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Protein

Rho GTPase-activating protein 21

Gene

ARHGAP21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.2 Publications

GO - Molecular functioni

GO - Biological processi

  • establishment of Golgi localization Source: BHF-UCL
  • Golgi organization Source: BHF-UCL
  • maintenance of Golgi location Source: BHF-UCL
  • organelle transport along microtubule Source: BHF-UCL
  • positive regulation of GTPase activity Source: GO_Central
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 21
Alternative name(s):
Rho GTPase-activating protein 10
Rho-type GTPase-activating protein 21
Gene namesi
Name:ARHGAP21
Synonyms:ARHGAP10, KIAA1424
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23725. ARHGAP21.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-SubCell
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • cytoskeleton Source: UniProtKB-SubCell
  • Golgi apparatus Source: BHF-UCL
  • Golgi membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi999Y → A: Altered interaction with ARF1 and loss of association to membranes. 1 Publication1
Mutagenesisi1053I → A: Altered interaction with ARF1 and loss of association to membranes. 1 Publication1
Mutagenesisi1183R → A: Loss of GTPase activity and loss of function. 2 Publications1

Organism-specific databases

DisGeNETi57584.
PharmGKBiPA134973559.

Polymorphism and mutation databases

BioMutaiARHGAP21.
DMDMi74745129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052451 – 1957Rho GTPase-activating protein 21Add BLAST1957

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineBy similarity1
Modified residuei56PhosphoserineCombined sources1
Modified residuei458PhosphoserineCombined sources1
Modified residuei553Omega-N-methylarginineCombined sources1
Modified residuei574Omega-N-methylarginineCombined sources1
Modified residuei611PhosphoserineCombined sources1
Modified residuei615PhosphoserineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei716PhosphoserineCombined sources1
Modified residuei746PhosphothreonineCombined sources1
Modified residuei856PhosphoserineCombined sources1
Modified residuei861PhosphoserineBy similarity1
Modified residuei880PhosphoserineCombined sources1
Modified residuei881PhosphotyrosineCombined sources1
Modified residuei923PhosphoserineCombined sources1
Modified residuei925PhosphoserineBy similarity1
Modified residuei953PhosphoserineCombined sources1
Modified residuei1098PhosphoserineBy similarity1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1417PhosphoserineCombined sources1
Modified residuei1431PhosphoserineCombined sources1
Modified residuei1432PhosphoserineCombined sources1
Cross-linki1443Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei1503PhosphoserineCombined sources1
Modified residuei1515PhosphothreonineCombined sources1
Modified residuei1526PhosphoserineCombined sources1
Modified residuei1668PhosphoserineCombined sources1
Modified residuei1681PhosphothreonineBy similarity1
Modified residuei1741PhosphoserineCombined sources1
Modified residuei1916PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes.1 Publication

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5T5U3.
MaxQBiQ5T5U3.
PaxDbiQ5T5U3.
PeptideAtlasiQ5T5U3.
PRIDEiQ5T5U3.

PTM databases

iPTMnetiQ5T5U3.
PhosphoSitePlusiQ5T5U3.

Expressioni

Tissue specificityi

Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.1 Publication

Inductioni

Up-regulated upon cell differentiation.1 Publication

Gene expression databases

BgeeiENSG00000107863.
CleanExiHS_ARHGAP10.
HS_ARHGAP21.
ExpressionAtlasiQ5T5U3. baseline and differential.
GenevisibleiQ5T5U3. HS.

Organism-specific databases

HPAiHPA036610.
HPA057861.

Interactioni

Subunit structurei

Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Arf1P840783EBI-1642518,EBI-2308190From a different organism.
EEF1DP296922EBI-1642518,EBI-358607

Protein-protein interaction databases

BioGridi121636. 41 interactors.
IntActiQ5T5U3. 45 interactors.
MINTiMINT-2811611.
STRINGi9606.ENSP00000379709.

Structurei

Secondary structure

11957
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi50 – 53Combined sources4
Beta strandi56 – 58Combined sources3
Beta strandi79 – 81Combined sources3
Beta strandi108 – 110Combined sources3
Helixi111 – 115Combined sources5
Helixi136 – 144Combined sources9
Beta strandi149 – 153Combined sources5
Beta strandi933 – 943Combined sources11
Beta strandi958 – 965Combined sources8
Beta strandi968 – 973Combined sources6
Beta strandi978 – 980Combined sources3
Beta strandi983 – 985Combined sources3
Beta strandi994 – 997Combined sources4
Beta strandi999 – 1001Combined sources3
Beta strandi1005 – 1011Combined sources7
Beta strandi1016 – 1020Combined sources5
Helixi1024 – 1037Combined sources14
Helixi1042 – 1062Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DHJNMR-A930-1041[»]
2J59X-ray2.10M/N/O/P/Q/R929-1096[»]
2YUYNMR-A46-158[»]
ProteinModelPortaliQ5T5U3.
SMRiQ5T5U3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5T5U3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 158PDZPROSITE-ProRule annotationAdd BLAST110
Domaini930 – 1039PHPROSITE-ProRule annotationAdd BLAST110
Domaini1146 – 1338Rho-GAPPROSITE-ProRule annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni929 – 1096Interaction with ARF1 and ARF61 PublicationAdd BLAST168
Regioni1591 – 1860Interaction with CTNNA11 PublicationAdd BLAST270

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410KD1S. Eukaryota.
ENOG410YY7B. LUCA.
HOVERGENiHBG106694.
InParanoidiQ5T5U3.
KOiK20315.
OMAiLLNQQTW.
OrthoDBiEOG091G011C.
PhylomeDBiQ5T5U3.
TreeFamiTF329345.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T5U3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRRTGLSE GDGDKLKACE VSKNKDGKEQ SETVSLSEDE TFSWPGPKTV
60 70 80 90 100
TLKRTSQGFG FTLRHFIVYP PESAIQFSYK DEENGNRGGK QRNRLEPMDT
110 120 130 140 150
IFVKQVKEGG PAFEAGLCTG DRIIKVNGES VIGKTYSQVI ALIQNSDTTL
160 170 180 190 200
ELSVMPKDED ILQVLQFTKD VTALAYSQDA YLKGNEAYSG NARNIPEPPP
210 220 230 240 250
ICYPWLPSAP SAMAQPVEIS PPDSSLSKQQ TSTPVLTQPG RAYRMEIQVP
260 270 280 290 300
PSPTDVAKSN TAVCVCNESV RTVIVPSEKV VDLLSNRNNH TGPSHRTEEV
310 320 330 340 350
RYGVSEQTSL KTVSRTTSPP LSIPTTHLIH QPAGSRSLEP SGILLKSGNY
360 370 380 390 400
SGHSDGISSS RSQAVEAPSV SVNHYSPNSH QHIDWKNYKT YKEYIDNRRL
410 420 430 440 450
HIGCRTIQER LDSLRAASQS TTDYNQVVPN RTTLQGRRRS TSHDRVPQSV
460 470 480 490 500
QIRQRSVSQE RLEDSVLMKY CPRSASQGAL TSPSVSFSNH RTRSWDYIEG
510 520 530 540 550
QDETLENVNS GTPIPDSNGE KKQTYKWSGF TEQDDRRGIC ERPRQQEIHK
560 570 580 590 600
SFRGSNFTVA PSVVNSDNRR MSGRGVGSVS QFKKIPPDLK TLQSNRNFQT
610 620 630 640 650
TCGMSLPRGI SQDRSPLVKV RSNSLKAPST HVTKPSFSQK SFVSIKDQRP
660 670 680 690 700
VNHLHQNSLL NQQTWVRTDS APDQQVETGK SPSLSGASAK PAPQSSENAG
710 720 730 740 750
TSDLELPVSQ RNQDLSLQEA ETEQSDTLDN KEAVILREKP PSGRQTPQPL
760 770 780 790 800
RHQSYILAVN DQETGSDTTC WLPNDARREV HIKRMEERKA SSTSPPGDSL
810 820 830 840 850
ASIPFIDEPT SPSIDHDIAH IPASAVISAS TSQVPSIATV PPCLTTSAPL
860 870 880 890 900
IRRQLSHDHE SVGPPSLDAQ PNSKTERSKS YDEGLDDYRE DAKLSFKHVS
910 920 930 940 950
SLKGIKIADS QKSSEDSGSR KDSSSEVFSD AAKEGWLHFR PLVTDKGKRV
960 970 980 990 1000
GGSIRPWKQM YVVLRGHSLY LYKDKREQTT PSEEEQPISV NACLIDISYS
1010 1020 1030 1040 1050
ETKRKNVFRL TTSDCECLFQ AEDRDDMLAW IKTIQESSNL NEEDTGVTNR
1060 1070 1080 1090 1100
DLISRRIKEY NNLMSKAEQL PKTPRQSLSI RQTLLGAKSE PKTQSPHSPK
1110 1120 1130 1140 1150
EESERKLLSK DDTSPPKDKG TWRKGIPSIM RKTFEKKPTA TGTFGVRLDD
1160 1170 1180 1190 1200
CPPAHTNRYI PLIVDICCKL VEERGLEYTG IYRVPGNNAA ISSMQEELNK
1210 1220 1230 1240 1250
GMADIDIQDD KWRDLNVISS LLKSFFRKLP EPLFTNDKYA DFIEANRKED
1260 1270 1280 1290 1300
PLDRLKTLKR LIHDLPEHHY ETLKFLSAHL KTVAENSEKN KMEPRNLAIV
1310 1320 1330 1340 1350
FGPTLVRTSE DNMTHMVTHM PDQYKIVETL IQHHDWFFTE EGAEEPLTTV
1360 1370 1380 1390 1400
QEESTVDSQP VPNIDHLLTN IGRTGVSPGD VSDSATSDST KSKGSWGSGK
1410 1420 1430 1440 1450
DQYSRELLVS SIFAAASRKR KKPKEKAQPS SSEDELDNVF FKKENVEQCH
1460 1470 1480 1490 1500
NDTKEESKKE SETLGRKQKI IIAKENSTRK DPSTTKDEKI SLGKESTPSE
1510 1520 1530 1540 1550
EPSPPHNSKH NKSPTLSCRF AILKESPRSL LAQKSSHLEE TGSDSGTLLS
1560 1570 1580 1590 1600
TSSQASLARF SMKKSTSPET KHSEFLANVS TITSDYSTTS SATYLTSLDS
1610 1620 1630 1640 1650
SRLSPEVQSV AESKGDEADD ERSELISEGR PVETDSESEF PVFPTALTSE
1660 1670 1680 1690 1700
RLFRGKLQEV TKSSRRNSEG SELSCTEGSL TSSLDSRRQL FSSHKLIECD
1710 1720 1730 1740 1750
TLSRKKSARF KSDSGSLGDA KNEKEAPSLT KVFDVMKKGK STGSLLTPTR
1760 1770 1780 1790 1800
GESEKQEPTW KTKIADRLKL RPRAPADDMF GVGNHKVNAE TAKRKSIRRR
1810 1820 1830 1840 1850
HTLGGHRDAT EISVLNFWKV HEQSGERESE LSAVNRLKPK CSAQDLSISD
1860 1870 1880 1890 1900
WLARERLRTS TSDLSRGEIG DPQTENPSTR EIATTDTPLS LHCNTGSSSS
1910 1920 1930 1940 1950
TLASTNRPLL SIPPQSPDQI NGESFQNVSK NASSAANAQP HKLSETPGSK

AEFHPCL
Length:1,957
Mass (Da):217,331
Last modified:December 21, 2004 - v1
Checksum:iEEE781DED0166E69
GO
Isoform 3 (identifier: Q5T5U3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-174: Missing.
     1159-1174: YIPLIVDICCKLVEER → VGDTSPPDFLKSLIQF
     1175-1957: Missing.

Note: No experimental confirmation available.
Show »
Length:1,164
Mass (Da):129,244
Checksum:i80CF3F8A87B81B90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti305S → N in AAM22955 (PubMed:12056806).Curated1
Sequence conflicti900S → P in AAM22955 (PubMed:12056806).Curated1
Sequence conflicti1782V → A in AAM22955 (PubMed:12056806).Curated1
Sequence conflicti1949S → T in AAM22955 (PubMed:12056806).Curated1
Sequence conflicti1949S → T in CAD39153 (PubMed:17974005).Curated1
Sequence conflicti1949S → T in AAH22931 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035187712N → S.2 PublicationsCorresponds to variant rs3748222dbSNPEnsembl.1
Natural variantiVAR_0351881593T → A.Corresponds to variant rs1133897dbSNPEnsembl.1
Natural variantiVAR_0351891610V → A.Corresponds to variant rs1143051dbSNPEnsembl.1
Natural variantiVAR_0351901628E → K.Corresponds to variant rs1143057dbSNPEnsembl.1
Natural variantiVAR_0351911726A → T.Corresponds to variant rs1143075dbSNPEnsembl.1
Natural variantiVAR_0351921949S → N.Corresponds to variant rs1127893dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028298165 – 174Missing in isoform 3. 1 Publication10
Alternative sequenceiVSP_0283001159 – 1174YIPLI…LVEER → VGDTSPPDFLKSLIQF in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0283011175 – 1957Missing in isoform 3. 1 PublicationAdd BLAST783

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480466 mRNA. Translation: AAM22955.1.
AL355979, AL392104 Genomic DNA. Translation: CAI14323.1.
AL392104, AL355979 Genomic DNA. Translation: CAI40176.1.
AB037845 mRNA. Translation: BAA92662.2.
BX537570 mRNA. Translation: CAD97787.1.
AL834495 mRNA. Translation: CAD39153.1.
BC022931 mRNA. Translation: AAH22931.1.
PIRiA59438.
RefSeqiNP_065875.3. NM_020824.3.
UniGeneiHs.524195.

Genome annotation databases

EnsembliENST00000320481; ENSP00000365604; ENSG00000107863.
ENST00000396432; ENSP00000379709; ENSG00000107863.
GeneIDi57584.
KEGGihsa:57584.
UCSCiuc001isb.2. human. [Q5T5U3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480466 mRNA. Translation: AAM22955.1.
AL355979, AL392104 Genomic DNA. Translation: CAI14323.1.
AL392104, AL355979 Genomic DNA. Translation: CAI40176.1.
AB037845 mRNA. Translation: BAA92662.2.
BX537570 mRNA. Translation: CAD97787.1.
AL834495 mRNA. Translation: CAD39153.1.
BC022931 mRNA. Translation: AAH22931.1.
PIRiA59438.
RefSeqiNP_065875.3. NM_020824.3.
UniGeneiHs.524195.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DHJNMR-A930-1041[»]
2J59X-ray2.10M/N/O/P/Q/R929-1096[»]
2YUYNMR-A46-158[»]
ProteinModelPortaliQ5T5U3.
SMRiQ5T5U3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121636. 41 interactors.
IntActiQ5T5U3. 45 interactors.
MINTiMINT-2811611.
STRINGi9606.ENSP00000379709.

PTM databases

iPTMnetiQ5T5U3.
PhosphoSitePlusiQ5T5U3.

Polymorphism and mutation databases

BioMutaiARHGAP21.
DMDMi74745129.

Proteomic databases

EPDiQ5T5U3.
MaxQBiQ5T5U3.
PaxDbiQ5T5U3.
PeptideAtlasiQ5T5U3.
PRIDEiQ5T5U3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320481; ENSP00000365604; ENSG00000107863.
ENST00000396432; ENSP00000379709; ENSG00000107863.
GeneIDi57584.
KEGGihsa:57584.
UCSCiuc001isb.2. human. [Q5T5U3-1]

Organism-specific databases

CTDi57584.
DisGeNETi57584.
GeneCardsiARHGAP21.
HGNCiHGNC:23725. ARHGAP21.
HPAiHPA036610.
HPA057861.
MIMi609870. gene.
neXtProtiNX_Q5T5U3.
PharmGKBiPA134973559.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KD1S. Eukaryota.
ENOG410YY7B. LUCA.
HOVERGENiHBG106694.
InParanoidiQ5T5U3.
KOiK20315.
OMAiLLNQQTW.
OrthoDBiEOG091G011C.
PhylomeDBiQ5T5U3.
TreeFamiTF329345.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiARHGAP21. human.
EvolutionaryTraceiQ5T5U3.
GenomeRNAii57584.
PROiQ5T5U3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107863.
CleanExiHS_ARHGAP10.
HS_ARHGAP21.
ExpressionAtlasiQ5T5U3. baseline and differential.
GenevisibleiQ5T5U3. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHG21_HUMAN
AccessioniPrimary (citable) accession number: Q5T5U3
Secondary accession number(s): Q0VF98
, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers.
Required for In1A-dependent entry of Listeria monocytogenes into cells.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.