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Protein

Sickle tail protein homolog

Gene

KIAA1217

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal development of intervertebral disks.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Sickle tail protein homolog
Gene namesi
Name:KIAA1217
Synonyms:SKT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:25428. KIAA1217.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134893343.

Polymorphism and mutation databases

BioMutaiKIAA1217.
DMDMi147733121.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19431943Sickle tail protein homologPRO_0000287897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei169 – 1691PhosphoserineBy similarity
Modified residuei244 – 2441PhosphotyrosineBy similarity
Glycosylationi357 – 3571O-linked (GlcNAc)By similarity
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei365 – 3651PhosphoserineBy similarity
Modified residuei393 – 3931PhosphotyrosineCombined sources
Modified residuei470 – 4701PhosphothreonineCombined sources
Modified residuei474 – 4741PhosphoserineBy similarity
Modified residuei526 – 5261PhosphoserineCombined sources
Modified residuei809 – 8091PhosphoserineBy similarity
Modified residuei1027 – 10271PhosphoserineBy similarity
Modified residuei1030 – 10301PhosphoserineBy similarity
Modified residuei1033 – 10331PhosphoserineBy similarity
Modified residuei1044 – 10441PhosphoserineCombined sources
Modified residuei1461 – 14611PhosphoserineBy similarity
Modified residuei1739 – 17391PhosphoserineCombined sources
Modified residuei1841 – 18411PhosphoserineBy similarity
Modified residuei1896 – 18961PhosphoserineBy similarity
Modified residuei1899 – 18991PhosphoserineBy similarity
Modified residuei1902 – 19021PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ5T5P2.
MaxQBiQ5T5P2.
PaxDbiQ5T5P2.
PRIDEiQ5T5P2.

PTM databases

iPTMnetiQ5T5P2.
PhosphoSiteiQ5T5P2.

Expressioni

Gene expression databases

BgeeiQ5T5P2.
CleanExiHS_KIAA1217.
ExpressionAtlasiQ5T5P2. baseline and differential.
GenevisibleiQ5T5P2. HS.

Organism-specific databases

HPAiHPA004941.

Interactioni

Subunit structurei

Interacts with CPNE4 (via VWFA domain).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-10188326,EBI-743598
FHL2Q141923EBI-10188326,EBI-701903
GOLGA2Q083793EBI-10188326,EBI-618309
HSBP1O755065EBI-10188326,EBI-748664
KRT15P190123EBI-10188326,EBI-739566
SIAH1Q8IUQ43EBI-10188326,EBI-747107
TRAF1Q130773EBI-10188326,EBI-359224
VPS52Q8N1B43EBI-10188326,EBI-2799833

Protein-protein interaction databases

BioGridi121111. 24 interactions.
IntActiQ5T5P2. 19 interactions.
MINTiMINT-1464937.
STRINGi9606.ENSP00000365637.

Structurei

3D structure databases

ProteinModelPortaliQ5T5P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili557 – 58125Sequence analysisAdd
BLAST
Coiled coili644 – 68542Sequence analysisAdd
BLAST
Coiled coili957 – 98529Sequence analysisAdd
BLAST
Coiled coili1464 – 149027Sequence analysisAdd
BLAST
Coiled coili1656 – 168631Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi295 – 36470Pro-richSequence analysisAdd
BLAST
Compositional biasi1794 – 1905112Ser-richSequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG2A. Eukaryota.
ENOG410ZC52. LUCA.
GeneTreeiENSGT00390000012399.
HOGENOMiHOG000293351.
HOVERGENiHBG019587.
InParanoidiQ5T5P2.
OMAiQAFQKCS.
OrthoDBiEOG78H3TN.
PhylomeDBiQ5T5P2.
TreeFamiTF332255.

Family and domain databases

InterProiIPR022782. AIP3_C.
IPR026725. Skt.
[Graphical view]
PANTHERiPTHR22741:SF4. PTHR22741:SF4. 1 hit.
PfamiPF03915. AIP3. 2 hits.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T5P2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEENESQKCE PCLPYSADRR QMQEQGKGNL HVTSPEDAEC RRTKERLSNG
60 70 80 90 100
NSRGSVSKSS RNIPRRHTLG GPRSSKEILG MQTSEMDRKR EAFLEHLKQK
110 120 130 140 150
YPHHASAIMG HQERLRDQTR SPKLSHSPQP PSLGDPVEHL SETSADSLEA
160 170 180 190 200
MSEGDAPTPF SRGSRTRASL PVVRSTNQTK ERSLGVLYLQ YGDETKQLRM
210 220 230 240 250
PNEITSADTI RALFVSAFPQ QLTMKMLESP SVAIYIKDES RNVYYELNDV
260 270 280 290 300
RNIQDRSLLK VYNKDPAHAF NHTPKTMNGD MRMQRELVYA RGDGPGAPRP
310 320 330 340 350
GSTAHPPHAI PNSPPSTPVP HSMPPSPSRI PYGGTRSMVV PGNATIPRDR
360 370 380 390 400
ISSLPVSRPI SPSPSAILER RDVKPDEDMS GKNIAMYRNE GFYADPYLYH
410 420 430 440 450
EGRMSIASSH GGHPLDVPDH IIAYHRTAIR SASAYCNPSM QAEMHMEQSL
460 470 480 490 500
YRQKSRKYPD SHLPTLGSKT PPASPHRVSD LRMIDMHAHY NAHGPPHTMQ
510 520 530 540 550
PDRASPSRQA FKKEPGTLVY IEKPRSAAGL SSLVDLGPPL MEKQVFAYST
560 570 580 590 600
ATIPKDRETR ERMQAMEKQI ASLTGLVQSA LFKGPITSYS KDASSEKMMK
610 620 630 640 650
TTANRNHTDS AGTPHVSGGK MLSALESTVP PSQPPPVGTS AIHMSLLEMR
660 670 680 690 700
RSVAELRLQL QQMRQLQLQN QELLRAMMKK AELEISGKVM ETMKRLEDPV
710 720 730 740 750
QRQRVLVEQE RQKYLHEEEK IVKKLCELED FVEDLKKDST AASRLVTLKD
760 770 780 790 800
VEDGAFLLRQ VGEAVATLKG EFPTLQNKMR AILRIEVEAV RFLKEEPHKL
810 820 830 840 850
DSLLKRVRSM TDVLTMLRRH VTDGLLKGTD AAQAAQYMAM EKATAAEVLK
860 870 880 890 900
SQEEAAHTSG QPFHSTGAPG DAKSEVVPLS GMMVRHAQSS PVVIQPSQHS
910 920 930 940 950
VALLNPAQNL PHVASSPAVP QEATSTLQMS QAPQSPQIPM NGSAMQSLFI
960 970 980 990 1000
EEIHSVSAKN RAVSIEKAEK KWEEKRQNLD HYNGKEFEKL LEEAQANIMK
1010 1020 1030 1040 1050
SIPNLEMPPA TGPLPRGDAP VDKVELSEDS PNSEQDLEKL GGKSPPPPPP
1060 1070 1080 1090 1100
PPRRSYLPGS GLTTTRSGDV VYTGRKENIT AKASSEDAGP SPQTRATKYP
1110 1120 1130 1140 1150
AEEPASAWTP SPPPVTTSSS KDEEEEEEEG DKIMAELQAF QKCSFMDVNS
1160 1170 1180 1190 1200
NSHAEPSRAD SHVKDTRSGA TVPPKEKKNL EFFHEDVRKS DVEYENGPQM
1210 1220 1230 1240 1250
EFQKVTTGAV RPSDPPKWER GMENSISDAS RTSEYKTEII MKENSISNMS
1260 1270 1280 1290 1300
LLRDSRNYSQ ETVPKASFGF SGISPLEDEI NKGSKISGLQ YSIPDTENQT
1310 1320 1330 1340 1350
LNYGKTKEME KQNTDKCHVS SHTRLTESSV HDFKTEDQEV ITTDFGQVVL
1360 1370 1380 1390 1400
RPKEARHANV NPNEDGESSS SSPTEENAAT DNIAFMITET TVQVLSSGEV
1410 1420 1430 1440 1450
HDIVSQKGED IQTVNIDARK EMTPRQEGTD NEDPVVCLDK KPVIIIFDEP
1460 1470 1480 1490 1500
MDIRSAYKRL STIFEECDEE LERMMMEEKI EEEEEEENGD SVVQNNNTSQ
1510 1520 1530 1540 1550
MSHKKVAPGN LRTGQQVETK SQPHSLATET RNPGGQEMNR TELNKFSHVD
1560 1570 1580 1590 1600
SPNSECKGED ATDDQFESPK KKFKFKFPKK QLAALTQAIR TGTKTGKKTL
1610 1620 1630 1640 1650
QVVVYEEEEE DGTLKQHKEA KRFEIARSQP EDTPENTVRR QEQPSIESTS
1660 1670 1680 1690 1700
PISRTDEIRK NTYRTLDSLE QTIKQLENTI SEMSPKALVD TSCSSNRDSV
1710 1720 1730 1740 1750
ASSSHIAQEA SPRPLLVPDE GPTALEPPTS IPSASRKGSS GAPQTSRMPV
1760 1770 1780 1790 1800
PMSAKNRPGT LDKPGKQSKL QDPRQYRQAN GSAKKSGGDF KPTSPSLPAS
1810 1820 1830 1840 1850
KIPALSPSSG KSSSLPSSSG DSSNLPNPPA TKPSIASNPL SPQTGPPAHS
1860 1870 1880 1890 1900
ASLIPSVSNG SLKFQSLTHT GKGHHLSFSP QSQNGRAPPP LSFSSSPPSP
1910 1920 1930 1940
ASSVSLNQGA KGTRTIHTPS LTSYKAQNGS SSKATPSTAK ETS
Length:1,943
Mass (Da):214,116
Last modified:May 15, 2007 - v2
Checksum:iDFE67FADE56E0349
GO
Isoform 21 Publication (identifier: Q5T5P2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1139-1737: Missing.

Show »
Length:1,344
Mass (Da):146,879
Checksum:i5648CE8248B1ADA7
GO
Isoform 3 (identifier: Q5T5P2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:1,465
Mass (Da):162,360
Checksum:i418F12AC78926686
GO
Isoform 41 Publication (identifier: Q5T5P2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1139-1737: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:866
Mass (Da):95,123
Checksum:i24CDAF47EE1EBB7E
GO
Isoform 5 (identifier: Q5T5P2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     560-594: Missing.
     1179-1737: Missing.

Show »
Length:1,349
Mass (Da):147,424
Checksum:iF2BA6806FFB23CB1
GO
Isoform 61 Publication (identifier: Q5T5P2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1205-1737: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:932
Mass (Da):102,692
Checksum:iFA65349E05AFBC5B
GO
Isoform 7 (identifier: Q5T5P2-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1179-1737: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:906
Mass (Da):99,494
Checksum:i14A5BFA2BE6A6007
GO
Isoform 9 (identifier: Q5T5P2-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     1139-1737: Missing.

Show »
Length:1,264
Mass (Da):137,913
Checksum:iBCD625CB6C41767D
GO
Isoform 10 (identifier: Q5T5P2-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     560-594: Missing.
     1028-1028: Missing.
     1205-1737: Missing.

Note: No experimental confirmation available.
Show »
Length:1,374
Mass (Da):150,493
Checksum:i16DF21048B2134CE
GO

Sequence cautioni

The sequence AAH18764.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AL833280 differs from that shown. Reason: Frameshift at position 976. Curated
The sequence BAC86241.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAF63529.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAE45879.1 differs from that shown. Reason: Erroneous termination at position 1251. Translated as Leu.Curated
The sequence CAI12212.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI14084.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI40182.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti498 – 4981T → A in AL833280 (PubMed:17974005).Curated
Sequence conflicti508 – 5081R → H in BX648451 (PubMed:17974005).Curated
Sequence conflicti679 – 6791K → R in AL833280 (PubMed:17974005).Curated
Sequence conflicti795 – 7951E → G in CAE45879 (PubMed:17974005).Curated
Sequence conflicti829 – 8291T → M in BX648451 (PubMed:17974005).Curated
Sequence conflicti914 – 9141A → P in BX648451 (PubMed:17974005).Curated
Sequence conflicti1267 – 12671S → N in BAC86241 (PubMed:14702039).Curated
Sequence conflicti1306 – 13061T → A in AL833280 (PubMed:17974005).Curated
Sequence conflicti1743 – 17431P → L in AL833280 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451A → G.
Corresponds to variant rs17506606 [ dbSNP | Ensembl ].
VAR_051358
Natural varianti887 – 8871A → T.1 Publication
Corresponds to variant rs10828663 [ dbSNP | Ensembl ].
VAR_051359
Natural varianti1362 – 13621P → A.
Corresponds to variant rs16924863 [ dbSNP | Ensembl ].
VAR_051360

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 282282Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 3 PublicationsVSP_052427Add
BLAST
Alternative sequencei1 – 8080Missing in isoform 9. 1 PublicationVSP_054107Add
BLAST
Alternative sequencei560 – 59435Missing in isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 10. 4 PublicationsVSP_052428Add
BLAST
Alternative sequencei1028 – 10281Missing in isoform 10. 1 PublicationVSP_054874
Alternative sequencei1139 – 1737599Missing in isoform 2, isoform 4 and isoform 9. 3 PublicationsVSP_052429Add
BLAST
Alternative sequencei1179 – 1737559Missing in isoform 5 and isoform 7. 2 PublicationsVSP_030353Add
BLAST
Alternative sequencei1205 – 1737533Missing in isoform 6 and isoform 10. 1 PublicationVSP_052430Add
BLAST
Alternative sequencei1779 – 17824ANGS → VVLP in isoform 3, isoform 4, isoform 6 and isoform 7. 3 PublicationsVSP_052431
Alternative sequencei1783 – 1943161Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 3 PublicationsVSP_052432Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033043 mRNA. Translation: BAA86531.2.
AL157473 mRNA. Translation: CAB75668.1.
AL833280 mRNA. No translation available.
BX640796 mRNA. Translation: CAE45879.1. Sequence problems.
BX648451 mRNA. No translation available.
AL353583, AL392104 Genomic DNA. Translation: CAI12211.2.
AL353583
, AC063961, AL356113, AL392104 Genomic DNA. Translation: CAI12212.1. Sequence problems.
AL353583
, AC063961, AL356113, AL392104 Genomic DNA. Translation: CAI12213.2.
AL353583, AL392104 Genomic DNA. Translation: CAO03598.1.
AL353583, AL392104 Genomic DNA. Translation: CAO03599.1.
AL353583, AL392104 Genomic DNA. Translation: CAO03600.1.
AL356113
, AC063961, AL353583, AL392104 Genomic DNA. Translation: CAI14084.1. Sequence problems.
AL356113
, AC063961, AL353583, AL392104 Genomic DNA. Translation: CAI14085.2.
AL392104, AL353583 Genomic DNA. Translation: CAI40179.2.
AL392104
, AC063961, AL353583, AL356113 Genomic DNA. Translation: CAI40182.1. Sequence problems.
AL392104
, AC063961, AL353583, AL356113 Genomic DNA. Translation: CAI40183.2.
AL392104, AL353583 Genomic DNA. Translation: CAO03477.1.
AL392104, AL353583 Genomic DNA. Translation: CAO03478.1.
AL392104, AL353583 Genomic DNA. Translation: CAO03479.1.
AL157781 Genomic DNA. No translation available.
AL353650 Genomic DNA. No translation available.
AL355977 Genomic DNA. No translation available.
AL356477 Genomic DNA. No translation available.
AL391499 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86124.1.
BC018764 mRNA. Translation: AAH18764.1. Different initiation.
BC098577 mRNA. Translation: AAH98577.1.
BC136521 mRNA. Translation: AAI36522.1.
AB291616 mRNA. Translation: BAF63529.1. Different initiation.
AK125675 mRNA. Translation: BAC86241.1. Different initiation.
CCDSiCCDS31165.1. [Q5T5P2-1]
CCDS41496.1. [Q5T5P2-9]
CCDS60501.1. [Q5T5P2-7]
CCDS60502.1. [Q5T5P2-10]
CCDS60504.1. [Q5T5P2-6]
CCDS60505.1. [Q5T5P2-4]
PIRiT46910.
RefSeqiNP_001091970.1. NM_001098500.2. [Q5T5P2-9]
NP_001269696.1. NM_001282767.1. [Q5T5P2-10]
NP_001269697.1. NM_001282768.1. [Q5T5P2-7]
NP_001269698.1. NM_001282769.1. [Q5T5P2-6]
NP_001269699.1. NM_001282770.1. [Q5T5P2-4]
NP_062536.2. NM_019590.4. [Q5T5P2-1]
XP_005252573.1. XM_005252516.2. [Q5T5P2-3]
XP_011517867.1. XM_011519565.1. [Q5T5P2-9]
UniGeneiHs.445885.

Genome annotation databases

EnsembliENST00000307544; ENSP00000302343; ENSG00000120549. [Q5T5P2-6]
ENST00000376451; ENSP00000365634; ENSG00000120549. [Q5T5P2-3]
ENST00000376452; ENSP00000365635; ENSG00000120549. [Q5T5P2-10]
ENST00000376454; ENSP00000365637; ENSG00000120549. [Q5T5P2-1]
ENST00000376462; ENSP00000365645; ENSG00000120549. [Q5T5P2-9]
ENST00000396445; ENSP00000379722; ENSG00000120549. [Q5T5P2-8]
ENST00000396446; ENSP00000379723; ENSG00000120549. [Q5T5P2-4]
ENST00000430453; ENSP00000389680; ENSG00000120549. [Q5T5P2-9]
ENST00000458595; ENSP00000392625; ENSG00000120549. [Q5T5P2-7]
GeneIDi56243.
KEGGihsa:56243.
UCSCiuc001irs.5. human. [Q5T5P2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033043 mRNA. Translation: BAA86531.2.
AL157473 mRNA. Translation: CAB75668.1.
AL833280 mRNA. No translation available.
BX640796 mRNA. Translation: CAE45879.1. Sequence problems.
BX648451 mRNA. No translation available.
AL353583, AL392104 Genomic DNA. Translation: CAI12211.2.
AL353583
, AC063961, AL356113, AL392104 Genomic DNA. Translation: CAI12212.1. Sequence problems.
AL353583
, AC063961, AL356113, AL392104 Genomic DNA. Translation: CAI12213.2.
AL353583, AL392104 Genomic DNA. Translation: CAO03598.1.
AL353583, AL392104 Genomic DNA. Translation: CAO03599.1.
AL353583, AL392104 Genomic DNA. Translation: CAO03600.1.
AL356113
, AC063961, AL353583, AL392104 Genomic DNA. Translation: CAI14084.1. Sequence problems.
AL356113
, AC063961, AL353583, AL392104 Genomic DNA. Translation: CAI14085.2.
AL392104, AL353583 Genomic DNA. Translation: CAI40179.2.
AL392104
, AC063961, AL353583, AL356113 Genomic DNA. Translation: CAI40182.1. Sequence problems.
AL392104
, AC063961, AL353583, AL356113 Genomic DNA. Translation: CAI40183.2.
AL392104, AL353583 Genomic DNA. Translation: CAO03477.1.
AL392104, AL353583 Genomic DNA. Translation: CAO03478.1.
AL392104, AL353583 Genomic DNA. Translation: CAO03479.1.
AL157781 Genomic DNA. No translation available.
AL353650 Genomic DNA. No translation available.
AL355977 Genomic DNA. No translation available.
AL356477 Genomic DNA. No translation available.
AL391499 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86124.1.
BC018764 mRNA. Translation: AAH18764.1. Different initiation.
BC098577 mRNA. Translation: AAH98577.1.
BC136521 mRNA. Translation: AAI36522.1.
AB291616 mRNA. Translation: BAF63529.1. Different initiation.
AK125675 mRNA. Translation: BAC86241.1. Different initiation.
CCDSiCCDS31165.1. [Q5T5P2-1]
CCDS41496.1. [Q5T5P2-9]
CCDS60501.1. [Q5T5P2-7]
CCDS60502.1. [Q5T5P2-10]
CCDS60504.1. [Q5T5P2-6]
CCDS60505.1. [Q5T5P2-4]
PIRiT46910.
RefSeqiNP_001091970.1. NM_001098500.2. [Q5T5P2-9]
NP_001269696.1. NM_001282767.1. [Q5T5P2-10]
NP_001269697.1. NM_001282768.1. [Q5T5P2-7]
NP_001269698.1. NM_001282769.1. [Q5T5P2-6]
NP_001269699.1. NM_001282770.1. [Q5T5P2-4]
NP_062536.2. NM_019590.4. [Q5T5P2-1]
XP_005252573.1. XM_005252516.2. [Q5T5P2-3]
XP_011517867.1. XM_011519565.1. [Q5T5P2-9]
UniGeneiHs.445885.

3D structure databases

ProteinModelPortaliQ5T5P2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121111. 24 interactions.
IntActiQ5T5P2. 19 interactions.
MINTiMINT-1464937.
STRINGi9606.ENSP00000365637.

PTM databases

iPTMnetiQ5T5P2.
PhosphoSiteiQ5T5P2.

Polymorphism and mutation databases

BioMutaiKIAA1217.
DMDMi147733121.

Proteomic databases

EPDiQ5T5P2.
MaxQBiQ5T5P2.
PaxDbiQ5T5P2.
PRIDEiQ5T5P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307544; ENSP00000302343; ENSG00000120549. [Q5T5P2-6]
ENST00000376451; ENSP00000365634; ENSG00000120549. [Q5T5P2-3]
ENST00000376452; ENSP00000365635; ENSG00000120549. [Q5T5P2-10]
ENST00000376454; ENSP00000365637; ENSG00000120549. [Q5T5P2-1]
ENST00000376462; ENSP00000365645; ENSG00000120549. [Q5T5P2-9]
ENST00000396445; ENSP00000379722; ENSG00000120549. [Q5T5P2-8]
ENST00000396446; ENSP00000379723; ENSG00000120549. [Q5T5P2-4]
ENST00000430453; ENSP00000389680; ENSG00000120549. [Q5T5P2-9]
ENST00000458595; ENSP00000392625; ENSG00000120549. [Q5T5P2-7]
GeneIDi56243.
KEGGihsa:56243.
UCSCiuc001irs.5. human. [Q5T5P2-1]

Organism-specific databases

CTDi56243.
GeneCardsiKIAA1217.
H-InvDBHIX0008709.
HGNCiHGNC:25428. KIAA1217.
HPAiHPA004941.
neXtProtiNX_Q5T5P2.
PharmGKBiPA134893343.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG2A. Eukaryota.
ENOG410ZC52. LUCA.
GeneTreeiENSGT00390000012399.
HOGENOMiHOG000293351.
HOVERGENiHBG019587.
InParanoidiQ5T5P2.
OMAiQAFQKCS.
OrthoDBiEOG78H3TN.
PhylomeDBiQ5T5P2.
TreeFamiTF332255.

Miscellaneous databases

ChiTaRSiKIAA1217. human.
GenomeRNAii56243.
NextBioi35462657.
PROiQ5T5P2.

Gene expression databases

BgeeiQ5T5P2.
CleanExiHS_KIAA1217.
ExpressionAtlasiQ5T5P2. baseline and differential.
GenevisibleiQ5T5P2. HS.

Family and domain databases

InterProiIPR022782. AIP3_C.
IPR026725. Skt.
[Graphical view]
PANTHERiPTHR22741:SF4. PTHR22741:SF4. 1 hit.
PfamiPF03915. AIP3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9).
    Tissue: BrainImported.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 925-1943 (ISOFORM 2).
    Tissue: Amygdala, Carcinoma, Endometrial adenocarcinoma and Skeletal muscle.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 6 AND 10), VARIANT THR-887.
    Tissue: ChondrosarcomaImported, Testis and UterusImported.
  7. "A human Sickle tail (SKT) expresses especially in notochordal cells."
    Semba K., Araki K., Araki M., Abe K., Yamamura K.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-1943 (ISOFORM 5).
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1248-1943 (ISOFORM 3).
    Tissue: Mammary glandImported.
  9. "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules."
    Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J., Lauffenburger D.A., White F.M.
    Mol. Cell. Proteomics 4:1240-1250(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-393, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mammary epithelium.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-470; SER-526; SER-1044 AND SER-1739, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSKT_HUMAN
AccessioniPrimary (citable) accession number: Q5T5P2
Secondary accession number(s): A5LHW9
, A6NLF3, A6PVQ5, A6PVQ6, A6PVQ7, B9EGK4, Q4KMG4, Q5T5P3, Q5T7H3, Q6MZZ6, Q6ZUI4, Q8WV45, Q9NSR2, Q9ULK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 11, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.