Q5T750 (XP32_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Skin-specific protein 32

Gene names

Name:	XP32
Synonyms:	C1orf68

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed at high levels in normal and psoriatic skin, but not in normal keratinocytes, A-431 cells, or any of the other cell lines or tissues tested. Ref.3
Sequence caution	The sequence AAB83961.1 differs from that shown. Reason: Frameshift at position 241.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	epidermis development Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	Skin-specific protein 32		PRO_0000307808
Regions
	Compositional bias	33 – 250	218	Cys-rich
Natural variations
	Natural variant	26	1	S → T. Corresponds to variant rs1332500 [ dbSNP | Ensembl ].		VAR_059739
	Natural variant	159	1	T → P. Corresponds to variant rs873775 [ dbSNP | Ensembl ].		VAR_059740
	Natural variant	173	1	L → V. Corresponds to variant rs59194678 [ dbSNP | Ensembl ].		VAR_061726
Experimental info
	Sequence conflict	235	1	R → K in AAB83961. Ref.3
	Sequence conflict	238	1	G → S in AAB83961. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q5T750 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 098B586CCE67D6E3	FASTA	250	26,238
	10 20 30 40 50 60 MCDQQKQPQF PPSCVKGSGL GAGQGSNGAS VKCPVPCQTQ TVCVTGPAPC PTQTYVKYQV 70 80 90 100 110 120 PCQTQTYVKC PAPCQRTYVK YPTPCQTYVK CPAPCQTTYV KCPTPCQTYV KCPAPCQMTY 130 140 150 160 170 180 IKSPAPCQTQ TCYVQGASPC QSYYVQAPAS GSTSQYCVTD PCSAPCSTSY CCLAPRTFGV 190 200 210 220 230 240 SPLRRWIQRP QNCNTGSSGC CENSGSSGCC GSGGCGCSCG CGSSGCCCLG IIPMRSRGPA 250 CCDHEDDCCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Positional cloning of novel skin-specific genes from the human epidermal differentiation complex." Zhao X.P., Elder J.T. Genomics 45:250-258(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-250, TISSUE SPECIFICITY. Tissue: Skin.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL353779 Genomic DNA. Translation: CAI20975.1. CH471121 Genomic DNA. Translation: EAW53369.1. AF005081 mRNA. Translation: AAB83961.1. Frameshift.
IPI	IPI00023078.
RefSeq	NP_001019850.1. NM_001024679.2.
UniGene	Hs.601077.
3D structure databases
ProteinModelPortal	Q5T750.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5T750. 1 interaction.
STRING	9606.ENSP00000354769.
Polymorphism databases
DMDM	74745320.
Proteomic databases
PaxDb	Q5T750.
PRIDE	Q5T750.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000362017; ENSP00000354769; ENSG00000198854. ENST00000368775; ENSP00000357764; ENSG00000198854.
GeneID	100129271.
KEGG	hsa:100129271.
UCSC	uc010pdu.2. human.
Organism-specific databases
CTD	100129271.
GeneCards	GC01P152691.
H-InvDB	HIX0200014.
HGNC	HGNC:29468. C1orf68.
HPA	HPA040836.
neXtProt	NX_Q5T750.
PharmGKB	PA142672518.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG123992.
HOGENOM	HOG000154874.
InParanoid	Q5T750.
OMA	VKCPPPC.
OrthoDB	EOG4G4GR8.
Gene expression databases
Bgee	Q5T750.
CleanEx	HS_C1orf68.
Genevestigator	Q5T750.
Family and domain databases
InterPro	IPR026078. Skin_specific_32. IPR026075. SPRR/LCE. [Graphical view]
PANTHER	PTHR23263. PTHR23263. 1 hit. PTHR23263:SF4. PTHR23263:SF4. 1 hit.
ProtoNet	Search...
Other
NextBio	20789195.

Entry information

Entry name

XP32_HUMAN

Accession

Primary (citable) accession number: Q5T750
Secondary accession number(s): O14634

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.