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Q5T5C0

- STXB5_HUMAN

UniProt

Q5T5C0 - STXB5_HUMAN

Protein

Syntaxin-binding protein 5

Gene

STXBP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding By similarity.By similarity

    GO - Molecular functioni

    1. syntaxin-1 binding Source: BHF-UCL

    GO - Biological processi

    1. exocytosis Source: UniProtKB-KW
    2. positive regulation of exocytosis Source: BHF-UCL
    3. protein transport Source: UniProtKB-KW
    4. regulation of blood coagulation Source: UniProt
    5. regulation of gene expression Source: UniProt

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Enzyme and pathway databases

    SignaLinkiQ5T5C0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-binding protein 5
    Alternative name(s):
    Lethal(2) giant larvae protein homolog 3
    Tomosyn-1
    Gene namesi
    Name:STXBP5
    Synonyms:LLGL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:19665. STXBP5.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle By similarity. Cell junctionsynapse By similarity
    Note: Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles By similarity.By similarity

    GO - Cellular componenti

    1. acetylcholine-gated channel complex Source: BHF-UCL
    2. cell junction Source: UniProtKB-KW
    3. cytoplasm Source: HPA
    4. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    5. synaptic vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134954258.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11511151Syntaxin-binding protein 5PRO_0000051244Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei723 – 7231Phosphoserine; by PKABy similarity
    Modified residuei759 – 7591Phosphoserine1 Publication
    Modified residuei762 – 7621Phosphothreonine1 Publication
    Modified residuei782 – 7821PhosphoserineBy similarity
    Modified residuei785 – 7851Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5T5C0.
    PaxDbiQ5T5C0.
    PRIDEiQ5T5C0.

    PTM databases

    PhosphoSiteiQ5T5C0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5T5C0.
    BgeeiQ5T5C0.
    CleanExiHS_STXBP5.
    GenevestigatoriQ5T5C0.

    Organism-specific databases

    HPAiHPA039991.
    HPA049727.

    Interactioni

    Subunit structurei

    Interacts with STX1A and STX1B via its v-SNARE homology domain. Part of a complex that contains STX1, STXBP5, SNAP25 and SYT1. Part of a complex that contains STXBP5, STX4A and SNAP23 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi126417. 6 interactions.
    IntActiQ5T5C0. 1 interaction.
    STRINGi9606.ENSP00000321826.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T5C0.
    SMRiQ5T5C0. Positions 1087-1143.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati61 – 9434WD 1Add
    BLAST
    Repeati101 – 14040WD 2Add
    BLAST
    Repeati145 – 18137WD 3Add
    BLAST
    Repeati200 – 23435WD 4Add
    BLAST
    Repeati240 – 27233WD 5Add
    BLAST
    Repeati294 – 33643WD 6Add
    BLAST
    Repeati344 – 37835WD 7Add
    BLAST
    Repeati400 – 47778WD 8Add
    BLAST
    Repeati505 – 619115WD 9Add
    BLAST
    Repeati633 – 69563WD 10Add
    BLAST
    Repeati794 – 85158WD 11Add
    BLAST
    Repeati860 – 93475WD 12Add
    BLAST
    Repeati939 – 98345WD 13Add
    BLAST
    Repeati997 – 102024WD 14Add
    BLAST
    Domaini1086 – 114661v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi22 – 276Poly-Gln
    Compositional biasi584 – 5907Poly-Ser

    Sequence similaritiesi

    Belongs to the WD repeat L(2)GL family.Curated
    Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation
    Contains 14 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG289584.
    HOGENOMiHOG000110929.
    HOVERGENiHBG083064.
    InParanoidiQ5T5C0.
    KOiK08518.
    OMAiRYTHDEA.
    OrthoDBiEOG7DVD96.
    PhylomeDBiQ5T5C0.
    TreeFamiTF314585.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR000664. Lethal2_giant.
    IPR013905. Lgl_C_dom.
    IPR013577. LLGL2.
    IPR001388. Synaptobrevin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF08596. Lgl_C. 1 hit.
    PF08366. LLGL. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view]
    PRINTSiPR00962. LETHAL2GIANT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 6 hits.
    PROSITEiPS50892. V_SNARE. 1 hit.
    PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T5C0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRKFNIRKVL DGLTAGSSSA SQQQQQQHPP GNREPEIQET LQSEHFQLCK     50
    TVRHGFPYQP SALAFDPVQK ILAVGTQTGA LRLFGRPGVE CYCQHDSGAA 100
    VIQLQFLINE GALVSALADD TLHLWNLRQK RPAILHSLKF CRERVTFCHL 150
    PFQSKWLYVG TERGNIHIVN VESFTLSGYV IMWNKAIELS SKSHPGPVVH 200
    ISDNPMDEGK LLIGFESGTV VLWDLKSKKA DYRYTYDEAI HSVAWHHEGK 250
    QFICSHSDGT LTIWNVRSPA KPVQTITPHG KQLKDGKKPE PCKPILKVEF 300
    KTTRSGEPFI ILSGGLSYDT VGRRPCLTVM HGKSTAVLEM DYSIVDFLTL 350
    CETPYPNDFQ EPYAVVVLLE KDLVLIDLAQ NGYPIFENPY PLSIHESPVT 400
    CCEYFADCPV DLIPALYSVG ARQKRQGYSK KEWPINGGNW GLGAQSYPEI 450
    IITGHADGSV KFWDASAITL QVLYKLKTSK VFEKSRNKDD RPNTDIVDED 500
    PYAIQIISWC PESRMLCIAG VSAHVIIYRF SKQEVITEVI PMLEVRLLYE 550
    INDVETPEGE QPPPLPTPVG GSNPQPIPPQ SHPSTSSSSS DGLRDNVPCL 600
    KVKNSPLKQS PGYQTELVIQ LVWVGGEPPQ QITSLAVNSS YGLVVFGNCN 650
    GIAMVDYLQK AVLLNLGTIE LYGSNDPYRR EPRSPRKSRQ PSGAGLCDIS 700
    EGTVVPEDRC KSPTSGSSSP HNSDDEQKMN NFIEKVKTKS RKFSKMVAND 750
    IAKMSRKLSL PTDLKPDLDV KDNSFSRSRS SSVTSIDKES REAISALHFC 800
    ETFTRKTDSS PSPCLWVGTT LGTVLVIALN LPPGGEQRLL QPVIVSPSGT 850
    ILRLKGAILR MAFLDTTGCL IPPAYEPWRE HNVPEEKDEK EKLKKRRPVS 900
    VSPSSSQEIS ENQYAVICSE KQAKVISLPT QNCAYKQNIT ETSFVLRGDI 950
    VALSNSICLA CFCANGHIMT FSLPSLRPLL DVYYLPLTNM RIARTFCFTN 1000
    NGQALYLVSP TEIQRLTYSQ ETCENLQEML GELFTPVETP EAPNRGFFKG 1050
    LFGGGAQSLD REELFGESSS GKASRSLAQH IPGPGGIEGV KGAASGVVGE 1100
    LARARLALDE RGQKLGDLEE RTAAMLSSAE SFSKHAHEIM LKYKDKKWYQ 1150
    F 1151
    Length:1,151
    Mass (Da):127,573
    Last modified:December 21, 2004 - v1
    Checksum:i247083A17DEA4811
    GO
    Isoform 2 (identifier: Q5T5C0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         716-751: Missing.

    Show »
    Length:1,115
    Mass (Da):123,492
    Checksum:i2F1874662D9B30F6
    GO
    Isoform 3 (identifier: Q5T5C0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         716-768: Missing.

    Show »
    Length:1,098
    Mass (Da):121,597
    Checksum:iB8EAE43977084610
    GO

    Sequence cautioni

    The sequence BAC03475.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti436 – 4361N → S.
    Corresponds to variant rs1039084 [ dbSNP | Ensembl ].
    VAR_035235

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei716 – 76853Missing in isoform 3. CuratedVSP_016204Add
    BLAST
    Alternative sequencei716 – 75136Missing in isoform 2. 2 PublicationsVSP_016205Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20239.1.
    AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20240.1.
    AL356415, AL355365, AL590709 Genomic DNA. Translation: CAI20241.1.
    AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40423.1.
    AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40424.1.
    AL355365, AL356415, AL590709 Genomic DNA. Translation: CAI40425.1.
    AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40739.1.
    AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40740.1.
    AL590709, AL355365, AL356415 Genomic DNA. Translation: CAI40741.1.
    BC113382 mRNA. Translation: AAI13383.1.
    AK055484 mRNA. Translation: BAB70930.1.
    AK090549 mRNA. Translation: BAC03475.1. Different initiation.
    CCDSiCCDS47499.1. [Q5T5C0-1]
    CCDS5211.1. [Q5T5C0-2]
    RefSeqiNP_001121187.1. NM_001127715.2. [Q5T5C0-1]
    NP_640337.3. NM_139244.4. [Q5T5C0-2]
    UniGeneiHs.736439.
    Hs.86320.

    Genome annotation databases

    EnsembliENST00000321680; ENSP00000321826; ENSG00000164506. [Q5T5C0-1]
    ENST00000367480; ENSP00000356450; ENSG00000164506. [Q5T5C0-3]
    ENST00000367481; ENSP00000356451; ENSG00000164506. [Q5T5C0-2]
    GeneIDi134957.
    KEGGihsa:134957.
    UCSCiuc003qlz.3. human. [Q5T5C0-1]
    uc010khz.2. human. [Q5T5C0-2]

    Polymorphism databases

    DMDMi74762236.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL356415 , AL355365 , AL590709 Genomic DNA. Translation: CAI20239.1 .
    AL356415 , AL355365 , AL590709 Genomic DNA. Translation: CAI20240.1 .
    AL356415 , AL355365 , AL590709 Genomic DNA. Translation: CAI20241.1 .
    AL355365 , AL356415 , AL590709 Genomic DNA. Translation: CAI40423.1 .
    AL355365 , AL356415 , AL590709 Genomic DNA. Translation: CAI40424.1 .
    AL355365 , AL356415 , AL590709 Genomic DNA. Translation: CAI40425.1 .
    AL590709 , AL355365 , AL356415 Genomic DNA. Translation: CAI40739.1 .
    AL590709 , AL355365 , AL356415 Genomic DNA. Translation: CAI40740.1 .
    AL590709 , AL355365 , AL356415 Genomic DNA. Translation: CAI40741.1 .
    BC113382 mRNA. Translation: AAI13383.1 .
    AK055484 mRNA. Translation: BAB70930.1 .
    AK090549 mRNA. Translation: BAC03475.1 . Different initiation.
    CCDSi CCDS47499.1. [Q5T5C0-1 ]
    CCDS5211.1. [Q5T5C0-2 ]
    RefSeqi NP_001121187.1. NM_001127715.2. [Q5T5C0-1 ]
    NP_640337.3. NM_139244.4. [Q5T5C0-2 ]
    UniGenei Hs.736439.
    Hs.86320.

    3D structure databases

    ProteinModelPortali Q5T5C0.
    SMRi Q5T5C0. Positions 1087-1143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126417. 6 interactions.
    IntActi Q5T5C0. 1 interaction.
    STRINGi 9606.ENSP00000321826.

    PTM databases

    PhosphoSitei Q5T5C0.

    Polymorphism databases

    DMDMi 74762236.

    Proteomic databases

    MaxQBi Q5T5C0.
    PaxDbi Q5T5C0.
    PRIDEi Q5T5C0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321680 ; ENSP00000321826 ; ENSG00000164506 . [Q5T5C0-1 ]
    ENST00000367480 ; ENSP00000356450 ; ENSG00000164506 . [Q5T5C0-3 ]
    ENST00000367481 ; ENSP00000356451 ; ENSG00000164506 . [Q5T5C0-2 ]
    GeneIDi 134957.
    KEGGi hsa:134957.
    UCSCi uc003qlz.3. human. [Q5T5C0-1 ]
    uc010khz.2. human. [Q5T5C0-2 ]

    Organism-specific databases

    CTDi 134957.
    GeneCardsi GC06P147566.
    H-InvDB HIX0019766.
    HGNCi HGNC:19665. STXBP5.
    HPAi HPA039991.
    HPA049727.
    MIMi 604586. gene.
    neXtProti NX_Q5T5C0.
    PharmGKBi PA134954258.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289584.
    HOGENOMi HOG000110929.
    HOVERGENi HBG083064.
    InParanoidi Q5T5C0.
    KOi K08518.
    OMAi RYTHDEA.
    OrthoDBi EOG7DVD96.
    PhylomeDBi Q5T5C0.
    TreeFami TF314585.

    Enzyme and pathway databases

    SignaLinki Q5T5C0.

    Miscellaneous databases

    ChiTaRSi STXBP5. human.
    GeneWikii STXBP5.
    GenomeRNAii 134957.
    NextBioi 83439.
    PROi Q5T5C0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5T5C0.
    Bgeei Q5T5C0.
    CleanExi HS_STXBP5.
    Genevestigatori Q5T5C0.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR000664. Lethal2_giant.
    IPR013905. Lgl_C_dom.
    IPR013577. LLGL2.
    IPR001388. Synaptobrevin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF08596. Lgl_C. 1 hit.
    PF08366. LLGL. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view ]
    PRINTSi PR00962. LETHAL2GIANT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 6 hits.
    PROSITEi PS50892. V_SNARE. 1 hit.
    PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 373-1151 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 670-1151 (ISOFORM 2).
      Tissue: Brain.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-762, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-785, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiSTXB5_HUMAN
    AccessioniPrimary (citable) accession number: Q5T5C0
    Secondary accession number(s): Q14DF3
    , Q5T5C1, Q5T5C2, Q8NBG8, Q96NG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3