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Q5T6J7

- GNTK_HUMAN

UniProt

Q5T6J7 - GNTK_HUMAN

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Protein
Probable gluconokinase
Gene
IDNK, C9orf103
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-gluconate = ADP + 6-phospho-D-gluconate.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. gluconokinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. D-gluconate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00792.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable gluconokinase (EC:2.7.1.12)
Alternative name(s):
Gluconate kinase
Gene namesi
Name:IDNK
Synonyms:C9orf103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:31367. IDNK.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Probable gluconokinase
PRO_0000327370Add
BLAST

Proteomic databases

MaxQBiQ5T6J7.
PaxDbiQ5T6J7.
PRIDEiQ5T6J7.

PTM databases

PhosphoSiteiQ5T6J7.

Expressioni

Gene expression databases

ArrayExpressiQ5T6J7.
BgeeiQ5T6J7.
CleanExiHS_C9orf103.
GenevestigatoriQ5T6J7.

Organism-specific databases

HPAiHPA020378.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277124.

Structurei

3D structure databases

ProteinModelPortaliQ5T6J7.
SMRiQ5T6J7. Positions 7-177.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3265.
HOGENOMiHOG000032567.
HOVERGENiHBG107958.
InParanoidiQ5T6J7.
OMAiRDGPERL.
PhylomeDBiQ5T6J7.
TreeFamiTF315136.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR006001. Therm_gnt_kin.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01313. therm_gnt_kin. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T6J7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAPGALLVM GVSGSGKSTV GALLASELGW KFYDADDYHP EENRRKMGKG    50
IPLNDQDRIP WLCNLHDILL RDVASGQRVV LACSALKKTY RDILTQGKDG 100
VALKCEESGK EAKQAEMQLL VVHLSGSFEV ISGRLLKREG HFMPPELLQS 150
QFETLEPPAA PENFIQISVD KNVSEIIATI METLKMK 187
Length:187
Mass (Da):20,578
Last modified:December 21, 2004 - v1
Checksum:i3E95DDC781422BF5
GO
Isoform 2 (identifier: Q5T6J7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAAPGALLVMGVSGSGK → MKKPRPAAAA...PEQAAAGPRR

Note: No experimental confirmation available.

Show »
Length:230
Mass (Da):25,297
Checksum:iF14D598D616EA58B
GO
Isoform 3 (identifier: Q5T6J7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.

Show »
Length:141
Mass (Da):15,699
Checksum:i4CD5B0CFCD0047C3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti185 – 1851K → T.
Corresponds to variant rs1052690 [ dbSNP | Ensembl ].
VAR_042433

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4646Missing in isoform 3.
VSP_032735Add
BLAST
Alternative sequencei1 – 1717MAAPG…SGSGK → MKKPRPAAAAPSPRPPACSR GAHPGTASELRVPALRRGGC GDRRLREEAAPEQAAAGPRR in isoform 2.
VSP_032736Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY615889 mRNA. Translation: AAT27441.1.
AL354920 Genomic DNA. Translation: CAI15098.1.
AL354920 Genomic DNA. Translation: CAI15099.1.
CH471089 Genomic DNA. Translation: EAW62654.1.
CH471089 Genomic DNA. Translation: EAW62657.1.
BC142991 mRNA. Translation: AAI42992.1.
CCDSiCCDS35048.2. [Q5T6J7-1]
CCDS59134.1. [Q5T6J7-3]
RefSeqiNP_001001551.2. NM_001001551.3. [Q5T6J7-1]
NP_001243844.1. NM_001256915.1. [Q5T6J7-3]
XP_006717173.1. XM_006717110.1. [Q5T6J7-2]
UniGeneiHs.530261.

Genome annotation databases

EnsembliENST00000277124; ENSP00000277124; ENSG00000148057. [Q5T6J7-3]
ENST00000376419; ENSP00000365601; ENSG00000148057. [Q5T6J7-1]
ENST00000454393; ENSP00000403290; ENSG00000148057. [Q5T6J7-2]
GeneIDi414328.
KEGGihsa:414328.
UCSCiuc004amu.3. human. [Q5T6J7-1]

Polymorphism databases

DMDMi74745228.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY615889 mRNA. Translation: AAT27441.1 .
AL354920 Genomic DNA. Translation: CAI15098.1 .
AL354920 Genomic DNA. Translation: CAI15099.1 .
CH471089 Genomic DNA. Translation: EAW62654.1 .
CH471089 Genomic DNA. Translation: EAW62657.1 .
BC142991 mRNA. Translation: AAI42992.1 .
CCDSi CCDS35048.2. [Q5T6J7-1 ]
CCDS59134.1. [Q5T6J7-3 ]
RefSeqi NP_001001551.2. NM_001001551.3. [Q5T6J7-1 ]
NP_001243844.1. NM_001256915.1. [Q5T6J7-3 ]
XP_006717173.1. XM_006717110.1. [Q5T6J7-2 ]
UniGenei Hs.530261.

3D structure databases

ProteinModelPortali Q5T6J7.
SMRi Q5T6J7. Positions 7-177.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000277124.

PTM databases

PhosphoSitei Q5T6J7.

Polymorphism databases

DMDMi 74745228.

Proteomic databases

MaxQBi Q5T6J7.
PaxDbi Q5T6J7.
PRIDEi Q5T6J7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000277124 ; ENSP00000277124 ; ENSG00000148057 . [Q5T6J7-3 ]
ENST00000376419 ; ENSP00000365601 ; ENSG00000148057 . [Q5T6J7-1 ]
ENST00000454393 ; ENSP00000403290 ; ENSG00000148057 . [Q5T6J7-2 ]
GeneIDi 414328.
KEGGi hsa:414328.
UCSCi uc004amu.3. human. [Q5T6J7-1 ]

Organism-specific databases

CTDi 414328.
GeneCardsi GC09P086238.
HGNCi HGNC:31367. IDNK.
HPAi HPA020378.
MIMi 611343. gene.
neXtProti NX_Q5T6J7.
PharmGKBi PA134880846.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3265.
HOGENOMi HOG000032567.
HOVERGENi HBG107958.
InParanoidi Q5T6J7.
OMAi RDGPERL.
PhylomeDBi Q5T6J7.
TreeFami TF315136.

Enzyme and pathway databases

UniPathwayi UPA00792 .

Miscellaneous databases

GenomeRNAii 414328.
NextBioi 108592.
PROi Q5T6J7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5T6J7.
Bgeei Q5T6J7.
CleanExi HS_C9orf103.
Genevestigatori Q5T6J7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR006001. Therm_gnt_kin.
[Graphical view ]
Pfami PF01202. SKI. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01313. therm_gnt_kin. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia."
    Sweetser D.A., Peniket A.J., Haaland C., Blomberg A.A., Zhang Y., Zaidi S.T., Dayyani F., Zhao Z., Heerema N.A., Boultwood J., Dewald G.W., Paietta E., Slovak M.L., Willman C.L., Wainscoat J.S., Bernstein I.D., Daly S.B.
    Genes Chromosomes Cancer 44:279-291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiGNTK_HUMAN
AccessioniPrimary (citable) accession number: Q5T6J7
Secondary accession number(s): A5PLN6, Q5T6J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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