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Protein

Syntaxin-binding protein 5

Gene

STXBP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity).By similarity

GO - Molecular functioni

  1. syntaxin-1 binding Source: BHF-UCL

GO - Biological processi

  1. exocytosis Source: UniProtKB-KW
  2. positive regulation of exocytosis Source: BHF-UCL
  3. protein transport Source: UniProtKB-KW
  4. regulation of blood coagulation Source: UniProtKB
  5. regulation of exocytosis Source: ParkinsonsUK-UCL
  6. regulation of gene expression Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

SignaLinkiQ5T5C0.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 5
Alternative name(s):
Lethal(2) giant larvae protein homolog 3
Tomosyn-1
Gene namesi
Name:STXBP5
Synonyms:LLGL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:19665. STXBP5.

Subcellular locationi

Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle By similarity. Cell junctionsynapse By similarity
Note: Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity).By similarity

GO - Cellular componenti

  1. acetylcholine-gated channel complex Source: BHF-UCL
  2. cell junction Source: UniProtKB-KW
  3. cytoplasm Source: HPA
  4. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  5. synaptic vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134954258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11511151Syntaxin-binding protein 5PRO_0000051244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei723 – 7231Phosphoserine; by PKABy similarity
Modified residuei759 – 7591Phosphoserine2 Publications
Modified residuei762 – 7621Phosphothreonine1 Publication
Modified residuei782 – 7821PhosphoserineBy similarity
Modified residuei785 – 7851Phosphoserine1 Publication
Modified residuei1039 – 10391Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5T5C0.
PaxDbiQ5T5C0.
PRIDEiQ5T5C0.

PTM databases

PhosphoSiteiQ5T5C0.

Expressioni

Gene expression databases

BgeeiQ5T5C0.
CleanExiHS_STXBP5.
ExpressionAtlasiQ5T5C0. baseline and differential.
GenevestigatoriQ5T5C0.

Organism-specific databases

HPAiHPA039991.
HPA049727.

Interactioni

Subunit structurei

Interacts with STX1A and STX1B via its v-SNARE homology domain. Part of a complex that contains STX1, STXBP5, SNAP25 and SYT1. Part of a complex that contains STXBP5, STX4A and SNAP23 (By similarity).By similarity

Protein-protein interaction databases

BioGridi126417. 13 interactions.
IntActiQ5T5C0. 1 interaction.
STRINGi9606.ENSP00000321826.

Structurei

3D structure databases

ProteinModelPortaliQ5T5C0.
SMRiQ5T5C0. Positions 504-530, 1087-1143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati61 – 9434WD 1Add
BLAST
Repeati101 – 14040WD 2Add
BLAST
Repeati145 – 18137WD 3Add
BLAST
Repeati200 – 23435WD 4Add
BLAST
Repeati240 – 27233WD 5Add
BLAST
Repeati294 – 33643WD 6Add
BLAST
Repeati344 – 37835WD 7Add
BLAST
Repeati400 – 47778WD 8Add
BLAST
Repeati505 – 619115WD 9Add
BLAST
Repeati633 – 69563WD 10Add
BLAST
Repeati794 – 85158WD 11Add
BLAST
Repeati860 – 93475WD 12Add
BLAST
Repeati939 – 98345WD 13Add
BLAST
Repeati997 – 102024WD 14Add
BLAST
Domaini1086 – 114661v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 276Poly-Gln
Compositional biasi584 – 5907Poly-Ser

Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation
Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG289584.
GeneTreeiENSGT00390000000018.
HOGENOMiHOG000110929.
HOVERGENiHBG083064.
InParanoidiQ5T5C0.
KOiK08518.
OMAiRYTHDEA.
OrthoDBiEOG7DVD96.
PhylomeDBiQ5T5C0.
TreeFamiTF314585.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR000664. Lethal2_giant.
IPR013905. Lgl_C_dom.
IPR013577. LLGL2.
IPR001388. Synaptobrevin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
PF08366. LLGL. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00962. LETHAL2GIANT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS50892. V_SNARE. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T5C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRKFNIRKVL DGLTAGSSSA SQQQQQQHPP GNREPEIQET LQSEHFQLCK
60 70 80 90 100
TVRHGFPYQP SALAFDPVQK ILAVGTQTGA LRLFGRPGVE CYCQHDSGAA
110 120 130 140 150
VIQLQFLINE GALVSALADD TLHLWNLRQK RPAILHSLKF CRERVTFCHL
160 170 180 190 200
PFQSKWLYVG TERGNIHIVN VESFTLSGYV IMWNKAIELS SKSHPGPVVH
210 220 230 240 250
ISDNPMDEGK LLIGFESGTV VLWDLKSKKA DYRYTYDEAI HSVAWHHEGK
260 270 280 290 300
QFICSHSDGT LTIWNVRSPA KPVQTITPHG KQLKDGKKPE PCKPILKVEF
310 320 330 340 350
KTTRSGEPFI ILSGGLSYDT VGRRPCLTVM HGKSTAVLEM DYSIVDFLTL
360 370 380 390 400
CETPYPNDFQ EPYAVVVLLE KDLVLIDLAQ NGYPIFENPY PLSIHESPVT
410 420 430 440 450
CCEYFADCPV DLIPALYSVG ARQKRQGYSK KEWPINGGNW GLGAQSYPEI
460 470 480 490 500
IITGHADGSV KFWDASAITL QVLYKLKTSK VFEKSRNKDD RPNTDIVDED
510 520 530 540 550
PYAIQIISWC PESRMLCIAG VSAHVIIYRF SKQEVITEVI PMLEVRLLYE
560 570 580 590 600
INDVETPEGE QPPPLPTPVG GSNPQPIPPQ SHPSTSSSSS DGLRDNVPCL
610 620 630 640 650
KVKNSPLKQS PGYQTELVIQ LVWVGGEPPQ QITSLAVNSS YGLVVFGNCN
660 670 680 690 700
GIAMVDYLQK AVLLNLGTIE LYGSNDPYRR EPRSPRKSRQ PSGAGLCDIS
710 720 730 740 750
EGTVVPEDRC KSPTSGSSSP HNSDDEQKMN NFIEKVKTKS RKFSKMVAND
760 770 780 790 800
IAKMSRKLSL PTDLKPDLDV KDNSFSRSRS SSVTSIDKES REAISALHFC
810 820 830 840 850
ETFTRKTDSS PSPCLWVGTT LGTVLVIALN LPPGGEQRLL QPVIVSPSGT
860 870 880 890 900
ILRLKGAILR MAFLDTTGCL IPPAYEPWRE HNVPEEKDEK EKLKKRRPVS
910 920 930 940 950
VSPSSSQEIS ENQYAVICSE KQAKVISLPT QNCAYKQNIT ETSFVLRGDI
960 970 980 990 1000
VALSNSICLA CFCANGHIMT FSLPSLRPLL DVYYLPLTNM RIARTFCFTN
1010 1020 1030 1040 1050
NGQALYLVSP TEIQRLTYSQ ETCENLQEML GELFTPVETP EAPNRGFFKG
1060 1070 1080 1090 1100
LFGGGAQSLD REELFGESSS GKASRSLAQH IPGPGGIEGV KGAASGVVGE
1110 1120 1130 1140 1150
LARARLALDE RGQKLGDLEE RTAAMLSSAE SFSKHAHEIM LKYKDKKWYQ

F
Length:1,151
Mass (Da):127,573
Last modified:December 21, 2004 - v1
Checksum:i247083A17DEA4811
GO
Isoform 2 (identifier: Q5T5C0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-751: Missing.

Show »
Length:1,115
Mass (Da):123,492
Checksum:i2F1874662D9B30F6
GO
Isoform 3 (identifier: Q5T5C0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-768: Missing.

Show »
Length:1,098
Mass (Da):121,597
Checksum:iB8EAE43977084610
GO

Sequence cautioni

The sequence BAC03475.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti436 – 4361N → S.
Corresponds to variant rs1039084 [ dbSNP | Ensembl ].
VAR_035235

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei716 – 76853Missing in isoform 3. CuratedVSP_016204Add
BLAST
Alternative sequencei716 – 75136Missing in isoform 2. 2 PublicationsVSP_016205Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20239.1.
AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20240.1.
AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20241.1.
AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40423.1.
AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40424.1.
AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40425.1.
AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40739.1.
AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40740.1.
AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40741.1.
BC113382 mRNA. Translation: AAI13383.1.
AK055484 mRNA. Translation: BAB70930.1.
AK090549 mRNA. Translation: BAC03475.1. Different initiation.
CCDSiCCDS47499.1. [Q5T5C0-1]
CCDS5211.1. [Q5T5C0-2]
RefSeqiNP_001121187.1. NM_001127715.2. [Q5T5C0-1]
NP_640337.3. NM_139244.4. [Q5T5C0-2]
UniGeneiHs.736439.
Hs.86320.

Genome annotation databases

EnsembliENST00000321680; ENSP00000321826; ENSG00000164506. [Q5T5C0-1]
ENST00000367480; ENSP00000356450; ENSG00000164506. [Q5T5C0-3]
ENST00000367481; ENSP00000356451; ENSG00000164506. [Q5T5C0-2]
GeneIDi134957.
KEGGihsa:134957.
UCSCiuc003qlz.3. human. [Q5T5C0-1]
uc010khz.2. human. [Q5T5C0-2]

Polymorphism databases

DMDMi74762236.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20239.1.
AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20240.1.
AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20241.1.
AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40423.1.
AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40424.1.
AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40425.1.
AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40739.1.
AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40740.1.
AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40741.1.
BC113382 mRNA. Translation: AAI13383.1.
AK055484 mRNA. Translation: BAB70930.1.
AK090549 mRNA. Translation: BAC03475.1. Different initiation.
CCDSiCCDS47499.1. [Q5T5C0-1]
CCDS5211.1. [Q5T5C0-2]
RefSeqiNP_001121187.1. NM_001127715.2. [Q5T5C0-1]
NP_640337.3. NM_139244.4. [Q5T5C0-2]
UniGeneiHs.736439.
Hs.86320.

3D structure databases

ProteinModelPortaliQ5T5C0.
SMRiQ5T5C0. Positions 504-530, 1087-1143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126417. 13 interactions.
IntActiQ5T5C0. 1 interaction.
STRINGi9606.ENSP00000321826.

PTM databases

PhosphoSiteiQ5T5C0.

Polymorphism databases

DMDMi74762236.

Proteomic databases

MaxQBiQ5T5C0.
PaxDbiQ5T5C0.
PRIDEiQ5T5C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321680; ENSP00000321826; ENSG00000164506. [Q5T5C0-1]
ENST00000367480; ENSP00000356450; ENSG00000164506. [Q5T5C0-3]
ENST00000367481; ENSP00000356451; ENSG00000164506. [Q5T5C0-2]
GeneIDi134957.
KEGGihsa:134957.
UCSCiuc003qlz.3. human. [Q5T5C0-1]
uc010khz.2. human. [Q5T5C0-2]

Organism-specific databases

CTDi134957.
GeneCardsiGC06P147566.
H-InvDBHIX0019766.
HGNCiHGNC:19665. STXBP5.
HPAiHPA039991.
HPA049727.
MIMi604586. gene.
neXtProtiNX_Q5T5C0.
PharmGKBiPA134954258.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG289584.
GeneTreeiENSGT00390000000018.
HOGENOMiHOG000110929.
HOVERGENiHBG083064.
InParanoidiQ5T5C0.
KOiK08518.
OMAiRYTHDEA.
OrthoDBiEOG7DVD96.
PhylomeDBiQ5T5C0.
TreeFamiTF314585.

Enzyme and pathway databases

SignaLinkiQ5T5C0.

Miscellaneous databases

ChiTaRSiSTXBP5. human.
GeneWikiiSTXBP5.
GenomeRNAii134957.
NextBioi83439.
PROiQ5T5C0.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T5C0.
CleanExiHS_STXBP5.
ExpressionAtlasiQ5T5C0. baseline and differential.
GenevestigatoriQ5T5C0.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR000664. Lethal2_giant.
IPR013905. Lgl_C_dom.
IPR013577. LLGL2.
IPR001388. Synaptobrevin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
PF08366. LLGL. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00962. LETHAL2GIANT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS50892. V_SNARE. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 373-1151 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 670-1151 (ISOFORM 2).
    Tissue: Brain.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-762, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-785, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759 AND THR-1039, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSTXB5_HUMAN
AccessioniPrimary (citable) accession number: Q5T5C0
Secondary accession number(s): Q14DF3
, Q5T5C1, Q5T5C2, Q8NBG8, Q96NG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 21, 2004
Last modified: March 4, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.