233; ENSP00000316737; ENSG00000172155.
GeneIDi353134.
KEGGihsa:353134.
UCSCiuc009wnp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLCE1D_HUMAN
AccessioniPrimary (citable) accession number: Q5T752
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families