Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 684

Gene

ZNF684

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri159 – 181C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 684
Gene namesi
Name:ZNF684
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117010.15
HGNCiHGNC:28418 ZNF684
neXtProtiNX_Q5T5D7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117010
PharmGKBiPA142670485

Polymorphism and mutation databases

BioMutaiZNF684
DMDMi74756332

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340031 – 378Zinc finger protein 684Add BLAST378

Proteomic databases

EPDiQ5T5D7
PaxDbiQ5T5D7
PeptideAtlasiQ5T5D7
PRIDEiQ5T5D7

PTM databases

iPTMnetiQ5T5D7
PhosphoSitePlusiQ5T5D7

Expressioni

Gene expression databases

BgeeiENSG00000117010
CleanExiHS_ZNF684
ExpressionAtlasiQ5T5D7 baseline and differential
GenevisibleiQ5T5D7 HS

Organism-specific databases

HPAiHPA059153

Interactioni

Protein-protein interaction databases

BioGridi1260569 interactors.
IntActiQ5T5D7 1 interactor.
STRINGi9606.ENSP00000361784

Structurei

3D structure databases

ProteinModelPortaliQ5T5D7
SMRiQ5T5D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri159 – 181C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144275
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ5T5D7
KOiK09228
OMAiLNPTRKK
OrthoDBiEOG091G02KC
PhylomeDBiQ5T5D7
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequencei

Sequence statusi: Complete.

Q5T5D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISFQESVTF QDVAVDFTAE EWQLLDCAER TLYWDVMLEN YRNLISVGCP
60 70 80 90 100
ITKTKVILKV EQGQEPWMVE GANPHESSPE SDYPLVDEPG KHRESKDNFL
110 120 130 140 150
KSVLLTFNKI LTMERIHHYN MSTSLNPMRK KSYKSFEKCL PPNLDLLKYN
160 170 180 190 200
RSYTVENAYE CSECGKAFKK KFHFIRHEKN HTRKKPFECN DCGKAYSRKA
210 220 230 240 250
HLATHQKIHN GERPFVCNDC GKAFMHKAQL VVHQRLHTGE KPYECSQCGK
260 270 280 290 300
TFTWNSSFNQ HVKSHTLEKS FECKECGKTF RYSSSLYKHS RFHTGEKPYQ
310 320 330 340 350
CIICGKAFGN TSVLVTHQRI HTGEKPYSCI ECGKAFIKKS HLLRHQITHT
360 370
GEKPYECNRC GKAFSQKSNL IVHQKIHT
Length:378
Mass (Da):43,945
Last modified:December 21, 2004 - v1
Checksum:i47AD3D8DE2A8B613
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356379 Genomic DNA No translation available.
BC091518 mRNA Translation: AAH91518.1
BC111463 mRNA Translation: AAI11464.1
CCDSiCCDS454.1
RefSeqiNP_689586.3, NM_152373.3
XP_011538973.1, XM_011540671.2
XP_011538974.1, XM_011540672.2
XP_011538975.1, XM_011540673.2
XP_016855779.1, XM_017000290.1
UniGeneiHs.524767

Genome annotation databases

EnsembliENST00000372699; ENSP00000361784; ENSG00000117010
GeneIDi127396
KEGGihsa:127396
UCSCiuc001cft.2 human

Similar proteinsi

Entry informationi

Entry nameiZN684_HUMAN
AccessioniPrimary (citable) accession number: Q5T5D7
Secondary accession number(s): Q2NKY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 21, 2004
Last modified: February 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome