Q5T5C0 (STXB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syntaxin-binding protein 5

Alternative name(s):
Lethal(2) giant larvae protein homolog 3
Tomosyn-1

Gene names

Name:	STXBP5
Synonyms:	LLGL3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1151 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding By similarity.
Subunit structure	Interacts with STX1A and STX1B via its v-SNARE homology domain. Part of a complex that contains STX1, STXBP5, SNAP25 and SYT1. Part of a complex that contains STXBP5, STX4A and SNAP23 By similarity.
Subcellular location	Cytoplasm By similarity. Cell membrane; Peripheral membrane protein By similarity. Cytoplasmic vesicle membrane; Peripheral membrane protein By similarity. Cytoplasmic vesicle › secretory vesicle › synaptic vesicle By similarity. Cell junction › synapse By similarity. Note: Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles By similarity.
Sequence similarities	Belongs to the WD repeat L(2)GL family. Contains 1 v-SNARE coiled-coil homology domain. Contains 14 WD repeats.
Sequence caution	The sequence BAC03475.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Exocytosis Protein transport Transport
Cellular component	Cell junction Cell membrane Cytoplasm Cytoplasmic vesicle Membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of exocytosis Inferred from sequence or structural similarity. Source: BHF-UCL protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	acetylcholine-gated channel complex Inferred from sequence or structural similarity. Source: BHF-UCL cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synaptic vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	syntaxin-1 binding Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T5C0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T5C0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     716-751: Missing.

Isoform 3 (identifier: Q5T5C0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     716-768: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1151	1151	Syntaxin-binding protein 5		PRO_0000051244
Regions
	Repeat	61 – 94	34	WD 1
	Repeat	101 – 140	40	WD 2
	Repeat	145 – 181	37	WD 3
	Repeat	200 – 234	35	WD 4
	Repeat	240 – 272	33	WD 5
	Repeat	294 – 336	43	WD 6
	Repeat	344 – 378	35	WD 7
	Repeat	400 – 477	78	WD 8
	Repeat	505 – 619	115	WD 9
	Repeat	633 – 695	63	WD 10
	Repeat	794 – 851	58	WD 11
	Repeat	860 – 934	75	WD 12
	Repeat	939 – 983	45	WD 13
	Repeat	997 – 1020	24	WD 14
	Domain	1086 – 1146	61	v-SNARE coiled-coil homology
	Compositional bias	22 – 27	6	Poly-Gln
	Compositional bias	584 – 590	7	Poly-Ser
Amino acid modifications
	Modified residue	723	1	Phosphoserine; by PKA By similarity
	Modified residue	759	1	Phosphoserine Ref.5
	Modified residue	762	1	Phosphothreonine Ref.4
	Modified residue	782	1	Phosphoserine By similarity
	Modified residue	785	1	Phosphoserine Ref.6
	Modified residue	1058	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	716 – 768	53	Missing in isoform 3.		VSP_016204
	Alternative sequence	716 – 751	36	Missing in isoform 2.		VSP_016205
	Natural variant	436	1	N → S. Corresponds to variant rs1039084 [ dbSNP | Ensembl ].		VAR_035235

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 247083A17DEA4811	FASTA	1,151	127,573
	10 20 30 40 50 60 MRKFNIRKVL DGLTAGSSSA SQQQQQQHPP GNREPEIQET LQSEHFQLCK TVRHGFPYQP 70 80 90 100 110 120 SALAFDPVQK ILAVGTQTGA LRLFGRPGVE CYCQHDSGAA VIQLQFLINE GALVSALADD 130 140 150 160 170 180 TLHLWNLRQK RPAILHSLKF CRERVTFCHL PFQSKWLYVG TERGNIHIVN VESFTLSGYV 190 200 210 220 230 240 IMWNKAIELS SKSHPGPVVH ISDNPMDEGK LLIGFESGTV VLWDLKSKKA DYRYTYDEAI 250 260 270 280 290 300 HSVAWHHEGK QFICSHSDGT LTIWNVRSPA KPVQTITPHG KQLKDGKKPE PCKPILKVEF 310 320 330 340 350 360 KTTRSGEPFI ILSGGLSYDT VGRRPCLTVM HGKSTAVLEM DYSIVDFLTL CETPYPNDFQ 370 380 390 400 410 420 EPYAVVVLLE KDLVLIDLAQ NGYPIFENPY PLSIHESPVT CCEYFADCPV DLIPALYSVG 430 440 450 460 470 480 ARQKRQGYSK KEWPINGGNW GLGAQSYPEI IITGHADGSV KFWDASAITL QVLYKLKTSK 490 500 510 520 530 540 VFEKSRNKDD RPNTDIVDED PYAIQIISWC PESRMLCIAG VSAHVIIYRF SKQEVITEVI 550 560 570 580 590 600 PMLEVRLLYE INDVETPEGE QPPPLPTPVG GSNPQPIPPQ SHPSTSSSSS DGLRDNVPCL 610 620 630 640 650 660 KVKNSPLKQS PGYQTELVIQ LVWVGGEPPQ QITSLAVNSS YGLVVFGNCN GIAMVDYLQK 670 680 690 700 710 720 AVLLNLGTIE LYGSNDPYRR EPRSPRKSRQ PSGAGLCDIS EGTVVPEDRC KSPTSGSSSP 730 740 750 760 770 780 HNSDDEQKMN NFIEKVKTKS RKFSKMVAND IAKMSRKLSL PTDLKPDLDV KDNSFSRSRS 790 800 810 820 830 840 SSVTSIDKES REAISALHFC ETFTRKTDSS PSPCLWVGTT LGTVLVIALN LPPGGEQRLL 850 860 870 880 890 900 QPVIVSPSGT ILRLKGAILR MAFLDTTGCL IPPAYEPWRE HNVPEEKDEK EKLKKRRPVS 910 920 930 940 950 960 VSPSSSQEIS ENQYAVICSE KQAKVISLPT QNCAYKQNIT ETSFVLRGDI VALSNSICLA 970 980 990 1000 1010 1020 CFCANGHIMT FSLPSLRPLL DVYYLPLTNM RIARTFCFTN NGQALYLVSP TEIQRLTYSQ 1030 1040 1050 1060 1070 1080 ETCENLQEML GELFTPVETP EAPNRGFFKG LFGGGAQSLD REELFGESSS GKASRSLAQH 1090 1100 1110 1120 1130 1140 IPGPGGIEGV KGAASGVVGE LARARLALDE RGQKLGDLEE RTAAMLSSAE SFSKHAHEIM 1150 LKYKDKKWYQ F
	Isoform 2 [UniParc]. Checksum: 2F1874662D9B30F6	FASTA	1,115	123,492
	10 20 30 40 50 60 MRKFNIRKVL DGLTAGSSSA SQQQQQQHPP GNREPEIQET LQSEHFQLCK TVRHGFPYQP 70 80 90 100 110 120 SALAFDPVQK ILAVGTQTGA LRLFGRPGVE CYCQHDSGAA VIQLQFLINE GALVSALADD 130 140 150 160 170 180 TLHLWNLRQK RPAILHSLKF CRERVTFCHL PFQSKWLYVG TERGNIHIVN VESFTLSGYV 190 200 210 220 230 240 IMWNKAIELS SKSHPGPVVH ISDNPMDEGK LLIGFESGTV VLWDLKSKKA DYRYTYDEAI 250 260 270 280 290 300 HSVAWHHEGK QFICSHSDGT LTIWNVRSPA KPVQTITPHG KQLKDGKKPE PCKPILKVEF 310 320 330 340 350 360 KTTRSGEPFI ILSGGLSYDT VGRRPCLTVM HGKSTAVLEM DYSIVDFLTL CETPYPNDFQ 370 380 390 400 410 420 EPYAVVVLLE KDLVLIDLAQ NGYPIFENPY PLSIHESPVT CCEYFADCPV DLIPALYSVG 430 440 450 460 470 480 ARQKRQGYSK KEWPINGGNW GLGAQSYPEI IITGHADGSV KFWDASAITL QVLYKLKTSK 490 500 510 520 530 540 VFEKSRNKDD RPNTDIVDED PYAIQIISWC PESRMLCIAG VSAHVIIYRF SKQEVITEVI 550 560 570 580 590 600 PMLEVRLLYE INDVETPEGE QPPPLPTPVG GSNPQPIPPQ SHPSTSSSSS DGLRDNVPCL 610 620 630 640 650 660 KVKNSPLKQS PGYQTELVIQ LVWVGGEPPQ QITSLAVNSS YGLVVFGNCN GIAMVDYLQK 670 680 690 700 710 720 AVLLNLGTIE LYGSNDPYRR EPRSPRKSRQ PSGAGLCDIS EGTVVPEDRC KSPTSAKMSR 730 740 750 760 770 780 KLSLPTDLKP DLDVKDNSFS RSRSSSVTSI DKESREAISA LHFCETFTRK TDSSPSPCLW 790 800 810 820 830 840 VGTTLGTVLV IALNLPPGGE QRLLQPVIVS PSGTILRLKG AILRMAFLDT TGCLIPPAYE 850 860 870 880 890 900 PWREHNVPEE KDEKEKLKKR RPVSVSPSSS QEISENQYAV ICSEKQAKVI SLPTQNCAYK 910 920 930 940 950 960 QNITETSFVL RGDIVALSNS ICLACFCANG HIMTFSLPSL RPLLDVYYLP LTNMRIARTF 970 980 990 1000 1010 1020 CFTNNGQALY LVSPTEIQRL TYSQETCENL QEMLGELFTP VETPEAPNRG FFKGLFGGGA 1030 1040 1050 1060 1070 1080 QSLDREELFG ESSSGKASRS LAQHIPGPGG IEGVKGAASG VVGELARARL ALDERGQKLG 1090 1100 1110 DLEERTAAML SSAESFSKHA HEIMLKYKDK KWYQF
	Isoform 3 [UniParc]. Checksum: B8EAE43977084610	FASTA	1,098	121,597
	10 20 30 40 50 60 MRKFNIRKVL DGLTAGSSSA SQQQQQQHPP GNREPEIQET LQSEHFQLCK TVRHGFPYQP 70 80 90 100 110 120 SALAFDPVQK ILAVGTQTGA LRLFGRPGVE CYCQHDSGAA VIQLQFLINE GALVSALADD 130 140 150 160 170 180 TLHLWNLRQK RPAILHSLKF CRERVTFCHL PFQSKWLYVG TERGNIHIVN VESFTLSGYV 190 200 210 220 230 240 IMWNKAIELS SKSHPGPVVH ISDNPMDEGK LLIGFESGTV VLWDLKSKKA DYRYTYDEAI 250 260 270 280 290 300 HSVAWHHEGK QFICSHSDGT LTIWNVRSPA KPVQTITPHG KQLKDGKKPE PCKPILKVEF 310 320 330 340 350 360 KTTRSGEPFI ILSGGLSYDT VGRRPCLTVM HGKSTAVLEM DYSIVDFLTL CETPYPNDFQ 370 380 390 400 410 420 EPYAVVVLLE KDLVLIDLAQ NGYPIFENPY PLSIHESPVT CCEYFADCPV DLIPALYSVG 430 440 450 460 470 480 ARQKRQGYSK KEWPINGGNW GLGAQSYPEI IITGHADGSV KFWDASAITL QVLYKLKTSK 490 500 510 520 530 540 VFEKSRNKDD RPNTDIVDED PYAIQIISWC PESRMLCIAG VSAHVIIYRF SKQEVITEVI 550 560 570 580 590 600 PMLEVRLLYE INDVETPEGE QPPPLPTPVG GSNPQPIPPQ SHPSTSSSSS DGLRDNVPCL 610 620 630 640 650 660 KVKNSPLKQS PGYQTELVIQ LVWVGGEPPQ QITSLAVNSS YGLVVFGNCN GIAMVDYLQK 670 680 690 700 710 720 AVLLNLGTIE LYGSNDPYRR EPRSPRKSRQ PSGAGLCDIS EGTVVPEDRC KSPTSDVKDN 730 740 750 760 770 780 SFSRSRSSSV TSIDKESREA ISALHFCETF TRKTDSSPSP CLWVGTTLGT VLVIALNLPP 790 800 810 820 830 840 GGEQRLLQPV IVSPSGTILR LKGAILRMAF LDTTGCLIPP AYEPWREHNV PEEKDEKEKL 850 860 870 880 890 900 KKRRPVSVSP SSSQEISENQ YAVICSEKQA KVISLPTQNC AYKQNITETS FVLRGDIVAL 910 920 930 940 950 960 SNSICLACFC ANGHIMTFSL PSLRPLLDVY YLPLTNMRIA RTFCFTNNGQ ALYLVSPTEI 970 980 990 1000 1010 1020 QRLTYSQETC ENLQEMLGEL FTPVETPEAP NRGFFKGLFG GGAQSLDREE LFGESSSGKA 1030 1040 1050 1060 1070 1080 SRSLAQHIPG PGGIEGVKGA ASGVVGELAR ARLALDERGQ KLGDLEERTA AMLSSAESFS 1090 KHAHEIMLKY KDKKWYQF

References

[1]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Cerebellum.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 373-1151 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 670-1151 (ISOFORM 2). Tissue: Brain.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-762, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759, MASS SPECTROMETRY. Tissue: Platelet.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-785, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20239.1. AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20240.1. AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20241.1. AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40423.1. AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40424.1. AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40425.1. AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40739.1. AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40740.1. AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40741.1. BC113382 mRNA. Translation: AAI13383.1. AK055484 mRNA. Translation: BAB70930.1. AK090549 mRNA. Translation: BAC03475.1. Different initiation.
IPI	IPI00171407. IPI00640500. IPI00645854.
RefSeq	NP_001121187.1. NM_001127715.2. NP_640337.3. NM_139244.4.
UniGene	Hs.86320.
3D structure databases
ProteinModelPortal	Q5T5C0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5T5C0. 1 interaction.
STRING	9606.ENSP00000321826.
PTM databases
PhosphoSite	Q5T5C0.
Polymorphism databases
DMDM	74762236.
Proteomic databases
PaxDb	Q5T5C0.
PRIDE	Q5T5C0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321680; ENSP00000321826; ENSG00000164506. ENST00000367480; ENSP00000356450; ENSG00000164506. ENST00000367481; ENSP00000356451; ENSG00000164506.
GeneID	134957.
KEGG	hsa:134957.
UCSC	uc003qlz.3. human. uc010khz.2. human.
Organism-specific databases
CTD	134957.
GeneCards	GC06P147566.
H-InvDB	HIX0019766.
HGNC	HGNC:19665. STXBP5.
HPA	HPA039991.
MIM	604586. gene.
neXtProt	NX_Q5T5C0.
PharmGKB	PA134954258.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG289584.
HOGENOM	HOG000110929.
HOVERGEN	HBG083064.
InParanoid	Q5T5C0.
KO	K08518.
OMA	RYTHDEA.
Gene expression databases
ArrayExpress	Q5T5C0.
Bgee	Q5T5C0.
CleanEx	HS_STXBP5.
Genevestigator	Q5T5C0.
GermOnline	ENSG00000164506. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 2 hits.
InterPro	IPR000664. Lethal2_giant. IPR013905. Lgl_C. IPR013577. LLGL2. IPR001388. Synaptobrevin. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF08596. Lgl_C. 1 hit. PF08366. LLGL. 1 hit. PF00400. WD40. 2 hits. [Graphical view]
PRINTS	PR00962. LETHAL2GIANT.
SMART	SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 2 hits.
PROSITE	PS50892. V_SNARE. 1 hit. PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	STXBP5. human.
GenomeRNAi	134957.
NextBio	83439.
SOURCE	Search...

Entry information

Entry name

STXB5_HUMAN

Accession

Primary (citable) accession number: Q5T5C0
Secondary accession number(s): Q14DF3 , Q5T5C1, Q5T5C2, Q8NBG8, Q96NG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.