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Q5T5X7

- BEND3_HUMAN

UniProt

Q5T5X7 - BEND3_HUMAN

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Protein

BEN domain-containing protein 3

Gene

BEND3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BEN domain-containing protein 3
Gene namesi
Name:BEND3
Synonyms:KIAA1553
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:23040. BEND3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716540.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 828828BEN domain-containing protein 3PRO_0000290200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei164 – 1641Phosphoserine2 Publications
Modified residuei379 – 3791Phosphoserine2 Publications
Modified residuei489 – 4891Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5T5X7.
PaxDbiQ5T5X7.
PRIDEiQ5T5X7.

PTM databases

PhosphoSiteiQ5T5X7.

Expressioni

Gene expression databases

BgeeiQ5T5X7.
CleanExiHS_BEND3.
GenevestigatoriQ5T5X7.

Organism-specific databases

HPAiHPA017891.

Interactioni

Protein-protein interaction databases

BioGridi121704. 11 interactions.
IntActiQ5T5X7. 6 interactions.
MINTiMINT-8173827.
STRINGi9606.ENSP00000340166.

Structurei

3D structure databases

ProteinModelPortaliQ5T5X7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini242 – 343102BEN 1PROSITE-ProRule annotationAdd
BLAST
Domaini387 – 487101BEN 2PROSITE-ProRule annotationAdd
BLAST
Domaini548 – 650103BEN 3PROSITE-ProRule annotationAdd
BLAST
Domaini715 – 816102BEN 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 BEN domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG70983.
GeneTreeiENSGT00390000010827.
HOGENOMiHOG000082471.
HOVERGENiHBG091074.
InParanoidiQ5T5X7.
OMAiLFDHRKL.
OrthoDBiEOG7T4MJG.
PhylomeDBiQ5T5X7.
TreeFamiTF300204.

Family and domain databases

InterProiIPR018379. BEN_domain.
[Graphical view]
PfamiPF10523. BEN. 4 hits.
[Graphical view]
SMARTiSM01025. BEN. 4 hits.
[Graphical view]
PROSITEiPS51457. BEN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T5X7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSTEFTEDV EEVLKSITVK VETEAEDAAL DCSVNSRTSE KHSVDSVLTA
60 70 80 90 100
LQDSSKRKQL VSDGLLDSVP GVKRRRLIPE ALLAGMRNRE NSSPCQGNGE
110 120 130 140 150
QAGRGRSLGN VWPGEEEPCN DATTPSYKKP LYGISHKIME KKNPPSGDLL
160 170 180 190 200
NVYELFEKAN ASNSPSSLRL LNEPQKRDCG STGAGTDNDP NIYFLIQKMF
210 220 230 240 250
YMLNTLTSNM SQLHSKVDLL SLEVSRIKKQ VSPTEMVAKF QPPPEYQLTA
260 270 280 290 300
AELKQIVDQS LSGGDLACRL LVQLFPELFS DVDFSRGCSA CGFAAKRKLE
310 320 330 340 350
SLHLQLIRNY VEVYYPSVKD TAVWQAECLP QLNDFFSRFW AQREMEDSQP
360 370 380 390 400
SGQVASFFEA EQVDPGHFLD NKDQEEALSL DRSSTIASDH VVDTQDLTEF
410 420 430 440 450
LDEASSPGEF AVFLLHRLFP ELFDHRKLGE QYSCYGDGGK QELDPQRLQI
460 470 480 490 500
IRNYTEIYFP DMQEEEAWLQ QCAQRINDEL EGLGLDAGSE GDPPRDDCYD
510 520 530 540 550
SSSLPDDISV VKVEDSFEGE RPGRRSKKIW LVPIDFDKLE IPQPDFEVPG
560 570 580 590 600
ADCLLSKEQL RSIYESSLSI GNFASRLLVH LFPELFTHEN LRKQYNCSGS
610 620 630 640 650
LGKKQLDPSR IKLIRHYVQL LYPRAKNDRV WTLEFVGKLD ERCRRRDTEQ
660 670 680 690 700
RRSYQQQRKV HVPGPECRDL TSYAINPERF REEFEGPPLP PERSSKDFCK
710 720 730 740 750
IPLDELVVPS PDFPVPSPYL LSDKEVREIV QQSLSVGNFA ARLLVRLFPE
760 770 780 790 800
LFTAENLRLQ YNHSGACNKK QLDPTRLRLI RHYVEAVYPV EKMEEVWHYE
810 820
CIPSIDERCR RPNRKKCDIL KKAKKVEK
Length:828
Mass (Da):94,475
Last modified:December 21, 2004 - v1
Checksum:i28D8F39112DB7EAE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti409 – 4091E → D in BAB13379. (PubMed:10997877)Curated
Sequence conflicti596 – 5961N → S in AAI31629. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355586 Genomic DNA. Translation: CAI16110.1.
BC131628 mRNA. Translation: AAI31629.1.
AB046773 mRNA. Translation: BAB13379.1.
CCDSiCCDS34507.1.
RefSeqiNP_001073919.1. NM_001080450.2.
XP_005267136.1. XM_005267079.1.
XP_005267137.1. XM_005267080.1.
XP_006715595.1. XM_006715532.1.
UniGeneiHs.418045.

Genome annotation databases

EnsembliENST00000369042; ENSP00000358038; ENSG00000178409.
ENST00000429433; ENSP00000411268; ENSG00000178409.
GeneIDi57673.
KEGGihsa:57673.
UCSCiuc003prs.2. human.

Polymorphism databases

DMDMi74745144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355586 Genomic DNA. Translation: CAI16110.1 .
BC131628 mRNA. Translation: AAI31629.1 .
AB046773 mRNA. Translation: BAB13379.1 .
CCDSi CCDS34507.1.
RefSeqi NP_001073919.1. NM_001080450.2.
XP_005267136.1. XM_005267079.1.
XP_005267137.1. XM_005267080.1.
XP_006715595.1. XM_006715532.1.
UniGenei Hs.418045.

3D structure databases

ProteinModelPortali Q5T5X7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121704. 11 interactions.
IntActi Q5T5X7. 6 interactions.
MINTi MINT-8173827.
STRINGi 9606.ENSP00000340166.

PTM databases

PhosphoSitei Q5T5X7.

Polymorphism databases

DMDMi 74745144.

Proteomic databases

MaxQBi Q5T5X7.
PaxDbi Q5T5X7.
PRIDEi Q5T5X7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369042 ; ENSP00000358038 ; ENSG00000178409 .
ENST00000429433 ; ENSP00000411268 ; ENSG00000178409 .
GeneIDi 57673.
KEGGi hsa:57673.
UCSCi uc003prs.2. human.

Organism-specific databases

CTDi 57673.
GeneCardsi GC06M107386.
H-InvDB HIX0006107.
HIX0021350.
HIX0170379.
HGNCi HGNC:23040. BEND3.
HPAi HPA017891.
neXtProti NX_Q5T5X7.
PharmGKBi PA164716540.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG70983.
GeneTreei ENSGT00390000010827.
HOGENOMi HOG000082471.
HOVERGENi HBG091074.
InParanoidi Q5T5X7.
OMAi LFDHRKL.
OrthoDBi EOG7T4MJG.
PhylomeDBi Q5T5X7.
TreeFami TF300204.

Miscellaneous databases

GenomeRNAii 57673.
NextBioi 64470.
PROi Q5T5X7.

Gene expression databases

Bgeei Q5T5X7.
CleanExi HS_BEND3.
Genevestigatori Q5T5X7.

Family and domain databases

InterProi IPR018379. BEN_domain.
[Graphical view ]
Pfami PF10523. BEN. 4 hits.
[Graphical view ]
SMARTi SM01025. BEN. 4 hits.
[Graphical view ]
PROSITEi PS51457. BEN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-828.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-489, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164 AND SER-379, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-379 AND SER-489, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBEND3_HUMAN
AccessioniPrimary (citable) accession number: Q5T5X7
Secondary accession number(s): A2RRH2, Q9HCL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3