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Protein

Zinc finger protein 684

Gene

ZNF684

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri159 – 18123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 684
Gene namesi
Name:ZNF684
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28418. ZNF684.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670485.

Polymorphism and mutation databases

BioMutaiZNF684.
DMDMi74756332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Zinc finger protein 684PRO_0000234003Add
BLAST

Proteomic databases

PaxDbiQ5T5D7.
PRIDEiQ5T5D7.

PTM databases

iPTMnetiQ5T5D7.
PhosphoSiteiQ5T5D7.

Expressioni

Gene expression databases

BgeeiQ5T5D7.
CleanExiHS_ZNF684.
ExpressionAtlasiQ5T5D7. baseline and differential.
GenevisibleiQ5T5D7. HS.

Organism-specific databases

HPAiHPA059153.

Interactioni

Protein-protein interaction databases

BioGridi126056. 7 interactions.
IntActiQ5T5D7. 1 interaction.
STRINGi9606.ENSP00000361784.

Structurei

3D structure databases

ProteinModelPortaliQ5T5D7.
SMRiQ5T5D7. Positions 3-48, 146-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri159 – 18123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00780000122097.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5T5D7.
KOiK09228.
OMAiLNPTRKK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5T5D7.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T5D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISFQESVTF QDVAVDFTAE EWQLLDCAER TLYWDVMLEN YRNLISVGCP
60 70 80 90 100
ITKTKVILKV EQGQEPWMVE GANPHESSPE SDYPLVDEPG KHRESKDNFL
110 120 130 140 150
KSVLLTFNKI LTMERIHHYN MSTSLNPMRK KSYKSFEKCL PPNLDLLKYN
160 170 180 190 200
RSYTVENAYE CSECGKAFKK KFHFIRHEKN HTRKKPFECN DCGKAYSRKA
210 220 230 240 250
HLATHQKIHN GERPFVCNDC GKAFMHKAQL VVHQRLHTGE KPYECSQCGK
260 270 280 290 300
TFTWNSSFNQ HVKSHTLEKS FECKECGKTF RYSSSLYKHS RFHTGEKPYQ
310 320 330 340 350
CIICGKAFGN TSVLVTHQRI HTGEKPYSCI ECGKAFIKKS HLLRHQITHT
360 370
GEKPYECNRC GKAFSQKSNL IVHQKIHT
Length:378
Mass (Da):43,945
Last modified:December 21, 2004 - v1
Checksum:i47AD3D8DE2A8B613
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356379 Genomic DNA. Translation: CAI22134.1.
BC091518 mRNA. Translation: AAH91518.1.
BC111463 mRNA. Translation: AAI11464.1.
CCDSiCCDS454.1.
RefSeqiNP_689586.3. NM_152373.3.
XP_011538973.1. XM_011540671.1.
XP_011538974.1. XM_011540672.1.
XP_011538975.1. XM_011540673.1.
XP_011538976.1. XM_011540674.1.
UniGeneiHs.524767.

Genome annotation databases

EnsembliENST00000372699; ENSP00000361784; ENSG00000117010.
GeneIDi127396.
KEGGihsa:127396.
UCSCiuc001cft.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356379 Genomic DNA. Translation: CAI22134.1.
BC091518 mRNA. Translation: AAH91518.1.
BC111463 mRNA. Translation: AAI11464.1.
CCDSiCCDS454.1.
RefSeqiNP_689586.3. NM_152373.3.
XP_011538973.1. XM_011540671.1.
XP_011538974.1. XM_011540672.1.
XP_011538975.1. XM_011540673.1.
XP_011538976.1. XM_011540674.1.
UniGeneiHs.524767.

3D structure databases

ProteinModelPortaliQ5T5D7.
SMRiQ5T5D7. Positions 3-48, 146-378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126056. 7 interactions.
IntActiQ5T5D7. 1 interaction.
STRINGi9606.ENSP00000361784.

PTM databases

iPTMnetiQ5T5D7.
PhosphoSiteiQ5T5D7.

Polymorphism and mutation databases

BioMutaiZNF684.
DMDMi74756332.

Proteomic databases

PaxDbiQ5T5D7.
PRIDEiQ5T5D7.

Protocols and materials databases

DNASUi127396.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372699; ENSP00000361784; ENSG00000117010.
GeneIDi127396.
KEGGihsa:127396.
UCSCiuc001cft.2. human.

Organism-specific databases

CTDi127396.
GeneCardsiZNF684.
HGNCiHGNC:28418. ZNF684.
HPAiHPA059153.
neXtProtiNX_Q5T5D7.
PharmGKBiPA142670485.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00780000122097.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5T5D7.
KOiK09228.
OMAiLNPTRKK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5T5D7.
TreeFamiTF337898.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii127396.
PROiQ5T5D7.

Gene expression databases

BgeeiQ5T5D7.
CleanExiHS_ZNF684.
ExpressionAtlasiQ5T5D7. baseline and differential.
GenevisibleiQ5T5D7. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary and Skin.

Entry informationi

Entry nameiZN684_HUMAN
AccessioniPrimary (citable) accession number: Q5T5D7
Secondary accession number(s): Q2NKY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.