Q5T601 (GP110_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 110

Alternative name(s):
G-protein coupled receptor KPG_012
G-protein coupled receptor PGR19

Gene names

Name:	GPR110
Synonyms:	PGR19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	910 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 1 SEA domain.
Sequence caution	The sequence BAB70874.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB70874.1 differs from that shown. Reason: Probable cloning artifact. The sequence BAC45260.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI13873.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cell junction Inferred from direct assay. Source: HPA integral to membrane Traceable author statement PubMed 15203201. Source: GDB nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 15203201. Source: GDB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T601-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T601-2)

The sequence of this isoform differs from the canonical sequence as follows:
     205-218: NGSIVAGYEVVGSS → MSLLSPKLECNGTI
     219-910: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 910	891	Probable G-protein coupled receptor 110		PRO_0000012891
Regions
	Topological domain	20 – 590	571	Extracellular Potential
	Transmembrane	591 – 611	21	Helical; Name=1; Potential
	Topological domain	612 – 624	13	Cytoplasmic Potential
	Transmembrane	625 – 645	21	Helical; Name=2; Potential
	Topological domain	646 – 660	15	Extracellular Potential
	Transmembrane	661 – 681	21	Helical; Name=3; Potential
	Topological domain	682 – 699	18	Cytoplasmic Potential
	Transmembrane	700 – 720	21	Helical; Name=4; Potential
	Topological domain	721 – 744	24	Extracellular Potential
	Transmembrane	745 – 765	21	Helical; Name=5; Potential
	Topological domain	766 – 791	26	Cytoplasmic Potential
	Transmembrane	792 – 812	21	Helical; Name=6; Potential
	Topological domain	813 – 820	8	Extracellular Potential
	Transmembrane	821 – 841	21	Helical; Name=7; Potential
	Topological domain	842 – 910	69	Cytoplasmic Potential
	Domain	146 – 252	107	SEA
	Domain	531 – 578	48	GPS
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
	Glycosylation	168	1	N-linked (GlcNAc...) Potential
	Glycosylation	205	1	N-linked (GlcNAc...) Potential
	Glycosylation	282	1	N-linked (GlcNAc...) Potential
	Glycosylation	310	1	N-linked (GlcNAc...) Potential
	Glycosylation	317	1	N-linked (GlcNAc...) Potential
	Glycosylation	329	1	N-linked (GlcNAc...) Potential
	Glycosylation	354	1	N-linked (GlcNAc...) Potential
	Glycosylation	368	1	N-linked (GlcNAc...) Potential
	Glycosylation	389	1	N-linked (GlcNAc...) Potential
	Glycosylation	410	1	N-linked (GlcNAc...) Potential
	Glycosylation	423	1	N-linked (GlcNAc...) Potential
	Glycosylation	437	1	N-linked (GlcNAc...) Potential
	Glycosylation	455	1	N-linked (GlcNAc...) Potential
	Glycosylation	512	1	N-linked (GlcNAc...) Potential
	Glycosylation	528	1	N-linked (GlcNAc...) Potential
	Glycosylation	553	1	N-linked (GlcNAc...) Potential
	Glycosylation	736	1	N-linked (GlcNAc...) Potential
	Glycosylation	739	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	205 – 218	14	NGSIV…VVGSS → MSLLSPKLECNGTI in isoform 2.		VSP_039588
	Alternative sequence	219 – 910	692	Missing in isoform 2.		VSP_039589
	Natural variant	787	1	I → V. Corresponds to variant rs1226475 [ dbSNP | Ensembl ].		VAR_055928
Experimental info
	Sequence conflict	23	1	G → GV in CAI13874. Ref.4
	Sequence conflict	27	1	G → D in BAB15452. Ref.3
	Sequence conflict	198 – 203	6	VQVTQF → MDISIQ in AAN46666. Ref.7
	Sequence conflict	614	1	I → A in BAB70874. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 10, 2010. Version 2. Checksum: 07B5234A487E9F07	FASTA	910	101,365
	10 20 30 40 50 60 MKVGVLWLIS FFTFTDGHGG FLGKNDGIKT KKELIVNKKK HLGPVEEYQL LLQVTYRDSK 70 80 90 100 110 120 EKRDLRNFLK LLKPPLLWSH GLIRIIRAKA TTDCNSLNGV LQCTCEDSYT WFPPSCLDPQ 130 140 150 160 170 180 NCYLHTAGAL PSCECHLNNL SQSVNFCERT KIWGTFKINE RFTNDLLNSS SAIYSKYANG 190 200 210 220 230 240 IEIQLKKAYE RIQGFESVQV TQFRNGSIVA GYEVVGSSSA SELLSAIEHV AEKAKTALHK 250 260 270 280 290 300 LFPLEDGSFR VFGKAQCNDI VFGFGSKDDE YTLPCSSGYR GNITAKCESS GWQVIRETCV 310 320 330 340 350 360 LSLLEELNKN FSMIVGNATE AAVSSFVQNL SVIIRQNPST TVGNLASVVS ILSNISSLSL 370 380 390 400 410 420 ASHFRVSNST MEDVISIADN ILNSASVTNW TVLLREEKYA SSRLLETLEN ISTLVPPTAL 430 440 450 460 470 480 PLNFSRKFID WKGIPVNKSQ LKRGYSYQIK MCPQNTSIPI RGRVLIGSDQ FQRSLPETII 490 500 510 520 530 540 SMASLTLGNI LPVSKNGNAQ VNGPVISTVI QNYSINEVFL FFSKIESNLS QPHCVFWDFS 550 560 570 580 590 600 HLQWNDAGCH LVNETQDIVT CQCTHLTSFS ILMSPFVPST IFPVVKWITY VGLGISIGSL 610 620 630 640 650 660 ILCLIIEALF WKQIKKSQTS HTRRICMVNI ALSLLIADVW FIVGATVDTT VNPSGVCTAA 670 680 690 700 710 720 VFFTHFFYLS LFFWMLMLGI LLAYRIILVF HHMAQHLMMA VGFCLGYGCP LIISVITIAV 730 740 750 760 770 780 TQPSNTYKRK DVCWLNWSNG SKPLLAFVVP ALAIVAVNFV VVLLVLTKLW RPTVGERLSR 790 800 810 820 830 840 DDKATIIRVG KSLLILTPLL GLTWGFGIGT IVDSQNLAWH VIFALLNAFQ GFFILCFGIL 850 860 870 880 890 900 LDSKLRQLLF NKLSALSSWK QTEKQNSSDL SAKPKFSKPF NPLQNKGHYA FSHTGDSSDN 910 IMLTQFVSNE
	Isoform 2 [UniParc]. Checksum: BE49C1F12A0B3D4C	FASTA	218	24,876
	10 20 30 40 50 60 MKVGVLWLIS FFTFTDGHGG FLGKNDGIKT KKELIVNKKK HLGPVEEYQL LLQVTYRDSK 70 80 90 100 110 120 EKRDLRNFLK LLKPPLLWSH GLIRIIRAKA TTDCNSLNGV LQCTCEDSYT WFPPSCLDPQ 130 140 150 160 170 180 NCYLHTAGAL PSCECHLNNL SQSVNFCERT KIWGTFKINE RFTNDLLNSS SAIYSKYANG 190 200 210 IEIQLKKAYE RIQGFESVQV TQFRMSLLSP KLECNGTI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Probable G-protein coupled receptor KPG_012." Okazaki H., Inoue S., Yoshida S., Urakawa I., Mizutani S. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-613 (ISOFORM 1). Tissue: Small intestine and Tongue.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lung.
[7]	"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions." Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B. FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-910 (ISOFORM 1).
[8]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 460-636 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065679 Genomic DNA. Translation: BAC45260.1. Sequence problems. AB045123 mRNA. Translation: BAD83599.1. AK026337 mRNA. Translation: BAB15452.1. AK055208 mRNA. Translation: BAB70874.1. Sequence problems. AL355518 Genomic DNA. Translation: CAI13873.1. Sequence problems. AL355518 Genomic DNA. Translation: CAI13874.1. AL355518 Genomic DNA. Translation: CAI13875.1. CH471081 Genomic DNA. Translation: EAX04311.1. BC113634 mRNA. Translation: AAI13635.1. BC113636 mRNA. Translation: AAI13637.1. AY140952 mRNA. Translation: AAN46666.1. AY255595 mRNA. Translation: AAO85107.1.
IPI	IPI00017924. IPI00879033.
RefSeq	NP_079324.2. NM_025048.2. NP_722582.2. NM_153840.2.
UniGene	Hs.733762.
3D structure databases
ProteinModelPortal	Q5T601.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000360299.
Protein family/group databases
MEROPS	S63.025.
GPCRDB	Search...
PTM databases
PhosphoSite	Q5T601.
Polymorphism databases
DMDM	302393689.
Proteomic databases
PaxDb	Q5T601.
PRIDE	Q5T601.
Protocols and materials databases
DNASU	266977.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000283297; ENSP00000283297; ENSG00000153292. ENST00000371243; ENSP00000360289; ENSG00000153292. ENST00000371253; ENSP00000360299; ENSG00000153292.
GeneID	266977.
KEGG	hsa:266977.
UCSC	uc003oyt.3. human. uc003oyu.1. human.
Organism-specific databases
CTD	266977.
GeneCards	GC06M046976.
HGNC	HGNC:18990. GPR110.
HPA	HPA038438.
neXtProt	NX_Q5T601.
PharmGKB	PA128394769.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG235397.
HOVERGEN	HBG058365.
InParanoid	Q5T601.
KO	K08453.
OMA	VSNSTME.
Gene expression databases
ArrayExpress	Q5T601.
Bgee	Q5T601.
CleanEx	HS_GPR110.
Genevestigator	Q5T601.
GermOnline	ENSG00000153292. Homo sapiens.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR008078. GPCR_2_Ig-hepta_rcpt. IPR000832. GPCR_2_secretin-like. IPR000203. GPS_dom. IPR000082. SEA_dom. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF01825. GPS. 1 hit. PF01390. SEA. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN. PR01695. IGHEPTARCPTR.
SMART	SM00303. GPS. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. False negative. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS50024. SEA. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	266977.
NextBio	93369.

Entry information

Entry name

GP110_HUMAN

Accession

Primary (citable) accession number: Q5T601
Secondary accession number(s): Q5KU15 , Q5T5Z9, Q5T600, Q86SM1, Q8IXE3, Q8IZF8, Q96DQ1, Q9H615

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	August 10, 2010
Last modified:	May 29, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.