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Q5T6N4

- Q5T6N4_HUMAN

UniProt

Q5T6N4 - Q5T6N4_HUMAN

Protein
Submitted name:

Actin-binding LIM protein 1

Gene

ABLIM1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cytoskeleton organization Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Actin-binding LIM protein 1Imported
    Gene namesi
    Name:ABLIM1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:78. ABLIM1.

    PTM / Processingi

    Proteomic databases

    PRIDEiQ5T6N4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T6N4.
    SMRiQ5T6N4. Positions 110-344, 782-846.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 4 LIM zinc-binding domains.UniRule annotation

    Keywords - Domaini

    LIM domainUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000285997.
    HOVERGENiHBG031499.

    Family and domain databases

    Gene3Di1.10.950.10. 1 hit.
    2.10.110.10. 4 hits.
    InterProiIPR028448. ABLIM1.
    IPR003128. Villin_headpiece.
    IPR001781. Znf_LIM.
    [Graphical view]
    PANTHERiPTHR24213:SF18. PTHR24213:SF18. 1 hit.
    PfamiPF00412. LIM. 4 hits.
    PF02209. VHP. 1 hit.
    [Graphical view]
    SMARTiSM00132. LIM. 4 hits.
    SM00153. VHP. 1 hit.
    [Graphical view]
    SUPFAMiSSF47050. SSF47050. 1 hit.
    PROSITEiPS51089. HP. 1 hit.
    PS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5T6N4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAFLGLKCL GKLCSSEKSK VTSSERTSAR GSNRKRLIVE DRRVSGTSFT    50
    AHRRATITHL LYLCPKDYCP RGRVCNSVDP FVAHPQDPHH PSEKPVIHCH 100
    KCGEPCKGEV LRVQTKHFHI KCFTCKVCGC DLAQGGFFIK NGEYLCTLDY 150
    QRMYGTRCHG CGEFVEGEVV TALGKTYHPN CFACTICKRP FPPGDRVTFN 200
    GRDCLCQLCA QPMSSSPKET TFSSNCAGCG RDIKNGQALL ALDKQWHLGC 250
    FKCKSCGKVL TGEYISKDGA PYCEKDYQGL FGVKCEACHQ FITGKVLEAG 300
    DKHYHPSCAR CSRCNQMFTE GEEMYLQGST VWHPDCKQST KTEEKLRLPN 350
    IRRSSSDFFY SKSLIRRTGR SPSLQPTRTS SESIYSRPGS SIPGSPGHTI 400
    YAKVDNEILD YKDLAAIPKV KAIYDIERPD LITYEPFYTS GYDDKQERQS 450
    LGESPRTLSP TPSAEGYQDV RDRMIHRSTS QGSINSPVYS RHSYTPTTSR 500
    SPQHFHRPEL LSPGVQRLSY LRTSSLSPTH SDSRPNPPFR HHFIPHIKGN 550
    EPSSGRNSPL PYRPDSRPLT PTYAQAPKHF HVPDQGINIY RKPPIYKQHA 600
    ALAAQSKSSE DIIKFSKFPA AQAPDPSETP KIETDHWPGP PSFAVVGPDM 650
    KRRSSGREED DEELLRRRQL QEEQLMKLNS GLGQLILKEE MEKESRERSS 700
    LLASRYDSPI NSASHIPSSK TASLPGYGRN GLHRPVSTDF AQYNSYGDVS 750
    GGVRDYQTLP DGHMPAMRMD RGVSMPNMLE PKIFPYEMLM VTNRGRNKIL 800
    REVDRTRLER HLAPEVFREI FGMSIQEFDR LPLWRRNDMK KKAKLF 846
    Length:846
    Mass (Da):95,527
    Last modified:December 21, 2004 - v1
    Checksum:iEA300E3C7DBD4DCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133384 Genomic DNA. No translation available.
    AL354873 Genomic DNA. No translation available.
    AL590109 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000277895; ENSP00000277895; ENSG00000099204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133384 Genomic DNA. No translation available.
    AL354873 Genomic DNA. No translation available.
    AL590109 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali Q5T6N4.
    SMRi Q5T6N4. Positions 110-344, 782-846.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5T6N4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000277895 ; ENSP00000277895 ; ENSG00000099204 .

    Organism-specific databases

    HGNCi HGNC:78. ABLIM1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000285997.
    HOVERGENi HBG031499.

    Miscellaneous databases

    ChiTaRSi ABLIM1. human.
    NextBioi 35539780.

    Family and domain databases

    Gene3Di 1.10.950.10. 1 hit.
    2.10.110.10. 4 hits.
    InterProi IPR028448. ABLIM1.
    IPR003128. Villin_headpiece.
    IPR001781. Znf_LIM.
    [Graphical view ]
    PANTHERi PTHR24213:SF18. PTHR24213:SF18. 1 hit.
    Pfami PF00412. LIM. 4 hits.
    PF02209. VHP. 1 hit.
    [Graphical view ]
    SMARTi SM00132. LIM. 4 hits.
    SM00153. VHP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47050. SSF47050. 1 hit.
    PROSITEi PS51089. HP. 1 hit.
    PS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ5T6N4_HUMAN
    AccessioniPrimary (citable) accession number: Q5T6N4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3