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Protein
Submitted name:

Potassium channel subfamily K member 1

Gene

KCNK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel subfamily K member 1Imported
Gene namesi
Name:KCNK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6272. KCNK1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei53 – 75HelicalSequence analysisAdd BLAST23
Transmembranei96 – 121HelicalSequence analysisAdd BLAST26
Transmembranei133 – 150HelicalSequence analysisAdd BLAST18
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135750.

PTM / Processingi

Proteomic databases

PaxDbiQ5T5E6.
PeptideAtlasiQ5T5E6.
PRIDEiQ5T5E6.

Expressioni

Gene expression databases

BgeeiENSG00000135750.
ExpressionAtlasiQ5T5E6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355580.

Structurei

3D structure databases

ProteinModelPortaliQ5T5E6.
SMRiQ5T5E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 75Ion_trans_2InterPro annotationAdd BLAST42
Domaini111 – 185Ion_trans_2InterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR001779. 2pore_dom_K_chnl_TWIK1.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01096. TWIK1CHANNEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Fragment.

Q5T5E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLRVLSPDLV RRLLNLAVRA FQVPKGESLN FPESTPGYGH TVPLSDGGKA
60 70 80 90 100
FCIIYSVIGI PFTLLFLTAV VQRITVHVTR RPVLYFHIRW GFSKQVVAIV
110 120 130 140 150
HAVLLGFVTV SCFFFIPAAV FSVLEDDWNF LESFYFCFIS LSTIGLGDYV
160 170 180 190 200
PGEGYNQKFR ELYKIGITCY LLLGLIAMLV VLETFCELHE LKKFRKMFYV
210 220 230 240
KKDKDEDQVH IIEHDQLSFS SITDQAAGMK EDQKQNEPFV AT
Length:242
Mass (Da):27,531
Last modified:December 21, 2004 - v1
Checksum:i242014F43B1993DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei242Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356357 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000446915; ENSP00000409626; ENSG00000135750.
UCSCiuc057qll.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356357 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5T5E6.
SMRiQ5T5E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355580.

Proteomic databases

PaxDbiQ5T5E6.
PeptideAtlasiQ5T5E6.
PRIDEiQ5T5E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446915; ENSP00000409626; ENSG00000135750.
UCSCiuc057qll.1. human.

Organism-specific databases

HGNCiHGNC:6272. KCNK1.
OpenTargetsiENSG00000135750.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.

Miscellaneous databases

ChiTaRSiKCNK1. human.

Gene expression databases

BgeeiENSG00000135750.
ExpressionAtlasiQ5T5E6. baseline and differential.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR001779. 2pore_dom_K_chnl_TWIK1.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01096. TWIK1CHANNEL.
PR01586. TWIKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5T5E6_HUMAN
AccessioniPrimary (citable) accession number: Q5T5E6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.