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Protein

Probable gluconokinase

Gene

IDNK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-gluconate = ADP + 6-phospho-D-gluconate.

Pathwayi: D-gluconate degradation

This protein is involved in the pathway D-gluconate degradation, which is part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the pathway D-gluconate degradation and in Carbohydrate acid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS14230-MONOMER
UniPathwayiUPA00792

Names & Taxonomyi

Protein namesi
Recommended name:
Probable gluconokinase (EC:2.7.1.12)
Alternative name(s):
Gluconate kinase
Gene namesi
Name:IDNK
Synonyms:C9orf103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148057.15
HGNCiHGNC:31367 IDNK
MIMi611343 gene
neXtProtiNX_Q5T6J7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148057
PharmGKBiPA134880846

Polymorphism and mutation databases

BioMutaiIDNK
DMDMi74745228

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003273701 – 187Probable gluconokinaseAdd BLAST187

Proteomic databases

MaxQBiQ5T6J7
PaxDbiQ5T6J7
PeptideAtlasiQ5T6J7
PRIDEiQ5T6J7
ProteomicsDBi64588
64589 [Q5T6J7-2]
64590 [Q5T6J7-3]

PTM databases

iPTMnetiQ5T6J7
PhosphoSitePlusiQ5T6J7

Expressioni

Gene expression databases

BgeeiENSG00000148057
CleanExiHS_C9orf103
ExpressionAtlasiQ5T6J7 baseline and differential
GenevisibleiQ5T6J7 HS

Organism-specific databases

HPAiHPA020378
HPA058429

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365601

Structurei

3D structure databases

ProteinModelPortaliQ5T6J7
SMRiQ5T6J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gluconokinase GntK/GntV family.Curated

Phylogenomic databases

eggNOGiKOG3354 Eukaryota
COG3265 LUCA
GeneTreeiENSGT00390000003364
HOGENOMiHOG000032567
HOVERGENiHBG107958
InParanoidiQ5T6J7
KOiK00851
OMAiARKGHFM
OrthoDBiEOG091G0P4F
PhylomeDBiQ5T6J7
TreeFamiTF315136

Family and domain databases

CDDicd02021 GntK, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR031322 Shikimate/glucono_kinase
IPR006001 Therm_gnt_kin
PfamiView protein in Pfam
PF01202 SKI, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01313 therm_gnt_kin, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T6J7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGALLVM GVSGSGKSTV GALLASELGW KFYDADDYHP EENRRKMGKG
60 70 80 90 100
IPLNDQDRIP WLCNLHDILL RDVASGQRVV LACSALKKTY RDILTQGKDG
110 120 130 140 150
VALKCEESGK EAKQAEMQLL VVHLSGSFEV ISGRLLKREG HFMPPELLQS
160 170 180
QFETLEPPAA PENFIQISVD KNVSEIIATI METLKMK
Length:187
Mass (Da):20,578
Last modified:December 21, 2004 - v1
Checksum:i3E95DDC781422BF5
GO
Isoform 2 (identifier: Q5T6J7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAAPGALLVMGVSGSGK → MKKPRPAAAA...PEQAAAGPRR

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):25,297
Checksum:iF14D598D616EA58B
GO
Isoform 3 (identifier: Q5T6J7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):15,699
Checksum:i4CD5B0CFCD0047C3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042433185K → T. Corresponds to variant dbSNP:rs1052690Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0327351 – 46Missing in isoform 3. CuratedAdd BLAST46
Alternative sequenceiVSP_0327361 – 17MAAPG…SGSGK → MKKPRPAAAAPSPRPPACSR GAHPGTASELRVPALRRGGC GDRRLREEAAPEQAAAGPRR in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY615889 mRNA Translation: AAT27441.1
AL354920 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62654.1
CH471089 Genomic DNA Translation: EAW62657.1
BC142991 mRNA Translation: AAI42992.1
CCDSiCCDS35048.2 [Q5T6J7-1]
CCDS59134.1 [Q5T6J7-3]
RefSeqiNP_001001551.2, NM_001001551.3 [Q5T6J7-1]
NP_001243844.1, NM_001256915.1 [Q5T6J7-3]
XP_006717173.1, XM_006717110.3 [Q5T6J7-2]
XP_016870213.1, XM_017014724.1 [Q5T6J7-3]
XP_016870214.1, XM_017014725.1
UniGeneiHs.530261

Genome annotation databases

EnsembliENST00000376419; ENSP00000365601; ENSG00000148057 [Q5T6J7-1]
ENST00000454393; ENSP00000403290; ENSG00000148057 [Q5T6J7-3]
GeneIDi414328
KEGGihsa:414328
UCSCiuc004amu.4 human [Q5T6J7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGNTK_HUMAN
AccessioniPrimary (citable) accession number: Q5T6J7
Secondary accession number(s): A5PLN6, Q5T6J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 21, 2004
Last modified: June 20, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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