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Q5T6N2

- Q5T6N2_HUMAN

UniProt

Q5T6N2 - Q5T6N2_HUMAN

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Protein
Submitted name:

Actin-binding LIM protein 1

Gene

ABLIM1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. cytoskeleton organization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Actin-binding LIM protein 1Imported
Submitted name:
cDNA FLJ16546 fis, clone PERIC2006443, highly similar to Homo sapiens actin binding LIM protein 1 (ABLIM1), transcript variant 3, mRNAImported
Gene namesi
Name:ABLIM1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:78. ABLIM1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35023.

PTM / Processingi

Proteomic databases

PRIDEiQ5T6N2.

Expressioni

Gene expression databases

ExpressionAtlasiQ5T6N2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5T6N2.
SMRiQ5T6N2. Positions 50-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 LIM zinc-binding domains.UniRule annotation

Keywords - Domaini

LIM domainUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119039.
HOGENOMiHOG000285997.
HOVERGENiHBG031499.
KOiK07520.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
2.10.110.10. 4 hits.
InterProiIPR028448. ABLIM1.
IPR003128. Villin_headpiece.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24213:SF18. PTHR24213:SF18. 1 hit.
PfamiPF00412. LIM. 4 hits.
PF02209. VHP. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T6N2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLMTLEMTEL TDPHHTMGDY KVAHPQDPHH PSEKPVIHCH KCGEPCKGEV
60 70 80 90 100
LRVQTKHFHI KCFTCKVCGC DLAQGGFFIK NGEYLCTLDY QRMYGTRCHG
110 120 130 140 150
CGEFVEGEVV TALGKTYHPN CFACTICKRP FPPGDRVTFN GRDCLCQLCA
160 170 180 190 200
QPMSSSPKET TFSSNCAGCG RDIKNGQALL ALDKQWHLGC FKCKSCGKVL
210 220 230 240 250
TGEYISKDGA PYCEKDYQGL FGVKCEACHQ FITGKVLEAG DKHYHPSCAR
260 270 280 290 300
CSRCNQMFTE GEEMYLQGST VWHPDCKQST KTEEKLRLPN IRRSSSDFFY
310 320 330 340 350
SKSLIRRTGR SPSLQPTRTS SESIYSRPGS SIPGSPGHTI YAKVDNEILD
360 370 380 390 400
YKDLAAIPKV KAIYDIERPD LITYEPFYTS GYDDKQERQS LGESPRTLSP
410 420 430 440 450
TPSAEGYQDV RDRMIHRSTS QGSINSPVYS RHSYTPTTSR SPQHFHRPGN
460 470 480 490 500
EPSSGRNSPL PYRPDSRPLT PTYAQAPKHF HVPDQGINIY RKPPIYKQHD
510 520 530 540 550
AAALAAQSKS SEDIIKFSKF PAAQAPDPSE TPKIETDHWP GPPSFAVVGP
560 570 580 590 600
DMKRRSSGRE EDDEELLRRR QLQEEQLMKL NSGLGQLILK EEMEKESRER
610 620 630 640 650
SSLLASRYDS PINSASHIPS SKTASLPGYG RNGLHRPVST DFAQYNSYGD
660 670 680 690 700
VSGGVRDYQT LPDGHMPAMR MDRGVSMPNM LEPKIFPYEM LMVTNRGRNK
710 720 730 740
ILREVDRTRL ERHLAPEVFR EIFGMSIQEF DRLPLWRRND MKKKAKLF
Length:748
Mass (Da):84,559
Last modified:October 29, 2014 - v3
Checksum:i363E71622011A691
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL133384 Genomic DNA. No translation available.
AL354873 Genomic DNA. No translation available.
AL590109 Genomic DNA. No translation available.
AK122891 mRNA. Translation: BAG53784.1.
RefSeqiNP_001003407.1. NM_001003407.1.
NP_001003408.1. NM_001003408.1.
NP_002304.3. NM_002313.5.
NP_006711.3. NM_006720.3.
XP_005269875.1. XM_005269818.1.
UniGeneiHs.438236.
Hs.538331.
Hs.593868.

Genome annotation databases

EnsembliENST00000369256; ENSP00000358260; ENSG00000099204.
GeneIDi3983.
KEGGihsa:3983.
UCSCiuc021pyy.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL133384 Genomic DNA. No translation available.
AL354873 Genomic DNA. No translation available.
AL590109 Genomic DNA. No translation available.
AK122891 mRNA. Translation: BAG53784.1 .
RefSeqi NP_001003407.1. NM_001003407.1.
NP_001003408.1. NM_001003408.1.
NP_002304.3. NM_002313.5.
NP_006711.3. NM_006720.3.
XP_005269875.1. XM_005269818.1.
UniGenei Hs.438236.
Hs.538331.
Hs.593868.

3D structure databases

ProteinModelPortali Q5T6N2.
SMRi Q5T6N2. Positions 50-284.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5T6N2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369256 ; ENSP00000358260 ; ENSG00000099204 .
GeneIDi 3983.
KEGGi hsa:3983.
UCSCi uc021pyy.1. human.

Organism-specific databases

CTDi 3983.
HGNCi HGNC:78. ABLIM1.
PharmGKBi PA35023.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119039.
HOGENOMi HOG000285997.
HOVERGENi HBG031499.
KOi K07520.

Miscellaneous databases

ChiTaRSi ABLIM1. human.
GenomeRNAii 3983.
NextBioi 15616.

Gene expression databases

ExpressionAtlasi Q5T6N2. baseline and differential.

Family and domain databases

Gene3Di 1.10.950.10. 1 hit.
2.10.110.10. 4 hits.
InterProi IPR028448. ABLIM1.
IPR003128. Villin_headpiece.
IPR001781. Znf_LIM.
[Graphical view ]
PANTHERi PTHR24213:SF18. PTHR24213:SF18. 1 hit.
Pfami PF00412. LIM. 4 hits.
PF02209. VHP. 1 hit.
[Graphical view ]
SMARTi SM00132. LIM. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view ]
SUPFAMi SSF47050. SSF47050. 1 hit.
PROSITEi PS51089. HP. 1 hit.
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PericardiumImported.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Ensembl
    Submitted (MAY-2013) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ5T6N2_HUMAN
AccessioniPrimary (citable) accession number: Q5T6N2
Secondary accession number(s): B3KVH2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: October 29, 2014
Last modified: October 29, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3