Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Late cornified envelope protein 3C

Gene

LCE3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Enzyme and pathway databases

BioCyciZFISH:G66-31455-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 3C
Alternative name(s):
Late envelope protein 15
Small proline-rich-like epidermal differentiation complex protein 3A
Gene namesi
Name:LCE3C
Synonyms:LEP15, SPRL3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16612. LCE3C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi353144.
OpenTargetsiENSG00000244057.
PharmGKBiPA38407.

Polymorphism and mutation databases

BioMutaiLCE3C.
DMDMi74745051.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002353351 – 94Late cornified envelope protein 3CAdd BLAST94

Proteomic databases

PaxDbiQ5T5A8.
PRIDEiQ5T5A8.

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Gene expression databases

BgeeiENSG00000244057.
CleanExiHS_LCE3C.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-35EBI-10245291,EBI-10173507
EFEMP2O959673EBI-10245291,EBI-743414
KRTAP10-5P603706EBI-10245291,EBI-10172150
KRTAP10-8P604105EBI-10245291,EBI-10171774
KRTAP10-9P604113EBI-10245291,EBI-10172052
KRTAP3-2Q9BYR75EBI-10245291,EBI-751260
KRTAP3-3Q9BYR63EBI-10245291,EBI-3957694
KRTAP4-2Q9BYR53EBI-10245291,EBI-10172511
KRTAP5-9P263715EBI-10245291,EBI-3958099
KRTAP9-4Q9BYQ23EBI-10245291,EBI-10185730
NOTCH2NLQ7Z3S95EBI-10245291,EBI-945833
PCSK5Q928243EBI-10245291,EBI-751290
RGS17Q9UGC63EBI-10245291,EBI-3918154
SPRY2O435973EBI-10245291,EBI-742487

Protein-protein interaction databases

BioGridi131650. 16 interactors.
IntActiQ5T5A8. 29 interactors.
STRINGi9606.ENSP00000334644.

Structurei

3D structure databases

ProteinModelPortaliQ5T5A8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 33Pro-richAdd BLAST22

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000111493.
HOVERGENiHBG079887.
InParanoidiQ5T5A8.
OMAiGSCCGHG.
PhylomeDBiQ5T5A8.
TreeFamiTF338709.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T5A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQNQQQC QPPPSCPSPK CPPKSPAQCL PPPSSDCALS SGGCGPSSES
60 70 80 90
GCCLSHHRHF RSHQCRRQRS NSCDRGSGQQ GGGSCRGHGS GGCC
Length:94
Mass (Da):9,729
Last modified:December 21, 2004 - v1
Checksum:iACA3379E00D9562C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356426 Genomic DNA. Translation: CAI19188.1.
CH878618 Genomic DNA. Translation: EAW50650.1.
BC130365 mRNA. Translation: AAI30366.1.
BC130367 mRNA. Translation: AAI30368.1.
CCDSiCCDS1015.1.
RefSeqiNP_848521.1. NM_178434.2.
UniGeneiHs.490211.

Genome annotation databases

EnsembliENST00000333881; ENSP00000334644; ENSG00000244057.
GeneIDi353144.
KEGGihsa:353144.
UCSCiuc001fac.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356426 Genomic DNA. Translation: CAI19188.1.
CH878618 Genomic DNA. Translation: EAW50650.1.
BC130365 mRNA. Translation: AAI30366.1.
BC130367 mRNA. Translation: AAI30368.1.
CCDSiCCDS1015.1.
RefSeqiNP_848521.1. NM_178434.2.
UniGeneiHs.490211.

3D structure databases

ProteinModelPortaliQ5T5A8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131650. 16 interactors.
IntActiQ5T5A8. 29 interactors.
STRINGi9606.ENSP00000334644.

Polymorphism and mutation databases

BioMutaiLCE3C.
DMDMi74745051.

Proteomic databases

PaxDbiQ5T5A8.
PRIDEiQ5T5A8.

Protocols and materials databases

DNASUi353144.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333881; ENSP00000334644; ENSG00000244057.
GeneIDi353144.
KEGGihsa:353144.
UCSCiuc001fac.2. human.

Organism-specific databases

CTDi353144.
DisGeNETi353144.
GeneCardsiLCE3C.
HGNCiHGNC:16612. LCE3C.
MIMi612615. gene.
neXtProtiNX_Q5T5A8.
OpenTargetsiENSG00000244057.
PharmGKBiPA38407.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000111493.
HOVERGENiHBG079887.
InParanoidiQ5T5A8.
OMAiGSCCGHG.
PhylomeDBiQ5T5A8.
TreeFamiTF338709.

Enzyme and pathway databases

BioCyciZFISH:G66-31455-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GenomeRNAii353144.
PROiQ5T5A8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000244057.
CleanExiHS_LCE3C.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCE3C_HUMAN
AccessioniPrimary (citable) accession number: Q5T5A8
Secondary accession number(s): A1L420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Belongs to the LCE cluster present on 1q21.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.