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Protein
Submitted name:

Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain, isoform CRA_a

Gene

ACADM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

FADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Submitted name:
Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain, isoform CRA_aImported
Submitted name:
Medium-chain-specific acyl-CoA dehydrogenase, mitochondrialImported
Gene namesi
Name:ACADMImported
ORF Names:hCG_22915Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117054.13
HGNCiHGNC:89 ACADM

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117054

Expressioni

Gene expression databases

BgeeiENSG00000117054

Interactioni

Protein-protein interaction databases

IntActiQ5T4U5, 2 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 95Acyl-CoA_dh_NInterPro annotationAdd BLAST54
Domaini127 – 183Acyl-CoA_dh_NInterPro annotationAdd BLAST57
Domaini190 – 288Acyl-CoA_dh_MInterPro annotationAdd BLAST99
Domaini300 – 447Acyl-CoA_dh_1InterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119007
HOVERGENiHBG000224
OMAiCPPSKAF
OrthoDBiEOG091G04BS

Family and domain databases

CDDicd01157 MCAD, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR009100 AcylCoA_DH/oxidase_NM_dom
IPR034180 MCAD
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 2 hits
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 2 hits
PROSITEiView protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5T4U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGFGRCCR VLRSISRFHW RSQHTKANRQ REPGLGFSFE FTEQQKEFQA
60 70 80 90 100
TARKFAREEI IPVAAEYDKT GEYPVPLIRR AWELGLMNTH IPENCDYSVC
110 120 130 140 150
PLLEACTLYL DAFFLLLTGS NLNLHLNLGG LGLGTFDACL ISEELAYGCT
160 170 180 190 200
GVQTAIEGNS LGQMPIIIAG NDQQKKKYLG RMTEEPLMCA YCVTEPGAGS
210 220 230 240 250
DVAGIKTKAE KKGDEYIING QKMWITNGGK ANWYFLLARS DPDPKAPANK
260 270 280 290 300
AFTGFIVEAD TPGIQIGRKE LNMGQRCSDT RGIVFEDVKV PKENVLIGDG
310 320 330 340 350
AGFKVAMGAF DKTRPVVAAG AVGLAQRALD EATKYALERK TFGKLLVEHQ
360 370 380 390 400
AISFMLAEMA MKVELARMSY QRAAWEVDSG RRNTYYASIA KAFAGDIANQ
410 420 430 440 450
LATDAVQILG GNGFNTEYPV EKLMRDAKIY QIYEGTSQIQ RLIVAREHID

KYKN
Length:454
Mass (Da):50,271
Last modified:December 21, 2004 - v1
Checksum:iE71D822F35F96E2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357314 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06399.1
RefSeqiNP_001272972.1, NM_001286043.1
UniGeneiHs.445040

Genome annotation databases

EnsembliENST00000370834; ENSP00000359871; ENSG00000117054
GeneIDi34
UCSCiuc009wbr.5 human

Similar proteinsi

Entry informationi

Entry nameiQ5T4U5_HUMAN
AccessioniPrimary (citable) accession number: Q5T4U5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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