Q5T5X7 (BEND3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BEN domain-containing protein 3

Gene names

Name:	BEND3
Synonyms:	KIAA1553

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	828 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 4 BEN domains.

Ontologies

Keywords
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 828	828	BEN domain-containing protein 3		PRO_0000290200
Regions
	Domain	242 – 343	102	BEN 1
	Domain	387 – 487	101	BEN 2
	Domain	548 – 650	103	BEN 3
	Domain	715 – 816	102	BEN 4
Amino acid modifications
	Modified residue	164	1	Phosphoserine Ref.6 Ref.7
	Modified residue	379	1	Phosphoserine Ref.6 Ref.7
	Modified residue	489	1	Phosphoserine Ref.4 Ref.7
Experimental info
	Sequence conflict	409	1	E → D in BAB13379. Ref.3
	Sequence conflict	596	1	N → S in AAI31629. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5T5X7 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 28D8F39112DB7EAE	FASTA	828	94,475
	10 20 30 40 50 60 MNSTEFTEDV EEVLKSITVK VETEAEDAAL DCSVNSRTSE KHSVDSVLTA LQDSSKRKQL 70 80 90 100 110 120 VSDGLLDSVP GVKRRRLIPE ALLAGMRNRE NSSPCQGNGE QAGRGRSLGN VWPGEEEPCN 130 140 150 160 170 180 DATTPSYKKP LYGISHKIME KKNPPSGDLL NVYELFEKAN ASNSPSSLRL LNEPQKRDCG 190 200 210 220 230 240 STGAGTDNDP NIYFLIQKMF YMLNTLTSNM SQLHSKVDLL SLEVSRIKKQ VSPTEMVAKF 250 260 270 280 290 300 QPPPEYQLTA AELKQIVDQS LSGGDLACRL LVQLFPELFS DVDFSRGCSA CGFAAKRKLE 310 320 330 340 350 360 SLHLQLIRNY VEVYYPSVKD TAVWQAECLP QLNDFFSRFW AQREMEDSQP SGQVASFFEA 370 380 390 400 410 420 EQVDPGHFLD NKDQEEALSL DRSSTIASDH VVDTQDLTEF LDEASSPGEF AVFLLHRLFP 430 440 450 460 470 480 ELFDHRKLGE QYSCYGDGGK QELDPQRLQI IRNYTEIYFP DMQEEEAWLQ QCAQRINDEL 490 500 510 520 530 540 EGLGLDAGSE GDPPRDDCYD SSSLPDDISV VKVEDSFEGE RPGRRSKKIW LVPIDFDKLE 550 560 570 580 590 600 IPQPDFEVPG ADCLLSKEQL RSIYESSLSI GNFASRLLVH LFPELFTHEN LRKQYNCSGS 610 620 630 640 650 660 LGKKQLDPSR IKLIRHYVQL LYPRAKNDRV WTLEFVGKLD ERCRRRDTEQ RRSYQQQRKV 670 680 690 700 710 720 HVPGPECRDL TSYAINPERF REEFEGPPLP PERSSKDFCK IPLDELVVPS PDFPVPSPYL 730 740 750 760 770 780 LSDKEVREIV QQSLSVGNFA ARLLVRLFPE LFTAENLRLQ YNHSGACNKK QLDPTRLRLI 790 800 810 820 RHYVEAVYPV EKMEEVWHYE CIPSIDERCR RPNRKKCDIL KKAKKVEK

References

[1]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-828.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-489, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164 AND SER-379, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-379 AND SER-489, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL355586 Genomic DNA. Translation: CAI16110.1. BC131628 mRNA. Translation: AAI31629.1. AB046773 mRNA. Translation: BAB13379.1.
IPI	IPI00741958.
RefSeq	NP_001073919.1. NM_001080450.2.
UniGene	Hs.418045.
3D structure databases
ProteinModelPortal	Q5T5X7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5T5X7. 4 interactions.
STRING	9606.ENSP00000340166.
PTM databases
PhosphoSite	Q5T5X7.
Polymorphism databases
DMDM	74745144.
Proteomic databases
PaxDb	Q5T5X7.
PRIDE	Q5T5X7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369042; ENSP00000358038; ENSG00000178409. ENST00000429433; ENSP00000411268; ENSG00000178409.
GeneID	57673.
KEGG	hsa:57673.
UCSC	uc003prs.2. human.
Organism-specific databases
CTD	57673.
GeneCards	GC06M107386.
H-InvDB	HIX0006107. HIX0021350. HIX0170379.
HGNC	HGNC:23040. BEND3.
HPA	HPA017891.
neXtProt	NX_Q5T5X7.
PharmGKB	PA164716540.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG70983.
HOGENOM	HOG000082471.
HOVERGEN	HBG091074.
InParanoid	Q5T5X7.
OMA	LIQKMFY.
OrthoDB	EOG4ZS92R.
Gene expression databases
Bgee	Q5T5X7.
CleanEx	HS_BEND3.
Genevestigator	Q5T5X7.
Family and domain databases
InterPro	IPR018379. BEN_domain. [Graphical view]
Pfam	PF10523. BEN. 4 hits. [Graphical view]
SMART	SM01025. BEN. 4 hits. [Graphical view]
PROSITE	PS51457. BEN. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57673.
NextBio	64470.

Entry information

Entry name

BEND3_HUMAN

Accession

Primary (citable) accession number: Q5T5X7
Secondary accession number(s): A2RRH2, Q9HCL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.