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Q5T6N2

- Q5T6N2_HUMAN

UniProt

Q5T6N2 - Q5T6N2_HUMAN

Protein
Submitted name:

Actin-binding LIM protein 1

Gene

ABLIM1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (26 Jun 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Actin-binding LIM protein 1Imported
    Gene namesi
    Name:ABLIM1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:78. ABLIM1.

    PTM / Processingi

    Proteomic databases

    PRIDEiQ5T6N2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T6N2.
    SMRiQ5T6N2. Positions 50-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 4 LIM zinc-binding domains.UniRule annotation

    Keywords - Domaini

    LIM domainUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000285997.
    HOVERGENiHBG031499.

    Family and domain databases

    Gene3Di2.10.110.10. 4 hits.
    InterProiIPR028448. ABLIM1.
    IPR001781. Znf_LIM.
    [Graphical view]
    PANTHERiPTHR24213:SF18. PTHR24213:SF18. 1 hit.
    PfamiPF00412. LIM. 4 hits.
    [Graphical view]
    SMARTiSM00132. LIM. 4 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5T6N2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLMTLEMTEL TDPHHTMGDY KVAHPQDPHH PSEKPVIHCH KCGEPCKGEV    50
    LRVQTKHFHI KCFTCKVCGC DLAQGGFFIK NGEYLCTLDY QRMYGTRCHG 100
    CGEFVEGEVV TALGKTYHPN CFACTICKRP FPPGDRVTFN GRDCLCQLCA 150
    QPMSSSPKET TFSSNCAGCG RDIKNGQALL ALDKQWHLGC FKCKSCGKVL 200
    TGEYISKDGA PYCEKDYQGL FGVKCEACHQ FITGKVLEAG DKHYHPSCAR 250
    CSRCNQMFTE GEEMYLQGST VWHPDCKQST KTEEKLRLPN IRRSSSDFFY 300
    SKSLIRRTGR SPSLQPTRTS SESIYSRPGS SIPGSPGHTI YAKVDNEILD 350
    YKDLAAIPKV KAIYDIERPD LITYEPFYTS GYDDKQERQS LGESPRTLSP 400
    TPSAEGYQDV RDRMIHRSTS QGSINSPVYS RHSYTPTTSR SPQHFHRPGN 450
    EPSSGRNSPL PYRPDSRPLT PTYAQAPKHF HVPDQGINIY RKPPIYKQHD 500
    AAALAAQSKS SEDIIKFSKF PAAQAPDPSE TPKIETDHWP GPPSFAVVGP 550
    DMKRRSSGRE EDDEELLRRR QLQEEQLMKL NSGLGQLILK EEMEKESRER 600
    SSLLASRYDS PINSASHIPS SKTASLPGYG RNGLHRPVST DFAQYNSYGD 650
    VSGGVRDYQT LPDGHMPAMR MDRGVSMPNM LEPKIFPY 688
    Length:688
    Mass (Da):77,160
    Last modified:June 26, 2013 - v2
    Checksum:iF878BED793BCB981
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133384 Genomic DNA. No translation available.
    AL354873 Genomic DNA. No translation available.
    AL590109 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000369256; ENSP00000358260; ENSG00000099204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133384 Genomic DNA. No translation available.
    AL354873 Genomic DNA. No translation available.
    AL590109 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali Q5T6N2.
    SMRi Q5T6N2. Positions 50-284.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5T6N2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369256 ; ENSP00000358260 ; ENSG00000099204 .

    Organism-specific databases

    HGNCi HGNC:78. ABLIM1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000285997.
    HOVERGENi HBG031499.

    Miscellaneous databases

    ChiTaRSi ABLIM1. human.

    Family and domain databases

    Gene3Di 2.10.110.10. 4 hits.
    InterProi IPR028448. ABLIM1.
    IPR001781. Znf_LIM.
    [Graphical view ]
    PANTHERi PTHR24213:SF18. PTHR24213:SF18. 1 hit.
    Pfami PF00412. LIM. 4 hits.
    [Graphical view ]
    SMARTi SM00132. LIM. 4 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Ensembl
      Submitted (MAY-2013) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ5T6N2_HUMAN
    AccessioniPrimary (citable) accession number: Q5T6N2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3