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Protein

Calmodulin-regulated spectrin-associated protein 1

Gene

CAMSAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable microtubule-binding protein that plays a role in the regulation of cell morphology and cytoskeletal organization. Through interaction with spectrin may regulate neurite outgrowth.3 Publications

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • spectrin binding Source: UniProtKB

GO - Biological processi

  • cytoskeleton organization Source: UniProtKB
  • neuron projection development Source: UniProtKB
  • regulation of cell morphogenesis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-regulated spectrin-associated protein 1
Gene namesi
Name:CAMSAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:19946. CAMSAP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • microtubule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi885 – 8884LEEK → AAAA: Loss of interaction with SPTBN1. 1 Publication

Organism-specific databases

PharmGKBiPA134866541.

Polymorphism and mutation databases

BioMutaiCAMSAP1.
DMDMi166991445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16021602Calmodulin-regulated spectrin-associated protein 1PRO_0000316828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei217 – 2171PhosphoserineCombined sources
Modified residuei371 – 3711PhosphoserineCombined sources
Modified residuei375 – 3751PhosphoserineCombined sources
Modified residuei416 – 4161PhosphoserineCombined sources
Modified residuei431 – 4311PhosphoserineCombined sources
Modified residuei512 – 5121PhosphothreonineCombined sources
Modified residuei563 – 5631PhosphoserineCombined sources
Modified residuei575 – 5751PhosphoserineCombined sources
Modified residuei589 – 5891PhosphoserineCombined sources
Modified residuei629 – 6291PhosphoserineCombined sources
Modified residuei722 – 7221PhosphoserineCombined sources
Modified residuei728 – 7281PhosphoserineBy similarity
Modified residuei738 – 7381PhosphoserineBy similarity
Modified residuei740 – 7401PhosphoserineBy similarity
Modified residuei1080 – 10801PhosphoserineCombined sources
Modified residuei1398 – 13981PhosphoserineCombined sources
Modified residuei1427 – 14271PhosphoserineBy similarity
Modified residuei1537 – 15371PhosphotyrosineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T5Y3.
MaxQBiQ5T5Y3.
PaxDbiQ5T5Y3.
PeptideAtlasiQ5T5Y3.
PRIDEiQ5T5Y3.

PTM databases

iPTMnetiQ5T5Y3.
PhosphoSiteiQ5T5Y3.

Expressioni

Gene expression databases

BgeeiENSG00000130559.
CleanExiHS_CAMSAP1.
GenevisibleiQ5T5Y3. HS.

Organism-specific databases

HPAiHPA020521.
HPA020529.
HPA024161.

Interactioni

Subunit structurei

Interacts with spectrin via SPTBN1; the interaction is direct. Interacts with calmodulin; calcium-dependent it prevents interaction with spectrin.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • spectrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi127632. 24 interactions.
IntActiQ5T5Y3. 24 interactions.
MINTiMINT-1197654.
STRINGi9606.ENSP00000374183.

Structurei

3D structure databases

ProteinModelPortaliQ5T5Y3.
SMRiQ5T5Y3. Positions 1462-1591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini183 – 328146CHAdd
BLAST
Domaini1463 – 1597135CKKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni871 – 89222Sufficient for interaction with SPTBN1Add
BLAST
Regioni903 – 92220Sufficient for interaction with calmodulinAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi536 – 5416Poly-Glu
Compositional biasi1210 – 12134Poly-Ser

Domaini

The CKK domain binds microtubules.PROSITE-ProRule annotation1 Publication

Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation
Contains 1 CKK domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3654. Eukaryota.
ENOG4111D0B. LUCA.
GeneTreeiENSGT00390000010026.
HOVERGENiHBG107572.
InParanoidiQ5T5Y3.
KOiK17493.
OMAiKPPRLGQ.
OrthoDBiEOG091G00FI.
PhylomeDBiQ5T5Y3.
TreeFamiTF315529.

Family and domain databases

InterProiIPR032940. CAMSAP.
IPR031372. CAMSAP_CC1.
IPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR014797. CKK_domain.
IPR011033. PRC_barrel-like.
[Graphical view]
PANTHERiPTHR21595. PTHR21595. 1 hit.
PfamiPF17095. CAMSAP_CC1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF08683. CAMSAP_CKK. 1 hit.
[Graphical view]
SMARTiSM01051. CAMSAP_CKK. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50346. SSF50346. 1 hit.
PROSITEiPS51508. CKK. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T5Y3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDASGRAAA EGWRKMEAPP DGAADLVPLD RYDAARAKIA ANLQWICAKA
60 70 80 90 100
YGRDNIPEDL RDPFYVDQYE QEHIKPPVIK LLLSSELYCR VCSLILKGDQ
110 120 130 140 150
VAALQGHQSV IQALSRKGIY VMESDDTPVT ESDLSRAPIK MSAHMAMVDA
160 170 180 190 200
LMMAYTVEMI SIEKVVASVK RFSTFSASKE LPYDLEDAMV FWINKVNLKM
210 220 230 240 250
REITEKEVKL KQQLLESPAH QKVRYRREHL SARQSPYFPL LEDLMRDGSD
260 270 280 290 300
GAALLAVIHY YCPEQMKLDD ICLKEVTSMA DSLYNIRLLR EFSNEYLNKC
310 320 330 340 350
FYLTLEDMLY APLVLKPNVM VFIAELFWWF ENVKPDFVQP RDVQELKDAK
360 370 380 390 400
TVLHQKSSRP PVPISNATKR SFLGSPAAGT LAELQPPVQL PAEGCHRHYL
410 420 430 440 450
HPEEPEYLGK GTAAFSPSHP LLPLRQKQQK SIQGEDIPDQ RHRSNSLTRV
460 470 480 490 500
DGQPRGAAIA WPEKKTRPAS QPTPFALHHA ASCEVDPSSG DSISLARSIS
510 520 530 540 550
KDSLASNIVN LTPQNQPHPT ATKSHGKSLL SNVSIEDEEE ELVAIVRADV
560 570 580 590 600
VPQQADPEFP RASPRALGLT ANARSPQGQL DTSESKPDSF FLEPLMPAVL
610 620 630 640 650
KPAKEKQVIT KEDERGEGRP RSIVSRRPSE GPQPLVRRKM TGSRDLNRTF
660 670 680 690 700
TPIPCSEFPM GIDPTETGPL SVETAGEVCG GPLALGGFDP FPQGPSTDGF
710 720 730 740 750
FLHVGRADED TEGRLYVSCS KSPNSHDSEP WTLLRQDSDS DVVDIEEAEH
760 770 780 790 800
DFMGEAHPVV FSRYIGEEES AKLQEDMKVK EHEDKDDASG RSSPCLSTAS
810 820 830 840 850
QMSSVSMASG SVKMTSFAER KLQRLNSCET KSSTSSSQKT TPDASESCPA
860 870 880 890 900
PLTTWRQKRE QSPSQHGKDP ASLLASELVQ LHMQLEEKRR AIEAQKKKME
910 920 930 940 950
ALSARQRLKL GKAAFLHVVK KGKAEAAPPL RPEHFAKEYS QHNGEDCGDA
960 970 980 990 1000
VSKTEDFLVK EEQREELLHE PQDVDKESLA FAQQHKAKDP VALHELERNK
1010 1020 1030 1040 1050
VISAALLEDT VGEVVDVNEC DLSIEKLNET ISTLQQAILK ISQQQEQLLM
1060 1070 1080 1090 1100
KSPTVPVPGS KNNSQDHKVK APVHFVEPLS PTGVAGHRKA PRLGQGRNSR
1110 1120 1130 1140 1150
SGRPAELKVP KDRPQGSSRS KTPTPSVETL PHLRPFPASS HPRTPTDPGL
1160 1170 1180 1190 1200
DSALEPSGDP HGKCLFDSYR LHDESNQRTL TLSSSKDANI LSEQMSLKEV
1210 1220 1230 1240 1250
LDASVKEVGS SSSDVSGKES VPVEEPLRSR ASLIEVDLSD LKAPDEDGEL
1260 1270 1280 1290 1300
VSLDGSADLV SEGDQKPGVG FFFKDEQKAE DELAKKRAAF LLKQQRKAEE
1310 1320 1330 1340 1350
ARVRKQQLEA EVELKRDEAR RKAEEDRVRK EEEKARRELI KQEYLRRKQQ
1360 1370 1380 1390 1400
QILEEQGLGK PKSKPKKPRP KSVHREESCS DSGTKCSSTP DNLSRTQSGS
1410 1420 1430 1440 1450
SLSLASAATT EPESVHSGGT PSQRVESMEA LPILSRNPSR STDRDWETAS
1460 1470 1480 1490 1500
AASSLASVAE YTGPKLFKEP SSKSNKPIIH NAISHCCLAG KVNEPHKNSI
1510 1520 1530 1540 1550
LEELEKCDAN HYIILFRDAG CQFRALYCYY PDTEEIYKLT GTGPKNITKK
1560 1570 1580 1590 1600
MIDKLYKYSS DRKQFNLIPA KTMSVSVDAL TIHNHLWQPK RPAVPKKAQT

RK
Length:1,602
Mass (Da):177,972
Last modified:February 20, 2007 - v2
Checksum:i184823C2A151F8A7
GO
Isoform 2 (identifier: Q5T5Y3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-278: Missing.

Note: No experimental confirmation available.
Show »
Length:1,324
Mass (Da):146,546
Checksum:iFA81C36B97C9F87F
GO
Isoform 3 (identifier: Q5T5Y3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-222: K → KSPSKWYWKLVP

Note: No experimental confirmation available.
Show »
Length:1,613
Mass (Da):179,345
Checksum:i2B088369A51DB53D
GO

Sequence cautioni

The sequence AAI30581 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti823 – 8231Q → H in AAH12778 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti476 – 4761A → V.
Corresponds to variant rs35639321 [ dbSNP | Ensembl ].
VAR_038398

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 278278Missing in isoform 2. 1 PublicationVSP_030800Add
BLAST
Alternative sequencei222 – 2221K → KSPSKWYWKLVP in isoform 3. 1 PublicationVSP_030801

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ519841 mRNA. Translation: CAD58627.1.
AL355574, AL158822, AL353636 Genomic DNA. Translation: CAI14116.2.
AL158822, AL353636, AL355574 Genomic DNA. Translation: CAI39237.2.
AL353636, AL158822, AL355574 Genomic DNA. Translation: CAI40811.2.
AL355574, AL158822, AL353636 Genomic DNA. Translation: CAQ52438.1.
AL353636, AL158822, AL355574 Genomic DNA. Translation: CAQ52575.1.
AL353636, AL158822 Genomic DNA. Translation: CAQ52576.1.
AL158822, AL353636, AL355574 Genomic DNA. Translation: CAQ52650.1.
AL158822, AL353636 Genomic DNA. Translation: CAQ52651.1.
BC010646 mRNA. Translation: AAH10646.1.
BC012778 mRNA. Translation: AAH12778.2.
BC130580 mRNA. Translation: AAI30581.1. Different initiation.
AL117634 mRNA. Translation: CAB56024.2.
AL834528 mRNA. Translation: CAD39184.1.
CCDSiCCDS35176.2. [Q5T5Y3-1]
PIRiT17334.
RefSeqiNP_056262.3. NM_015447.3. [Q5T5Y3-1]
XP_005263453.1. XM_005263396.3. [Q5T5Y3-3]
XP_005263454.1. XM_005263397.1. [Q5T5Y3-2]
UniGeneiHs.522493.

Genome annotation databases

EnsembliENST00000312405; ENSP00000312463; ENSG00000130559. [Q5T5Y3-2]
ENST00000389532; ENSP00000374183; ENSG00000130559. [Q5T5Y3-1]
ENST00000409386; ENSP00000386420; ENSG00000130559. [Q5T5Y3-3]
GeneIDi157922.
KEGGihsa:157922.
UCSCiuc004cgr.5. human. [Q5T5Y3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ519841 mRNA. Translation: CAD58627.1.
AL355574, AL158822, AL353636 Genomic DNA. Translation: CAI14116.2.
AL158822, AL353636, AL355574 Genomic DNA. Translation: CAI39237.2.
AL353636, AL158822, AL355574 Genomic DNA. Translation: CAI40811.2.
AL355574, AL158822, AL353636 Genomic DNA. Translation: CAQ52438.1.
AL353636, AL158822, AL355574 Genomic DNA. Translation: CAQ52575.1.
AL353636, AL158822 Genomic DNA. Translation: CAQ52576.1.
AL158822, AL353636, AL355574 Genomic DNA. Translation: CAQ52650.1.
AL158822, AL353636 Genomic DNA. Translation: CAQ52651.1.
BC010646 mRNA. Translation: AAH10646.1.
BC012778 mRNA. Translation: AAH12778.2.
BC130580 mRNA. Translation: AAI30581.1. Different initiation.
AL117634 mRNA. Translation: CAB56024.2.
AL834528 mRNA. Translation: CAD39184.1.
CCDSiCCDS35176.2. [Q5T5Y3-1]
PIRiT17334.
RefSeqiNP_056262.3. NM_015447.3. [Q5T5Y3-1]
XP_005263453.1. XM_005263396.3. [Q5T5Y3-3]
XP_005263454.1. XM_005263397.1. [Q5T5Y3-2]
UniGeneiHs.522493.

3D structure databases

ProteinModelPortaliQ5T5Y3.
SMRiQ5T5Y3. Positions 1462-1591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127632. 24 interactions.
IntActiQ5T5Y3. 24 interactions.
MINTiMINT-1197654.
STRINGi9606.ENSP00000374183.

PTM databases

iPTMnetiQ5T5Y3.
PhosphoSiteiQ5T5Y3.

Polymorphism and mutation databases

BioMutaiCAMSAP1.
DMDMi166991445.

Proteomic databases

EPDiQ5T5Y3.
MaxQBiQ5T5Y3.
PaxDbiQ5T5Y3.
PeptideAtlasiQ5T5Y3.
PRIDEiQ5T5Y3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312405; ENSP00000312463; ENSG00000130559. [Q5T5Y3-2]
ENST00000389532; ENSP00000374183; ENSG00000130559. [Q5T5Y3-1]
ENST00000409386; ENSP00000386420; ENSG00000130559. [Q5T5Y3-3]
GeneIDi157922.
KEGGihsa:157922.
UCSCiuc004cgr.5. human. [Q5T5Y3-1]

Organism-specific databases

CTDi157922.
GeneCardsiCAMSAP1.
H-InvDBHIX0201359.
HGNCiHGNC:19946. CAMSAP1.
HPAiHPA020521.
HPA020529.
HPA024161.
MIMi613774. gene.
neXtProtiNX_Q5T5Y3.
PharmGKBiPA134866541.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3654. Eukaryota.
ENOG4111D0B. LUCA.
GeneTreeiENSGT00390000010026.
HOVERGENiHBG107572.
InParanoidiQ5T5Y3.
KOiK17493.
OMAiKPPRLGQ.
OrthoDBiEOG091G00FI.
PhylomeDBiQ5T5Y3.
TreeFamiTF315529.

Miscellaneous databases

ChiTaRSiCAMSAP1. human.
GenomeRNAii157922.
PROiQ5T5Y3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130559.
CleanExiHS_CAMSAP1.
GenevisibleiQ5T5Y3. HS.

Family and domain databases

InterProiIPR032940. CAMSAP.
IPR031372. CAMSAP_CC1.
IPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR014797. CKK_domain.
IPR011033. PRC_barrel-like.
[Graphical view]
PANTHERiPTHR21595. PTHR21595. 1 hit.
PfamiPF17095. CAMSAP_CC1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF08683. CAMSAP_CKK. 1 hit.
[Graphical view]
SMARTiSM01051. CAMSAP_CKK. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50346. SSF50346. 1 hit.
PROSITEiPS51508. CKK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAMP1_HUMAN
AccessioniPrimary (citable) accession number: Q5T5Y3
Secondary accession number(s): A1L4L2
, B2REB2, B2REB3, Q70W33, Q8NCY0, Q96E80, Q96FM3, Q9UFJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.