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Protein

Adhesion G-protein coupled receptor F1

Gene

ADGRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor F11 Publication
Alternative name(s):
G-protein coupled receptor 110
G-protein coupled receptor KPG_012
G-protein coupled receptor PGR19
Gene namesi
Name:ADGRF1Imported
Synonyms:GPR110, PGR19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18990. ADGRF1.

Subcellular locationi

Isoform 2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 590ExtracellularCuratedAdd BLAST571
Transmembranei591 – 611Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini612 – 624CytoplasmicCuratedAdd BLAST13
Transmembranei625 – 645Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini646 – 660ExtracellularCuratedAdd BLAST15
Transmembranei661 – 681Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini682 – 699CytoplasmicCuratedAdd BLAST18
Transmembranei700 – 720Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini721 – 744ExtracellularCuratedAdd BLAST24
Transmembranei745 – 765Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini766 – 791CytoplasmicCuratedAdd BLAST26
Transmembranei792 – 812Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini813 – 820ExtracellularCurated8
Transmembranei821 – 841Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini842 – 910CytoplasmicCuratedAdd BLAST69

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153292.
PharmGKBiPA128394769.

Polymorphism and mutation databases

BioMutaiGPR110.
DMDMi302393689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001289120 – 910Adhesion G-protein coupled receptor F1Add BLAST891

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Glycosylationi282N-linked (GlcNAc...)Sequence analysis1
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Glycosylationi329N-linked (GlcNAc...)Sequence analysis1
Glycosylationi354N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi389N-linked (GlcNAc...)Sequence analysis1
Glycosylationi410N-linked (GlcNAc...)Sequence analysis1
Glycosylationi423N-linked (GlcNAc...)Sequence analysis1
Glycosylationi437N-linked (GlcNAc...)Sequence analysis1
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Glycosylationi512N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1
Glycosylationi553N-linked (GlcNAc...)Sequence analysis1
Glycosylationi736N-linked (GlcNAc...)Sequence analysis1
Glycosylationi739N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5T601.
PeptideAtlasiQ5T601.
PRIDEiQ5T601.

PTM databases

iPTMnetiQ5T601.
PhosphoSitePlusiQ5T601.

Expressioni

Tissue specificityi

Mainly expressed in the kidney. Up-regulated in lung adenocarcinomas and prostate cancers.1 Publication

Gene expression databases

BgeeiENSG00000153292.
CleanExiHS_GPR110.
ExpressionAtlasiQ5T601. baseline and differential.
GenevisibleiQ5T601. HS.

Organism-specific databases

HPAiHPA038438.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360299.

Structurei

3D structure databases

ProteinModelPortaliQ5T601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 256SEAPROSITE-ProRule annotationAdd BLAST109
Domaini531 – 578GPSPROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128272.
HOVERGENiHBG058365.
InParanoidiQ5T601.
KOiK08453.
OMAiGNITARC.
OrthoDBiEOG091G00IU.
PhylomeDBiQ5T601.
TreeFamiTF316380.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF01390. SEA. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T601-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVGVLWLIS FFTFTDGHGG FLGKNDGIKT KKELIVNKKK HLGPVEEYQL
60 70 80 90 100
LLQVTYRDSK EKRDLRNFLK LLKPPLLWSH GLIRIIRAKA TTDCNSLNGV
110 120 130 140 150
LQCTCEDSYT WFPPSCLDPQ NCYLHTAGAL PSCECHLNNL SQSVNFCERT
160 170 180 190 200
KIWGTFKINE RFTNDLLNSS SAIYSKYANG IEIQLKKAYE RIQGFESVQV
210 220 230 240 250
TQFRNGSIVA GYEVVGSSSA SELLSAIEHV AEKAKTALHK LFPLEDGSFR
260 270 280 290 300
VFGKAQCNDI VFGFGSKDDE YTLPCSSGYR GNITAKCESS GWQVIRETCV
310 320 330 340 350
LSLLEELNKN FSMIVGNATE AAVSSFVQNL SVIIRQNPST TVGNLASVVS
360 370 380 390 400
ILSNISSLSL ASHFRVSNST MEDVISIADN ILNSASVTNW TVLLREEKYA
410 420 430 440 450
SSRLLETLEN ISTLVPPTAL PLNFSRKFID WKGIPVNKSQ LKRGYSYQIK
460 470 480 490 500
MCPQNTSIPI RGRVLIGSDQ FQRSLPETII SMASLTLGNI LPVSKNGNAQ
510 520 530 540 550
VNGPVISTVI QNYSINEVFL FFSKIESNLS QPHCVFWDFS HLQWNDAGCH
560 570 580 590 600
LVNETQDIVT CQCTHLTSFS ILMSPFVPST IFPVVKWITY VGLGISIGSL
610 620 630 640 650
ILCLIIEALF WKQIKKSQTS HTRRICMVNI ALSLLIADVW FIVGATVDTT
660 670 680 690 700
VNPSGVCTAA VFFTHFFYLS LFFWMLMLGI LLAYRIILVF HHMAQHLMMA
710 720 730 740 750
VGFCLGYGCP LIISVITIAV TQPSNTYKRK DVCWLNWSNG SKPLLAFVVP
760 770 780 790 800
ALAIVAVNFV VVLLVLTKLW RPTVGERLSR DDKATIIRVG KSLLILTPLL
810 820 830 840 850
GLTWGFGIGT IVDSQNLAWH VIFALLNAFQ GFFILCFGIL LDSKLRQLLF
860 870 880 890 900
NKLSALSSWK QTEKQNSSDL SAKPKFSKPF NPLQNKGHYA FSHTGDSSDN
910
IMLTQFVSNE
Length:910
Mass (Da):101,365
Last modified:August 10, 2010 - v2
Checksum:i07B5234A487E9F07
GO
Isoform 2 (identifier: Q5T601-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-218: NGSIVAGYEVVGSS → MSLLSPKLECNGTI
     219-910: Missing.

Show »
Length:218
Mass (Da):24,876
Checksum:iBE49C1F12A0B3D4C
GO

Sequence cautioni

The sequence BAB70874 differs from that shown. Probable cloning artifact.Curated
The sequence BAB70874 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC45260 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI13873 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23G → GV in CAI13874 (PubMed:14574404).Curated1
Sequence conflicti27G → D in BAB15452 (PubMed:14702039).Curated1
Sequence conflicti198 – 203VQVTQF → MDISIQ in AAN46666 (PubMed:12435584).Curated6
Sequence conflicti614I → A in BAB70874 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055928787I → V.Corresponds to variant rs1226475dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039588205 – 218NGSIV…VVGSS → MSLLSPKLECNGTI in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_039589219 – 910Missing in isoform 2. 2 PublicationsAdd BLAST692

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065679 Genomic DNA. Translation: BAC45260.1. Sequence problems.
AB045123 mRNA. Translation: BAD83599.1.
AK026337 mRNA. Translation: BAB15452.1.
AK055208 mRNA. Translation: BAB70874.1. Sequence problems.
AL355518 Genomic DNA. Translation: CAI13873.1. Sequence problems.
AL355518 Genomic DNA. Translation: CAI13874.1.
AL355518 Genomic DNA. Translation: CAI13875.1.
CH471081 Genomic DNA. Translation: EAX04311.1.
BC113634 mRNA. Translation: AAI13635.1.
BC113636 mRNA. Translation: AAI13637.1.
AY140952 mRNA. Translation: AAN46666.1.
AY255595 mRNA. Translation: AAO85107.1.
CCDSiCCDS34471.1. [Q5T601-1]
CCDS4920.1. [Q5T601-2]
RefSeqiNP_079324.2. NM_025048.3. [Q5T601-2]
NP_722582.2. NM_153840.3. [Q5T601-1]
UniGeneiHs.733762.

Genome annotation databases

EnsembliENST00000371243; ENSP00000360289; ENSG00000153292. [Q5T601-2]
ENST00000371253; ENSP00000360299; ENSG00000153292. [Q5T601-1]
GeneIDi266977.
KEGGihsa:266977.
UCSCiuc003oyt.4. human. [Q5T601-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065679 Genomic DNA. Translation: BAC45260.1. Sequence problems.
AB045123 mRNA. Translation: BAD83599.1.
AK026337 mRNA. Translation: BAB15452.1.
AK055208 mRNA. Translation: BAB70874.1. Sequence problems.
AL355518 Genomic DNA. Translation: CAI13873.1. Sequence problems.
AL355518 Genomic DNA. Translation: CAI13874.1.
AL355518 Genomic DNA. Translation: CAI13875.1.
CH471081 Genomic DNA. Translation: EAX04311.1.
BC113634 mRNA. Translation: AAI13635.1.
BC113636 mRNA. Translation: AAI13637.1.
AY140952 mRNA. Translation: AAN46666.1.
AY255595 mRNA. Translation: AAO85107.1.
CCDSiCCDS34471.1. [Q5T601-1]
CCDS4920.1. [Q5T601-2]
RefSeqiNP_079324.2. NM_025048.3. [Q5T601-2]
NP_722582.2. NM_153840.3. [Q5T601-1]
UniGeneiHs.733762.

3D structure databases

ProteinModelPortaliQ5T601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360299.

Protein family/group databases

MEROPSiP02.022.
GPCRDBiSearch...

PTM databases

iPTMnetiQ5T601.
PhosphoSitePlusiQ5T601.

Polymorphism and mutation databases

BioMutaiGPR110.
DMDMi302393689.

Proteomic databases

PaxDbiQ5T601.
PeptideAtlasiQ5T601.
PRIDEiQ5T601.

Protocols and materials databases

DNASUi266977.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371243; ENSP00000360289; ENSG00000153292. [Q5T601-2]
ENST00000371253; ENSP00000360299; ENSG00000153292. [Q5T601-1]
GeneIDi266977.
KEGGihsa:266977.
UCSCiuc003oyt.4. human. [Q5T601-1]

Organism-specific databases

CTDi266977.
GeneCardsiADGRF1.
HGNCiHGNC:18990. ADGRF1.
HPAiHPA038438.
neXtProtiNX_Q5T601.
OpenTargetsiENSG00000153292.
PharmGKBiPA128394769.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128272.
HOVERGENiHBG058365.
InParanoidiQ5T601.
KOiK08453.
OMAiGNITARC.
OrthoDBiEOG091G00IU.
PhylomeDBiQ5T601.
TreeFamiTF316380.

Miscellaneous databases

ChiTaRSiGPR110. human.
GeneWikiiGPR110.
GenomeRNAii266977.
PROiQ5T601.

Gene expression databases

BgeeiENSG00000153292.
CleanExiHS_GPR110.
ExpressionAtlasiQ5T601. baseline and differential.
GenevisibleiQ5T601. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF01390. SEA. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRF1_HUMAN
AccessioniPrimary (citable) accession number: Q5T601
Secondary accession number(s): Q5KU15
, Q5T5Z9, Q5T600, Q86SM1, Q8IXE3, Q8IZF8, Q96DQ1, Q9H615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: August 10, 2010
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.