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Protein

Transcriptional protein SWT1

Gene

SWT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional protein SWT1
Gene namesi
Name:SWT1
Synonyms:C1orf26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16785. SWT1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi54823.
OpenTargetsiENSG00000116668.
PharmGKBiPA25613.

Polymorphism and mutation databases

BioMutaiSWT1.
DMDMi74745081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002511841 – 900Transcriptional protein SWT1Add BLAST900

Proteomic databases

MaxQBiQ5T5J6.
PaxDbiQ5T5J6.
PeptideAtlasiQ5T5J6.
PRIDEiQ5T5J6.

PTM databases

iPTMnetiQ5T5J6.
PhosphoSitePlusiQ5T5J6.

Expressioni

Tissue specificityi

Expressed weakly in testis.1 Publication

Gene expression databases

BgeeiENSG00000116668.
CleanExiHS_C1orf26.
ExpressionAtlasiQ5T5J6. baseline and differential.
GenevisibleiQ5T5J6. HS.

Organism-specific databases

HPAiHPA024214.
HPA027334.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356470.

Structurei

3D structure databases

ProteinModelPortaliQ5T5J6.
SMRiQ5T5J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini388 – 515PINcAdd BLAST128

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 44Poly-Ser7

Sequence similaritiesi

Belongs to the SWT1 family.Curated
Contains 1 PINc domain.Curated

Phylogenomic databases

eggNOGiKOG4689. Eukaryota.
ENOG4110E76. LUCA.
GeneTreeiENSGT00390000001254.
HOVERGENiHBG080945.
InParanoidiQ5T5J6.
OMAiDFTTVKF.
OrthoDBiEOG091G0AVX.
PhylomeDBiQ5T5J6.
TreeFamiTF335526.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR002716. PIN_dom.
IPR029060. PIN_domain-like.
[Graphical view]
PfamiPF13638. PIN_4. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5T5J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKESCGKK ETSQRKDTTT SSPNFGEKDK KERKTPASST SSSSIRSVSS
60 70 80 90 100
EKRKLKSDHT DVLYYNIKRR QGLKRLSVEI DTLRRRPKIG SSSQRPIKLK
110 120 130 140 150
EASYSNDNQI ILQSPSSNGT KKDIHKCVDF KPKDIKLTNA GSKLDHGIKS
160 170 180 190 200
LSSPKIASDV KPKAEGQASE NKWSHLLVQR EKMKELKKGR NSKFRDNSEK
210 220 230 240 250
CVLEKWKRNQ FSQDYNSNKI IKEPLGSRRQ KISFKIPIKS RDTLQKLVEE
260 270 280 290 300
NVFNIDSNNS KTKQEEREYL ESSQVSLNVT RQKTEHLLSD FTYKRTVHEW
310 320 330 340 350
KRKHHYDHQE SNDSHSRENL TQSFEAPCCS VSSESIQDAD QEMQIVEELH
360 370 380 390 400
AARVGKSVDL PGELMSMEID LEDDVHSSSA NNTSDRKLLI VIDTNILMNH
410 420 430 440 450
LKFVRILKTT EVPGFDKLVL IIPWVVMQEL DRMKEGKLLK RAQHKAIPAV
460 470 480 490 500
HFINDSLKNQ DRKLWGQSIQ LASQKHYGLS DENNDDRVLK CCLQHQELFP
510 520 530 540 550
CSFVILCTDD RNLRNKGLIS GVKSLSKEEL SAELLHLSLN TDVCHQPCIP
560 570 580 590 600
KQQLKAETTP LKESYKEEST NSGLSILLES IVSDLEKSLG TGLSSILETE
610 620 630 640 650
MKIAFGNLWM EILYLKPPWT LLHLLQCFKK HWLAVFGLVM EKNLLLTIES
660 670 680 690 700
LYKNLRKANK AVDFTTVKFL LQDSRSLLHA FSTRSNYDGI LPQTFAQVNN
710 720 730 740 750
LLQTFAEVKT KLKPNSSENT VTKKQEGTSL KNSHNQEITV FSSSHLPQPS
760 770 780 790 800
RHQEIWSILE SVWITIYQNS TDVFQRLGSN SALTTSNIAS FEEAFICLQK
810 820 830 840 850
LMAAVRDILE GIQRILAPNS NYQDVETLYN FLIKYEVNKN VKFTAQEIYD
860 870 880 890 900
CVSQTEYREK LTIGCRQLVE MEYTMQQCNA SVYMEAKNRG WCEDMLNYRI
Length:900
Mass (Da):103,222
Last modified:December 21, 2004 - v1
Checksum:i9ED199DFDD4094C7
GO

Sequence cautioni

The sequence BAA90960 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti430L → V in AAG60612 (PubMed:11318611).Curated1
Sequence conflicti571N → S in AAH30781 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027652148I → V.1 PublicationCorresponds to variant rs10489579dbSNPEnsembl.1
Natural variantiVAR_027653536H → R.1 PublicationCorresponds to variant rs6698109dbSNPEnsembl.1
Natural variantiVAR_027654638L → F.Corresponds to variant rs2295950dbSNPEnsembl.1
Natural variantiVAR_027655821N → D.1 PublicationCorresponds to variant rs12041704dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288392 mRNA. Translation: AAG60612.1.
AL136133, AL356273 Genomic DNA. Translation: CAI17940.1.
AL356273, AL136133 Genomic DNA. Translation: CAI22095.1.
BC030781 mRNA. Translation: AAH30781.1.
AK000128 mRNA. Translation: BAA90960.1. Different initiation.
CCDSiCCDS1367.1.
RefSeqiNP_001098988.1. NM_001105518.1.
NP_060143.4. NM_017673.6.
XP_016857016.1. XM_017001527.1.
UniGeneiHs.134183.

Genome annotation databases

EnsembliENST00000367500; ENSP00000356470; ENSG00000116668.
ENST00000367501; ENSP00000356471; ENSG00000116668.
GeneIDi54823.
KEGGihsa:54823.
UCSCiuc001grg.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288392 mRNA. Translation: AAG60612.1.
AL136133, AL356273 Genomic DNA. Translation: CAI17940.1.
AL356273, AL136133 Genomic DNA. Translation: CAI22095.1.
BC030781 mRNA. Translation: AAH30781.1.
AK000128 mRNA. Translation: BAA90960.1. Different initiation.
CCDSiCCDS1367.1.
RefSeqiNP_001098988.1. NM_001105518.1.
NP_060143.4. NM_017673.6.
XP_016857016.1. XM_017001527.1.
UniGeneiHs.134183.

3D structure databases

ProteinModelPortaliQ5T5J6.
SMRiQ5T5J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356470.

PTM databases

iPTMnetiQ5T5J6.
PhosphoSitePlusiQ5T5J6.

Polymorphism and mutation databases

BioMutaiSWT1.
DMDMi74745081.

Proteomic databases

MaxQBiQ5T5J6.
PaxDbiQ5T5J6.
PeptideAtlasiQ5T5J6.
PRIDEiQ5T5J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367500; ENSP00000356470; ENSG00000116668.
ENST00000367501; ENSP00000356471; ENSG00000116668.
GeneIDi54823.
KEGGihsa:54823.
UCSCiuc001grg.5. human.

Organism-specific databases

CTDi54823.
DisGeNETi54823.
GeneCardsiSWT1.
H-InvDBHIX0001422.
HGNCiHGNC:16785. SWT1.
HPAiHPA024214.
HPA027334.
neXtProtiNX_Q5T5J6.
OpenTargetsiENSG00000116668.
PharmGKBiPA25613.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4689. Eukaryota.
ENOG4110E76. LUCA.
GeneTreeiENSGT00390000001254.
HOVERGENiHBG080945.
InParanoidiQ5T5J6.
OMAiDFTTVKF.
OrthoDBiEOG091G0AVX.
PhylomeDBiQ5T5J6.
TreeFamiTF335526.

Miscellaneous databases

GenomeRNAii54823.
PROiQ5T5J6.

Gene expression databases

BgeeiENSG00000116668.
CleanExiHS_C1orf26.
ExpressionAtlasiQ5T5J6. baseline and differential.
GenevisibleiQ5T5J6. HS.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR002716. PIN_dom.
IPR029060. PIN_domain-like.
[Graphical view]
PfamiPF13638. PIN_4. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSWT1_HUMAN
AccessioniPrimary (citable) accession number: Q5T5J6
Secondary accession number(s): Q8NEK9, Q9BZQ7, Q9NXQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.