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Protein

Ubiquitin-associated protein 2

Gene

UBAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated protein 2
Short name:
UBAP-2
Gene namesi
Name:UBAP2Imported
Synonyms:KIAA1491Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:14185. UBAP2.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi55833.
OpenTargetsiENSG00000137073.
PharmGKBiPA38379.

Polymorphism and mutation databases

DMDMi74745207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002709811 – 1119Ubiquitin-associated protein 2Add BLAST1119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166Omega-N-methylarginineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ5T6F2.
MaxQBiQ5T6F2.
PaxDbiQ5T6F2.
PeptideAtlasiQ5T6F2.
PRIDEiQ5T6F2.

PTM databases

iPTMnetiQ5T6F2.
PhosphoSitePlusiQ5T6F2.

Expressioni

Gene expression databases

BgeeiENSG00000137073.
CleanExiHS_UBAP2.
ExpressionAtlasiQ5T6F2. baseline and differential.
GenevisibleiQ5T6F2. HS.

Organism-specific databases

HPAiHPA021684.

Interactioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi120938. 27 interactors.
IntActiQ5T6F2. 3 interactors.
STRINGi9606.ENSP00000354039.

Structurei

3D structure databases

ProteinModelPortaliQ5T6F2.
SMRiQ5T6F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 92UBASequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili105 – 130Sequence analysisAdd BLAST26

Sequence similaritiesi

Contains 1 UBA domain.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGWX. Eukaryota.
ENOG4110RI8. LUCA.
GeneTreeiENSGT00390000003453.
HOGENOMiHOG000231679.
HOVERGENiHBG058387.
InParanoidiQ5T6F2.
OMAiPGTIMNG.
OrthoDBiEOG091G0GRY.
PhylomeDBiQ5T6F2.
TreeFamiTF328468.

Family and domain databases

InterProiIPR022166. DUF3697_Uba2.
IPR015940. UBA.
IPR009060. UBA-like.
[Graphical view]
PfamiPF12478. DUF3697. 1 hit.
[Graphical view]
SMARTiSM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T6F2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMTSVSSDHC RGAREKPQIS AAQSTQPQKQ VVQATAEQMR LAQVIFDKND
60 70 80 90 100
SDFEAKVKQL MEVTGKNQDE CIVALHDCNG DVNKAINILL EGNSDTTSWE
110 120 130 140 150
TVGCKKKNFA KENSENKENR EKKSEKESSR GRGNNNRKGR GGNRGREFRG
160 170 180 190 200
EENGIDCNQV DKPSDRGKRA RGRGFGRGRG RGAGRFSTQG MGTFNPADYS
210 220 230 240 250
DSTSTDVCGT KLVVWEAAQN GADEGTELAS NTHNIAQDLS NKSSYGLKGA
260 270 280 290 300
WKNSVEEWTT EDWTEDLSET KVFTASSAPA ENHILPGQSI DLVALLQKPV
310 320 330 340 350
PHSQASEANS FETSQQQGFG QALVFTNSQH NNQMAPGTGS STAVNSCSPQ
360 370 380 390 400
SLSSVLGSGF GELAPPKMAN ITSSQILDQL KAPSLGQFTT TPSTQQNSTS
410 420 430 440 450
HPTTTTSWDL KPPTSQSSVL SHLDFKSQPE PSPVLSQLSQ RQQHQSQAVT
460 470 480 490 500
VPPPGLESFP SQAKLRESTP GDSPSTVNKL LQLPSTTIEN ISVSVHQPQP
510 520 530 540 550
KHIKLAKRRI PPASKIPASA VEMPGSADVT GLNVQFGALE FGSEPSLSEF
560 570 580 590 600
GSAPSSENSN QIPISLYSKS LSEPLNTSLS MTSAVQNSTY TTSVITSCSL
610 620 630 640 650
TSSSLNSASP VAMSSSYDQS SVHNRIPYQS PVSSSESAPG TIMNGHGGGR
660 670 680 690 700
SQQTLDTPKT TGPPSALPSV SSLPSTTSCT ALLPSTSQHT GDLTSSPLSQ
710 720 730 740 750
LSSSLSSHQS SLSAHAALSS STSHTHASVE SASSHQSSAT FSTAATSVSS
760 770 780 790 800
SASSGASLSS SMNTANSLCL GGTPASASSS SSRAAPLVTS GKAPPNLPQG
810 820 830 840 850
VPPLLHNQYL VGPGGLLPAY PIYGYDELQM LQSRLPVDYY GIPFAAPTAL
860 870 880 890 900
ASRDGSLANN PYPGDVTKFG RGDSASPAPA TTPAQPQQSQ SQTHHTAQQP
910 920 930 940 950
FVNPALPPGY SYTGLPYYTG MPSAFQYGPT MFVPPASAKQ HGVNLSTPTP
960 970 980 990 1000
PFQQASGYGQ HGYSTGYDDL TQGTAAGDYS KGGYAGSSQA PNKSAGSGPG
1010 1020 1030 1040 1050
KGVSVSSSTT GLPDMTGSVY NKTQTFDKQG FHAGTPPPFS LPSVLGSTGP
1060 1070 1080 1090 1100
LASGAAPGYA PPPFLHILPA HQQPHSQLLH HHLPQDAQSG SGQRSQPSSL
1110
QPKSQASKPA YGNSPYWTN
Length:1,119
Mass (Da):117,116
Last modified:December 21, 2004 - v1
Checksum:i75E7DC542258F82E
GO
Isoform 2 (identifier: Q5T6F2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-761: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):36,918
Checksum:i35D33F34C925339C
GO

Sequence cautioni

The sequence AAI11763 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11266 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05267714R → Q.Corresponds to variant rs1785506dbSNPEnsembl.1
Natural variantiVAR_052678429P → L.Corresponds to variant rs10971809dbSNPEnsembl.1
Natural variantiVAR_029834606N → S.1 PublicationCorresponds to variant rs307658dbSNPEnsembl.1
Natural variantiVAR_029835756A → V.2 PublicationsCorresponds to variant rs307692dbSNPEnsembl.1
Natural variantiVAR_052679762M → I.Corresponds to variant rs16935295dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560731 – 761Missing in isoform 2. 1 PublicationAdd BLAST761

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074884 mRNA. Translation: BAC11266.1. Different initiation.
AK125935 mRNA. Translation: BAG54267.1.
AL139113, AL354989 Genomic DNA. Translation: CAI39657.1.
AL354989, AL139113 Genomic DNA. Translation: CAI15298.1.
BC007890 mRNA. Translation: AAH07890.1.
BC111762 mRNA. Translation: AAI11763.1. Different initiation.
AB040924 mRNA. Translation: BAA96015.1.
CCDSiCCDS6547.1. [Q5T6F2-1]
CCDS75828.1. [Q5T6F2-2]
RefSeqiNP_001269458.1. NM_001282529.1.
NP_001269459.1. NM_001282530.1. [Q5T6F2-2]
NP_060919.3. NM_018449.3.
UniGeneiHs.493739.

Genome annotation databases

EnsembliENST00000360802; ENSP00000354039; ENSG00000137073. [Q5T6F2-1]
ENST00000379238; ENSP00000368540; ENSG00000137073. [Q5T6F2-1]
ENST00000379239; ENSP00000368541; ENSG00000137073. [Q5T6F2-2]
GeneIDi55833.
KEGGihsa:55833.
UCSCiuc003zto.2. human. [Q5T6F2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074884 mRNA. Translation: BAC11266.1. Different initiation.
AK125935 mRNA. Translation: BAG54267.1.
AL139113, AL354989 Genomic DNA. Translation: CAI39657.1.
AL354989, AL139113 Genomic DNA. Translation: CAI15298.1.
BC007890 mRNA. Translation: AAH07890.1.
BC111762 mRNA. Translation: AAI11763.1. Different initiation.
AB040924 mRNA. Translation: BAA96015.1.
CCDSiCCDS6547.1. [Q5T6F2-1]
CCDS75828.1. [Q5T6F2-2]
RefSeqiNP_001269458.1. NM_001282529.1.
NP_001269459.1. NM_001282530.1. [Q5T6F2-2]
NP_060919.3. NM_018449.3.
UniGeneiHs.493739.

3D structure databases

ProteinModelPortaliQ5T6F2.
SMRiQ5T6F2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120938. 27 interactors.
IntActiQ5T6F2. 3 interactors.
STRINGi9606.ENSP00000354039.

PTM databases

iPTMnetiQ5T6F2.
PhosphoSitePlusiQ5T6F2.

Polymorphism and mutation databases

DMDMi74745207.

Proteomic databases

EPDiQ5T6F2.
MaxQBiQ5T6F2.
PaxDbiQ5T6F2.
PeptideAtlasiQ5T6F2.
PRIDEiQ5T6F2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360802; ENSP00000354039; ENSG00000137073. [Q5T6F2-1]
ENST00000379238; ENSP00000368540; ENSG00000137073. [Q5T6F2-1]
ENST00000379239; ENSP00000368541; ENSG00000137073. [Q5T6F2-2]
GeneIDi55833.
KEGGihsa:55833.
UCSCiuc003zto.2. human. [Q5T6F2-1]

Organism-specific databases

CTDi55833.
DisGeNETi55833.
GeneCardsiUBAP2.
H-InvDBHIX0007986.
HGNCiHGNC:14185. UBAP2.
HPAiHPA021684.
neXtProtiNX_Q5T6F2.
OpenTargetsiENSG00000137073.
PharmGKBiPA38379.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGWX. Eukaryota.
ENOG4110RI8. LUCA.
GeneTreeiENSGT00390000003453.
HOGENOMiHOG000231679.
HOVERGENiHBG058387.
InParanoidiQ5T6F2.
OMAiPGTIMNG.
OrthoDBiEOG091G0GRY.
PhylomeDBiQ5T6F2.
TreeFamiTF328468.

Miscellaneous databases

ChiTaRSiUBAP2. human.
GeneWikiiUBAP2.
GenomeRNAii55833.
PROiQ5T6F2.

Gene expression databases

BgeeiENSG00000137073.
CleanExiHS_UBAP2.
ExpressionAtlasiQ5T6F2. baseline and differential.
GenevisibleiQ5T6F2. HS.

Family and domain databases

InterProiIPR022166. DUF3697_Uba2.
IPR015940. UBA.
IPR009060. UBA-like.
[Graphical view]
PfamiPF12478. DUF3697. 1 hit.
[Graphical view]
SMARTiSM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBAP2_HUMAN
AccessioniPrimary (citable) accession number: Q5T6F2
Secondary accession number(s): Q2M2R4
, Q5JV03, Q6PK34, Q8NC94, Q9P237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.