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Protein

Late cornified envelope protein 3E

Gene

LCE3E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

Miscellaneous

Belongs to the LCE cluster present on 1q21.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 3E
Alternative name(s):
Late envelope protein 17
Gene namesi
Name:LCE3E
Synonyms:LEP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29463. LCE3E.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi353145.
OpenTargetsiENSG00000185966.
PharmGKBiPA134941153.

Polymorphism and mutation databases

DMDMi74745052.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002353371 – 92Late cornified envelope protein 3EAdd BLAST92

Proteomic databases

PaxDbiQ5T5B0.
PeptideAtlasiQ5T5B0.
PRIDEiQ5T5B0.

PTM databases

iPTMnetiQ5T5B0.
PhosphoSitePlusiQ5T5B0.

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Inductioni

By UVB.1 Publication

Gene expression databases

CleanExiHS_LCE3E.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131651. 19 interactors.
IntActiQ5T5B0. 40 interactors.
STRINGi9606.ENSP00000357778.

Structurei

3D structure databases

ProteinModelPortaliQ5T5B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000111493.
HOGENOMiHOG000236271.
HOVERGENiHBG080673.
InParanoidiQ5T5B0.
OMAiCRRQRSD.
OrthoDBi\N.
TreeFamiTF338709.

Family and domain databases

InterProiView protein in InterPro
IPR028205. LCE.
IPR026075. SPRR/LCE.
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiView protein in Pfam
PF14672. LCE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5T5B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQNQKQC QPPPKCPSPK CPPKNPVQCL PPASSGCAPS SGGCGPSSEG
60 70 80 90
GCFLNHHRRH HRCRRQRSNS CDRGSGQQGG GSGCCHGSGG CC
Length:92
Mass (Da):9,507
Last modified:December 21, 2004 - v1
Checksum:iBF6DE9D5CD7E849A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356426 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53378.1.
BC131716 mRNA. Translation: AAI31717.1.
CCDSiCCDS1013.1.
RefSeqiNP_848522.1. NM_178435.3.
XP_011507786.1. XM_011509484.1.
UniGeneiHs.490208.

Genome annotation databases

EnsembliENST00000368789; ENSP00000357778; ENSG00000185966.
GeneIDi353145.
KEGGihsa:353145.
UCSCiuc001faa.5. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLCE3E_HUMAN
AccessioniPrimary (citable) accession number: Q5T5B0
Secondary accession number(s): A2RRM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families