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Q5T5H8

- Q5T5H8_HUMAN

UniProt

Q5T5H8 - Q5T5H8_HUMAN

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Protein
Submitted name:

Estrogen receptor

Gene

ESR1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. DNA binding Source: InterPro
  3. estrogen receptor activity Source: InterPro
  4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  5. steroid binding Source: InterPro

GO - Biological processi

  1. androgen metabolic process Source: Ensembl
  2. antral ovarian follicle growth Source: Ensembl
  3. cellular response to estrogen stimulus Source: Ensembl
  4. epithelial cell development Source: Ensembl
  5. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
  6. male gonad development Source: Ensembl
  7. mammary gland alveolus development Source: Ensembl
  8. mammary gland branching involved in pregnancy Source: Ensembl
  9. positive regulation of fibroblast proliferation Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
  12. prostate epithelial cord elongation Source: Ensembl
  13. regulation of apoptotic process Source: Ensembl
  14. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  15. uterus development Source: Ensembl
  16. vagina development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptorImported
Gene namesi
Name:ESR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:3467. ESR1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ5T5H8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5T5H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118887.

Family and domain databases

InterProiIPR001292. Oestr_rcpt.
[Graphical view]
PfamiPF02159. Oest_recep. 1 hit.
[Graphical view]
PRINTSiPR00543. OESTROGENR.

Sequencei

Sequence statusi: Fragment.

Q5T5H8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA
60 70 80
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGS
Length:84
Mass (Da):9,033
Last modified:April 8, 2008 - v1
Checksum:iB1FB1A8BFDC55BC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei84 – 841Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035695 Genomic DNA. No translation available.
AL049821 Genomic DNA. No translation available.
AL078582 Genomic DNA. No translation available.
AL356311 Genomic DNA. No translation available.
AL590993 Genomic DNA. No translation available.
KF454881 Genomic DNA. No translation available.
KF458326 Genomic DNA. No translation available.
KF458327 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000404742; ENSP00000385373; ENSG00000091831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035695 Genomic DNA. No translation available.
AL049821 Genomic DNA. No translation available.
AL078582 Genomic DNA. No translation available.
AL356311 Genomic DNA. No translation available.
AL590993 Genomic DNA. No translation available.
KF454881 Genomic DNA. No translation available.
KF458326 Genomic DNA. No translation available.
KF458327 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q5T5H8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000404742 ; ENSP00000385373 ; ENSG00000091831 .

Organism-specific databases

HGNCi HGNC:3467. ESR1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118887.

Miscellaneous databases

ChiTaRSi ESR1. human.
NextBioi 35539764.

Gene expression databases

ExpressionAtlasi Q5T5H8. baseline and differential.

Family and domain databases

InterProi IPR001292. Oestr_rcpt.
[Graphical view ]
Pfami PF02159. Oest_recep. 1 hit.
[Graphical view ]
PRINTSi PR00543. OESTROGENR.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ5T5H8_HUMAN
AccessioniPrimary (citable) accession number: Q5T5H8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3