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Protein

Late cornified envelope protein 3E

Gene

LCE3E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 3E
Alternative name(s):
Late envelope protein 17
Gene namesi
Name:LCE3E
Synonyms:LEP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29463. LCE3E.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941153.

Polymorphism and mutation databases

DMDMi74745052.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Late cornified envelope protein 3EPRO_0000235337Add
BLAST

Proteomic databases

PaxDbiQ5T5B0.
PRIDEiQ5T5B0.

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Inductioni

By UVB.1 Publication

Gene expression databases

CleanExiHS_LCE3E.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-10245456,EBI-10173507
HOXA1P496393EBI-10245456,EBI-740785
KRT40Q6A1623EBI-10245456,EBI-10171697
KRTAP10-5P603703EBI-10245456,EBI-10172150
KRTAP10-7P604093EBI-10245456,EBI-10172290
KRTAP10-8P604103EBI-10245456,EBI-10171774
KRTAP10-9P604114EBI-10245456,EBI-10172052
KRTAP3-2Q9BYR73EBI-10245456,EBI-751260
KRTAP4-12Q9BQ663EBI-10245456,EBI-739863
KRTAP4-2Q9BYR53EBI-10245456,EBI-10172511
KRTAP5-9P263713EBI-10245456,EBI-3958099
KRTAP9-2Q9BYQ43EBI-10245456,EBI-1044640
KRTAP9-4Q9BYQ23EBI-10245456,EBI-10185730
MDFIQ997503EBI-10245456,EBI-724076
NOTCH2NLQ7Z3S93EBI-10245456,EBI-945833
RGS20O760813EBI-10245456,EBI-1052678
RGS20O76081-63EBI-10245456,EBI-10178530
SPRY2O435973EBI-10245456,EBI-742487

Protein-protein interaction databases

BioGridi131651. 19 interactions.
IntActiQ5T5B0. 17 interactions.
STRINGi9606.ENSP00000357778.

Structurei

3D structure databases

ProteinModelPortaliQ5T5B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

GeneTreeiENSGT00840000130608.
HOGENOMiHOG000236271.
HOVERGENiHBG080673.
InParanoidiQ5T5B0.
OMAiCRRQRSD.
TreeFamiTF338709.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T5B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQNQKQC QPPPKCPSPK CPPKNPVQCL PPASSGCAPS SGGCGPSSEG
60 70 80 90
GCFLNHHRRH HRCRRQRSNS CDRGSGQQGG GSGCCHGSGG CC
Length:92
Mass (Da):9,507
Last modified:December 21, 2004 - v1
Checksum:iBF6DE9D5CD7E849A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356426 Genomic DNA. Translation: CAI19186.1.
CH471121 Genomic DNA. Translation: EAW53378.1.
BC131716 mRNA. Translation: AAI31717.1.
CCDSiCCDS1013.1.
RefSeqiNP_848522.1. NM_178435.3.
XP_011507786.1. XM_011509484.1.
UniGeneiHs.490208.

Genome annotation databases

EnsembliENST00000368789; ENSP00000357778; ENSG00000185966.
GeneIDi353145.
KEGGihsa:353145.
UCSCiuc001faa.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356426 Genomic DNA. Translation: CAI19186.1.
CH471121 Genomic DNA. Translation: EAW53378.1.
BC131716 mRNA. Translation: AAI31717.1.
CCDSiCCDS1013.1.
RefSeqiNP_848522.1. NM_178435.3.
XP_011507786.1. XM_011509484.1.
UniGeneiHs.490208.

3D structure databases

ProteinModelPortaliQ5T5B0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131651. 19 interactions.
IntActiQ5T5B0. 17 interactions.
STRINGi9606.ENSP00000357778.

Polymorphism and mutation databases

DMDMi74745052.

Proteomic databases

PaxDbiQ5T5B0.
PRIDEiQ5T5B0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368789; ENSP00000357778; ENSG00000185966.
GeneIDi353145.
KEGGihsa:353145.
UCSCiuc001faa.5. human.

Organism-specific databases

CTDi353145.
GeneCardsiLCE3E.
HGNCiHGNC:29463. LCE3E.
MIMi612617. gene.
neXtProtiNX_Q5T5B0.
PharmGKBiPA134941153.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00840000130608.
HOGENOMiHOG000236271.
HOVERGENiHBG080673.
InParanoidiQ5T5B0.
OMAiCRRQRSD.
TreeFamiTF338709.

Miscellaneous databases

GenomeRNAii353145.
NextBioi99716.
PROiQ5T5B0.
SOURCEiSearch...

Gene expression databases

CleanExiHS_LCE3E.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Late cornified envelope family in differentiating epithelia --response to calcium and ultraviolet irradiation."
    Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G., Byrne C.
    J. Invest. Dermatol. 124:1062-1070(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION BY UVB.

Entry informationi

Entry nameiLCE3E_HUMAN
AccessioniPrimary (citable) accession number: Q5T5B0
Secondary accession number(s): A2RRM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Belongs to the LCE cluster present on 1q21.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.