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Q5T5X7

- BEND3_HUMAN

UniProt

Q5T5X7 - BEND3_HUMAN

Protein

BEN domain-containing protein 3

Gene

BEND3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BEN domain-containing protein 3
    Gene namesi
    Name:BEND3
    Synonyms:KIAA1553
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:23040. BEND3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164716540.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 828828BEN domain-containing protein 3PRO_0000290200Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei164 – 1641Phosphoserine2 Publications
    Modified residuei379 – 3791Phosphoserine2 Publications
    Modified residuei489 – 4891Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5T5X7.
    PaxDbiQ5T5X7.
    PRIDEiQ5T5X7.

    PTM databases

    PhosphoSiteiQ5T5X7.

    Expressioni

    Gene expression databases

    BgeeiQ5T5X7.
    CleanExiHS_BEND3.
    GenevestigatoriQ5T5X7.

    Organism-specific databases

    HPAiHPA017891.

    Interactioni

    Protein-protein interaction databases

    BioGridi121704. 11 interactions.
    IntActiQ5T5X7. 6 interactions.
    MINTiMINT-8173827.
    STRINGi9606.ENSP00000340166.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T5X7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini242 – 343102BEN 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini387 – 487101BEN 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini548 – 650103BEN 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini715 – 816102BEN 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 BEN domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG70983.
    HOGENOMiHOG000082471.
    HOVERGENiHBG091074.
    InParanoidiQ5T5X7.
    OMAiLFDHRKL.
    OrthoDBiEOG7T4MJG.
    PhylomeDBiQ5T5X7.
    TreeFamiTF300204.

    Family and domain databases

    InterProiIPR018379. BEN_domain.
    [Graphical view]
    PfamiPF10523. BEN. 4 hits.
    [Graphical view]
    SMARTiSM01025. BEN. 4 hits.
    [Graphical view]
    PROSITEiPS51457. BEN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5T5X7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSTEFTEDV EEVLKSITVK VETEAEDAAL DCSVNSRTSE KHSVDSVLTA    50
    LQDSSKRKQL VSDGLLDSVP GVKRRRLIPE ALLAGMRNRE NSSPCQGNGE 100
    QAGRGRSLGN VWPGEEEPCN DATTPSYKKP LYGISHKIME KKNPPSGDLL 150
    NVYELFEKAN ASNSPSSLRL LNEPQKRDCG STGAGTDNDP NIYFLIQKMF 200
    YMLNTLTSNM SQLHSKVDLL SLEVSRIKKQ VSPTEMVAKF QPPPEYQLTA 250
    AELKQIVDQS LSGGDLACRL LVQLFPELFS DVDFSRGCSA CGFAAKRKLE 300
    SLHLQLIRNY VEVYYPSVKD TAVWQAECLP QLNDFFSRFW AQREMEDSQP 350
    SGQVASFFEA EQVDPGHFLD NKDQEEALSL DRSSTIASDH VVDTQDLTEF 400
    LDEASSPGEF AVFLLHRLFP ELFDHRKLGE QYSCYGDGGK QELDPQRLQI 450
    IRNYTEIYFP DMQEEEAWLQ QCAQRINDEL EGLGLDAGSE GDPPRDDCYD 500
    SSSLPDDISV VKVEDSFEGE RPGRRSKKIW LVPIDFDKLE IPQPDFEVPG 550
    ADCLLSKEQL RSIYESSLSI GNFASRLLVH LFPELFTHEN LRKQYNCSGS 600
    LGKKQLDPSR IKLIRHYVQL LYPRAKNDRV WTLEFVGKLD ERCRRRDTEQ 650
    RRSYQQQRKV HVPGPECRDL TSYAINPERF REEFEGPPLP PERSSKDFCK 700
    IPLDELVVPS PDFPVPSPYL LSDKEVREIV QQSLSVGNFA ARLLVRLFPE 750
    LFTAENLRLQ YNHSGACNKK QLDPTRLRLI RHYVEAVYPV EKMEEVWHYE 800
    CIPSIDERCR RPNRKKCDIL KKAKKVEK 828
    Length:828
    Mass (Da):94,475
    Last modified:December 21, 2004 - v1
    Checksum:i28D8F39112DB7EAE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti409 – 4091E → D in BAB13379. (PubMed:10997877)Curated
    Sequence conflicti596 – 5961N → S in AAI31629. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL355586 Genomic DNA. Translation: CAI16110.1.
    BC131628 mRNA. Translation: AAI31629.1.
    AB046773 mRNA. Translation: BAB13379.1.
    CCDSiCCDS34507.1.
    RefSeqiNP_001073919.1. NM_001080450.2.
    XP_005267136.1. XM_005267079.1.
    XP_005267137.1. XM_005267080.1.
    XP_006715595.1. XM_006715532.1.
    UniGeneiHs.418045.

    Genome annotation databases

    EnsembliENST00000369042; ENSP00000358038; ENSG00000178409.
    ENST00000429433; ENSP00000411268; ENSG00000178409.
    GeneIDi57673.
    KEGGihsa:57673.
    UCSCiuc003prs.2. human.

    Polymorphism databases

    DMDMi74745144.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL355586 Genomic DNA. Translation: CAI16110.1 .
    BC131628 mRNA. Translation: AAI31629.1 .
    AB046773 mRNA. Translation: BAB13379.1 .
    CCDSi CCDS34507.1.
    RefSeqi NP_001073919.1. NM_001080450.2.
    XP_005267136.1. XM_005267079.1.
    XP_005267137.1. XM_005267080.1.
    XP_006715595.1. XM_006715532.1.
    UniGenei Hs.418045.

    3D structure databases

    ProteinModelPortali Q5T5X7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121704. 11 interactions.
    IntActi Q5T5X7. 6 interactions.
    MINTi MINT-8173827.
    STRINGi 9606.ENSP00000340166.

    PTM databases

    PhosphoSitei Q5T5X7.

    Polymorphism databases

    DMDMi 74745144.

    Proteomic databases

    MaxQBi Q5T5X7.
    PaxDbi Q5T5X7.
    PRIDEi Q5T5X7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369042 ; ENSP00000358038 ; ENSG00000178409 .
    ENST00000429433 ; ENSP00000411268 ; ENSG00000178409 .
    GeneIDi 57673.
    KEGGi hsa:57673.
    UCSCi uc003prs.2. human.

    Organism-specific databases

    CTDi 57673.
    GeneCardsi GC06M107386.
    H-InvDB HIX0006107.
    HIX0021350.
    HIX0170379.
    HGNCi HGNC:23040. BEND3.
    HPAi HPA017891.
    neXtProti NX_Q5T5X7.
    PharmGKBi PA164716540.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70983.
    HOGENOMi HOG000082471.
    HOVERGENi HBG091074.
    InParanoidi Q5T5X7.
    OMAi LFDHRKL.
    OrthoDBi EOG7T4MJG.
    PhylomeDBi Q5T5X7.
    TreeFami TF300204.

    Miscellaneous databases

    GenomeRNAii 57673.
    NextBioi 64470.
    PROi Q5T5X7.

    Gene expression databases

    Bgeei Q5T5X7.
    CleanExi HS_BEND3.
    Genevestigatori Q5T5X7.

    Family and domain databases

    InterProi IPR018379. BEN_domain.
    [Graphical view ]
    Pfami PF10523. BEN. 4 hits.
    [Graphical view ]
    SMARTi SM01025. BEN. 4 hits.
    [Graphical view ]
    PROSITEi PS51457. BEN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-828.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-489, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164 AND SER-379, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-379 AND SER-489, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBEND3_HUMAN
    AccessioniPrimary (citable) accession number: Q5T5X7
    Secondary accession number(s): A2RRH2, Q9HCL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3