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Q5T6J7 (GNTK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable gluconokinase

EC=2.7.1.12
Alternative name(s):
Gluconate kinase
Gene names
Name:IDNK
Synonyms:C9orf103
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + D-gluconate = ADP + 6-phospho-D-gluconate.

Pathway

Carbohydrate acid metabolism; D-gluconate degradation.

Sequence similarities

Belongs to the gluconokinase GntK/GntV family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processD-gluconate catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

gluconokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5T6J7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5T6J7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAAPGALLVMGVSGSGK → MKKPRPAAAA...PEQAAAGPRR
Note: No experimental confirmation available.
Isoform 3 (identifier: Q5T6J7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 187187Probable gluconokinase
PRO_0000327370

Regions

Nucleotide binding11 – 188ATP Potential

Natural variations

Alternative sequence1 – 4646Missing in isoform 3.
VSP_032735
Alternative sequence1 – 1717MAAPG…SGSGK → MKKPRPAAAAPSPRPPACSR GAHPGTASELRVPALRRGGC GDRRLREEAAPEQAAAGPRR in isoform 2.
VSP_032736
Natural variant1851K → T.
Corresponds to variant rs1052690 [ dbSNP | Ensembl ].
VAR_042433

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 3E95DDC781422BF5

FASTA18720,578
        10         20         30         40         50         60 
MAAPGALLVM GVSGSGKSTV GALLASELGW KFYDADDYHP EENRRKMGKG IPLNDQDRIP 

        70         80         90        100        110        120 
WLCNLHDILL RDVASGQRVV LACSALKKTY RDILTQGKDG VALKCEESGK EAKQAEMQLL 

       130        140        150        160        170        180 
VVHLSGSFEV ISGRLLKREG HFMPPELLQS QFETLEPPAA PENFIQISVD KNVSEIIATI 


METLKMK 

« Hide

Isoform 2 [UniParc].

Checksum: F14D598D616EA58B
Show »

FASTA23025,297
Isoform 3 [UniParc].

Checksum: 4CD5B0CFCD0047C3
Show »

FASTA14115,699

References

« Hide 'large scale' references
[1]"Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia."
Sweetser D.A., Peniket A.J., Haaland C., Blomberg A.A., Zhang Y., Zaidi S.T., Dayyani F., Zhao Z., Heerema N.A., Boultwood J., Dewald G.W., Paietta E., Slovak M.L., Willman C.L., Wainscoat J.S., Bernstein I.D., Daly S.B.
Genes Chromosomes Cancer 44:279-291(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Bone marrow.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY615889 mRNA. Translation: AAT27441.1.
AL354920 Genomic DNA. Translation: CAI15098.1.
AL354920 Genomic DNA. Translation: CAI15099.1.
CH471089 Genomic DNA. Translation: EAW62654.1.
CH471089 Genomic DNA. Translation: EAW62657.1.
BC142991 mRNA. Translation: AAI42992.1.
CCDSCCDS35048.2. [Q5T6J7-1]
CCDS59134.1. [Q5T6J7-3]
RefSeqNP_001001551.2. NM_001001551.3. [Q5T6J7-1]
NP_001243844.1. NM_001256915.1. [Q5T6J7-3]
XP_006717173.1. XM_006717110.1. [Q5T6J7-2]
UniGeneHs.530261.

3D structure databases

ProteinModelPortalQ5T6J7.
SMRQ5T6J7. Positions 7-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000277124.

PTM databases

PhosphoSiteQ5T6J7.

Polymorphism databases

DMDM74745228.

Proteomic databases

MaxQBQ5T6J7.
PaxDbQ5T6J7.
PRIDEQ5T6J7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000277124; ENSP00000277124; ENSG00000148057. [Q5T6J7-3]
ENST00000376419; ENSP00000365601; ENSG00000148057. [Q5T6J7-1]
ENST00000454393; ENSP00000403290; ENSG00000148057. [Q5T6J7-2]
GeneID414328.
KEGGhsa:414328.
UCSCuc004amu.3. human. [Q5T6J7-1]

Organism-specific databases

CTD414328.
GeneCardsGC09P086238.
HGNCHGNC:31367. IDNK.
HPAHPA020378.
MIM611343. gene.
neXtProtNX_Q5T6J7.
PharmGKBPA134880846.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG3265.
HOGENOMHOG000032567.
HOVERGENHBG107958.
InParanoidQ5T6J7.
OMARDGPERL.
PhylomeDBQ5T6J7.
TreeFamTF315136.

Enzyme and pathway databases

UniPathwayUPA00792.

Gene expression databases

ArrayExpressQ5T6J7.
BgeeQ5T6J7.
CleanExHS_C9orf103.
GenevestigatorQ5T6J7.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR006001. Therm_gnt_kin.
[Graphical view]
PfamPF01202. SKI. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01313. therm_gnt_kin. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi414328.
NextBio108592.
PROQ5T6J7.
SOURCESearch...

Entry information

Entry nameGNTK_HUMAN
AccessionPrimary (citable) accession number: Q5T6J7
Secondary accession number(s): A5PLN6, Q5T6J6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM