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Protein

Late cornified envelope protein 3E

Gene

LCE3E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

Miscellaneous

Belongs to the LCE cluster present on 1q21.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 3E
Alternative name(s):
Late envelope protein 17
Gene namesi
Name:LCE3E
Synonyms:LEP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000185966.3
HGNCiHGNC:29463 LCE3E
MIMi612617 gene
neXtProtiNX_Q5T5B0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185966
PharmGKBiPA134941153

Polymorphism and mutation databases

DMDMi74745052

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002353371 – 92Late cornified envelope protein 3EAdd BLAST92

Proteomic databases

PaxDbiQ5T5B0
PeptideAtlasiQ5T5B0
PRIDEiQ5T5B0

PTM databases

iPTMnetiQ5T5B0
PhosphoSitePlusiQ5T5B0

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Inductioni

By UVB.1 Publication

Gene expression databases

BgeeiENSG00000185966
CleanExiHS_LCE3E

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131651, 19 interactors
IntActiQ5T5B0, 40 interactors
STRINGi9606.ENSP00000357778

Structurei

3D structure databases

ProteinModelPortaliQ5T5B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

GeneTreeiENSGT00900000141386
HOGENOMiHOG000236271
HOVERGENiHBG080673
InParanoidiQ5T5B0
OMAiCRRQRSD
OrthoDBiEOG09370K72
TreeFamiTF338709

Family and domain databases

InterProiView protein in InterPro
IPR028205 LCE
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 1 hit
PfamiView protein in Pfam
PF14672 LCE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5T5B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQNQKQC QPPPKCPSPK CPPKNPVQCL PPASSGCAPS SGGCGPSSEG
60 70 80 90
GCFLNHHRRH HRCRRQRSNS CDRGSGQQGG GSGCCHGSGG CC
Length:92
Mass (Da):9,507
Last modified:December 21, 2004 - v1
Checksum:iBF6DE9D5CD7E849A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356426 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53378.1
BC131716 mRNA Translation: AAI31717.1
CCDSiCCDS1013.1
RefSeqiNP_848522.1, NM_178435.3
XP_011507786.1, XM_011509484.1
UniGeneiHs.490208

Genome annotation databases

EnsembliENST00000368789; ENSP00000357778; ENSG00000185966
GeneIDi353145
KEGGihsa:353145
UCSCiuc001faa.5 human

Similar proteinsi

Entry informationi

Entry nameiLCE3E_HUMAN
AccessioniPrimary (citable) accession number: Q5T5B0
Secondary accession number(s): A2RRM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health