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Protein

Sickle tail protein homolog

Gene

KIAA1217

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal development of intervertebral disks.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Sickle tail protein homolog
Gene namesi
Name:KIAA1217
Synonyms:SKT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:25428. KIAA1217.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi56243.
OpenTargetsiENSG00000120549.
PharmGKBiPA134893343.

Polymorphism and mutation databases

BioMutaiKIAA1217.
DMDMi147733121.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002878971 – 1943Sickle tail protein homologAdd BLAST1943

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei169PhosphoserineBy similarity1
Modified residuei244PhosphotyrosineBy similarity1
Glycosylationi357O-linked (GlcNAc)By similarity1
Modified residuei361PhosphoserineCombined sources1
Modified residuei365PhosphoserineBy similarity1
Modified residuei393PhosphotyrosineCombined sources1
Modified residuei470PhosphothreonineCombined sources1
Modified residuei474PhosphoserineBy similarity1
Modified residuei526PhosphoserineCombined sources1
Modified residuei809PhosphoserineBy similarity1
Modified residuei1027PhosphoserineBy similarity1
Modified residuei1030PhosphoserineBy similarity1
Modified residuei1033PhosphoserineBy similarity1
Modified residuei1044PhosphoserineCombined sources1
Modified residuei1461PhosphoserineBy similarity1
Modified residuei1739PhosphoserineCombined sources1
Modified residuei1841PhosphoserineBy similarity1
Modified residuei1896PhosphoserineBy similarity1
Modified residuei1899PhosphoserineBy similarity1
Modified residuei1902PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ5T5P2.
MaxQBiQ5T5P2.
PaxDbiQ5T5P2.
PeptideAtlasiQ5T5P2.
PRIDEiQ5T5P2.

PTM databases

iPTMnetiQ5T5P2.
PhosphoSitePlusiQ5T5P2.

Expressioni

Gene expression databases

BgeeiENSG00000120549.
CleanExiHS_KIAA1217.
ExpressionAtlasiQ5T5P2. baseline and differential.
GenevisibleiQ5T5P2. HS.

Organism-specific databases

HPAiHPA004941.

Interactioni

Subunit structurei

Interacts with CPNE4 (via VWFA domain).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-10188326,EBI-743598
FHL2Q141923EBI-10188326,EBI-701903
GOLGA2Q083793EBI-10188326,EBI-618309
HSBP1O755065EBI-10188326,EBI-748664
KRT15P190123EBI-10188326,EBI-739566
SIAH1Q8IUQ43EBI-10188326,EBI-747107
TRAF1Q130773EBI-10188326,EBI-359224
VPS52Q8N1B43EBI-10188326,EBI-2799833

Protein-protein interaction databases

BioGridi121111. 24 interactors.
IntActiQ5T5P2. 24 interactors.
MINTiMINT-1464937.
STRINGi9606.ENSP00000365637.

Structurei

3D structure databases

ProteinModelPortaliQ5T5P2.
SMRiQ5T5P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili557 – 581Sequence analysisAdd BLAST25
Coiled coili644 – 685Sequence analysisAdd BLAST42
Coiled coili957 – 985Sequence analysisAdd BLAST29
Coiled coili1464 – 1490Sequence analysisAdd BLAST27
Coiled coili1656 – 1686Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi295 – 364Pro-richSequence analysisAdd BLAST70
Compositional biasi1794 – 1905Ser-richSequence analysisAdd BLAST112

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG2A. Eukaryota.
ENOG410ZC52. LUCA.
GeneTreeiENSGT00390000012399.
HOGENOMiHOG000293351.
HOVERGENiHBG019587.
InParanoidiQ5T5P2.
OMAiENGPQME.
OrthoDBiEOG091G0GCS.
PhylomeDBiQ5T5P2.
TreeFamiTF332255.

Family and domain databases

InterProiIPR022782. AIP3_C.
IPR026725. Skt.
[Graphical view]
PANTHERiPTHR22741:SF4. PTHR22741:SF4. 1 hit.
PfamiPF03915. AIP3. 2 hits.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T5P2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEENESQKCE PCLPYSADRR QMQEQGKGNL HVTSPEDAEC RRTKERLSNG
60 70 80 90 100
NSRGSVSKSS RNIPRRHTLG GPRSSKEILG MQTSEMDRKR EAFLEHLKQK
110 120 130 140 150
YPHHASAIMG HQERLRDQTR SPKLSHSPQP PSLGDPVEHL SETSADSLEA
160 170 180 190 200
MSEGDAPTPF SRGSRTRASL PVVRSTNQTK ERSLGVLYLQ YGDETKQLRM
210 220 230 240 250
PNEITSADTI RALFVSAFPQ QLTMKMLESP SVAIYIKDES RNVYYELNDV
260 270 280 290 300
RNIQDRSLLK VYNKDPAHAF NHTPKTMNGD MRMQRELVYA RGDGPGAPRP
310 320 330 340 350
GSTAHPPHAI PNSPPSTPVP HSMPPSPSRI PYGGTRSMVV PGNATIPRDR
360 370 380 390 400
ISSLPVSRPI SPSPSAILER RDVKPDEDMS GKNIAMYRNE GFYADPYLYH
410 420 430 440 450
EGRMSIASSH GGHPLDVPDH IIAYHRTAIR SASAYCNPSM QAEMHMEQSL
460 470 480 490 500
YRQKSRKYPD SHLPTLGSKT PPASPHRVSD LRMIDMHAHY NAHGPPHTMQ
510 520 530 540 550
PDRASPSRQA FKKEPGTLVY IEKPRSAAGL SSLVDLGPPL MEKQVFAYST
560 570 580 590 600
ATIPKDRETR ERMQAMEKQI ASLTGLVQSA LFKGPITSYS KDASSEKMMK
610 620 630 640 650
TTANRNHTDS AGTPHVSGGK MLSALESTVP PSQPPPVGTS AIHMSLLEMR
660 670 680 690 700
RSVAELRLQL QQMRQLQLQN QELLRAMMKK AELEISGKVM ETMKRLEDPV
710 720 730 740 750
QRQRVLVEQE RQKYLHEEEK IVKKLCELED FVEDLKKDST AASRLVTLKD
760 770 780 790 800
VEDGAFLLRQ VGEAVATLKG EFPTLQNKMR AILRIEVEAV RFLKEEPHKL
810 820 830 840 850
DSLLKRVRSM TDVLTMLRRH VTDGLLKGTD AAQAAQYMAM EKATAAEVLK
860 870 880 890 900
SQEEAAHTSG QPFHSTGAPG DAKSEVVPLS GMMVRHAQSS PVVIQPSQHS
910 920 930 940 950
VALLNPAQNL PHVASSPAVP QEATSTLQMS QAPQSPQIPM NGSAMQSLFI
960 970 980 990 1000
EEIHSVSAKN RAVSIEKAEK KWEEKRQNLD HYNGKEFEKL LEEAQANIMK
1010 1020 1030 1040 1050
SIPNLEMPPA TGPLPRGDAP VDKVELSEDS PNSEQDLEKL GGKSPPPPPP
1060 1070 1080 1090 1100
PPRRSYLPGS GLTTTRSGDV VYTGRKENIT AKASSEDAGP SPQTRATKYP
1110 1120 1130 1140 1150
AEEPASAWTP SPPPVTTSSS KDEEEEEEEG DKIMAELQAF QKCSFMDVNS
1160 1170 1180 1190 1200
NSHAEPSRAD SHVKDTRSGA TVPPKEKKNL EFFHEDVRKS DVEYENGPQM
1210 1220 1230 1240 1250
EFQKVTTGAV RPSDPPKWER GMENSISDAS RTSEYKTEII MKENSISNMS
1260 1270 1280 1290 1300
LLRDSRNYSQ ETVPKASFGF SGISPLEDEI NKGSKISGLQ YSIPDTENQT
1310 1320 1330 1340 1350
LNYGKTKEME KQNTDKCHVS SHTRLTESSV HDFKTEDQEV ITTDFGQVVL
1360 1370 1380 1390 1400
RPKEARHANV NPNEDGESSS SSPTEENAAT DNIAFMITET TVQVLSSGEV
1410 1420 1430 1440 1450
HDIVSQKGED IQTVNIDARK EMTPRQEGTD NEDPVVCLDK KPVIIIFDEP
1460 1470 1480 1490 1500
MDIRSAYKRL STIFEECDEE LERMMMEEKI EEEEEEENGD SVVQNNNTSQ
1510 1520 1530 1540 1550
MSHKKVAPGN LRTGQQVETK SQPHSLATET RNPGGQEMNR TELNKFSHVD
1560 1570 1580 1590 1600
SPNSECKGED ATDDQFESPK KKFKFKFPKK QLAALTQAIR TGTKTGKKTL
1610 1620 1630 1640 1650
QVVVYEEEEE DGTLKQHKEA KRFEIARSQP EDTPENTVRR QEQPSIESTS
1660 1670 1680 1690 1700
PISRTDEIRK NTYRTLDSLE QTIKQLENTI SEMSPKALVD TSCSSNRDSV
1710 1720 1730 1740 1750
ASSSHIAQEA SPRPLLVPDE GPTALEPPTS IPSASRKGSS GAPQTSRMPV
1760 1770 1780 1790 1800
PMSAKNRPGT LDKPGKQSKL QDPRQYRQAN GSAKKSGGDF KPTSPSLPAS
1810 1820 1830 1840 1850
KIPALSPSSG KSSSLPSSSG DSSNLPNPPA TKPSIASNPL SPQTGPPAHS
1860 1870 1880 1890 1900
ASLIPSVSNG SLKFQSLTHT GKGHHLSFSP QSQNGRAPPP LSFSSSPPSP
1910 1920 1930 1940
ASSVSLNQGA KGTRTIHTPS LTSYKAQNGS SSKATPSTAK ETS
Length:1,943
Mass (Da):214,116
Last modified:May 15, 2007 - v2
Checksum:iDFE67FADE56E0349
GO
Isoform 21 Publication (identifier: Q5T5P2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1139-1737: Missing.

Show »
Length:1,344
Mass (Da):146,879
Checksum:i5648CE8248B1ADA7
GO
Isoform 3 (identifier: Q5T5P2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:1,465
Mass (Da):162,360
Checksum:i418F12AC78926686
GO
Isoform 41 Publication (identifier: Q5T5P2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1139-1737: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:866
Mass (Da):95,123
Checksum:i24CDAF47EE1EBB7E
GO
Isoform 5 (identifier: Q5T5P2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     560-594: Missing.
     1179-1737: Missing.

Show »
Length:1,349
Mass (Da):147,424
Checksum:iF2BA6806FFB23CB1
GO
Isoform 61 Publication (identifier: Q5T5P2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1205-1737: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:932
Mass (Da):102,692
Checksum:iFA65349E05AFBC5B
GO
Isoform 7 (identifier: Q5T5P2-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1179-1737: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:906
Mass (Da):99,494
Checksum:i14A5BFA2BE6A6007
GO
Isoform 9 (identifier: Q5T5P2-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     1139-1737: Missing.

Show »
Length:1,264
Mass (Da):137,913
Checksum:iBCD625CB6C41767D
GO
Isoform 10 (identifier: Q5T5P2-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     560-594: Missing.
     1028-1028: Missing.
     1205-1737: Missing.

Note: No experimental confirmation available.
Show »
Length:1,374
Mass (Da):150,493
Checksum:i16DF21048B2134CE
GO

Sequence cautioni

The sequence AAH18764 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AL833280 differs from that shown. Reason: Frameshift at position 976.Curated
The sequence BAC86241 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF63529 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAE45879 differs from that shown. Reason: Erroneous termination at position 1251. Translated as Leu.Curated
The sequence CAI12212 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI14084 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40182 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti498T → A in AL833280 (PubMed:17974005).Curated1
Sequence conflicti508R → H in BX648451 (PubMed:17974005).Curated1
Sequence conflicti679K → R in AL833280 (PubMed:17974005).Curated1
Sequence conflicti795E → G in CAE45879 (PubMed:17974005).Curated1
Sequence conflicti829T → M in BX648451 (PubMed:17974005).Curated1
Sequence conflicti914A → P in BX648451 (PubMed:17974005).Curated1
Sequence conflicti1267S → N in BAC86241 (PubMed:14702039).Curated1
Sequence conflicti1306T → A in AL833280 (PubMed:17974005).Curated1
Sequence conflicti1743P → L in AL833280 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051358145A → G.Corresponds to variant rs17506606dbSNPEnsembl.1
Natural variantiVAR_051359887A → T.1 PublicationCorresponds to variant rs10828663dbSNPEnsembl.1
Natural variantiVAR_0513601362P → A.Corresponds to variant rs16924863dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0524271 – 282Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 3 PublicationsAdd BLAST282
Alternative sequenceiVSP_0541071 – 80Missing in isoform 9. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_052428560 – 594Missing in isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 10. 4 PublicationsAdd BLAST35
Alternative sequenceiVSP_0548741028Missing in isoform 10. 1 Publication1
Alternative sequenceiVSP_0524291139 – 1737Missing in isoform 2, isoform 4 and isoform 9. 3 PublicationsAdd BLAST599
Alternative sequenceiVSP_0303531179 – 1737Missing in isoform 5 and isoform 7. 2 PublicationsAdd BLAST559
Alternative sequenceiVSP_0524301205 – 1737Missing in isoform 6 and isoform 10. 1 PublicationAdd BLAST533
Alternative sequenceiVSP_0524311779 – 1782ANGS → VVLP in isoform 3, isoform 4, isoform 6 and isoform 7. 3 Publications4
Alternative sequenceiVSP_0524321783 – 1943Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 3 PublicationsAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033043 mRNA. Translation: BAA86531.2.
AL157473 mRNA. Translation: CAB75668.1.
AL833280 mRNA. No translation available.
BX640796 mRNA. Translation: CAE45879.1. Sequence problems.
BX648451 mRNA. No translation available.
AL353583, AL392104 Genomic DNA. Translation: CAI12211.2.
AL353583
, AC063961, AL356113, AL392104 Genomic DNA. Translation: CAI12212.1. Sequence problems.
AL353583
, AC063961, AL356113, AL392104 Genomic DNA. Translation: CAI12213.2.
AL353583, AL392104 Genomic DNA. Translation: CAO03598.1.
AL353583, AL392104 Genomic DNA. Translation: CAO03599.1.
AL353583, AL392104 Genomic DNA. Translation: CAO03600.1.
AL356113
, AC063961, AL353583, AL392104 Genomic DNA. Translation: CAI14084.1. Sequence problems.
AL356113
, AC063961, AL353583, AL392104 Genomic DNA. Translation: CAI14085.2.
AL392104, AL353583 Genomic DNA. Translation: CAI40179.2.
AL392104
, AC063961, AL353583, AL356113 Genomic DNA. Translation: CAI40182.1. Sequence problems.
AL392104
, AC063961, AL353583, AL356113 Genomic DNA. Translation: CAI40183.2.
AL392104, AL353583 Genomic DNA. Translation: CAO03477.1.
AL392104, AL353583 Genomic DNA. Translation: CAO03478.1.
AL392104, AL353583 Genomic DNA. Translation: CAO03479.1.
AL157781 Genomic DNA. No translation available.
AL353650 Genomic DNA. No translation available.
AL355977 Genomic DNA. No translation available.
AL356477 Genomic DNA. No translation available.
AL391499 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86124.1.
BC018764 mRNA. Translation: AAH18764.1. Different initiation.
BC098577 mRNA. Translation: AAH98577.1.
BC136521 mRNA. Translation: AAI36522.1.
AB291616 mRNA. Translation: BAF63529.1. Different initiation.
AK125675 mRNA. Translation: BAC86241.1. Different initiation.
CCDSiCCDS31165.1. [Q5T5P2-1]
CCDS41496.1. [Q5T5P2-9]
CCDS60501.1. [Q5T5P2-7]
CCDS60502.1. [Q5T5P2-10]
CCDS60504.1. [Q5T5P2-6]
CCDS60505.1. [Q5T5P2-4]
PIRiT46910.
RefSeqiNP_001091970.1. NM_001098500.2. [Q5T5P2-9]
NP_001269696.1. NM_001282767.1. [Q5T5P2-10]
NP_001269697.1. NM_001282768.1. [Q5T5P2-7]
NP_001269698.1. NM_001282769.1. [Q5T5P2-6]
NP_001269699.1. NM_001282770.1. [Q5T5P2-4]
NP_062536.2. NM_019590.4. [Q5T5P2-1]
XP_005252573.1. XM_005252516.3. [Q5T5P2-3]
XP_016871918.1. XM_017016429.1. [Q5T5P2-9]
UniGeneiHs.445885.

Genome annotation databases

EnsembliENST00000307544; ENSP00000302343; ENSG00000120549. [Q5T5P2-6]
ENST00000376451; ENSP00000365634; ENSG00000120549. [Q5T5P2-3]
ENST00000376452; ENSP00000365635; ENSG00000120549. [Q5T5P2-10]
ENST00000376454; ENSP00000365637; ENSG00000120549. [Q5T5P2-1]
ENST00000376462; ENSP00000365645; ENSG00000120549. [Q5T5P2-9]
ENST00000396445; ENSP00000379722; ENSG00000120549. [Q5T5P2-8]
ENST00000396446; ENSP00000379723; ENSG00000120549. [Q5T5P2-4]
ENST00000430453; ENSP00000389680; ENSG00000120549. [Q5T5P2-9]
ENST00000458595; ENSP00000392625; ENSG00000120549. [Q5T5P2-7]
GeneIDi56243.
KEGGihsa:56243.
UCSCiuc001irs.5. human. [Q5T5P2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033043 mRNA. Translation: BAA86531.2.
AL157473 mRNA. Translation: CAB75668.1.
AL833280 mRNA. No translation available.
BX640796 mRNA. Translation: CAE45879.1. Sequence problems.
BX648451 mRNA. No translation available.
AL353583, AL392104 Genomic DNA. Translation: CAI12211.2.
AL353583
, AC063961, AL356113, AL392104 Genomic DNA. Translation: CAI12212.1. Sequence problems.
AL353583
, AC063961, AL356113, AL392104 Genomic DNA. Translation: CAI12213.2.
AL353583, AL392104 Genomic DNA. Translation: CAO03598.1.
AL353583, AL392104 Genomic DNA. Translation: CAO03599.1.
AL353583, AL392104 Genomic DNA. Translation: CAO03600.1.
AL356113
, AC063961, AL353583, AL392104 Genomic DNA. Translation: CAI14084.1. Sequence problems.
AL356113
, AC063961, AL353583, AL392104 Genomic DNA. Translation: CAI14085.2.
AL392104, AL353583 Genomic DNA. Translation: CAI40179.2.
AL392104
, AC063961, AL353583, AL356113 Genomic DNA. Translation: CAI40182.1. Sequence problems.
AL392104
, AC063961, AL353583, AL356113 Genomic DNA. Translation: CAI40183.2.
AL392104, AL353583 Genomic DNA. Translation: CAO03477.1.
AL392104, AL353583 Genomic DNA. Translation: CAO03478.1.
AL392104, AL353583 Genomic DNA. Translation: CAO03479.1.
AL157781 Genomic DNA. No translation available.
AL353650 Genomic DNA. No translation available.
AL355977 Genomic DNA. No translation available.
AL356477 Genomic DNA. No translation available.
AL391499 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86124.1.
BC018764 mRNA. Translation: AAH18764.1. Different initiation.
BC098577 mRNA. Translation: AAH98577.1.
BC136521 mRNA. Translation: AAI36522.1.
AB291616 mRNA. Translation: BAF63529.1. Different initiation.
AK125675 mRNA. Translation: BAC86241.1. Different initiation.
CCDSiCCDS31165.1. [Q5T5P2-1]
CCDS41496.1. [Q5T5P2-9]
CCDS60501.1. [Q5T5P2-7]
CCDS60502.1. [Q5T5P2-10]
CCDS60504.1. [Q5T5P2-6]
CCDS60505.1. [Q5T5P2-4]
PIRiT46910.
RefSeqiNP_001091970.1. NM_001098500.2. [Q5T5P2-9]
NP_001269696.1. NM_001282767.1. [Q5T5P2-10]
NP_001269697.1. NM_001282768.1. [Q5T5P2-7]
NP_001269698.1. NM_001282769.1. [Q5T5P2-6]
NP_001269699.1. NM_001282770.1. [Q5T5P2-4]
NP_062536.2. NM_019590.4. [Q5T5P2-1]
XP_005252573.1. XM_005252516.3. [Q5T5P2-3]
XP_016871918.1. XM_017016429.1. [Q5T5P2-9]
UniGeneiHs.445885.

3D structure databases

ProteinModelPortaliQ5T5P2.
SMRiQ5T5P2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121111. 24 interactors.
IntActiQ5T5P2. 24 interactors.
MINTiMINT-1464937.
STRINGi9606.ENSP00000365637.

PTM databases

iPTMnetiQ5T5P2.
PhosphoSitePlusiQ5T5P2.

Polymorphism and mutation databases

BioMutaiKIAA1217.
DMDMi147733121.

Proteomic databases

EPDiQ5T5P2.
MaxQBiQ5T5P2.
PaxDbiQ5T5P2.
PeptideAtlasiQ5T5P2.
PRIDEiQ5T5P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307544; ENSP00000302343; ENSG00000120549. [Q5T5P2-6]
ENST00000376451; ENSP00000365634; ENSG00000120549. [Q5T5P2-3]
ENST00000376452; ENSP00000365635; ENSG00000120549. [Q5T5P2-10]
ENST00000376454; ENSP00000365637; ENSG00000120549. [Q5T5P2-1]
ENST00000376462; ENSP00000365645; ENSG00000120549. [Q5T5P2-9]
ENST00000396445; ENSP00000379722; ENSG00000120549. [Q5T5P2-8]
ENST00000396446; ENSP00000379723; ENSG00000120549. [Q5T5P2-4]
ENST00000430453; ENSP00000389680; ENSG00000120549. [Q5T5P2-9]
ENST00000458595; ENSP00000392625; ENSG00000120549. [Q5T5P2-7]
GeneIDi56243.
KEGGihsa:56243.
UCSCiuc001irs.5. human. [Q5T5P2-1]

Organism-specific databases

CTDi56243.
DisGeNETi56243.
GeneCardsiKIAA1217.
H-InvDBHIX0008709.
HGNCiHGNC:25428. KIAA1217.
HPAiHPA004941.
neXtProtiNX_Q5T5P2.
OpenTargetsiENSG00000120549.
PharmGKBiPA134893343.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG2A. Eukaryota.
ENOG410ZC52. LUCA.
GeneTreeiENSGT00390000012399.
HOGENOMiHOG000293351.
HOVERGENiHBG019587.
InParanoidiQ5T5P2.
OMAiENGPQME.
OrthoDBiEOG091G0GCS.
PhylomeDBiQ5T5P2.
TreeFamiTF332255.

Miscellaneous databases

ChiTaRSiKIAA1217. human.
GenomeRNAii56243.
PROiQ5T5P2.

Gene expression databases

BgeeiENSG00000120549.
CleanExiHS_KIAA1217.
ExpressionAtlasiQ5T5P2. baseline and differential.
GenevisibleiQ5T5P2. HS.

Family and domain databases

InterProiIPR022782. AIP3_C.
IPR026725. Skt.
[Graphical view]
PANTHERiPTHR22741:SF4. PTHR22741:SF4. 1 hit.
PfamiPF03915. AIP3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSKT_HUMAN
AccessioniPrimary (citable) accession number: Q5T5P2
Secondary accession number(s): A5LHW9
, A6NLF3, A6PVQ5, A6PVQ6, A6PVQ7, B9EGK4, Q4KMG4, Q5T5P3, Q5T7H3, Q6MZZ6, Q6ZUI4, Q8WV45, Q9NSR2, Q9ULK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.