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Q5T6V5

- CI064_HUMAN

UniProt

Q5T6V5 - CI064_HUMAN

Protein

UPF0553 protein C9orf64

Gene

C9orf64

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0553 protein C9orf64
    Gene namesi
    Name:C9orf64
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:28144. C9orf64.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134865965.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341UPF0553 protein C9orf64PRO_0000089700Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ5T6V5.
    PaxDbiQ5T6V5.
    PRIDEiQ5T6V5.

    PTM databases

    PhosphoSiteiQ5T6V5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5T6V5.
    BgeeiQ5T6V5.
    CleanExiHS_C9orf64.
    GenevestigatoriQ5T6V5.

    Organism-specific databases

    HPAiHPA054903.

    Interactioni

    Protein-protein interaction databases

    BioGridi123994. 2 interactions.
    STRINGi9606.ENSP00000365522.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T6V5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0553 family.Curated

    Phylogenomic databases

    eggNOGiNOG241762.
    HOGENOMiHOG000010664.
    HOVERGENiHBG054936.
    InParanoidiQ5T6V5.
    OMAiFSFWSEL.
    OrthoDBiEOG7CK379.
    PhylomeDBiQ5T6V5.
    TreeFamiTF105811.

    Family and domain databases

    InterProiIPR019438. DUF2419.
    [Graphical view]
    PANTHERiPTHR21314. PTHR21314. 1 hit.
    PfamiPF10343. DUF2419. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5T6V5-1 [UniParc]FASTAAdd to Basket

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    MDGLLNPRES SKFIAENSRD VFIDSGGVRR VAELLLAKAA GPELRVEGWK    50
    ALHELNPRAA DEAAVNWVFV TDTLNFSFWS EQDEHKCVVR YRGKTYSGYW 100
    SLCAAVNRAL DEGIPITSAS YYATVTLDQV RNILRSDTDV SMPLVEERHR 150
    ILNETGKILL EKFGGSFLNC VRESENSAQK LMHLVVESFP SYRDVTLFEG 200
    KRVSFYKRAQ ILVADTWSVL EGKGDGCFKD ISSITMFADY RLPQVLAHLG 250
    ALKYSDDLLK KLLKGEMLSY GDRQEVEIRG CSLWCVELIR DCLLELIEQK 300
    GEKPNGEINS ILLDYYLWDY AHDHREDMKG IPFHRIRCIY Y 341
    Length:341
    Mass (Da):39,029
    Last modified:December 21, 2004 - v1
    Checksum:i50AF5A7D7197D7B2
    GO

    Sequence cautioni

    The sequence BAC03538.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti324 – 3241H → Y in BAC03538. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL354733 Genomic DNA. Translation: CAI16017.1.
    CH471089 Genomic DNA. Translation: EAW62673.1.
    BC137461 mRNA. Translation: AAI37462.1.
    BC137462 mRNA. Translation: AAI37463.1.
    BC004407 mRNA. No translation available.
    AK090882 mRNA. Translation: BAC03538.1. Different initiation.
    CCDSiCCDS6666.2.
    RefSeqiNP_115683.3. NM_032307.3.
    UniGeneiHs.208914.

    Genome annotation databases

    EnsembliENST00000376344; ENSP00000365522; ENSG00000165118.
    GeneIDi84267.
    KEGGihsa:84267.
    UCSCiuc004anb.3. human.

    Polymorphism databases

    DMDMi73620030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL354733 Genomic DNA. Translation: CAI16017.1 .
    CH471089 Genomic DNA. Translation: EAW62673.1 .
    BC137461 mRNA. Translation: AAI37462.1 .
    BC137462 mRNA. Translation: AAI37463.1 .
    BC004407 mRNA. No translation available.
    AK090882 mRNA. Translation: BAC03538.1 . Different initiation.
    CCDSi CCDS6666.2.
    RefSeqi NP_115683.3. NM_032307.3.
    UniGenei Hs.208914.

    3D structure databases

    ProteinModelPortali Q5T6V5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123994. 2 interactions.
    STRINGi 9606.ENSP00000365522.

    PTM databases

    PhosphoSitei Q5T6V5.

    Polymorphism databases

    DMDMi 73620030.

    Proteomic databases

    MaxQBi Q5T6V5.
    PaxDbi Q5T6V5.
    PRIDEi Q5T6V5.

    Protocols and materials databases

    DNASUi 84267.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376344 ; ENSP00000365522 ; ENSG00000165118 .
    GeneIDi 84267.
    KEGGi hsa:84267.
    UCSCi uc004anb.3. human.

    Organism-specific databases

    CTDi 84267.
    GeneCardsi GC09M086553.
    HGNCi HGNC:28144. C9orf64.
    HPAi HPA054903.
    MIMi 611342. gene.
    neXtProti NX_Q5T6V5.
    PharmGKBi PA134865965.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241762.
    HOGENOMi HOG000010664.
    HOVERGENi HBG054936.
    InParanoidi Q5T6V5.
    OMAi FSFWSEL.
    OrthoDBi EOG7CK379.
    PhylomeDBi Q5T6V5.
    TreeFami TF105811.

    Miscellaneous databases

    GeneWikii C9orf64.
    GenomeRNAii 84267.
    NextBioi 73816.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5T6V5.
    Bgeei Q5T6V5.
    CleanExi HS_C9orf64.
    Genevestigatori Q5T6V5.

    Family and domain databases

    InterProi IPR019438. DUF2419.
    [Graphical view ]
    PANTHERi PTHR21314. PTHR21314. 1 hit.
    Pfami PF10343. DUF2419. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Placenta.
    4. Bienvenut W.V., Glen H., Frame M.C.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 31-38; 136-148 AND 163-172, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Osteosarcoma.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-341.
      Tissue: Amygdala.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCI064_HUMAN
    AccessioniPrimary (citable) accession number: Q5T6V5
    Secondary accession number(s): B2RPI6, Q8N2B1, Q9BT18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    4. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3