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Q5T6J7

- GNTK_HUMAN

UniProt

Q5T6J7 - GNTK_HUMAN

Protein

Probable gluconokinase

Gene

IDNK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-gluconate = ADP + 6-phospho-D-gluconate.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. gluconokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00792.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable gluconokinase (EC:2.7.1.12)
    Alternative name(s):
    Gluconate kinase
    Gene namesi
    Name:IDNK
    Synonyms:C9orf103
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:31367. IDNK.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134880846.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 187187Probable gluconokinasePRO_0000327370Add
    BLAST

    Proteomic databases

    MaxQBiQ5T6J7.
    PaxDbiQ5T6J7.
    PRIDEiQ5T6J7.

    PTM databases

    PhosphoSiteiQ5T6J7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5T6J7.
    BgeeiQ5T6J7.
    CleanExiHS_C9orf103.
    GenevestigatoriQ5T6J7.

    Organism-specific databases

    HPAiHPA020378.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000277124.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T6J7.
    SMRiQ5T6J7. Positions 7-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gluconokinase GntK/GntV family.Curated

    Phylogenomic databases

    eggNOGiCOG3265.
    HOGENOMiHOG000032567.
    HOVERGENiHBG107958.
    InParanoidiQ5T6J7.
    OMAiRDGPERL.
    PhylomeDBiQ5T6J7.
    TreeFamiTF315136.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    IPR006001. Therm_gnt_kin.
    [Graphical view]
    PfamiPF01202. SKI. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01313. therm_gnt_kin. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T6J7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAPGALLVM GVSGSGKSTV GALLASELGW KFYDADDYHP EENRRKMGKG    50
    IPLNDQDRIP WLCNLHDILL RDVASGQRVV LACSALKKTY RDILTQGKDG 100
    VALKCEESGK EAKQAEMQLL VVHLSGSFEV ISGRLLKREG HFMPPELLQS 150
    QFETLEPPAA PENFIQISVD KNVSEIIATI METLKMK 187
    Length:187
    Mass (Da):20,578
    Last modified:December 21, 2004 - v1
    Checksum:i3E95DDC781422BF5
    GO
    Isoform 2 (identifier: Q5T6J7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: MAAPGALLVMGVSGSGK → MKKPRPAAAA...PEQAAAGPRR

    Note: No experimental confirmation available.

    Show »
    Length:230
    Mass (Da):25,297
    Checksum:iF14D598D616EA58B
    GO
    Isoform 3 (identifier: Q5T6J7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-46: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:141
    Mass (Da):15,699
    Checksum:i4CD5B0CFCD0047C3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti185 – 1851K → T.
    Corresponds to variant rs1052690 [ dbSNP | Ensembl ].
    VAR_042433

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4646Missing in isoform 3. CuratedVSP_032735Add
    BLAST
    Alternative sequencei1 – 1717MAAPG…SGSGK → MKKPRPAAAAPSPRPPACSR GAHPGTASELRVPALRRGGC GDRRLREEAAPEQAAAGPRR in isoform 2. 1 PublicationVSP_032736Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY615889 mRNA. Translation: AAT27441.1.
    AL354920 Genomic DNA. Translation: CAI15098.1.
    AL354920 Genomic DNA. Translation: CAI15099.1.
    CH471089 Genomic DNA. Translation: EAW62654.1.
    CH471089 Genomic DNA. Translation: EAW62657.1.
    BC142991 mRNA. Translation: AAI42992.1.
    CCDSiCCDS35048.2. [Q5T6J7-1]
    CCDS59134.1. [Q5T6J7-3]
    RefSeqiNP_001001551.2. NM_001001551.3. [Q5T6J7-1]
    NP_001243844.1. NM_001256915.1. [Q5T6J7-3]
    XP_006717173.1. XM_006717110.1. [Q5T6J7-2]
    UniGeneiHs.530261.

    Genome annotation databases

    EnsembliENST00000376419; ENSP00000365601; ENSG00000148057. [Q5T6J7-1]
    ENST00000454393; ENSP00000403290; ENSG00000148057. [Q5T6J7-2]
    GeneIDi414328.
    KEGGihsa:414328.
    UCSCiuc004amu.3. human. [Q5T6J7-1]

    Polymorphism databases

    DMDMi74745228.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY615889 mRNA. Translation: AAT27441.1 .
    AL354920 Genomic DNA. Translation: CAI15098.1 .
    AL354920 Genomic DNA. Translation: CAI15099.1 .
    CH471089 Genomic DNA. Translation: EAW62654.1 .
    CH471089 Genomic DNA. Translation: EAW62657.1 .
    BC142991 mRNA. Translation: AAI42992.1 .
    CCDSi CCDS35048.2. [Q5T6J7-1 ]
    CCDS59134.1. [Q5T6J7-3 ]
    RefSeqi NP_001001551.2. NM_001001551.3. [Q5T6J7-1 ]
    NP_001243844.1. NM_001256915.1. [Q5T6J7-3 ]
    XP_006717173.1. XM_006717110.1. [Q5T6J7-2 ]
    UniGenei Hs.530261.

    3D structure databases

    ProteinModelPortali Q5T6J7.
    SMRi Q5T6J7. Positions 7-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000277124.

    PTM databases

    PhosphoSitei Q5T6J7.

    Polymorphism databases

    DMDMi 74745228.

    Proteomic databases

    MaxQBi Q5T6J7.
    PaxDbi Q5T6J7.
    PRIDEi Q5T6J7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376419 ; ENSP00000365601 ; ENSG00000148057 . [Q5T6J7-1 ]
    ENST00000454393 ; ENSP00000403290 ; ENSG00000148057 . [Q5T6J7-2 ]
    GeneIDi 414328.
    KEGGi hsa:414328.
    UCSCi uc004amu.3. human. [Q5T6J7-1 ]

    Organism-specific databases

    CTDi 414328.
    GeneCardsi GC09P086238.
    HGNCi HGNC:31367. IDNK.
    HPAi HPA020378.
    MIMi 611343. gene.
    neXtProti NX_Q5T6J7.
    PharmGKBi PA134880846.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3265.
    HOGENOMi HOG000032567.
    HOVERGENi HBG107958.
    InParanoidi Q5T6J7.
    OMAi RDGPERL.
    PhylomeDBi Q5T6J7.
    TreeFami TF315136.

    Enzyme and pathway databases

    UniPathwayi UPA00792 .

    Miscellaneous databases

    GenomeRNAii 414328.
    NextBioi 108592.
    PROi Q5T6J7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5T6J7.
    Bgeei Q5T6J7.
    CleanExi HS_C9orf103.
    Genevestigatori Q5T6J7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    IPR006001. Therm_gnt_kin.
    [Graphical view ]
    Pfami PF01202. SKI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01313. therm_gnt_kin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia."
      Sweetser D.A., Peniket A.J., Haaland C., Blomberg A.A., Zhang Y., Zaidi S.T., Dayyani F., Zhao Z., Heerema N.A., Boultwood J., Dewald G.W., Paietta E., Slovak M.L., Willman C.L., Wainscoat J.S., Bernstein I.D., Daly S.B.
      Genes Chromosomes Cancer 44:279-291(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiGNTK_HUMAN
    AccessioniPrimary (citable) accession number: Q5T6J7
    Secondary accession number(s): A5PLN6, Q5T6J6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3