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Protein

Zinc finger protein 648

Gene

ZNF648

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 301C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 648
Gene namesi
Name:ZNF648
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18190. ZNF648.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179930.
PharmGKBiPA134974398.

Polymorphism and mutation databases

BioMutaiZNF648.
DMDMi74762240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002521621 – 568Zinc finger protein 648Add BLAST568

Proteomic databases

PaxDbiQ5T619.
PeptideAtlasiQ5T619.
PRIDEiQ5T619.

PTM databases

iPTMnetiQ5T619.
PhosphoSitePlusiQ5T619.

Expressioni

Gene expression databases

BgeeiENSG00000179930.
CleanExiHS_ZNF648.

Organism-specific databases

HPAiHPA053897.

Interactioni

Protein-protein interaction databases

IntActiQ5T619. 38 interactors.
STRINGi9606.ENSP00000344129.

Structurei

3D structure databases

ProteinModelPortaliQ5T619.
SMRiQ5T619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 301C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00490000043434.
HOGENOMiHOG000234617.
InParanoidiQ5T619.
OMAiGTCKKEP.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5T619.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVDSQDRW GEASPLSSLT EEAHDTQMLS MNLESDDEDG GEAEKEGTAD
60 70 80 90 100
PVACPRGSSP VTHENPDLPW PHPLGKEEEK FSDSSSAGGM GQKPVEMSGK
110 120 130 140 150
ASWSRDVTKI NETQGSPGAS RALGSLPSGL AHKLLGQMQP LGDRLPAGDD
160 170 180 190 200
GYSGANQDAV LDVPPSFPSN GKYLCAHKSV DTSAGNSSLL CFPRPGSNWD
210 220 230 240 250
LPTQETHTPA QASATPASLA AAVLAKARNS RKVQNQAGRR EGGEAEARPY
260 270 280 290 300
RCLRGGRAFQ KPSKPLSPAE TRGGAAKRYA CELCGKAYSH RGTLQQHRRL
310 320 330 340 350
HTGERPYQCS FCDKAYTWSS DHRKHIRTHT GEKPYPCPDC GKAFVRSSDL
360 370 380 390 400
RKHQRNMHSN NKPFPCSECG LTFNKPLSLL RHQRTHLGAK PFRCPACDRE
410 420 430 440 450
FAVASRMVEH QRVHSGERPF PCPTCGKCFT KSSNLSEHQT LHTGQRPFKC
460 470 480 490 500
ADCGVAFAQP SRLVRHQRIH TGERPFPCTQ CGQAFARSST LKRHQQIHSG
510 520 530 540 550
EKGFLCAECG RAFRIASELA QHIRMHNGER PYQCEDCGQA FTRSNHLQRH
560
RAKHGTCKKE PIPSSSDE
Length:568
Mass (Da):62,341
Last modified:December 21, 2004 - v1
Checksum:iA751072B8C9810F4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05288742E → K.Corresponds to variant rs12564283dbSNPEnsembl.1
Natural variantiVAR_033585111N → K.Corresponds to variant rs12568050dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355482 Genomic DNA. Translation: CAI15305.1.
BC137223 mRNA. Translation: AAI37224.1.
BC137224 mRNA. Translation: AAI37225.1.
CCDSiCCDS30952.1.
RefSeqiNP_001009992.1. NM_001009992.1.
XP_016855790.1. XM_017000301.1.
XP_016855791.1. XM_017000302.1.
UniGeneiHs.684328.

Genome annotation databases

EnsembliENST00000339948; ENSP00000344129; ENSG00000179930.
GeneIDi127665.
KEGGihsa:127665.
UCSCiuc001goz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355482 Genomic DNA. Translation: CAI15305.1.
BC137223 mRNA. Translation: AAI37224.1.
BC137224 mRNA. Translation: AAI37225.1.
CCDSiCCDS30952.1.
RefSeqiNP_001009992.1. NM_001009992.1.
XP_016855790.1. XM_017000301.1.
XP_016855791.1. XM_017000302.1.
UniGeneiHs.684328.

3D structure databases

ProteinModelPortaliQ5T619.
SMRiQ5T619.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5T619. 38 interactors.
STRINGi9606.ENSP00000344129.

PTM databases

iPTMnetiQ5T619.
PhosphoSitePlusiQ5T619.

Polymorphism and mutation databases

BioMutaiZNF648.
DMDMi74762240.

Proteomic databases

PaxDbiQ5T619.
PeptideAtlasiQ5T619.
PRIDEiQ5T619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339948; ENSP00000344129; ENSG00000179930.
GeneIDi127665.
KEGGihsa:127665.
UCSCiuc001goz.3. human.

Organism-specific databases

CTDi127665.
GeneCardsiZNF648.
HGNCiHGNC:18190. ZNF648.
HPAiHPA053897.
neXtProtiNX_Q5T619.
OpenTargetsiENSG00000179930.
PharmGKBiPA134974398.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00490000043434.
HOGENOMiHOG000234617.
InParanoidiQ5T619.
OMAiGTCKKEP.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5T619.
TreeFamiTF337055.

Miscellaneous databases

GenomeRNAii127665.
PROiQ5T619.

Gene expression databases

BgeeiENSG00000179930.
CleanExiHS_ZNF648.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN648_HUMAN
AccessioniPrimary (citable) accession number: Q5T619
Secondary accession number(s): B2RP16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.