Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-J

Gene

CCNJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Cyclin

Enzyme and pathway databases

SignaLinkiQ5T5M9.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-J
Gene namesi
Name:CCNJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23434. CCNJ.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi54619.
OpenTargetsiENSG00000107443.
PharmGKBiPA134911603.

Polymorphism and mutation databases

BioMutaiCCNJ.
DMDMi160380581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093161 – 372Cyclin-JAdd BLAST372

Proteomic databases

PaxDbiQ5T5M9.
PRIDEiQ5T5M9.

PTM databases

iPTMnetiQ5T5M9.
PhosphoSitePlusiQ5T5M9.

Expressioni

Gene expression databases

BgeeiENSG00000107443.
CleanExiHS_CCNJ.
GenevisibleiQ5T5M9. HS.

Organism-specific databases

HPAiHPA036531.
HPA058151.

Interactioni

Protein-protein interaction databases

BioGridi120077. 5 interactors.
IntActiQ5T5M9. 1 interactor.
STRINGi9606.ENSP00000388902.

Structurei

3D structure databases

ProteinModelPortaliQ5T5M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 143Cyclin N-terminalAdd BLAST129

Sequence similaritiesi

Belongs to the cyclin family.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiENOG410IEPY. Eukaryota.
ENOG410Y1BM. LUCA.
GeneTreeiENSGT00390000001183.
HOGENOMiHOG000006591.
HOVERGENiHBG106031.
InParanoidiQ5T5M9.
OMAiRHPVSEQ.
OrthoDBiEOG091G09DD.
PhylomeDBiQ5T5M9.
TreeFamiTF101009.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR028859. Cyclin-J.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF62. PTHR10177:SF62. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T5M9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELEGQWWRG QLAADIHQAL RYKELKLPSY KGQSPQLSLR RYFADLIAIV
60 70 80 90 100
SNRFTLCPSA RHLAVYLLDL FMDRYDISIQ QLHLVALSCL LLASKFEEKE
110 120 130 140 150
DSVPKLEQLN SLGCMTNMNL VLTKQNLLHM ELLLLETFQW NLCLPTAAHF
160 170 180 190 200
IEYYLSEAVH ETDLHDGWPM ICLEKTKLYM AKYADYFLEV SLQVAAACVA
210 220 230 240 250
SSRIILRLSP TWPTRLHRLT AYSWDFLVQC IERLLIAHDN DVKEANKQRG
260 270 280 290 300
QAGPQSAQLS VFQTASQPSR PVHFQQPQYL HQTHQTSLQY RHPTSEQPSC
310 320 330 340 350
QQIVSTTHTS SYTLQTCPAG FQTSVQGLGH MQTGVGMSLA IPVEVKPCLS
360 370
VSYNRSYQIN EHYPCITPCF ER
Length:372
Mass (Da):42,581
Last modified:February 20, 2007 - v2
Checksum:i5CCADA91E11CF5D7
GO
Isoform 2 (identifier: Q5T5M9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-194: Missing.

Show »
Length:371
Mass (Da):42,482
Checksum:i9A4B47A6230CD78B
GO
Isoform 3 (identifier: Q5T5M9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-193: Q → QDYAFLNYAPSL

Show »
Length:383
Mass (Da):43,836
Checksum:iC6FAE3DDD5AFBEB8
GO

Sequence cautioni

The sequence BAA91887 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041163193Q → QDYAFLNYAPSL in isoform 3. 1 Publication1
Alternative sequenceiVSP_029128194Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001757 mRNA. Translation: BAA91887.1. Different initiation.
AK297264 mRNA. Translation: BAH12533.1.
AL356155 Genomic DNA. Translation: CAI16401.2.
BC043175 mRNA. Translation: AAH43175.1.
CCDSiCCDS44462.1. [Q5T5M9-3]
CCDS44463.1. [Q5T5M9-2]
CCDS7445.1. [Q5T5M9-1]
RefSeqiNP_001127847.1. NM_001134375.1. [Q5T5M9-3]
NP_001127848.1. NM_001134376.1. [Q5T5M9-2]
NP_061957.2. NM_019084.4. [Q5T5M9-1]
XP_011538187.1. XM_011539885.2. [Q5T5M9-3]
UniGeneiHs.596479.

Genome annotation databases

EnsembliENST00000265992; ENSP00000265992; ENSG00000107443. [Q5T5M9-1]
ENST00000403870; ENSP00000384498; ENSG00000107443. [Q5T5M9-2]
ENST00000465148; ENSP00000435373; ENSG00000107443. [Q5T5M9-3]
GeneIDi54619.
KEGGihsa:54619.
UCSCiuc001klm.4. human. [Q5T5M9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001757 mRNA. Translation: BAA91887.1. Different initiation.
AK297264 mRNA. Translation: BAH12533.1.
AL356155 Genomic DNA. Translation: CAI16401.2.
BC043175 mRNA. Translation: AAH43175.1.
CCDSiCCDS44462.1. [Q5T5M9-3]
CCDS44463.1. [Q5T5M9-2]
CCDS7445.1. [Q5T5M9-1]
RefSeqiNP_001127847.1. NM_001134375.1. [Q5T5M9-3]
NP_001127848.1. NM_001134376.1. [Q5T5M9-2]
NP_061957.2. NM_019084.4. [Q5T5M9-1]
XP_011538187.1. XM_011539885.2. [Q5T5M9-3]
UniGeneiHs.596479.

3D structure databases

ProteinModelPortaliQ5T5M9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120077. 5 interactors.
IntActiQ5T5M9. 1 interactor.
STRINGi9606.ENSP00000388902.

PTM databases

iPTMnetiQ5T5M9.
PhosphoSitePlusiQ5T5M9.

Polymorphism and mutation databases

BioMutaiCCNJ.
DMDMi160380581.

Proteomic databases

PaxDbiQ5T5M9.
PRIDEiQ5T5M9.

Protocols and materials databases

DNASUi54619.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265992; ENSP00000265992; ENSG00000107443. [Q5T5M9-1]
ENST00000403870; ENSP00000384498; ENSG00000107443. [Q5T5M9-2]
ENST00000465148; ENSP00000435373; ENSG00000107443. [Q5T5M9-3]
GeneIDi54619.
KEGGihsa:54619.
UCSCiuc001klm.4. human. [Q5T5M9-1]

Organism-specific databases

CTDi54619.
DisGeNETi54619.
GeneCardsiCCNJ.
HGNCiHGNC:23434. CCNJ.
HPAiHPA036531.
HPA058151.
neXtProtiNX_Q5T5M9.
OpenTargetsiENSG00000107443.
PharmGKBiPA134911603.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEPY. Eukaryota.
ENOG410Y1BM. LUCA.
GeneTreeiENSGT00390000001183.
HOGENOMiHOG000006591.
HOVERGENiHBG106031.
InParanoidiQ5T5M9.
OMAiRHPVSEQ.
OrthoDBiEOG091G09DD.
PhylomeDBiQ5T5M9.
TreeFamiTF101009.

Enzyme and pathway databases

SignaLinkiQ5T5M9.

Miscellaneous databases

GenomeRNAii54619.
PROiQ5T5M9.

Gene expression databases

BgeeiENSG00000107443.
CleanExiHS_CCNJ.
GenevisibleiQ5T5M9. HS.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR028859. Cyclin-J.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF62. PTHR10177:SF62. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNJ_HUMAN
AccessioniPrimary (citable) accession number: Q5T5M9
Secondary accession number(s): B7Z4E7, Q86XL1, Q9NV69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.