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Q5T601 (GP110_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 110
Alternative name(s):
G-protein coupled receptor KPG_012
G-protein coupled receptor PGR19
Gene names
Name:GPR110
Synonyms:PGR19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Contains 1 SEA domain.

Sequence caution

The sequence BAB70874.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB70874.1 differs from that shown. Reason: Probable cloning artifact.

The sequence BAC45260.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI13873.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5T601-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5T601-2)

The sequence of this isoform differs from the canonical sequence as follows:
     205-218: NGSIVAGYEVVGSS → MSLLSPKLECNGTI
     219-910: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 910891Probable G-protein coupled receptor 110
PRO_0000012891

Regions

Topological domain20 – 590571Extracellular Potential
Transmembrane591 – 61121Helical; Name=1; Potential
Topological domain612 – 62413Cytoplasmic Potential
Transmembrane625 – 64521Helical; Name=2; Potential
Topological domain646 – 66015Extracellular Potential
Transmembrane661 – 68121Helical; Name=3; Potential
Topological domain682 – 69918Cytoplasmic Potential
Transmembrane700 – 72021Helical; Name=4; Potential
Topological domain721 – 74424Extracellular Potential
Transmembrane745 – 76521Helical; Name=5; Potential
Topological domain766 – 79126Cytoplasmic Potential
Transmembrane792 – 81221Helical; Name=6; Potential
Topological domain813 – 8208Extracellular Potential
Transmembrane821 – 84121Helical; Name=7; Potential
Topological domain842 – 91069Cytoplasmic Potential
Domain148 – 256109SEA
Domain531 – 57848GPS

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Potential
Glycosylation2821N-linked (GlcNAc...) Potential
Glycosylation3101N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation3291N-linked (GlcNAc...) Potential
Glycosylation3541N-linked (GlcNAc...) Potential
Glycosylation3681N-linked (GlcNAc...) Potential
Glycosylation3891N-linked (GlcNAc...) Potential
Glycosylation4101N-linked (GlcNAc...) Potential
Glycosylation4231N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation4551N-linked (GlcNAc...) Potential
Glycosylation5121N-linked (GlcNAc...) Potential
Glycosylation5281N-linked (GlcNAc...) Potential
Glycosylation5531N-linked (GlcNAc...) Potential
Glycosylation7361N-linked (GlcNAc...) Potential
Glycosylation7391N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence205 – 21814NGSIV…VVGSS → MSLLSPKLECNGTI in isoform 2.
VSP_039588
Alternative sequence219 – 910692Missing in isoform 2.
VSP_039589
Natural variant7871I → V.
Corresponds to variant rs1226475 [ dbSNP | Ensembl ].
VAR_055928

Experimental info

Sequence conflict231G → GV in CAI13874. Ref.4
Sequence conflict271G → D in BAB15452. Ref.3
Sequence conflict198 – 2036VQVTQF → MDISIQ in AAN46666. Ref.7
Sequence conflict6141I → A in BAB70874. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 10, 2010. Version 2.
Checksum: 07B5234A487E9F07

FASTA910101,365
        10         20         30         40         50         60 
MKVGVLWLIS FFTFTDGHGG FLGKNDGIKT KKELIVNKKK HLGPVEEYQL LLQVTYRDSK 

        70         80         90        100        110        120 
EKRDLRNFLK LLKPPLLWSH GLIRIIRAKA TTDCNSLNGV LQCTCEDSYT WFPPSCLDPQ 

       130        140        150        160        170        180 
NCYLHTAGAL PSCECHLNNL SQSVNFCERT KIWGTFKINE RFTNDLLNSS SAIYSKYANG 

       190        200        210        220        230        240 
IEIQLKKAYE RIQGFESVQV TQFRNGSIVA GYEVVGSSSA SELLSAIEHV AEKAKTALHK 

       250        260        270        280        290        300 
LFPLEDGSFR VFGKAQCNDI VFGFGSKDDE YTLPCSSGYR GNITAKCESS GWQVIRETCV 

       310        320        330        340        350        360 
LSLLEELNKN FSMIVGNATE AAVSSFVQNL SVIIRQNPST TVGNLASVVS ILSNISSLSL 

       370        380        390        400        410        420 
ASHFRVSNST MEDVISIADN ILNSASVTNW TVLLREEKYA SSRLLETLEN ISTLVPPTAL 

       430        440        450        460        470        480 
PLNFSRKFID WKGIPVNKSQ LKRGYSYQIK MCPQNTSIPI RGRVLIGSDQ FQRSLPETII 

       490        500        510        520        530        540 
SMASLTLGNI LPVSKNGNAQ VNGPVISTVI QNYSINEVFL FFSKIESNLS QPHCVFWDFS 

       550        560        570        580        590        600 
HLQWNDAGCH LVNETQDIVT CQCTHLTSFS ILMSPFVPST IFPVVKWITY VGLGISIGSL 

       610        620        630        640        650        660 
ILCLIIEALF WKQIKKSQTS HTRRICMVNI ALSLLIADVW FIVGATVDTT VNPSGVCTAA 

       670        680        690        700        710        720 
VFFTHFFYLS LFFWMLMLGI LLAYRIILVF HHMAQHLMMA VGFCLGYGCP LIISVITIAV 

       730        740        750        760        770        780 
TQPSNTYKRK DVCWLNWSNG SKPLLAFVVP ALAIVAVNFV VVLLVLTKLW RPTVGERLSR 

       790        800        810        820        830        840 
DDKATIIRVG KSLLILTPLL GLTWGFGIGT IVDSQNLAWH VIFALLNAFQ GFFILCFGIL 

       850        860        870        880        890        900 
LDSKLRQLLF NKLSALSSWK QTEKQNSSDL SAKPKFSKPF NPLQNKGHYA FSHTGDSSDN 

       910 
IMLTQFVSNE 

« Hide

Isoform 2 [UniParc].

Checksum: BE49C1F12A0B3D4C
Show »

FASTA21824,876

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Probable G-protein coupled receptor KPG_012."
Okazaki H., Inoue S., Yoshida S., Urakawa I., Mizutani S.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-613 (ISOFORM 1).
Tissue: Small intestine and Tongue.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung.
[7]"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-910 (ISOFORM 1).
[8]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 460-636 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065679 Genomic DNA. Translation: BAC45260.1. Sequence problems.
AB045123 mRNA. Translation: BAD83599.1.
AK026337 mRNA. Translation: BAB15452.1.
AK055208 mRNA. Translation: BAB70874.1. Sequence problems.
AL355518 Genomic DNA. Translation: CAI13873.1. Sequence problems.
AL355518 Genomic DNA. Translation: CAI13874.1.
AL355518 Genomic DNA. Translation: CAI13875.1.
CH471081 Genomic DNA. Translation: EAX04311.1.
BC113634 mRNA. Translation: AAI13635.1.
BC113636 mRNA. Translation: AAI13637.1.
AY140952 mRNA. Translation: AAN46666.1.
AY255595 mRNA. Translation: AAO85107.1.
RefSeqNP_079324.2. NM_025048.2.
NP_722582.2. NM_153840.2.
XP_005249062.1. XM_005249005.2.
UniGeneHs.733762.

3D structure databases

ProteinModelPortalQ5T601.
SMRQ5T601. Positions 584-842.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000360299.

Protein family/group databases

MEROPSS63.025.
GPCRDBSearch...

PTM databases

PhosphoSiteQ5T601.

Polymorphism databases

DMDM302393689.

Proteomic databases

PaxDbQ5T601.
PRIDEQ5T601.

Protocols and materials databases

DNASU266977.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283297; ENSP00000283297; ENSG00000153292.
ENST00000371243; ENSP00000360289; ENSG00000153292. [Q5T601-2]
ENST00000371253; ENSP00000360299; ENSG00000153292. [Q5T601-1]
GeneID266977.
KEGGhsa:266977.
UCSCuc003oyt.3. human. [Q5T601-1]
uc003oyu.1. human. [Q5T601-2]

Organism-specific databases

CTD266977.
GeneCardsGC06M046976.
HGNCHGNC:18990. GPR110.
HPAHPA038438.
neXtProtNX_Q5T601.
PharmGKBPA128394769.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG235397.
HOVERGENHBG058365.
InParanoidQ5T601.
KOK08453.
OMAVSNSTME.
OrthoDBEOG771264.
PhylomeDBQ5T601.
TreeFamTF316380.

Gene expression databases

ArrayExpressQ5T601.
BgeeQ5T601.
CleanExHS_GPR110.
GenevestigatorQ5T601.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000082. SEA_dom.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF01390. SEA. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTSM00303. GPS. 1 hit.
[Graphical view]
PROSITEPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR110.
GenomeRNAi266977.
NextBio93369.
PROQ5T601.

Entry information

Entry nameGP110_HUMAN
AccessionPrimary (citable) accession number: Q5T601
Secondary accession number(s): Q5KU15 expand/collapse secondary AC list , Q5T5Z9, Q5T600, Q86SM1, Q8IXE3, Q8IZF8, Q96DQ1, Q9H615
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: August 10, 2010
Last modified: April 16, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

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Index of human polymorphisms and disease mutations

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