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Protein

Cilia- and flagella-associated protein 58

Gene

CFAP58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 58Imported
Alternative name(s):
Coiled-coil domain-containing protein 147Curated
Gene namesi
Name:CFAP58Imported
Synonyms:C10orf80Imported, CCDC147Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:26676. CFAP58.

Subcellular locationi

  • Cell projectioncilium By similarity

GO - Cellular componenti

  • cilium Source: UniProtKB-SubCell
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

DisGeNETi159686.
OpenTargetsiENSG00000120051.
PharmGKBiPA162381518.

Polymorphism and mutation databases

BioMutaiCCDC147.
DMDMi74745166.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743171 – 872Cilia- and flagella-associated protein 58Add BLAST872

Proteomic databases

EPDiQ5T655.
MaxQBiQ5T655.
PaxDbiQ5T655.
PeptideAtlasiQ5T655.
PRIDEiQ5T655.

PTM databases

iPTMnetiQ5T655.
PhosphoSitePlusiQ5T655.

Expressioni

Gene expression databases

BgeeiENSG00000120051.
CleanExiHS_CCDC147.
ExpressionAtlasiQ5T655. baseline and differential.
GenevisibleiQ5T655. HS.

Organism-specific databases

HPAiHPA036555.
HPA036556.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NAV2Q8IVL13EBI-10245749,EBI-741200

Protein-protein interaction databases

BioGridi127743. 7 interactors.
IntActiQ5T655. 5 interactors.
STRINGi9606.ENSP00000358718.

Structurei

3D structure databases

ProteinModelPortaliQ5T655.
SMRiQ5T655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili106 – 595Sequence analysisAdd BLAST490
Coiled coili642 – 839Sequence analysisAdd BLAST198

Sequence similaritiesi

Belongs to the CFAP58 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFZN. Eukaryota.
ENOG410XNPB. LUCA.
GeneTreeiENSGT00530000063534.
HOGENOMiHOG000261467.
HOVERGENiHBG081187.
InParanoidiQ5T655.
OMAiKLHAVMK.
OrthoDBiEOG091G04GF.
PhylomeDBiQ5T655.
TreeFamiTF328680.

Sequencei

Sequence statusi: Complete.

Q5T655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEKGGKQV LEESAFEEME RDFQGVLHEL SGDKSLEKFR IEYERLHAVM
60 70 80 90 100
KKSYDNEKRL MAKCRELNAE IVVNSAKVAT ALKLSQDDQT TIASLKKEIE
110 120 130 140 150
KAWKMVDSAY DKEQKAKETI LALKEEIVNL TKLVEQGSGL SMDQHSNIRD
160 170 180 190 200
LLRFKEEVTK ERDQLLSEVV KLRESLAQTT EQQQETERSK EEAEHAISQF
210 220 230 240 250
QQEIQQRQNE ASREFRKKEK LEKELKQIQA DMDSRQTEIK ALQQYVQKSK
260 270 280 290 300
EELQKLEQQL KEQKILNERA AKELEQFQMR NAKLQQENEQ HSLVCEQLSQ
310 320 330 340 350
ENQQKALELK AKEEEVHQMR LDIGKLNKIR EQIHKKLHHT EDQKAEVEQH
360 370 380 390 400
KETLKNQIVG LEREVEASKK QAELDRKAMD ELLRERDILN KNMLKAVNAT
410 420 430 440 450
QKQTDLVKLH EQAKRNLEGE IQNYKDEAQK QRKIIFHLEK ERDRYINQAS
460 470 480 490 500
DLTQKVLMNM EDIKVRETQI FDYRKKIAES EIKLKQQQNL YEAVRSDRNL
510 520 530 540 550
YSKNLVEAQD EITDMKRKLK IMIHQVDELK EDISAKESAL VKLHLEQQRI
560 570 580 590 600
EKEKETLKAE LQKLRQQALE TKHFIEKQEA EERKLLRIIA EADGERLRQK
610 620 630 640 650
KELDQVISER DILGSQLVRR NDELALLYEK IKIQQSVLNK GESQYNQRLE
660 670 680 690 700
DMRILRLEIK KLRREKGILA RSMANVEELR QEFFHMQREL LKERTRCRAL
710 720 730 740 750
EEELENPLNV HRWRKLEASD PNAYELIQKI HTLQKRLISK TEEVVEKELL
760 770 780 790 800
LQEKEKLYME LKHVLARQPG PEAAEQLKLY RRTLHDKKQQ LKVLSSELNM
810 820 830 840 850
YEVQSKEYKY EVEKLTNELQ NLKKKYLAQK RKEQLQKNKD TAPMDNTFLM
860 870
VKPNGPGFTG GGFPLRSTKM TF
Length:872
Mass (Da):103,417
Last modified:December 21, 2004 - v1
Checksum:iE4393742E91D81DD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030255496S → T.Corresponds to variant rs11192036dbSNPEnsembl.1
Natural variantiVAR_030256804Q → H.Corresponds to variant rs7087328dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162742, AL355378 Genomic DNA. Translation: CAI12110.1.
AL355378, AL162742 Genomic DNA. Translation: CAI15667.1.
CH471066 Genomic DNA. Translation: EAW49595.1.
BC036225 mRNA. Translation: AAH36225.1.
BC109126 mRNA. Translation: AAI09127.1.
AK093227 mRNA. Translation: BAC04102.1.
CCDSiCCDS31282.1.
RefSeqiNP_001008723.1. NM_001008723.1.
UniGeneiHs.253576.

Genome annotation databases

EnsembliENST00000369704; ENSP00000358718; ENSG00000120051.
GeneIDi159686.
KEGGihsa:159686.
UCSCiuc001kyh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162742, AL355378 Genomic DNA. Translation: CAI12110.1.
AL355378, AL162742 Genomic DNA. Translation: CAI15667.1.
CH471066 Genomic DNA. Translation: EAW49595.1.
BC036225 mRNA. Translation: AAH36225.1.
BC109126 mRNA. Translation: AAI09127.1.
AK093227 mRNA. Translation: BAC04102.1.
CCDSiCCDS31282.1.
RefSeqiNP_001008723.1. NM_001008723.1.
UniGeneiHs.253576.

3D structure databases

ProteinModelPortaliQ5T655.
SMRiQ5T655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127743. 7 interactors.
IntActiQ5T655. 5 interactors.
STRINGi9606.ENSP00000358718.

PTM databases

iPTMnetiQ5T655.
PhosphoSitePlusiQ5T655.

Polymorphism and mutation databases

BioMutaiCCDC147.
DMDMi74745166.

Proteomic databases

EPDiQ5T655.
MaxQBiQ5T655.
PaxDbiQ5T655.
PeptideAtlasiQ5T655.
PRIDEiQ5T655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369704; ENSP00000358718; ENSG00000120051.
GeneIDi159686.
KEGGihsa:159686.
UCSCiuc001kyh.3. human.

Organism-specific databases

CTDi159686.
DisGeNETi159686.
GeneCardsiCFAP58.
HGNCiHGNC:26676. CFAP58.
HPAiHPA036555.
HPA036556.
neXtProtiNX_Q5T655.
OpenTargetsiENSG00000120051.
PharmGKBiPA162381518.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFZN. Eukaryota.
ENOG410XNPB. LUCA.
GeneTreeiENSGT00530000063534.
HOGENOMiHOG000261467.
HOVERGENiHBG081187.
InParanoidiQ5T655.
OMAiKLHAVMK.
OrthoDBiEOG091G04GF.
PhylomeDBiQ5T655.
TreeFamiTF328680.

Miscellaneous databases

GenomeRNAii159686.
PROiQ5T655.

Gene expression databases

BgeeiENSG00000120051.
CleanExiHS_CCDC147.
ExpressionAtlasiQ5T655. baseline and differential.
GenevisibleiQ5T655. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCFA58_HUMAN
AccessioniPrimary (citable) accession number: Q5T655
Secondary accession number(s): D3DRA6, Q8NA27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.