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Protein
Submitted name:

Xaa-Pro aminopeptidase 1

Gene

XPNPEP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Xaa-Pro aminopeptidase 1Imported
Gene namesi
Name:XPNPEP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000108039.17.
HGNCiHGNC:12822. XPNPEP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108039.

PTM / Processingi

Proteomic databases

EPDiQ5T6H7.
MaxQBiQ5T6H7.
PaxDbiQ5T6H7.
PeptideAtlasiQ5T6H7.
PRIDEiQ5T6H7.

Expressioni

Gene expression databases

BgeeiENSG00000108039.
ExpressionAtlasiQ5T6H7. baseline and differential.

Interactioni

Protein-protein interaction databases

MINTiMINT-1382650.

Structurei

3D structure databases

ProteinModelPortaliQ5T6H7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 79Creatinase_NInterPro annotationAdd BLAST79
Domaini257 – 471Peptidase_M24InterPro annotationAdd BLAST215
Domaini486 – 548Peptidase_M24_CInterPro annotationAdd BLAST63

Sequence similaritiesi

Belongs to the peptidase M24B family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2413. Eukaryota.
COG0006. LUCA.
GeneTreeiENSGT00390000013970.
HOVERGENiHBG002934.

Family and domain databases

CDDicd01085. APP. 1 hit.
Gene3Di3.40.350.10. 2 hits.
InterProiView protein in InterPro
IPR029149. Creatin/AminoP/Spt16_NTD.
IPR000587. Creatinase_N.
IPR000994. Pept_M24.
IPR033740. Pept_M24B.
IPR032416. Peptidase_M24_C.
IPR001131. Peptidase_M24B_aminopep-P_CS.
PfamiView protein in Pfam
PF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
PF16188. Peptidase_M24_C. 1 hit.
SUPFAMiSSF55920. SSF55920. 1 hit.
PROSITEiView protein in PROSITE
PS00491. PROLINE_PEPTIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5T6H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTDGRYFLQ AAKQMDSNWT LMKMGLKDTP TQEDWLVSVL PEGSRVGVDP
60 70 80 90 100
LIIPTDYWKK MAKVLRSAGH HLIPVKENLV DKIWTDRPER PCKPLLTLGL
110 120 130 140 150
DYTGISWKDK VADLRLKMAE RNVMWFVVTA LDEIAWLFNL RGSDVEHNPV
160 170 180 190 200
FFSYAIIGLE TIMLFIDGDR IDAPSVKEHL LLDLGLEAEY RIQVHPYKSI
210 220 230 240 250
LSELKALCAD LSPREKVWVS DKASYAVSET IPKDHRCCMP YTPICIAKAV
260 270 280 290 300
KNSAESEGMR RAHIKDAVAL CELFNWLEKE VPKGGVTEIS AADKAEEFRR
310 320 330 340 350
QQADFVDLSF PTISSTGPNG AIIHYAPVPE TNRTLSLDEV YLIDSGAQYK
360 370 380 390 400
DGTTDVTRTM HFGTPTAYEK ECFTYVLKGH IAVSAAVFPT GTKGHLLDSF
410 420 430 440 450
ARSALWDSGL DYLHGTGHGV GSFLNVHEGP CGISYKTFSD EPLEAGMIVT
460 470 480 490 500
DEPGYYEDGA FGIRIENVVL VVPVKTKYNF NNRGSLTFEP LTLVPIQTKM
510 520 530 540 550
IDVDSLTDKE CDWLNNYHLT CRDVIGKELQ KQGRQEALEW LIRETQPISK

QH
Length:552
Mass (Da):62,139
Last modified:December 21, 2004 - v1
Checksum:i627539255505E5CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354951 Genomic DNA. No translation available.
RefSeqiNP_001311057.1. NM_001324128.1.
XP_016872103.1. XM_017016614.1.
XP_016872104.1. XM_017016615.1.
UniGeneiHs.390623.

Genome annotation databases

EnsembliENST00000369683; ENSP00000358697; ENSG00000108039.
GeneIDi7511.
UCSCiuc001kyq.3. human.

Similar proteinsi

Entry informationi

Entry nameiQ5T6H7_HUMAN
AccessioniPrimary (citable) accession number: Q5T6H7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported