Q5T6F2 (UBAP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-associated protein 2
Short name=UBAP-2

Gene names

Name:	UBAP2
Synonyms:	KIAA1491

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1119 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9
Sequence similarities	Contains 1 UBA domain.
Sequence caution	The sequence AAI11763.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC11266.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1119	1119	Ubiquitin-associated protein 2		PRO_0000270981
Regions
	Domain	48 – 92	45	UBA
	Coiled coil	105 – 130	26	Potential
Amino acid modifications
	Modified residue	432	1	Phosphoserine Ref.9
	Modified residue	439	1	Phosphoserine Ref.8
	Modified residue	473	1	Phosphoserine Ref.9
	Modified residue	633	1	Phosphoserine Ref.9
	Modified residue	839	1	Phosphotyrosine Ref.5 Ref.6 Ref.7
	Modified residue	840	1	Phosphotyrosine Ref.5
	Modified residue	862	1	Phosphotyrosine Ref.6 Ref.7
Natural variations
	Natural variant	14	1	R → Q. Corresponds to variant rs1785506 [ dbSNP | Ensembl ].		VAR_052677
	Natural variant	429	1	P → L. Corresponds to variant rs10971809 [ dbSNP | Ensembl ].		VAR_052678
	Natural variant	606	1	N → S. Ref.4 Corresponds to variant rs307658 [ dbSNP | Ensembl ].		VAR_029834
	Natural variant	756	1	A → V. Ref.3 Ref.4 Corresponds to variant rs307692 [ dbSNP | Ensembl ].		VAR_029835
	Natural variant	762	1	M → I. Corresponds to variant rs16935295 [ dbSNP | Ensembl ].		VAR_052679

Sequences

	Sequence		Length	Mass (Da)
	Q5T6F2 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 75E7DC542258F82E	FASTA	1,119	117,116
	10 20 30 40 50 60 MMTSVSSDHC RGAREKPQIS AAQSTQPQKQ VVQATAEQMR LAQVIFDKND SDFEAKVKQL 70 80 90 100 110 120 MEVTGKNQDE CIVALHDCNG DVNKAINILL EGNSDTTSWE TVGCKKKNFA KENSENKENR 130 140 150 160 170 180 EKKSEKESSR GRGNNNRKGR GGNRGREFRG EENGIDCNQV DKPSDRGKRA RGRGFGRGRG 190 200 210 220 230 240 RGAGRFSTQG MGTFNPADYS DSTSTDVCGT KLVVWEAAQN GADEGTELAS NTHNIAQDLS 250 260 270 280 290 300 NKSSYGLKGA WKNSVEEWTT EDWTEDLSET KVFTASSAPA ENHILPGQSI DLVALLQKPV 310 320 330 340 350 360 PHSQASEANS FETSQQQGFG QALVFTNSQH NNQMAPGTGS STAVNSCSPQ SLSSVLGSGF 370 380 390 400 410 420 GELAPPKMAN ITSSQILDQL KAPSLGQFTT TPSTQQNSTS HPTTTTSWDL KPPTSQSSVL 430 440 450 460 470 480 SHLDFKSQPE PSPVLSQLSQ RQQHQSQAVT VPPPGLESFP SQAKLRESTP GDSPSTVNKL 490 500 510 520 530 540 LQLPSTTIEN ISVSVHQPQP KHIKLAKRRI PPASKIPASA VEMPGSADVT GLNVQFGALE 550 560 570 580 590 600 FGSEPSLSEF GSAPSSENSN QIPISLYSKS LSEPLNTSLS MTSAVQNSTY TTSVITSCSL 610 620 630 640 650 660 TSSSLNSASP VAMSSSYDQS SVHNRIPYQS PVSSSESAPG TIMNGHGGGR SQQTLDTPKT 670 680 690 700 710 720 TGPPSALPSV SSLPSTTSCT ALLPSTSQHT GDLTSSPLSQ LSSSLSSHQS SLSAHAALSS 730 740 750 760 770 780 STSHTHASVE SASSHQSSAT FSTAATSVSS SASSGASLSS SMNTANSLCL GGTPASASSS 790 800 810 820 830 840 SSRAAPLVTS GKAPPNLPQG VPPLLHNQYL VGPGGLLPAY PIYGYDELQM LQSRLPVDYY 850 860 870 880 890 900 GIPFAAPTAL ASRDGSLANN PYPGDVTKFG RGDSASPAPA TTPAQPQQSQ SQTHHTAQQP 910 920 930 940 950 960 FVNPALPPGY SYTGLPYYTG MPSAFQYGPT MFVPPASAKQ HGVNLSTPTP PFQQASGYGQ 970 980 990 1000 1010 1020 HGYSTGYDDL TQGTAAGDYS KGGYAGSSQA PNKSAGSGPG KGVSVSSSTT GLPDMTGSVY 1030 1040 1050 1060 1070 1080 NKTQTFDKQG FHAGTPPPFS LPSVLGSTGP LASGAAPGYA PPPFLHILPA HQQPHSQLLH 1090 1100 1110 HHLPQDAQSG SGQRSQPSSL QPKSQASKPA YGNSPYWTN

References

[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-669 AND 857-1119. Tissue: Brain.
[3]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed: 10819331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 363-1119, VARIANT VAL-756. Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 511-1119, VARIANTS SER-606 AND VAL-756.
[5]	"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C. Anal. Chem. 76:2763-2772(2004) [PubMed: 15144186] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-839 AND TYR-840, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[6]	"Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules." Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J., Lauffenburger D.A., White F.M. Mol. Cell. Proteomics 4:1240-1250(2005) [PubMed: 15951569] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-839 AND TYR-862, MASS SPECTROMETRY. Tissue: Mammary epithelium.
[7]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-839 AND TYR-862, MASS SPECTROMETRY.
[8]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432; SER-473 AND SER-633, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL139113, AL354989 Genomic DNA. Translation: CAI39657.1. AL354989, AL139113 Genomic DNA. Translation: CAI15298.1. BC007890 mRNA. Translation: AAH07890.1. BC111762 mRNA. Translation: AAI11763.1. Different initiation. AB040924 mRNA. Translation: BAA96015.1. AK074884 mRNA. Translation: BAC11266.1. Different initiation.
IPI	IPI00171127.
RefSeq	NP_060919.2. NM_018449.2.
UniGene	Hs.493739.
3D structure databases
HSSP	HSSP built from PDB template 1WJ7 based on UniProtKB Q80X50.
ProteinModelPortal	Q5T6F2.
SMR	Q5T6F2. Positions 20-106.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5T6F2. 1 interaction.
STRING	Q5T6F2.
PTM databases
PhosphoSite	Q5T6F2.
Polymorphism databases
DMDM	74745207.
Proteomic databases
PRIDE	Q5T6F2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360802; ENSP00000354039; ENSG00000137073. ENST00000379238; ENSP00000368540; ENSG00000137073. ENST00000449054; ENSP00000416932; ENSG00000137073.
GeneID	55833.
KEGG	hsa:55833.
UCSC	uc003ztq.1. human.
Organism-specific databases
CTD	55833.
GeneCards	GC09M033921.
H-InvDB	HIX0007986.
HGNC	HGNC:14185. UBAP2.
HPA	HPA021684.
neXtProt	NX_Q5T6F2.
PharmGKB	PA38379.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000003453.
HOGENOM	HBG714879.
HOVERGEN	HBG058387.
InParanoid	Q5T6F2.
OMA	QMRLAQV.
OrthoDB	EOG415GCT.
Gene expression databases
ArrayExpress	Q5T6F2.
Bgee	Q5T6F2.
CleanEx	HS_UBAP2.
Genevestigator	Q5T6F2.
Family and domain databases
InterPro	IPR022166. DUF3697_Uba2. IPR009060. UBA-like. IPR000449. UBA/transl_elong_EF1B_N. IPR015940. UBA/transl_elong_EF1B_N_euk. [Graphical view]
Pfam	PF12478. DUF3697. 1 hit. PF00627. UBA. 1 hit. [Graphical view]
SMART	SM00165. UBA. 1 hit. [Graphical view]
SUPFAM	SSF46934. UBA_like. 1 hit.
PROSITE	PS50030. UBA. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	61053.

Entry information

Entry name

UBAP2_HUMAN

Accession

Primary (citable) accession number: Q5T6F2
Secondary accession number(s): Q2M2R4 , Q6PK34, Q8NC94, Q9P237

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.