Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratinocyte proline-rich protein

Gene

KPRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Keratinocyte proline-rich protein
Short name:
hKPRP
Gene namesi
Name:KPRP
Synonyms:C1orf45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000203786.6.
HGNCiHGNC:31823. KPRP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi448834.
OpenTargetsiENSG00000203786.
PharmGKBiPA162393640.

Polymorphism and mutation databases

BioMutaiKPRP.
DMDMi74745319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710081 – 579Keratinocyte proline-rich proteinAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei394PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5T749.
PaxDbiQ5T749.
PeptideAtlasiQ5T749.
PRIDEiQ5T749.

PTM databases

iPTMnetiQ5T749.
PhosphoSitePlusiQ5T749.

Expressioni

Tissue specificityi

Expressed in the upper layer of epidermis and psoriasis (at protein level). Expressed in the upper layer of epidermis and psoriasis.1 Publication

Developmental stagei

Expressed in the periderm of fetal skin from 16th week gestational age and in the granular and horny layers of the epidermis at 24th week gestational age and thereafter (at protein level).1 Publication

Inductioni

By calcium and in psoriatic lesions.1 Publication

Gene expression databases

BgeeiENSG00000203786.
CleanExiHS_KPRP.

Organism-specific databases

HPAiHPA031988.
HPA031990.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi138665. 28 interactors.
IntActiQ5T749. 102 interactors.
STRINGi9606.ENSP00000357762.

Structurei

3D structure databases

ProteinModelPortaliQ5T749.
SMRiQ5T749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 209Gln-richAdd BLAST206
Compositional biasi257 – 510Pro-richAdd BLAST254

Phylogenomic databases

eggNOGiENOG410J21S. Eukaryota.
ENOG410XY8H. LUCA.
GeneTreeiENSGT00730000111554.
HOGENOMiHOG000113243.
HOVERGENiHBG081862.
InParanoidiQ5T749.
OMAiYTETCYV.
OrthoDBiEOG091G0LDF.
PhylomeDBiQ5T749.
TreeFamiTF351578.

Family and domain databases

InterProiView protein in InterPro
IPR033193. KPRP.
PANTHERiPTHR12241:SF98. PTHR12241:SF98. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5T749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDQQQIQCR LPLQQCCVKG PSFCSSQSPF AQSQVVVQAP CEMQIVDCPA
60 70 80 90 100
SCPVQVCQVS DQAPCQSQTT QVKCQSKTKQ VKGQAQCQSK TTQVKGQAAS
110 120 130 140 150
QSQTSSVQSQ APCQSEVSYV QCEASQPVQT CFVECAPVCY TETCYVECPV
160 170 180 190 200
QNYVPCPAPQ PVQMYRGRPA VCQPQGRFST QCQYQGSYSS CGPQFQSRAT
210 220 230 240 250
CNNYTPQFQL RPSYSSCFPQ YRSRTSFSPC VPQCQTQGSY GSFTEQHRSR
260 270 280 290 300
STSRCLPPPR RLQLFPRSCS PPRRFEPCSS SYLPLRPSEG FPNYCTPPRR
310 320 330 340 350
SEPIYNSRCP RRPISSCSQR RGPKCRIEIS SPCCPRQVPP QRCPVEIPPI
360 370 380 390 400
RRRSQSCGPQ PSWGASCPEL RPHVEPRPLP SFCPPRRLDQ CPESPLQRCP
410 420 430 440 450
PPAPRPRLRP EPCISLEPRP RPLPRQLSEP CLYPEPLPAL RPTPRPVPLP
460 470 480 490 500
RPGQCEIPEP RPCLQPCEHP EPCPRPEPIP LPAPCPSPEP CRETWRSPSP
510 520 530 540 550
CWGPNPVPYP GDLGCHESSP HRLDTEAPYC GPSSYNQGQE SGAGCGPGDV
560 570
FPERRGQDGH GDQGNAFAGV KGEAKSAYF
Length:579
Mass (Da):64,136
Last modified:December 21, 2004 - v1
Checksum:iAB29AE2276D15A04
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02984014Q → H. Corresponds to variant dbSNP:rs17612167Ensembl.1
Natural variantiVAR_02984137V → A. Corresponds to variant dbSNP:rs944683Ensembl.1
Natural variantiVAR_029842113C → R. Corresponds to variant dbSNP:rs16834457Ensembl.1
Natural variantiVAR_029843168R → H. Corresponds to variant dbSNP:rs16834461Ensembl.1
Natural variantiVAR_029844413C → S. Corresponds to variant dbSNP:rs4329520Ensembl.1
Natural variantiVAR_029845532P → T. Corresponds to variant dbSNP:rs6703294Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY960854 mRNA. Translation: AAX59055.1.
AL353779 Genomic DNA. No translation available.
CCDSiCCDS30862.1.
RefSeqiNP_001020402.1. NM_001025231.1.
XP_011507873.1. XM_011509571.1.
UniGeneiHs.149386.

Genome annotation databases

EnsembliENST00000606109; ENSP00000475216; ENSG00000203786.
GeneIDi448834.
KEGGihsa:448834.
UCSCiuc057lai.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKPRP_HUMAN
AccessioniPrimary (citable) accession number: Q5T749
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot