Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arginine vasopressin-induced protein 1

Gene

AVPI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine vasopressin-induced protein 1
Short name:
AVP-induced protein 1
Gene namesi
Name:AVPI1
ORF Names:NPD013, PP5395
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:30898. AVPI1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905326.

Polymorphism and mutation databases

BioMutaiAVPI1.
DMDMi317373474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Arginine vasopressin-induced protein 1PRO_0000282402Add
BLAST

Proteomic databases

EPDiQ5T686.
MaxQBiQ5T686.
PaxDbiQ5T686.
PeptideAtlasiQ5T686.
PRIDEiQ5T686.

PTM databases

iPTMnetiQ5T686.

Expressioni

Gene expression databases

BgeeiQ5T686.
CleanExiHS_AVPI1.
GenevisibleiQ5T686. HS.

Organism-specific databases

HPAiHPA037649.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-8640233,EBI-10171697
KRTAP10-7P604093EBI-8640233,EBI-10172290
KRTAP10-9P604113EBI-8640233,EBI-10172052
KRTAP12-2P599913EBI-8640233,EBI-10176379
MDFIQ997504EBI-8640233,EBI-724076

Protein-protein interaction databases

BioGridi121901. 10 interactions.
IntActiQ5T686. 6 interactions.
STRINGi9606.ENSP00000359660.

Structurei

3D structure databases

ProteinModelPortaliQ5T686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J3FQ. Eukaryota.
ENOG410Y6AI. LUCA.
GeneTreeiENSGT00510000049872.
HOGENOMiHOG000034240.
HOVERGENiHBG057214.
InParanoidiQ5T686.
OMAiYLHQIRH.
OrthoDBiEOG7327R9.
PhylomeDBiQ5T686.
TreeFamiTF338287.

Family and domain databases

InterProiIPR020282. Avpi1/C8orf4.
[Graphical view]
PfamiPF15063. TC1. 1 hit.
[Graphical view]
ProDomiPD287216. Arg_vasopressin-induced_prot_1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q5T686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTPASVVSE PPPWQAPIEA RGRKQASANI FQDAELLQIQ ALFQRSGDQL
60 70 80 90 100
AEERAQIIWE CAGDHRVAEA LKRLRRKRPP RQKPLGHSLH HCSRLRILEP
110 120 130 140
HSALANPQSA TETASSEQYL HSRKKSARIR RNWRKSGPTS YLHQIRH
Length:147
Mass (Da):16,773
Last modified:January 11, 2011 - v3
Checksum:iE01AEFEEF3F9006B
GO

Sequence cautioni

The sequence AAG44474.1 differs from that shown. Reason: Frameshift at position 28. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651H → R in AAG44474 (Ref. 2) Curated
Sequence conflicti81 – 811R → K in BAD96819 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411A → G.3 Publications
Corresponds to variant rs2275047 [ dbSNP | Ensembl ].
VAR_031405

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218019 mRNA. Translation: AAG17261.1.
AF241786 mRNA. Translation: AAG44474.1. Frameshift.
AK223099 mRNA. Translation: BAD96819.1.
AK222493 mRNA. Translation: BAD96213.1.
AL355315 Genomic DNA. Translation: CAI15464.1.
BC000877 mRNA. Translation: AAH00877.1.
CCDSiCCDS7470.1.
RefSeqiNP_068378.2. NM_021732.2.
UniGeneiHs.23918.

Genome annotation databases

EnsembliENST00000370626; ENSP00000359660; ENSG00000119986.
GeneIDi60370.
KEGGihsa:60370.
UCSCiuc057vge.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218019 mRNA. Translation: AAG17261.1.
AF241786 mRNA. Translation: AAG44474.1. Frameshift.
AK223099 mRNA. Translation: BAD96819.1.
AK222493 mRNA. Translation: BAD96213.1.
AL355315 Genomic DNA. Translation: CAI15464.1.
BC000877 mRNA. Translation: AAH00877.1.
CCDSiCCDS7470.1.
RefSeqiNP_068378.2. NM_021732.2.
UniGeneiHs.23918.

3D structure databases

ProteinModelPortaliQ5T686.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121901. 10 interactions.
IntActiQ5T686. 6 interactions.
STRINGi9606.ENSP00000359660.

PTM databases

iPTMnetiQ5T686.

Polymorphism and mutation databases

BioMutaiAVPI1.
DMDMi317373474.

Proteomic databases

EPDiQ5T686.
MaxQBiQ5T686.
PaxDbiQ5T686.
PeptideAtlasiQ5T686.
PRIDEiQ5T686.

Protocols and materials databases

DNASUi60370.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370626; ENSP00000359660; ENSG00000119986.
GeneIDi60370.
KEGGihsa:60370.
UCSCiuc057vge.1. human.

Organism-specific databases

CTDi60370.
GeneCardsiAVPI1.
H-InvDBHIX0009099.
HGNCiHGNC:30898. AVPI1.
HPAiHPA037649.
neXtProtiNX_Q5T686.
PharmGKBiPA134905326.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3FQ. Eukaryota.
ENOG410Y6AI. LUCA.
GeneTreeiENSGT00510000049872.
HOGENOMiHOG000034240.
HOVERGENiHBG057214.
InParanoidiQ5T686.
OMAiYLHQIRH.
OrthoDBiEOG7327R9.
PhylomeDBiQ5T686.
TreeFamiTF338287.

Miscellaneous databases

ChiTaRSiAVPI1. human.
GeneWikiiAVPI1.
GenomeRNAii60370.
PROiQ5T686.

Gene expression databases

BgeeiQ5T686.
CleanExiHS_AVPI1.
GenevisibleiQ5T686. HS.

Family and domain databases

InterProiIPR020282. Avpi1/C8orf4.
[Graphical view]
PfamiPF15063. TC1. 1 hit.
[Graphical view]
ProDomiPD287216. Arg_vasopressin-induced_prot_1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-41.
  2. Cheng Z., Gao G., Peng Y., Ren S., Chen Z., Han Z.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-41.
    Tissue: Adipose tissue.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-41.
    Tissue: Cervix.

Entry informationi

Entry nameiAVPI1_HUMAN
AccessioniPrimary (citable) accession number: Q5T686
Secondary accession number(s): Q53G32, Q9H2R9, Q9HBN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 11, 2011
Last modified: July 6, 2016
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.