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Protein

Low-density lipoprotein receptor class A domain-containing protein 1

Gene

LDLRAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor class A domain-containing protein 1
Gene namesi
Name:LDLRAD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32069. LDLRAD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671554.

Polymorphism and mutation databases

DMDMi74745299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Low-density lipoprotein receptor class A domain-containing protein 1PRO_0000299376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 ↔ 89PROSITE-ProRule annotation
Disulfide bondi83 ↔ 102PROSITE-ProRule annotation
Disulfide bondi96 ↔ 113PROSITE-ProRule annotation
Disulfide bondi141 ↔ 160PROSITE-ProRule annotation
Disulfide bondi163 ↔ 180PROSITE-ProRule annotation
Disulfide bondi170 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Lipoprotein

Proteomic databases

PaxDbiQ5T700.
PRIDEiQ5T700.

Expressioni

Gene expression databases

BgeeiQ5T700.
CleanExiHS_LDLRAD1.

Organism-specific databases

HPAiHPA052489.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADGRG7Q96K783EBI-10173166,EBI-10290200
BNIP3Q129833EBI-10173166,EBI-749464
BNIP3LO602383EBI-10173166,EBI-849893
GIMAP5Q96F153EBI-10173166,EBI-6166686
LAPTM5Q135713EBI-10173166,EBI-2865663
MALP211453EBI-10173166,EBI-3932027
MALLQ130213EBI-10173166,EBI-750078
MARCH2Q9P0N83EBI-10173166,EBI-10317612
OLFM4Q6UX063EBI-10173166,EBI-2804156
PTTG1IPP538013EBI-10173166,EBI-3906138
SLC1A1P430053EBI-10173166,EBI-745376
TMEM147Q9BVK83EBI-10173166,EBI-348587
TMEM190Q8WZ593EBI-10173166,EBI-10278423
TMEM218A2RU143EBI-10173166,EBI-10173151
VTI1BQ9UEU03EBI-10173166,EBI-723716

Protein-protein interaction databases

BioGridi132783. 16 interactions.
IntActiQ5T700. 15 interactions.
STRINGi9606.ENSP00000360411.

Structurei

3D structure databases

ProteinModelPortaliQ5T700.
SMRiQ5T700. Positions 35-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 11444LDL-receptor class A 1PROSITE-ProRule annotationAdd
BLAST
Domaini115 – 16147LDL-receptor class A 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Domaini162 – 20342LDL-receptor class A 3; atypicalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the LDLR family.Curated
Contains 3 LDL-receptor class A domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXG1. Eukaryota.
ENOG410YIDU. LUCA.
GeneTreeiENSGT00390000008557.
HOGENOMiHOG000113361.
HOVERGENiHBG106620.
InParanoidiQ5T700.
OMAiEYSCPGP.
OrthoDBiEOG789CCR.
PhylomeDBiQ5T700.
TreeFamiTF343451.

Family and domain databases

Gene3Di4.10.400.10. 2 hits.
InterProiIPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00192. LDLa. 3 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 2 hits.
PROSITEiPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T700-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKVFPQGEN GYTAAESKAH PGGEAGGGHL CCSRRGACLS ASLLLLLATV
60 70 80 90 100
AALIALVTIL GLPSCTPGAQ ACITLTNRTG FLCHDQRSCI PASGVCDGVR
110 120 130 140 150
TCTHGEDEDE SLCRDVPQSL PHFLVAHCGD PASWIYSDQK CDGTNNCGDC
160 170 180 190 200
SDELSPVTVC PPCGPGWWRC PSTFFKYCDC IPRHLCRDHV QHCSDWSDEY

ACPGP
Length:205
Mass (Da):21,834
Last modified:December 21, 2004 - v1
Checksum:i49CF4F64F9EC6C9A
GO
Isoform 2 (identifier: Q5T700-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MNKVFPQGEN...VTILGLPSCT → MQGTRAELSAHSPSRAAGNRRHEQGLP

Show »
Length:166
Mass (Da):18,166
Checksum:i6580B3D296EC7BB6
GO
Isoform 3 (identifier: Q5T700-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-114: AGGGHLCCSR...GEDEDESLCR → G

Show »
Length:116
Mass (Da):12,721
Checksum:i2EC3AED3E5BDFC90
GO
Isoform 4 (identifier: Q5T700-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-67: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):17,674
Checksum:iABC08174AA5ABF6F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6666MNKVF…LPSCT → MQGTRAELSAHSPSRAAGNR RHEQGLP in isoform 2. 1 PublicationVSP_027617Add
BLAST
Alternative sequencei25 – 11490AGGGH…ESLCR → G in isoform 3. 1 PublicationVSP_027618Add
BLAST
Alternative sequencei25 – 6743Missing in isoform 4. 1 PublicationVSP_054532Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353898 Genomic DNA. Translation: CAI22661.1.
AL353898 Genomic DNA. Translation: CAI22662.1.
BC103740 mRNA. No translation available.
BC127708 mRNA. Translation: AAI27709.1.
BC127709 mRNA. Translation: AAI27710.1.
BC140760 mRNA. Translation: AAI40761.1.
BC144466 mRNA. Translation: AAI44467.1.
CCDSiCCDS30725.1. [Q5T700-1]
CCDS60145.1. [Q5T700-3]
CCDS60146.1. [Q5T700-4]
CCDS60147.1. [Q5T700-2]
RefSeqiNP_001010978.2. NM_001010978.3. [Q5T700-1]
NP_001263321.1. NM_001276392.1. [Q5T700-2]
NP_001263322.1. NM_001276393.1. [Q5T700-4]
NP_001263323.1. NM_001276394.1. [Q5T700-3]
UniGeneiHs.439583.

Genome annotation databases

EnsembliENST00000371360; ENSP00000360411; ENSG00000203985. [Q5T700-1]
ENST00000371362; ENSP00000360413; ENSG00000203985. [Q5T700-3]
ENST00000420619; ENSP00000411017; ENSG00000203985. [Q5T700-2]
ENST00000545928; ENSP00000445871; ENSG00000203985. [Q5T700-4]
GeneIDi388633.
KEGGihsa:388633.
UCSCiuc001cwm.3. human. [Q5T700-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353898 Genomic DNA. Translation: CAI22661.1.
AL353898 Genomic DNA. Translation: CAI22662.1.
BC103740 mRNA. No translation available.
BC127708 mRNA. Translation: AAI27709.1.
BC127709 mRNA. Translation: AAI27710.1.
BC140760 mRNA. Translation: AAI40761.1.
BC144466 mRNA. Translation: AAI44467.1.
CCDSiCCDS30725.1. [Q5T700-1]
CCDS60145.1. [Q5T700-3]
CCDS60146.1. [Q5T700-4]
CCDS60147.1. [Q5T700-2]
RefSeqiNP_001010978.2. NM_001010978.3. [Q5T700-1]
NP_001263321.1. NM_001276392.1. [Q5T700-2]
NP_001263322.1. NM_001276393.1. [Q5T700-4]
NP_001263323.1. NM_001276394.1. [Q5T700-3]
UniGeneiHs.439583.

3D structure databases

ProteinModelPortaliQ5T700.
SMRiQ5T700. Positions 35-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132783. 16 interactions.
IntActiQ5T700. 15 interactions.
STRINGi9606.ENSP00000360411.

Polymorphism and mutation databases

DMDMi74745299.

Proteomic databases

PaxDbiQ5T700.
PRIDEiQ5T700.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371360; ENSP00000360411; ENSG00000203985. [Q5T700-1]
ENST00000371362; ENSP00000360413; ENSG00000203985. [Q5T700-3]
ENST00000420619; ENSP00000411017; ENSG00000203985. [Q5T700-2]
ENST00000545928; ENSP00000445871; ENSG00000203985. [Q5T700-4]
GeneIDi388633.
KEGGihsa:388633.
UCSCiuc001cwm.3. human. [Q5T700-1]

Organism-specific databases

CTDi388633.
GeneCardsiLDLRAD1.
HGNCiHGNC:32069. LDLRAD1.
HPAiHPA052489.
neXtProtiNX_Q5T700.
PharmGKBiPA142671554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXG1. Eukaryota.
ENOG410YIDU. LUCA.
GeneTreeiENSGT00390000008557.
HOGENOMiHOG000113361.
HOVERGENiHBG106620.
InParanoidiQ5T700.
OMAiEYSCPGP.
OrthoDBiEOG789CCR.
PhylomeDBiQ5T700.
TreeFamiTF343451.

Miscellaneous databases

GenomeRNAii388633.
PROiQ5T700.

Gene expression databases

BgeeiQ5T700.
CleanExiHS_LDLRAD1.

Family and domain databases

Gene3Di4.10.400.10. 2 hits.
InterProiIPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00192. LDLa. 3 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 2 hits.
PROSITEiPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Tissue: Lung.

Entry informationi

Entry nameiLRAD1_HUMAN
AccessioniPrimary (citable) accession number: Q5T700
Secondary accession number(s): A0PJY0, B7ZME3, Q5T6Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.