ID   T170B_HUMAN             Reviewed;         132 AA.
AC   Q5T4T1;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   24-JAN-2024, entry version 116.
DE   RecName: Full=Transmembrane protein 170B;
GN   Name=TMEM170B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH
RP   CTNNB1.
RX   PubMed=29367600; DOI=10.1038/s41419-017-0128-y;
RA   Li M., Han Y., Zhou H., Li X., Lin C., Zhang E., Chi X., Hu J., Xu H.;
RT   "Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene
RT   that inhibits the Wnt/beta-catenin pathway.";
RL   Cell Death Dis. 9:91-91(2018).
CC   -!- FUNCTION: Negatively regulates the canonical Wnt signaling in breast
CC       cancer cells. Exerts an inhibitory effect on breast cancer growth by
CC       inhibiting CTNNB1 stabilization and nucleus translocation, which
CC       reduces the activity of Wnt targets (PubMed:29367600).
CC       {ECO:0000269|PubMed:29367600}.
CC   -!- SUBUNIT: Interacts with CTNNB1(PubMed:29367600).
CC       {ECO:0000269|PubMed:29367600}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29367600};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in normal breast tissues. Down-regulated
CC       in breast cancer cells (at protein level) (PubMed:29367600).
CC       {ECO:0000269|PubMed:29367600}.
CC   -!- SIMILARITY: Belongs to the TMEM170 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL357518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS43425.1; -.
DR   RefSeq; NP_001094299.1; NM_001100829.2.
DR   AlphaFoldDB; Q5T4T1; -.
DR   STRING; 9606.ENSP00000368737; -.
DR   GlyCosmos; Q5T4T1; 1 site, No reported glycans.
DR   GlyGen; Q5T4T1; 1 site.
DR   iPTMnet; Q5T4T1; -.
DR   PhosphoSitePlus; Q5T4T1; -.
DR   BioMuta; TMEM170B; -.
DR   DMDM; 74744982; -.
DR   PaxDb; 9606-ENSP00000368737; -.
DR   Antibodypedia; 71126; 5 antibodies from 5 providers.
DR   DNASU; 100113407; -.
DR   Ensembl; ENST00000379426.2; ENSP00000368737.1; ENSG00000205269.6.
DR   GeneID; 100113407; -.
DR   KEGG; hsa:100113407; -.
DR   MANE-Select; ENST00000379426.2; ENSP00000368737.1; NM_001100829.3; NP_001094299.1.
DR   UCSC; uc010jpa.5; human.
DR   AGR; HGNC:34244; -.
DR   CTD; 100113407; -.
DR   DisGeNET; 100113407; -.
DR   GeneCards; TMEM170B; -.
DR   HGNC; HGNC:34244; TMEM170B.
DR   HPA; ENSG00000205269; Tissue enhanced (bone).
DR   neXtProt; NX_Q5T4T1; -.
DR   OpenTargets; ENSG00000205269; -.
DR   PharmGKB; PA162405923; -.
DR   VEuPathDB; HostDB:ENSG00000205269; -.
DR   eggNOG; KOG4349; Eukaryota.
DR   GeneTree; ENSGT00940000160424; -.
DR   HOGENOM; CLU_149050_0_0_1; -.
DR   InParanoid; Q5T4T1; -.
DR   OMA; EAGENSM; -.
DR   OrthoDB; 2905873at2759; -.
DR   PhylomeDB; Q5T4T1; -.
DR   TreeFam; TF314615; -.
DR   PathwayCommons; Q5T4T1; -.
DR   SignaLink; Q5T4T1; -.
DR   BioGRID-ORCS; 100113407; 35 hits in 1148 CRISPR screens.
DR   Pharos; Q5T4T1; Tdark.
DR   PRO; PR:Q5T4T1; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q5T4T1; Protein.
DR   Bgee; ENSG00000205269; Expressed in Brodmann (1909) area 23 and 168 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR019334; Transmembrane_pr_170.
DR   PANTHER; PTHR22779:SF4; TRANSMEMBRANE PROTEIN 170B; 1.
DR   PANTHER; PTHR22779; UNCHARACTERIZED; 1.
DR   Pfam; PF10190; Tmemb_170; 1.
DR   Genevisible; Q5T4T1; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Wnt signaling pathway.
FT   CHAIN           1..132
FT                   /note="Transmembrane protein 170B"
FT                   /id="PRO_0000342267"
FT   TOPO_DOM        1..37
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..104
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..132
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   132 AA;  14360 MW;  DA9D091B59214A52 CRC64;
     MKAEGGDHSM INLSVQQVLS LWAHGTVLRN LTEMWYWIFL WALFSSLFVH GAAGVLMFVM
     LQRHRQGRVI SVIAVSIGFL ASVTGAMITS AAVAGIYRVA GKNMAPLEAL VWGVGQTVLT
     LIISFSRILA TL
//