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Q5T5C0

- STXB5_HUMAN

UniProt

Q5T5C0 - STXB5_HUMAN

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Protein
Syntaxin-binding protein 5
Gene
STXBP5, LLGL3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding By similarity.

GO - Molecular functioni

  1. syntaxin-1 binding Source: BHF-UCL

GO - Biological processi

  1. exocytosis Source: UniProtKB-KW
  2. positive regulation of exocytosis Source: BHF-UCL
  3. protein transport Source: UniProtKB-KW
  4. regulation of blood coagulation Source: UniProt
  5. regulation of gene expression Source: UniProt
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

SignaLinkiQ5T5C0.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 5
Alternative name(s):
Lethal(2) giant larvae protein homolog 3
Tomosyn-1
Gene namesi
Name:STXBP5
Synonyms:LLGL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:19665. STXBP5.

Subcellular locationi

Cytoplasm By similarity. Cell membrane; Peripheral membrane protein By similarity. Cytoplasmic vesicle membrane; Peripheral membrane protein By similarity. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle By similarity. Cell junctionsynapse By similarity
Note: Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles By similarity.

GO - Cellular componenti

  1. acetylcholine-gated channel complex Source: BHF-UCL
  2. cell junction Source: UniProtKB-KW
  3. cytoplasm Source: HPA
  4. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  5. synaptic vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134954258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11511151Syntaxin-binding protein 5
PRO_0000051244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei723 – 7231Phosphoserine; by PKA By similarity
Modified residuei759 – 7591Phosphoserine1 Publication
Modified residuei762 – 7621Phosphothreonine1 Publication
Modified residuei782 – 7821Phosphoserine By similarity
Modified residuei785 – 7851Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5T5C0.
PaxDbiQ5T5C0.
PRIDEiQ5T5C0.

PTM databases

PhosphoSiteiQ5T5C0.

Expressioni

Gene expression databases

ArrayExpressiQ5T5C0.
BgeeiQ5T5C0.
CleanExiHS_STXBP5.
GenevestigatoriQ5T5C0.

Organism-specific databases

HPAiHPA039991.
HPA049727.

Interactioni

Subunit structurei

Interacts with STX1A and STX1B via its v-SNARE homology domain. Part of a complex that contains STX1, STXBP5, SNAP25 and SYT1. Part of a complex that contains STXBP5, STX4A and SNAP23 By similarity.

Protein-protein interaction databases

BioGridi126417. 5 interactions.
IntActiQ5T5C0. 1 interaction.
STRINGi9606.ENSP00000321826.

Structurei

3D structure databases

ProteinModelPortaliQ5T5C0.
SMRiQ5T5C0. Positions 1087-1143.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati61 – 9434WD 1
Add
BLAST
Repeati101 – 14040WD 2
Add
BLAST
Repeati145 – 18137WD 3
Add
BLAST
Repeati200 – 23435WD 4
Add
BLAST
Repeati240 – 27233WD 5
Add
BLAST
Repeati294 – 33643WD 6
Add
BLAST
Repeati344 – 37835WD 7
Add
BLAST
Repeati400 – 47778WD 8
Add
BLAST
Repeati505 – 619115WD 9
Add
BLAST
Repeati633 – 69563WD 10
Add
BLAST
Repeati794 – 85158WD 11
Add
BLAST
Repeati860 – 93475WD 12
Add
BLAST
Repeati939 – 98345WD 13
Add
BLAST
Repeati997 – 102024WD 14
Add
BLAST
Domaini1086 – 114661v-SNARE coiled-coil homology
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 276Poly-Gln
Compositional biasi584 – 5907Poly-Ser

Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.
Contains 14 WD repeats.

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG289584.
HOGENOMiHOG000110929.
HOVERGENiHBG083064.
InParanoidiQ5T5C0.
KOiK08518.
OMAiRYTHDEA.
OrthoDBiEOG7DVD96.
PhylomeDBiQ5T5C0.
TreeFamiTF314585.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR000664. Lethal2_giant.
IPR013905. Lgl_C_dom.
IPR013577. LLGL2.
IPR001388. Synaptobrevin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
PF08366. LLGL. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00962. LETHAL2GIANT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
PROSITEiPS50892. V_SNARE. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T5C0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRKFNIRKVL DGLTAGSSSA SQQQQQQHPP GNREPEIQET LQSEHFQLCK     50
TVRHGFPYQP SALAFDPVQK ILAVGTQTGA LRLFGRPGVE CYCQHDSGAA 100
VIQLQFLINE GALVSALADD TLHLWNLRQK RPAILHSLKF CRERVTFCHL 150
PFQSKWLYVG TERGNIHIVN VESFTLSGYV IMWNKAIELS SKSHPGPVVH 200
ISDNPMDEGK LLIGFESGTV VLWDLKSKKA DYRYTYDEAI HSVAWHHEGK 250
QFICSHSDGT LTIWNVRSPA KPVQTITPHG KQLKDGKKPE PCKPILKVEF 300
KTTRSGEPFI ILSGGLSYDT VGRRPCLTVM HGKSTAVLEM DYSIVDFLTL 350
CETPYPNDFQ EPYAVVVLLE KDLVLIDLAQ NGYPIFENPY PLSIHESPVT 400
CCEYFADCPV DLIPALYSVG ARQKRQGYSK KEWPINGGNW GLGAQSYPEI 450
IITGHADGSV KFWDASAITL QVLYKLKTSK VFEKSRNKDD RPNTDIVDED 500
PYAIQIISWC PESRMLCIAG VSAHVIIYRF SKQEVITEVI PMLEVRLLYE 550
INDVETPEGE QPPPLPTPVG GSNPQPIPPQ SHPSTSSSSS DGLRDNVPCL 600
KVKNSPLKQS PGYQTELVIQ LVWVGGEPPQ QITSLAVNSS YGLVVFGNCN 650
GIAMVDYLQK AVLLNLGTIE LYGSNDPYRR EPRSPRKSRQ PSGAGLCDIS 700
EGTVVPEDRC KSPTSGSSSP HNSDDEQKMN NFIEKVKTKS RKFSKMVAND 750
IAKMSRKLSL PTDLKPDLDV KDNSFSRSRS SSVTSIDKES REAISALHFC 800
ETFTRKTDSS PSPCLWVGTT LGTVLVIALN LPPGGEQRLL QPVIVSPSGT 850
ILRLKGAILR MAFLDTTGCL IPPAYEPWRE HNVPEEKDEK EKLKKRRPVS 900
VSPSSSQEIS ENQYAVICSE KQAKVISLPT QNCAYKQNIT ETSFVLRGDI 950
VALSNSICLA CFCANGHIMT FSLPSLRPLL DVYYLPLTNM RIARTFCFTN 1000
NGQALYLVSP TEIQRLTYSQ ETCENLQEML GELFTPVETP EAPNRGFFKG 1050
LFGGGAQSLD REELFGESSS GKASRSLAQH IPGPGGIEGV KGAASGVVGE 1100
LARARLALDE RGQKLGDLEE RTAAMLSSAE SFSKHAHEIM LKYKDKKWYQ 1150
F 1151
Length:1,151
Mass (Da):127,573
Last modified:December 21, 2004 - v1
Checksum:i247083A17DEA4811
GO
Isoform 2 (identifier: Q5T5C0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-751: Missing.

Show »
Length:1,115
Mass (Da):123,492
Checksum:i2F1874662D9B30F6
GO
Isoform 3 (identifier: Q5T5C0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-768: Missing.

Show »
Length:1,098
Mass (Da):121,597
Checksum:iB8EAE43977084610
GO

Sequence cautioni

The sequence BAC03475.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti436 – 4361N → S.
Corresponds to variant rs1039084 [ dbSNP | Ensembl ].
VAR_035235

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei716 – 76853Missing in isoform 3.
VSP_016204Add
BLAST
Alternative sequencei716 – 75136Missing in isoform 2.
VSP_016205Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20239.1.
AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20240.1.
AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20241.1.
AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40423.1.
AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40424.1.
AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40425.1.
AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40739.1.
AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40740.1.
AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40741.1.
BC113382 mRNA. Translation: AAI13383.1.
AK055484 mRNA. Translation: BAB70930.1.
AK090549 mRNA. Translation: BAC03475.1. Different initiation.
CCDSiCCDS47499.1. [Q5T5C0-1]
CCDS5211.1. [Q5T5C0-2]
RefSeqiNP_001121187.1. NM_001127715.2. [Q5T5C0-1]
NP_640337.3. NM_139244.4. [Q5T5C0-2]
UniGeneiHs.736439.
Hs.86320.

Genome annotation databases

EnsembliENST00000321680; ENSP00000321826; ENSG00000164506. [Q5T5C0-1]
ENST00000367480; ENSP00000356450; ENSG00000164506. [Q5T5C0-3]
ENST00000367481; ENSP00000356451; ENSG00000164506. [Q5T5C0-2]
GeneIDi134957.
KEGGihsa:134957.
UCSCiuc003qlz.3. human. [Q5T5C0-1]
uc010khz.2. human. [Q5T5C0-2]

Polymorphism databases

DMDMi74762236.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL356415 , AL355365 , AL590709 Genomic DNA. Translation: CAI20239.1 .
AL356415 , AL355365 , AL590709 Genomic DNA. Translation: CAI20240.1 .
AL356415 , AL355365 , AL590709 Genomic DNA. Translation: CAI20241.1 .
AL355365 , AL356415 , AL590709 Genomic DNA. Translation: CAI40423.1 .
AL355365 , AL356415 , AL590709 Genomic DNA. Translation: CAI40424.1 .
AL355365 , AL356415 , AL590709 Genomic DNA. Translation: CAI40425.1 .
AL590709 , AL355365 , AL356415 Genomic DNA. Translation: CAI40739.1 .
AL590709 , AL355365 , AL356415 Genomic DNA. Translation: CAI40740.1 .
AL590709 , AL355365 , AL356415 Genomic DNA. Translation: CAI40741.1 .
BC113382 mRNA. Translation: AAI13383.1 .
AK055484 mRNA. Translation: BAB70930.1 .
AK090549 mRNA. Translation: BAC03475.1 . Different initiation.
CCDSi CCDS47499.1. [Q5T5C0-1 ]
CCDS5211.1. [Q5T5C0-2 ]
RefSeqi NP_001121187.1. NM_001127715.2. [Q5T5C0-1 ]
NP_640337.3. NM_139244.4. [Q5T5C0-2 ]
UniGenei Hs.736439.
Hs.86320.

3D structure databases

ProteinModelPortali Q5T5C0.
SMRi Q5T5C0. Positions 1087-1143.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126417. 5 interactions.
IntActi Q5T5C0. 1 interaction.
STRINGi 9606.ENSP00000321826.

PTM databases

PhosphoSitei Q5T5C0.

Polymorphism databases

DMDMi 74762236.

Proteomic databases

MaxQBi Q5T5C0.
PaxDbi Q5T5C0.
PRIDEi Q5T5C0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321680 ; ENSP00000321826 ; ENSG00000164506 . [Q5T5C0-1 ]
ENST00000367480 ; ENSP00000356450 ; ENSG00000164506 . [Q5T5C0-3 ]
ENST00000367481 ; ENSP00000356451 ; ENSG00000164506 . [Q5T5C0-2 ]
GeneIDi 134957.
KEGGi hsa:134957.
UCSCi uc003qlz.3. human. [Q5T5C0-1 ]
uc010khz.2. human. [Q5T5C0-2 ]

Organism-specific databases

CTDi 134957.
GeneCardsi GC06P147566.
H-InvDB HIX0019766.
HGNCi HGNC:19665. STXBP5.
HPAi HPA039991.
HPA049727.
MIMi 604586. gene.
neXtProti NX_Q5T5C0.
PharmGKBi PA134954258.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289584.
HOGENOMi HOG000110929.
HOVERGENi HBG083064.
InParanoidi Q5T5C0.
KOi K08518.
OMAi RYTHDEA.
OrthoDBi EOG7DVD96.
PhylomeDBi Q5T5C0.
TreeFami TF314585.

Enzyme and pathway databases

SignaLinki Q5T5C0.

Miscellaneous databases

ChiTaRSi STXBP5. human.
GeneWikii STXBP5.
GenomeRNAii 134957.
NextBioi 83439.
PROi Q5T5C0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5T5C0.
Bgeei Q5T5C0.
CleanExi HS_STXBP5.
Genevestigatori Q5T5C0.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR000664. Lethal2_giant.
IPR013905. Lgl_C_dom.
IPR013577. LLGL2.
IPR001388. Synaptobrevin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF08596. Lgl_C. 1 hit.
PF08366. LLGL. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view ]
PRINTSi PR00962. LETHAL2GIANT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 6 hits.
PROSITEi PS50892. V_SNARE. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 373-1151 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 670-1151 (ISOFORM 2).
    Tissue: Brain.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-762, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-785, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiSTXB5_HUMAN
AccessioniPrimary (citable) accession number: Q5T5C0
Secondary accession number(s): Q14DF3
, Q5T5C1, Q5T5C2, Q8NBG8, Q96NG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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